Abstract: Devices, kits, and methods related to embodiments of an improved liquid test sample injection device for use in diagnostic assays.

Abstract: A structured substrate (100) including a substrate body (102) having an active side (104). The substrate body (102) includes reaction cavities or sites (106) that open along the active side (104) and interstitial regions (118) that separate the reaction cavities (106). The structured substrate (100) includes an ensemble amplifier (120) positioned within each of the reaction cavities (106). The ensemble amplifier (120) includes a plurality of nanostructures (116), such as dimers, trimers, bowtie nanoantenna, nanorods, nanorings, nanoplugs, configured to at least one of amplify electromagnetic energy (108) that propagates into the corresponding reaction cavity (106) or amplify electromagnetic energy (110), such as emitted fluorescence, that is generated within the corresponding reaction cavity (106). Preferably the nanostructures (116) within the cavities (106) are covered with a organic material such as a gel (122).

Abstract: Materials and methods for generating nanowires are described. Krogmann salt potassium tetracyanoplatinate sesquihydrate (K(def)TCP) nanowires are synthesized as interconnects on metal lithographic patterns in which the K(def)TCP nanowires grow across the metal lines. The chemical sensing capability of the K(def)TCP chips is demonstrated by impedance measurements.

Abstract: A solution containing a target molecule and a reference molecule is illuminated to obtain Raman signals. An optical metasurface is used as a diffractive optical element to split the Raman signal from the target molecule and the Raman signal from the reference molecule. The target and reference Raman signals can be detected at different locations with different photodetectors, and the target molecule concentration in the solution is determined by comparing the target and reference Raman signals.

Abstract: An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.

Abstract: An sensor (2) based on an optical-sensing technique measures gaseous or dissolved analytes in a measurement medium (4). The sensor has a sensor housing (6) and an optochemical sensor element (20, 220) arranged within the sensor housing. The optochemical sensor element (220) has a substrate (222), a sensing layer (224) and a barrier layer (230). The barrier layer is arranged to protect the optochemical sensor element from interfering substances (234) present in the measurement medium.

Abstract: The invention relates to a device for obtaining biological material and/or biological information from a sample with a heterogeneous matrix, to the uses of said device, to methods implementing said device, and to kits for obtaining biological material and/or biological information from a sample with a heterogeneous matrix, comprising the different constituents of said device.

Abstract: A medicine-holding body is disposed in a flow path of a nozzle portion of an adapter for blood dispensing. The medicine-holding body is formed of a plurality of fibers which is made of polyester and is bundled by aligning a longitudinal direction thereof in a flowing direction which is a direction in which blood flows. The medicine-holding body holds an anticoagulant for suppressing coagulation of blood, as a medicine to be mixed into blood. The surface area of the medicine-holding body is greater than or equal to 10 mm2 and less than 600 mm2. In a case where the surface area of the medicine-holding body is greater than or equal to 10 mm2, the concentration of the anticoagulant becomes greater than or equal to a lower limit value of 10 U/mL even under most severe conditions such as a dispensing speed of 500 ?L/second. In a case where the surface area of the medicine-holding body is less than 600 mm2, it is possible to maintain the occurrence rate of hemolysis to be less than or equal to 10%.

Abstract: Embodiments of this technology may include an apparatus for drying tissue. The apparatus may include human donor tissue placed in contact with and between at least two layers of backing material. This tissue and backing layer may then be restrained by two plates. This tissue may be amniotic tissue. The backing layer may include woven or nonwoven material. This backing layer may be wetted with a saline solution. At least one of the plates of the tissue drying apparatus may be perforated. The tissue assembly along with the plates may then be placed inside a chamber configured to receive the plates and tissue assembly. The chamber may be configured so that gas can be forced into the chamber with the gas flow going around the plates and the tissue assembly.

Abstract: An object is to make a bridge of DNA expanding between a pair of electrodes, and to characterize the bridge of DNA, to thereby detect DNA easily and surely without employing any marker or labeling substances, such as fluorescent reagents. A method of detecting DNA using a detection device with at least a couple of electrodes, the method comprising immobilizing a primer on the electrodes; making a bridge of the DNA expanded between the electrodes, by immersing the electrodes in a solution including circular templates of single stranded DNA, annealing the circular templates, and generating single stranded DNA product utilizing RCA (Rolling Circle Amplification), with impressing a designated voltage between the electrodes; and characterizing the bridge of DNA which includes multiple single stranded DNA molecules between the electrodes.

Abstract: A reader for a lateral flow test device includes a tray or drawer, extendable from the reader, which receives the test device. The tray includes a calibration test pattern affixed or printed thereon placed proximate to the test device and in alignment with the axis of the test device. As the tray is closed and the test device is inserted to the reader, the calibration test pattern is first read by an optics unit including a photodiode. The resulting photodiode output provides a calibration curve S that the reader then uses to correct for any non-linear response of the reader's optical or electronic systems, thus insuring that every reader will yield the same readout for a given test cartridge, despite reader-to-reader variations or reader degradation with time. One use of the reader is for detection of SARS-CoV-2 infection.

Abstract: A liquid storage and release chip provided according to the present application includes a structural layer and an elastic cover sheet. An end surface of one side of the structural layer is provided with a liquid storage cell and a liquid quantitation cell, the liquid storage cell and the liquid quantitation cell are separated by a common partition wall, and the partition wall is provided with a valve opening passing through end surfaces of two sides of the structural layer. The elastic cover sheet is attached to the structural layer and covers the liquid storage cell, the liquid quantitation cell and the valve opening in a sealed manner, and the valve opening allows a spool to be inserted in the valve opening in a sealed manner to push up a portion, covering the valve opening, of the elastic cover sheet.

Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.

Abstract: A tag for detecting an analyte can include a radio frequency identification tag including a sensor portion, the sensor portion configured to change resistivity when the radio frequency identification tag contacts or interacts with an analyte, whereby the resistivity change alters an output of the radio frequency identification tag, wherein the sensor portion includes a circuit, and wherein the sensor portion is configured to activate the circuit or deactivate the circuit when contacted or having interacted with the analyte, where the sensor portion includes a plurality of carbon nanotubes associated with a chemically-degradable polymer. In certain embodiments, the chemically degradable polymer can be a metallo-supramolecular polymer.

Abstract: A fluidic system that includes at least one channel for the transport of a liquid, the channel being formed of an absorbent material; and at least one switchable polymer gel that functions as a storage reservoir and/or valve for the liquid and is in contact with the absorbent material of the channel.

Abstract: A system and method for preparing a crystal delivery medium comprising agarose for serial femtosecond crystallography and uses thereof.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: A method for operating a field testing device to detect an additive in a refrigerant and/or lubricant. The method includes mixing a reactive medium with the refrigerant and/or lubricant. The reactive medium is configured to react with any additive present in the lubricant and/or refrigerant to form a product that has a different color than the reactive medium. The method also includes determining the additive concentration of the lubricant and/or refrigerant by utilizing the color of the reaction mixture. The field operating device is portable such that the additive concentration may be determined while in the field.

Abstract: The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and/or in using the device, donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.

Abstract: A biomolecule magnetic sensor configured to sense magnetic beads attached with biomolecules includes an adsorption pad, a magnetic field line generator and at least one magnetic sensor. The adsorption pad is configured to adsorb the magnetic beads. The magnetic field line generator is configured to generate a plurality of first magnetic field lines, and at least one of the first magnetic field lines passes through the magnetic beads along a first direction to induce a plurality of second magnetic field lines, wherein the magnetic field line generator is disposed between the adsorption pad and the magnetic sensor in the first direction. The magnetic sensor is configured to sense a magnetic field component of at least one of the second magnetic field lines in a second direction. A second shift is provided between the magnetic sensor and the adsorption pad in the second direction.