Patents Examined by Jacqueline Brazin
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Patent number: 11806717Abstract: One aspect of the present invention is to provide the device and methods for performing an assay that uses the multiplexing of sample thicknesses on the same plate. The sample thickness multiplexing can offer many information that are unavailable in using a single sample thickness.Type: GrantFiled: August 16, 2019Date of Patent: November 7, 2023Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang
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Patent number: 11772098Abstract: The invention relates to kits and components thereof used in the conduct of solid-phase binding assays.Type: GrantFiled: September 13, 2019Date of Patent: October 3, 2023Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Yihong Claire Lu, Pankaj Oberoi
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Patent number: 11772986Abstract: A mobile device reads a test strip to determine a chemical condition of a liquid or a user inputs a treatment plan into the mobile device. The mobile device transmits the determined chemical condition or the input treatment plan to a liquid treatment system which treats the fluid in response to the determined chemical condition or the input treatment plan.Type: GrantFiled: June 22, 2021Date of Patent: October 3, 2023Assignee: Digital Concepts of Missouri, Inc.Inventors: Paul Decker, Jack Greenwood
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Patent number: 11771814Abstract: Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.Type: GrantFiled: July 26, 2019Date of Patent: October 3, 2023Assignee: Terumo BCT Biotechnologies, LLCInventors: Jon A. Dodd, Daniel R. Clement, Dennis J. Hlavinka, Jeremy T. Parsons, Haralambos P. Apostolopoulos
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Patent number: 11766672Abstract: An apparatus for manipulating magnetic particles includes a latch mechanism. The latch mechanism has a pivoting part provided on a door and an engaging part provided on a main body. In the apparatus for manipulating magnetic particles, a first contact portion of a latch engages with the engaging part at a contact point in a state that the door is closed. The contact point is located more outside of the main body than the pivot axis. Accordingly, in a case where an external force is applied to the door in a direction to open the door in a state that the door is closed, a force is applied from the engaging part to the first contact portion, thereby generating a rotational force in a C direction to the pivoting part. As a result, in the state that the door is closed, it is possible to suppress the door from being opened without a manipulation by the user.Type: GrantFiled: November 12, 2019Date of Patent: September 26, 2023Assignee: SHIMADZU CORPORATIONInventors: Nobuhiro Hanafusa, Ayaka Minamimoto
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Patent number: 11759775Abstract: A device for extracting plasma from a fluid collection tube comprising: a tubular barrel having sidewall surrounding a lumen which extends between proximal and distal ends thereof, the tubular barrel forming a tip at a distal end; a barrel seal movingly seated within the lumen of the tubular barrel, the barrel seal closing and sealing the proximal end of the tubular barrel; a tube seal having a proximal end, a distal end, and a lumen extending therebetween, the proximal end having a frustoconical or chamfered face, the tube seal having an outer diameter sized to sealingly engage with an inner surface of the fluid collection tube, and an inner diameter sized to sealingly engage with an outer surface of the tip of the tubular barrel, the tube seal mounted on the tubular barrel such that the tip of the tubular barrel extends into the tube seal lumen.Type: GrantFiled: July 15, 2020Date of Patent: September 19, 2023Inventors: Ryszard Kowalewski, Marcin Kowalewski
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Patent number: 11759783Abstract: The present invention relates to an assay device for determining the presence and/or amount of an analyte of interest in a sample, the assay device comprising: a) a housing that includes a liquid receiving unit that is adapted to accommodate one or more types of liquid; b) a mixing chamber adapted for containing a solution that is a product of one more types of liquid, and for receiving a sample to interact with said solution; c) an actuating lid which is capable of being actuated to enable the transfer of the liquid into the mixing chamber; and d) an assay means that is in fluid communication with said mixing chamber for determining the presence and/or amount of an analyte of interest in the sample after the interaction of said sample with said solution in the mixing chamber.Type: GrantFiled: November 24, 2016Date of Patent: September 19, 2023Assignee: Novamed Ltd.Inventors: Emil Katz, Gadi Porath, Ural Rashitov
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Patent number: 11745177Abstract: A system and method for lysing of whole blood for CO-Ox measurement uses a lysing chamber for acoustic lysing of whole blood in a module in which the lysing chamber is separate from a CO-Ox measurement chamber. The disclosed acoustic lysing system and method avoids the expense and complexity of chemical lysing methods and allows the whole blood sample to be lysed while under continuous flow through the lysing chamber. The acoustic lysing chamber is provided upstream from a CO-Ox measurement chamber. The separation of the lysing chamber from the Co-Ox measurement chamber provides freedom to arrange and orient various optical components and/or other CO-Ox measuring components around the CO-Ox measurement chamber. The decoupling of the lysing chamber from the CO-Ox measurement chamber allows for more efficient design of the ultrasonic lysing transducer and CO-Ox measurement optics.Type: GrantFiled: January 9, 2020Date of Patent: September 5, 2023Assignee: INSTRUMENTATION LABORATORY COMPANYInventors: Brian Joseph Bosy, Josef Kerimo
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Patent number: 11731134Abstract: Example apparatus including septums and related methods are disclosed. An example apparatus includes a septum that includes a first surface and a membrane coupled to at least a portion of the first surface. In addition, the example septum includes a second surface and ribs extending between the membrane and the second surface.Type: GrantFiled: September 24, 2019Date of Patent: August 22, 2023Assignee: ABBOTT LABORATORIESInventor: Robert P. Luoma, II
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Patent number: 11723358Abstract: The invention relates to a container system for transport of biological material comprising a container casing and an insulating device, wherein the container casing defines a container interior space for accommodation of the insulating device and for accommodation of biological material to be transported, and wherein the insulating device is constituted of at least two insulating portions, which are formed so as to surround the biological material inside the container interior space. The invention further relates to uses of such a container system for packaging and transport of biological material, as well as methods of packaging biological material for transport.Type: GrantFiled: June 16, 2020Date of Patent: August 15, 2023Assignee: MLM Medical Labs GmbHInventor: Stephan Wnendt
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Patent number: 11714034Abstract: A method and device performing the method for estimation of cell count, such as sperm cell count, is disclosed. The device may be a kit including a cartridge configured to hold fluid, such as seminal fluid, and an instrument configured to centrifuge the cartridge. The cartridge and instrument are configured such that, during operation or centrifugation, they are securely attached to each other. The cartridge has a component with a defined cross-sectional volume. The defined cross-sectional volume is used to mark the component with markings, allowing a user of the device to read the markings and estimate cell volume and, thus, concentration. Various embodiments of the device are disclosed.Type: GrantFiled: January 17, 2019Date of Patent: August 1, 2023Assignee: Laboratory Corporation of America HoldingsInventors: Ulrich Schaff, Greg Sommer, Christopher Tomkins-Tinch
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Patent number: 11712692Abstract: A biological sample collection system can include a sample collection vessel having an opening configured to receive a biological sample and a selectively movable valve configured to at least partially associate with the opening of the sample collection vessel. The selectively movable valve can include a post and a valve head associated with a distal portion of the post. The system can additionally include a sealing cap configured to associate with the selectively movable valve and with the sample collection vessel. The sealing cap can include a reagent chamber for storing a measure of sample preservation reagent and associating the sealing cap with the sample collection vessel causes a physical rearrangement of the post and the valve head such that a fluid vent associated with the post aligns with an aperture defined by the valve head allowing fluid communication between the reagent chamber and the sample collection vessel.Type: GrantFiled: November 20, 2019Date of Patent: August 1, 2023Assignee: Spectrum Solutions L.L.C.Inventors: Kevin Gregg Williams, Neil Jeremy Johnson
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Patent number: 11712691Abstract: A biological fluid separation device and a separation process that allows for efficient separation of plasma from a blood sample is disclosed. A biological fluid separation device of the present disclosure is adapted to receive a blood sample having a cellular portion or cells and a plasma portion or plasma. A biological fluid separation device of the present disclosure separates plasma from cells using a track-etched membrane and cross-flow filtration.Type: GrantFiled: June 7, 2018Date of Patent: August 1, 2023Assignee: Becton, Dickinson and CompanyInventors: Milan Ivosevic, Peng Li, Scott Wentzell
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Patent number: 11701660Abstract: A specimen sample collection device is disclosed, the device including: a base having a neck extending therefrom, a film-puncture element disposed within the neck, and one or more fluid ports extending through the base within the neck; a cap engaged with the neck, the cap comprising a film attached about an inner cylinder of the cap along a periphery thereof; wherein the film defines a buffer-containing cavity within the cap, and wherein the buffer-containing cavity is configured to hold a preservation buffer for preserving a sample stored within a collection reservoir of the device.Type: GrantFiled: July 27, 2020Date of Patent: July 18, 2023Assignee: Clinical Reference Laboratory, Inc.Inventor: Serhat Pala
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Patent number: 11701650Abstract: A pipette tip according to certain embodiments includes a proximal end, a distal end, and a reagent chamber. The proximal end is dimensioned to fit on an end of a pipettor, and includes a proximal end opening. The distal end includes a distal end opening. The reagent chamber has a reagent composition disposed therein. The reagent chamber is defined at least in part by a proximal barrier and a distal barrier. The reagent composition is operable to pass through the distal end opening upon rupturing of the distal barrier.Type: GrantFiled: February 20, 2020Date of Patent: July 18, 2023Inventor: Sergey Smulevitch
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Patent number: 11678658Abstract: The present disclosure relates to devices, systems, and methods for modeling ocular translaminar pressure gradients ex vivo. A first fluid pressure level can be applied to a first side of a wall of donor eye cup (e.g., a posterior human eye cup) to simulate intracranial pressure (ICP), for example around the optical nerve head (ONH), and a second fluid pressure level can be applied to a second side of the wall of the donor eye cup to simulate intraocular pressure (IOP). These devices, systems, and methods are unique in that they allow ex vivo modeling of dynamic changes in translaminar pressure gradients.Type: GrantFiled: April 26, 2019Date of Patent: June 20, 2023Assignee: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTERInventors: Tasneem Putliwala Sharma, Colleen Mary McDowell, Abbot Frederick Clark, Husain Lohawala
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Patent number: 11673135Abstract: The present invention relates to a flexible bag, a perfusion filter and a fluid port. The fluid port comprises: —a first fluid connection (3; 3?); —a second fluid connection (5; 5?) being in fluid communication with the first fluid connection (3; 3?); —an intermediate fluid path (7: 7?) connecting the first fluid connection (3; 3?) with the second fluid connection (5; 5?); wherein said intermediate fluid path (7; 7?) at least a portion of which comprises a substantially right-angled bend (9; 9?); —a protection cap (11; 11?) protecting at least the bend (9; 9?) of the intermediate fluid part (7; 7?) from contact with other objects; and —a connection surface (13; 13?) configured for sealing to a film of an object to be supplied by said port, said connection surface will, when sealed to the film of the object, together with the film provide a fluid tight seal surrounding the first fluid connection (3; 3?).Type: GrantFiled: December 14, 2018Date of Patent: June 13, 2023Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Donald M. Fraser, Yasser Ali, Mathew Wecharatana, James Brueggeman
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Patent number: 11673140Abstract: A device for separating and concentrating target particles or molecules from a fibrinogen containing sample of liquid comprises a container (1) for collecting the sample and a closure (2). The container (1) comprises a first end and a second end and at least one interior wall defining a reservoir portion (5) for receiving the sample. The reservoir portion (5) comprises at least one anchor element (4) to locally catch a polymerized fibrin pellet formed upon the addition of the sample into the container. The separation and concentration process is operated by trapping the target particles or molecules into the so-formed polymerized fibrin pellet that are captured on the anchor element (4).Type: GrantFiled: March 13, 2020Date of Patent: June 13, 2023Assignee: DEBIOPHARM INTERNATIONAL S.A.Inventors: Amar Rida, Sélène Ferrari
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Patent number: 11660078Abstract: A sample collection device including a collection tube at least partially defining a storage volume therein, a mouthpiece coupled to the collection tube, the mouthpiece defining a channel providing access to the storage volume, and a filter at least partially positioned within the channel, where the filter is configured to filter a sample as it passes through the channel and into the storage volume.Type: GrantFiled: August 10, 2017Date of Patent: May 30, 2023Assignee: MAWI DNA TECHNOLOGIES LLCInventor: Bassam El-Fahmawi
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Patent number: 11656197Abstract: A sequencing device is disclosed. The sequence device includes an array of conducting electrode pairs, each pair of electrodes comprising a source and a drain electrode arrangement separated by a nanogap, the electrode array deposited and patterned on a dielectric substrate; at least one transition metal dichalcogenide (TMD) layer disposed on each pair of electrodes, wherein the TMD layer connects each source and drain electrode within each pair, and bridges each nanogap of each pair of electrodes; and a dielectric masking layer disposed on the TMD layer and comprising at least one opening that defines an exposed TMD region, wherein the at least one opening is sized so as to allow a single biomolecule to fit therein and to attach on to the exposed TMD region. In embodiments of the disclosure, the TMD layer be a defective TMD layer.Type: GrantFiled: November 22, 2017Date of Patent: May 23, 2023Assignee: Roswell ME Inc.Inventors: Chulmin Choi, Sungho Jin, Barry L. Merriman, Paul Mola, Tim Geiser