Patents Examined by Howard C. Lee
  • Alkyl polyglycoside ether carboxylates
    Patent number: 5908928
    Abstract: A novel surfactant of formula I:R.sub.1 O(R.sub.2 O).sub.b (Z).sub.a OCH.sub.2 COO.sup.- X.sup.+Iwherein R.sub.1 is a monovalent organic radical having from about 6 to about 30 carbon atoms; R.sub.2 is divalent alkylene radical having from 2 to 4 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; b is a number having a value from 0 to about 12; a is a number having a value from 1 to about 6; and X is an alkali metal ion.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: June 1, 1999
    Assignee: Henkel Corporation
    Inventors: Norman Milstein, Barry A. Salka
  • Colon or ileum-specific steroid derivatives
    Patent number: 5908833
    Abstract: Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formulaGCS.sup.1 --O--Sugar.sup.1for colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their preparation, pharmaceutical preparations containing the compounds and the use of said compounds in therapy.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: June 1, 1999
    Assignee: Aktiebolaget Astra
    Inventors: Ralph Lennart Brattsand, Peter Edman, Thomas Hogberg, Stinabritt Nilsson, Bror Arne Thalen, Jan Erik Ulmius
  • Cellulosic ion-exchange medium, and method of making and using the same
    Patent number: 5907037
    Abstract: A cellulosic cationic ion-exchange composition is formed by sulfonation of activated cellulose having of high surface area characteristics, using an acid such as concentrated H.sub.2 SO.sub.4. The sulfonated material is convertible into different forms, viz., H-form, Na-form, K-form, NH.sub.4.sup.+ form, Ba-form, Ca-form, and Cu-form by appropriate reaction. The cation-exchanger has been found useful to treat industrial effluents for the removal of heavy metals, to achieve recovery of precious metals, to carry out water-softening, and the like.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: May 25, 1999
    Assignee: Central Technology, Inc.
    Inventors: Bir Singh Gujral, Harpreet S. Chadha
  • Halopropargyl inclusion complexes
    Patent number: 5906981
    Abstract: A biocidal composition which comprises an inclusion complex of a halopropargyl compound and a cyclodextrin or a modified cyclodextrin, useful broadly in industrial systems and more particularly in aqueous compositions used in connection with paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, and the like.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: May 25, 1999
    Assignee: Troy Corporation
    Inventor: Kamlesh D. Gaglani
  • Dextran formulations and method for treatment of inflammatory joint disorders
    Patent number: 5902800
    Abstract: This disclosure describes pharmaceutical compositions and a method for treatment of joint inflammation and pain bought about by e.g. arthritis, physical trauma, bacterial or viral infection. In one embodiment, the method comprises administration of a bimodal molecular weight dextran formulation comprising 0.2 to 32% w/v of a dextran fraction with average molecular weight between 30,000 and 110,000 daltons and 0.2 to 6% dextran with an average molecular weight between 500 and 3,000 daltons, into the joint of a warm blooded animal.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: May 11, 1999
    Assignee: Glenpharma
    Inventors: June Ha Green, Peter B. Buckley
  • Bioactive factors of aloe vera plants
    Patent number: 5902796
    Abstract: A bioactive Factor produced, separated and isolated from either an aloe vera leaf or a product derived and processed from an aloe leaf, such as raw aloe vera gel, freeze-dried aloe vera gel extract, bulk acetylated mannan and bulk pharmaceutical mannan, utilizing different sizing processes, their processes or preparations, and their uses. The process of sizing can be accomplished by centrifugation, filtration, ultrafiltration, chromatography, dialysis, selective precipitation, pH adjustment, irradiation, homogenizing, or a combination of such processes. Compounding or mixing two or more different bioactive Factors from aloe at various concentration ratios, each Factor with its own specific bioactivity or bioactivities, to obtain a new bioactive Factor having desired optimal additive or synergistic effects.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: May 11, 1999
    Assignee: Carrington Laboratories, Inc.
    Inventors: David G. Shand, Kenneth Yates, D. Eric Moore, Bill H. McAnalley, Santiago Rodriguez
  • Methods of modulating tissue growth and regeneration
    Patent number: 5902799
    Abstract: Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: May 11, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Howard C. Herrmann, Elliot Barnathan, Paul B. Weisz
  • Activated mono-, di-, and polysaccharides reaction products thereof, their preparation and uses
    Patent number: 5900478
    Abstract: Reaction at the interface of an organic solution containing an acidic reactant and an aqueous alkaline solution containing nonreducing carbohydrates such as sucrose, sugar alcohols, cyclodextrins, and polysaccharides imparts a specificity to the reaction for one or more of the primary alcohol groups of the carbohydrate reactant. The resulting activated, nonreducing carbohydrate intermediate can then be converted to a series of substantially pure, low molecular weight reaction products, including a sucrose trimer and dianhydrosucrose, and to a series of substantially pure, higher molecular weight reaction products, including 6-O-sucro cyclodextrins and poly-6-O-sucro amylose.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: May 4, 1999
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: John F. Robyt, Rupendra Mukerjea
  • Method for treatment of cancer by oral administration of modified pectin
    Patent number: 5895784
    Abstract: A method for the treatment of cancer in mammals. A subject afflicted with cancer receives by oral administration a pH modified citrus pectin which inhibits metastasis of primary tumors.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: April 20, 1999
    Assignees: Michigan Cancer Foundation, Wayne State University
    Inventors: Avraham Raz, Kenneth J. Pienta
  • Treatment of traveller's diarrhea
    Patent number: 5891860
    Abstract: This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxigenic Escherichia coli (ETEC), using an oligosaccharide-containing composition. The composition contains an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm. The oligosaccharide-containing composition binds E. coli heat-labile toxin (LT). More specifically, the invention concerns neutralization and removal of LT associated with traveller's diarrhea.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: April 6, 1999
    Assignee: Synsorb Biotech, Inc.
    Inventors: Louis D. Heerze, Glen D. Armstrong
  • Diagnostic method for assessing the serum cholesterol response to low diets
    Patent number: 5891925
    Abstract: A diagnostic method for assessing how a hypercholesterolemic person's serum cholesterol level will respond to a low total fat and saturated fat diet. The method involves defining a target cholesterol level, measuring a baseline level, feeding for a term of 3-25 days a NCEP Step I diet of which at least 50% of the caloric intake is provided by a fortified, low-fat nutritional product, and comparing the post term cholesterol level to the defined goal to see if the target is met. If the target is met, the person is predicted to respond to dietary intervention. If the target is not met, the person is deemed a non-responder and is considered for drug therapy. A fortified, low-fat nutritional product supplies in about 1000 kcal (i) 100% of the adult RDI for vitamins and minerals; and (ii) total fat, saturated fat and cholesterol levels that are at or below the levels specified for a Step II diet.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: April 6, 1999
    Assignee: Abbott Laboratories
    Inventor: Stephen R. Behr
  • Composition and method for treating fungal disease in animals
    Patent number: 5891861
    Abstract: An oligomer comprised of repeat units of beta glucosamine exhibits broad antifungal activity. The oligomer preferably has a molecular weight in the range of 4,000-18,000 dalton, and may be partially acetylated. These materials are highly effective against a variety of fungi including various species of Candida.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: April 6, 1999
    Inventor: David Platt
  • Chromanol glycoside and method for production thereof
    Patent number: 5889164
    Abstract: This invention provides a novel chromanol glycoside which is a water soluble antioxidant excellent in heat and pH stability and production method thereof. It is a chromanol glycoside represented by the general formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 independently are a hydrogen atom or a lower alkyl group, R.sup.5 is a hydrogen atom, a lower alkyl group, or a lower acyl group, X is a monosaccharide residue or an oligosacoharide residue, providing the hydrogen atom of the hydroxyl group of saccharide residue may be substituted by a lower alkyl group or a lower acyl group, n is an integer in the range of 0 to 4, and m is an integer in the range of 1 to 6.
    Type: Grant
    Filed: September 27, 1995
    Date of Patent: March 30, 1999
    Assignee: CCI Corporation
    Inventors: Hironobu Murase, Tsutomu Kunieda, Tetsuya Tsujii
  • Solvent dried polysaccharide sponges
    Patent number: 5888987
    Abstract: The invention provides a method of preparing water-insoluble polysaccharide sponges, and sponges obtained by means of the method. The method comprises: (a) providing an aqueous solution of a soluble polysaccharide; (b) freezing the solution; (c) treating the frozen solution with a water-miscible organic solvent such as isopropanol to effect solvent exchange for the water in the frozen solution; and (d) drying the resulting polysaccharide material. The organic solvent contains a cross-linking agent such as calcium chloride to render the polysaccharide water-insoluble in the solvent-exchange step (c). The resulting materials are more conformable and less friable than freeze-dried polysaccharide sponges.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: March 30, 1999
    Assignee: Johnson & Johnson Medical, Inc.
    Inventors: Carla Anne Haynes, Elaine Lorimer
  • Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
    Patent number: 5888984
    Abstract: The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates and natural or synthetic essential oils can work effectively as a topical pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion cascade.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: March 30, 1999
    Assignee: Dermal Research Laboratories, Inc.
    Inventor: Harold G. Brown
  • Use of small pore silicas as a support for a chiral stationary phase
    Patent number: 5889180
    Abstract: Small pore silicas serving as the inert core support in chiral stationary phases show a surprising increase in column capacity relative to conventional chiral stationary phases having large pore silicas as the inert core support. This affords increased productivity and lower overall costs for chiral resolutions using a chiral stationary phase as adsorbent and an achiral liquid as eluant.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: March 30, 1999
    Assignee: UOP LLC
    Inventors: Beth Mc Culloch, Peter K. Nickl, Timothy A. Brandvold
  • Starch for paper making
    Patent number: 5883242
    Abstract: The present invention provides a cationic starch prepared by roasting starch under the presence of a cationic polymer, a method for preparing the cationic starch, and a method for making paper board with the cationic starch. The method for making paper board of the present invention provides high retention of starch in paper board, enhances paper board strength in a high level and reduces a load of treating waste water from a paper machine, in comparison with the starch which has conventionally been employed for paper making.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: March 16, 1999
    Assignee: Sanwa Cornstarch Co., Ltd.
    Inventors: Satoshi Kubota, Akitomo Terada, Yoshiteru Yamamoto
  • Process for isomerization of compound of aldose structure into compound of ketose structure, and isomerization agent or accelerator used therin
    Patent number: 5877311
    Abstract: A process is provided which comprises isomerizing a compound having a ketose structure by the use of or in the presence of an organogermanium compound having a structural portion represented by formula (I): ##STR1## Due to the use or presence of the organogermanium compound, the process is free from the problems of the prior art, and is capable of isomerizing a compound having an aldose structure into a compound having a ketose structure at a high isomerization ratio without requiring any special apparatus or any complicated operation.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: March 2, 1999
    Assignees: National Food Research Institute, Ministry of Agriculture, Forestry & Fisheries, Asai Germanium Research Institute Co., Ltd.
    Inventors: Keiji Umeda, Norihiro Kakimoto, Takafumi Kasumi
  • Process for obtaining medically active fractions from sea cucumbers
    Patent number: 5876762
    Abstract: The invention concerns fractions from echinoderms of the class Holothuroidea (sea cucumber) that can be used directly as active therapeutic agents or as raw materials in producing biologically active derivatives thereof. The fractions can be used alone or in combination and are derived from a) the epithelial layer, free of muscle and collagenous tissues, b) the isolated flower, or c) the whole body wall substantially free muscle, viscera and flower. The invention also concerns processes for obtaining these fractions that involve the use of thermal/mechanical and/or enzymatic means.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: March 2, 1999
    Assignee: Coastside Bio Resources
    Inventor: Peter Donald Collin
  • Functionalized derivatives of hyaluronic acid
    Patent number: 5874417
    Abstract: A composition of matter comprising a hyaluronate functionalized with a hydrazide at glucuronic acid sites of said hyaluronate, wherein the hydrazide is chosen from a group consisting of: monohydrazide and hydrazides comprising three or more amine groups.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: February 23, 1999
    Assignee: The Research Foundation of State University of New York
    Inventors: Glenn D. Prestwich, Dale M. Marecak