Patents Examined by Jacqueline Brazin
  • Patent number: 10953123
    Abstract: A sterilization process challenge pack including a base tray, a first cover, and a second cover is configured to provide a restrictive flow path for gaseous sterilization medium to test the efficacy of a sterilization process. The base tray includes at least one chamber containing a biological indicator and/or chemical indicator. The first cover including a notch is configured to cover the at least one chamber. The second cover is attached to peripheral surfaces of the base tray except at an unsealed portion. A flow path through the unsealed portion and the notch in the first cover provides the only fluid communication between an external environment and the at least one chamber.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 23, 2021
    Assignee: American Sterilizer Company
    Inventor: Harry Bala
  • Patent number: 10941374
    Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: March 9, 2021
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Patent number: 10934324
    Abstract: A method of improving protein functionality includes obtaining a protein such as protein contained within exclusion bodies contained within bacteria or yeast used for the recombinant expression of the protein. The exclusion bodies are solubilized using a chaotropic agent such as guanidine or urea. The protein is then subject to denaturation conditions and optionally purified. A liquid containing the denatured protein is loaded into a vessel that is angled relative to horizontal. The vessel is then rotated in the angled configuration at a rate within that is less than 10,000 RPM for period of time. Refolded protein is formed by the high shear conditions formed in the thin film of fluid formed in the inner surface of the rotating vessel. Refolding can be performed in a batch mode or a continuous mode. The process may be scaled up for industrial applications by using multiple vessels.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: March 2, 2021
    Inventors: Gregory A. Weiss, Colin L. Raston, Tom Z. Yuan, Callum Ormonde, Stephan Timothy Kudlacek
  • Patent number: 10933419
    Abstract: A pipetting reservoir kit includes a base, a disposable liner, and a lid. The disposable liner includes anti-vacuum channels on the bottom wall to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels located on the bottom surface of the liner face upward into the basin that holds liquid samples or reagents. The groupings of anti-vacuum channels are spaced in an array 4.5 mm apart for a 384 pipetting head and 9 mm apart for a 96 pipetting head. The anti-vacuum channels also lower the required working volume for the liner and reduce liquid waste.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: March 2, 2021
    Assignee: Integra Biosciences AG
    Inventors: Terrence Kelly, Jonathan Harkins, George Kalmakis, Gary Nelson
  • Patent number: 10928410
    Abstract: Devices, kits, and methods related to embodiments of an improved liquid test sample injection device for use in diagnostic assays.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: February 23, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Aaron Kauffmann
  • Patent number: 10900030
    Abstract: A structured substrate (100) including a substrate body (102) having an active side (104). The substrate body (102) includes reaction cavities or sites (106) that open along the active side (104) and interstitial regions (118) that separate the reaction cavities (106). The structured substrate (100) includes an ensemble amplifier (120) positioned within each of the reaction cavities (106). The ensemble amplifier (120) includes a plurality of nanostructures (116), such as dimers, trimers, bowtie nanoantenna, nanorods, nanorings, nanoplugs, configured to at least one of amplify electromagnetic energy (108) that propagates into the corresponding reaction cavity (106) or amplify electromagnetic energy (110), such as emitted fluorescence, that is generated within the corresponding reaction cavity (106). Preferably the nanostructures (116) within the cavities (106) are covered with a organic material such as a gel (122).
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: January 26, 2021
    Assignee: ILLUMINA, INC.
    Inventors: M Shane Bowen, Dajun Yuan
  • Patent number: 10890556
    Abstract: Materials and methods for generating nanowires are described. Krogmann salt potassium tetracyanoplatinate sesquihydrate (K(def)TCP) nanowires are synthesized as interconnects on metal lithographic patterns in which the K(def)TCP nanowires grow across the metal lines. The chemical sensing capability of the K(def)TCP chips is demonstrated by impedance measurements.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: January 12, 2021
    Inventor: Guangzhao Mao
  • Patent number: 10881336
    Abstract: A solution containing a target molecule and a reference molecule is illuminated to obtain Raman signals. An optical metasurface is used as a diffractive optical element to split the Raman signal from the target molecule and the Raman signal from the reference molecule. The target and reference Raman signals can be detected at different locations with different photodetectors, and the target molecule concentration in the solution is determined by comparing the target and reference Raman signals.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: January 5, 2021
    Inventors: Andrei Faraon, Amir Arbabi, Yu Horie
  • Patent number: 10876937
    Abstract: An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: December 29, 2020
    Assignee: BioGenex Laboratories, Inc.
    Inventor: Krishan L. Kalra
  • Patent number: 10876968
    Abstract: An sensor (2) based on an optical-sensing technique measures gaseous or dissolved analytes in a measurement medium (4). The sensor has a sensor housing (6) and an optochemical sensor element (20, 220) arranged within the sensor housing. The optochemical sensor element (220) has a substrate (222), a sensing layer (224) and a barrier layer (230). The barrier layer is arranged to protect the optochemical sensor element from interfering substances (234) present in the measurement medium.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: December 29, 2020
    Assignee: Mettler-Toledo GmbH
    Inventors: Daniel Aigner, Robert Lettow, Toni Schneider, Martin Winkler, Stefanie Zuber
  • Patent number: 10856854
    Abstract: The invention relates to a device for obtaining biological material and/or biological information from a sample with a heterogeneous matrix, to the uses of said device, to methods implementing said device, and to kits for obtaining biological material and/or biological information from a sample with a heterogeneous matrix, comprising the different constituents of said device.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: December 8, 2020
    Assignee: BIOMERIEUX
    Inventors: Hervé Rostaing, Agnès Dupont-Filliard, Sandrine Gicquel, Carole Vachon, Patrick Broyer, Jérôme Blaze
  • Patent number: 10842910
    Abstract: Embodiments of this technology may include an apparatus for drying tissue. The apparatus may include human donor tissue placed in contact with and between at least two layers of backing material. This tissue and backing layer may then be restrained by two plates. This tissue may be amniotic tissue. The backing layer may include woven or nonwoven material. This backing layer may be wetted with a saline solution. At least one of the plates of the tissue drying apparatus may be perforated. The tissue assembly along with the plates may then be placed inside a chamber configured to receive the plates and tissue assembly. The chamber may be configured so that gas can be forced into the chamber with the gas flow going around the plates and the tissue assembly.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 24, 2020
    Inventors: Adrian C. Samaniego, Matthew Southard
  • Patent number: 10842928
    Abstract: A medicine-holding body is disposed in a flow path of a nozzle portion of an adapter for blood dispensing. The medicine-holding body is formed of a plurality of fibers which is made of polyester and is bundled by aligning a longitudinal direction thereof in a flowing direction which is a direction in which blood flows. The medicine-holding body holds an anticoagulant for suppressing coagulation of blood, as a medicine to be mixed into blood. The surface area of the medicine-holding body is greater than or equal to 10 mm2 and less than 600 mm2. In a case where the surface area of the medicine-holding body is greater than or equal to 10 mm2, the concentration of the anticoagulant becomes greater than or equal to a lower limit value of 10 U/mL even under most severe conditions such as a dispensing speed of 500 ?L/second. In a case where the surface area of the medicine-holding body is less than 600 mm2, it is possible to maintain the occurrence rate of hemolysis to be less than or equal to 10%.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: November 24, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Toshihito Kimura, Toshiaki Kuniyasu, Hirotaka Watano, Akira Wakabayashi, Hiroshi Makino
  • Patent number: 10845333
    Abstract: An object is to make a bridge of DNA expanding between a pair of electrodes, and to characterize the bridge of DNA, to thereby detect DNA easily and surely without employing any marker or labeling substances, such as fluorescent reagents. A method of detecting DNA using a detection device with at least a couple of electrodes, the method comprising immobilizing a primer on the electrodes; making a bridge of the DNA expanded between the electrodes, by immersing the electrodes in a solution including circular templates of single stranded DNA, annealing the circular templates, and generating single stranded DNA product utilizing RCA (Rolling Circle Amplification), with impressing a designated voltage between the electrodes; and characterizing the bridge of DNA which includes multiple single stranded DNA molecules between the electrodes.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: November 24, 2020
    Assignees: The Foundation for the Promotion of Industrial Science, Neuroindx, Inc., Centre National de la Recherche Scientifique (CNRS)
    Inventors: Hiroyuki Fujita, Stanislav L. Karsten, Dominique Collard, Momoko Kumemura
  • Patent number: 10823746
    Abstract: A reader for a lateral flow test device includes a tray or drawer, extendable from the reader, which receives the test device. The tray includes a calibration test pattern affixed or printed thereon placed proximate to the test device and in alignment with the axis of the test device. As the tray is closed and the test device is inserted to the reader, the calibration test pattern is first read by an optics unit including a photodiode. The resulting photodiode output provides a calibration curve S that the reader then uses to correct for any non-linear response of the reader's optical or electronic systems, thus insuring that every reader will yield the same readout for a given test cartridge, despite reader-to-reader variations or reader degradation with time. One use of the reader is for detection of SARS-CoV-2 infection.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: November 3, 2020
    Assignee: Thermogenesis Holdings, Inc.
    Inventors: William Busa, Phillip H. Coelho, Paul Getchel
  • Patent number: 10821443
    Abstract: A liquid storage and release chip provided according to the present application includes a structural layer and an elastic cover sheet. An end surface of one side of the structural layer is provided with a liquid storage cell and a liquid quantitation cell, the liquid storage cell and the liquid quantitation cell are separated by a common partition wall, and the partition wall is provided with a valve opening passing through end surfaces of two sides of the structural layer. The elastic cover sheet is attached to the structural layer and covers the liquid storage cell, the liquid quantitation cell and the valve opening in a sealed manner, and the valve opening allows a spool to be inserted in the valve opening in a sealed manner to push up a portion, covering the valve opening, of the elastic cover sheet.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: November 3, 2020
    Inventors: Youchun Xu, Haoying Shao, Cheng Chen, Liangbin Pan
  • Patent number: 10792661
    Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: October 6, 2020
    Inventors: Eng Seng Lim, Siah Chong Cheong, Namyong Kim
  • Patent number: 10788485
    Abstract: A tag for detecting an analyte can include a radio frequency identification tag including a sensor portion, the sensor portion configured to change resistivity when the radio frequency identification tag contacts or interacts with an analyte, whereby the resistivity change alters an output of the radio frequency identification tag, wherein the sensor portion includes a circuit, and wherein the sensor portion is configured to activate the circuit or deactivate the circuit when contacted or having interacted with the analyte, where the sensor portion includes a plurality of carbon nanotubes associated with a chemically-degradable polymer. In certain embodiments, the chemically degradable polymer can be a metallo-supramolecular polymer.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: September 29, 2020
    Inventors: Timothy Manning Swager, Joseph Michael Azzarelli, Shinsuke Ishihara
  • Patent number: 10782213
    Abstract: A fluidic system that includes at least one channel for the transport of a liquid, the channel being formed of an absorbent material; and at least one switchable polymer gel that functions as a storage reservoir and/or valve for the liquid and is in contact with the absorbent material of the channel.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: September 22, 2020
    Inventors: André Laschewsky, Erik Wishcherhoff, Carsten Beta, Robert Niedl
  • Patent number: 10775322
    Abstract: A system and method for preparing a crystal delivery medium comprising agarose for serial femtosecond crystallography and uses thereof.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: September 15, 2020
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Chelsie Conrad, Petra Fromme, Daniel James, Christopher Kupitz