Patents Examined by Jacqueline Brazin
  • Patent number: 12290067
    Abstract: Systems and devices with enhanced stability to kinetic impact for the containment of cryogenically preserved material. A device comprising a vessel with increased surface to volume ratio when compared to cylindrical vessels of like capacity, and further comprising a material that remains resistant to shock and impact at cryogenic temperatures while providing a continuous barrier of a single material surrounding the vessel contents. The device further comprising a design that may be readily modified to include internalized sensors, enhanced interfacing to external instruments, provide optimized thaw rate, and post-thawing sample processing capabilities.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: May 6, 2025
    Assignee: BIOLIFE SOLUTIONS, INC.
    Inventor: Brian Schryver
  • Patent number: 12287264
    Abstract: A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.
    Type: Grant
    Filed: July 25, 2024
    Date of Patent: April 29, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: David Maurice Cox, Layla Katiraee
  • Patent number: 12287321
    Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.
    Type: Grant
    Filed: September 8, 2023
    Date of Patent: April 29, 2025
    Assignee: Truvian Sciences, Inc.
    Inventors: Dena Marrinucci, Nicholas Haase, Ryan Morgan, Michael Adams, Derek Arndt, Graeme Cross, Jeffrey A. Hawkins, David Hecht, Johnny Steve Rachele, Roger Taylor, Scott Thompson, Kyoung-Ho Kim, David Luke McDonald, Michael White, Kevin Yang
  • Patent number: 12275932
    Abstract: A cell manipulation panel includes a pixel array defining multiple pixels, an insulating layer forming multiple vias, and a cell gap provided with a fluid medium having cells therein. Each pixel has a TFT and corresponds to a corresponding via. The TFT includes a gate electrode, a first electrode, and a second electrode partially exposed to the fluid medium through the corresponding via. For each pixel, in an operational mode, when the gate electrode is provided with an OFF signal and the first electrode is not grounded, the TFT is turned off, allowing one of the cells in the fluid medium to be captured in the corresponding via by a dielectrophoresis (DEP) force. When the gate electrode is provided with an ON signal and the first electrode is grounded, the TFT is turned on, and the second electrode is grounded to release the captured cell to the fluid medium.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: April 15, 2025
    Assignee: A.U. VISTA, INC.
    Inventors: Tung-Tsun Lin, Chih-Che Kuo, Yuan Mao
  • Patent number: 12268371
    Abstract: A multi-chamber saliva-collection device is configured to segregate a saliva sample into at least two aliquots, each of the at least two aliquots being contained within a distinct chamber of the multi-chamber device, wherein the multi-chamber device is useful for performing an instant analyte test and a subsequent DNA confirmation to validate the identity of the tested individual. Related methods for using the device to obtain each of: an analyte test result, and a DNA confirmation of the identity of the individual from which the tested saliva sample, are also disclosed.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: April 8, 2025
    Assignee: Clinical Reference Laboratory, Inc.
    Inventor: Serhat Pala
  • Patent number: 12263422
    Abstract: A filter insert, a sample vial incorporating a filter insert, a method of using a sample vial containing a filter insert for chemical analysis, and a sample vial kit including a filter insert. The filter insert includes a cylindrical body having a proximal end, a protrusion extending radially from the proximal end of the cylindrical body and configured to set on the open end of a sample vial, a distal end, a cavity extending longitudinally through the cylindrical body from the proximal end to the distal end, and a filter assembly coupled with the distal end of the cylindrical body.
    Type: Grant
    Filed: March 20, 2023
    Date of Patent: April 1, 2025
    Assignee: Reaction Analytics, Inc.
    Inventor: Michael Lopez Antonio
  • Patent number: 12259322
    Abstract: Disclosed are a detection method and detection system using suspension liquid biochip detection. The detection method using suspension liquid biochip comprises the following steps: an excitation step and a signal acquisition step. In the excitation step, a laser light emitted by a single laser device is used to excite a classification fluorescence of nanocrystalline fluorescent microspheres and a report fluorescence of an object to be detected; and in the signal acquisition step, fluorescence detection signals are obtained through multiple acquisition channels, respectively. In the present invention, the classification fluorescence in the nanocrystalline fluorescent microspheres and the report fluorescence in the object to be detected in a sample are excited by a single laser device, which is convenient for operation and reduces the production cost of the system, thereby reducing the detection cost.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: March 25, 2025
    Inventors: Jianqiu Fang, Wanwan Li, Chunmei Zhong
  • Patent number: 12257576
    Abstract: Since a few kilovolts of an application voltage is necessary to take in a biological sample, an EWOD electrode, for example, is destroyed, and the electrode becomes non-reusable for moving a droplet. Therefore, an object of the present invention is to provide a biochemical cartridge usable for multiple times for taking in a biological sample by a capillary array, for example, and a biochemical analysis device using the biochemical cartridge. In order to solve the problem, the biochemical cartridge according to the present invention includes a passage through which a sample is transported, a plurality of electrodes disposed on the passage along a direction in which a sample is transported, the plurality of electrodes being provided to transport a sample, and an opening provided opposite to the plurality of electrodes disposed on a downstream side of the passage.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: March 25, 2025
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Michiru Fujioka, Sakuichiro Adachi, Toshiaki Hiratsuka, Asami Terakado
  • Patent number: 12247975
    Abstract: Disclosed is a detection apparatus that transfers magnetic particles through a plurality of chambers in a cartridge which includes the plurality of chambers and a channel connecting between the plurality of chambers, and that causes the magnetic particles to carry a complex of a test substance and a labelling substance, to detect the test substance on the basis of the labelling substance in the complex. The detection apparatus includes: a rotation mechanism configured to rotate the cartridge about a rotation shaft; a magnet configured to collect the magnetic particles in the chambers; a movement mechanism configured to move the magnet in a direction different from a circumferential direction of a circle in which the rotation shaft is centered; a detector configured to detect the test substance; and a controller programmed to control the rotation mechanism and the movement mechanism so as to transfer the magnetic particles from one of the chambers to another one of the chambers.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: March 11, 2025
    Assignee: Sysmex Corporation
    Inventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Sayuri Tomoda, Yusuke Miida, Yasunori Maekawa, Noriaki Sasaki
  • Patent number: 12239979
    Abstract: Provided is a genome extraction device to which a dual chamber structure of an outer chamber and an inner chamber is applied, more particularly a genome extraction device to which the above-described dual chamber structure is applied so that the genome extraction device can be stored stably for a long time without the risk of reagent leakage.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: March 4, 2025
    Assignee: SD BIOSENSOR, INC.
    Inventors: Young-Shik Cho, Hae-Joon Park, Sunyoung Lee, Kwanhun Lim, In-Ae Kim, Dong-Hun Kim
  • Patent number: 12233414
    Abstract: A non-healthcare setting kit for diagnosing a biological sample from a user is disclosed. The kit includes a mobile application that may run on a mobile device, a collection container for the biological sample, a cartridge that docks with the collection container and a reader that docks with the cartridge and that optically reads the biological sample.
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: February 25, 2025
    Assignee: Intrigue Health, Inc.
    Inventors: Dereck Tatman, Ron Mccullough
  • Patent number: 12226766
    Abstract: Techniques for replacing nanopores within a nanopore based sequencing chip are provided. A first electrolyte solution is added to the external reservoir of the sequencing chip, introducing an osmotic imbalance between the reservoir and the well chamber located on the opposite side of a lipid bilayer membrane. The osmotic imbalance causes the membrane to change shape, and a nanopore within the membrane to be ejected. A second electrolyte solution is then added to the external reservoir to provide replacement nanopores and to restore the membrane shape. The replacement nanopores can be inserted into the membrane, effectively replacing the initial pore without causing the destruction of the membrane.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: February 18, 2025
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Geoffrey Barrall, Takeshi Harada, Jason Komadina, Pirooz Parvarandeh, Charlotte Yang
  • Patent number: 12222279
    Abstract: A flowcell device, including a flow pathway and an optical subassembly, has a flowcell body that is continuous with a sample being analyzed and a temperature controlled surface. The flowcell body can be disposed between a thermalplate, actively regulated by a thermoelectric cooler, and an insulating member. The flowcell device can be employed in a bioreactor monitoring system.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: February 11, 2025
    Assignee: Nirrin Technologies, Inc.
    Inventors: Bryan A. Hassell, Aaron Delahanty
  • Patent number: 12209962
    Abstract: A target substance detection method includes forming a complex by causing a target substance and a dielectric particle to bind to each other, the dielectric particle being modified with a substance having a property of specifically binding to the target substance; separating the complex and an unbound particle from each other in a liquid by dielectrophoresis, the unbound particle being a dielectric particle not constituting the complex; and detecting the target substance included in the separated complex by using an imaging element.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: January 28, 2025
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventor: Satoshi Arimoto
  • Patent number: 12201977
    Abstract: The present invention describes an integrated apparatus that enables identification of migratory cells directly from a specimen. The apparatus only requires a small number of cells to perform an assay and includes novel topographic features which can reliably differentiate between migratory and non-migratory cell populations in a sample. Both the spontaneous and chemotactic migration of cancer cells may be measured to distinguish between subpopulations within a tumor sample. The migratory cells identified using the apparatus and methods of the present invention may be separated and further analyzed to distinguish factors promoting metastasis within the population. Cells in the apparatus can be treated with chemotherapeutic or other agents to determine drug strategies to most strongly inhibit migration. The use of optically transparent materials in some embodiments allows a wide range of imaging techniques to be used for in situ imaging of migratory and non migratory cells in the apparatus.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: January 21, 2025
    Assignees: THE JOHNS HOPKINS UNIVERSITY, UNIVERSITY OF MARYLAND, BALTIMORE OFFICE OF RESEARCH AND DEVELOPMENT
    Inventors: Konstantinos Konstantopoulos, Colin Dowlin Paul, Alfredo Quinones-Hinojosa, Aikaterini Kontrogianni-Konstantopoulos
  • Patent number: 12194458
    Abstract: A portable, self-contained drug test kit for testing for the presence or absence of a drug has a housing having a hollow portion with a liquid solvent accessible from outside to enable introduction of a test solute therein. A lateral flow test strip is in user-selective fluid communication with the liquid solvent in the hollow portion. The lateral flow test strip is selectively moveable from a first position in which the lateral flow test strip is not in fluid communication with the liquid solvent in the hollow portion to a second position in which it is in fluid communication with the liquid solvent. When the lateral flow test strip is moved into the second position and the test solute is introduced into the hollow portion, the liquid solvent mixes with the test solute to form a test solution and thereby activate the lateral flow test strip.
    Type: Grant
    Filed: August 15, 2023
    Date of Patent: January 14, 2025
    Inventor: Nicole Shamayev
  • Patent number: 12179190
    Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: December 31, 2024
    Assignee: ILLUMINA, INC.
    Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
  • Patent number: 12162012
    Abstract: A solid phase microextraction device is disclosed, including a substrate having a planar surface and a sorbent layer disposed on the planar surface. The planar surface is defined by a base edge, a spray edge disposed distal across the substrate from the base edge, the spray edge including a tapering tip extending away from the base edge, a first lateral edge extending from the base edge to the tapering tip, and a second lateral edge extending from the base edge to the tapering tip, the second lateral edge being disposed distal across the substrate from the first lateral edge. The sorbent layer extends a sampling length from the spray edge toward the base edge and includes sorbent particles. A method for forming the solid phase microextraction device is disclosed, including applying the sorbent layer on the planar surface utilizing at least one of screen printing, stencil printing, or additive manufacturing.
    Type: Grant
    Filed: March 5, 2024
    Date of Patent: December 10, 2024
    Assignee: Restek Corporation
    Inventors: Tracey A. Peters, German A. Gomez-Rios, Thomas E. Kane
  • Patent number: 12163111
    Abstract: There is described a method of reducing or preventing the agglomeration of spheroids comprising the use of a cell culture device comprising: a cell culture chamber comprising a base and side walls extending from the base to enclose a volume of the cell culture chamber; an inlet in the base or side walls of the cell culture chamber adapted for fluid communication into the chamber; and an outlet in the base or side walls of the cell culture chamber adapted for fluid communication out of the chamber; wherein the base of the cell culture chamber comprises a discontinuous surface adapted to reduce or prevent the agglomeration of spheroids.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 10, 2024
    Assignee: Philip Morris Products S.A.
    Inventors: Antonin Sandoz, David Bovard
  • Patent number: 12163183
    Abstract: Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: December 10, 2024
    Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Rajesh Sardar, Thakshila Liyanage, Adrianna Masterson, Hristos Z. Kaimakliotis