Abstract: The present invention generally relates to the measuring and monitoring of blood pressure. More specifically, embodiments may apply the theory of applanation tonometry for the measurement of blood pressure. Some embodiments provide a method for measuring mean arterial pressure. Some embodiments provide a device that may be worn by a user that may non-invasively measure and monitor blood pressure of a user. In some embodiments, the invention generally relates to sensor arrays for use with a wrist-worn device to measure blood pressure. Embodiments of the sensor array designs described may be configured to improve resolution by decoupling nodes of the sensor array.
Type:
Grant
Filed:
September 23, 2016
Date of Patent:
May 12, 2020
Assignee:
Apple Inc.
Inventors:
Ravi K. Narasimhan, Zijing Zeng, Zhipeng Zhang
Abstract: An Internet-based disease monitoring system may include a network-based disease sensor device, which is coupled to a sensor, such as a spirometer. A remote server may be coupled to the network-based disease sensor device to provide analysis of input signals from the sensor. The remote server may be able to provide various services for grouping or handling functions relating to such input signals. A service may provide the ability to aggregate input signals from multiple sensors coupled to sensor devices and provide predictive modeling or statistical analysis, which may then be used to adjust future input signals. A service may also contain instructions how to handle billing based on usage of the network-based disease sensor device.
Abstract: Systems, apparatus, and methods related to modeling, monitoring, and/or managing metabolism of a subject include measuring a respiratory quotient (RQ) level in a subject and/or optimizing and executing a nonlinear feedback model to model energy substrate utilization in the subject based on at least one of a macronutrient composition and caloric value of food consumed by the subject, an intensity and duration of activity by the subject, a rate and maximum capacity of glycogen storage in the subject, a rate and maximum capacity of de novo lipogenesis in the subject, a quality and duration of sleep by the subject, and/or an RQ level in the subject.
Type:
Grant
Filed:
December 7, 2017
Date of Patent:
May 5, 2020
Assignee:
Massachusetts Institute of Technology
Inventors:
Lawrence M. Candell, Christopher Ferraiolo, Gary A. Shaw, Andrew M. Siegel, George Zogbi, Holly Lehmann McClung, Reed Wasson Hoyt, Kyle Thompson
Abstract: A method of diagnosis is disclosed. The method comprises: acquiring an absolute component and a phase component of an input signal indicative of an impedance of an organ of a subject; determining baseline blood flow of the subject based on the phase component; determining transient changes in blood flow based on at least the absolute component; and displaying the baseline blood flow and the transient changes in blood flow.
Type:
Grant
Filed:
September 22, 2009
Date of Patent:
April 28, 2020
Assignee:
Cheetah Medical, Inc.
Inventors:
Yoav Avidor, Baruch Levy, Dan Avidor, Daniel Burkhoff
Abstract: An apparatus includes a strap configured to enable the apparatus to be worn by a user; an optical measurement element configured to be placed on a skin of the user, and to measure data related to heart activity of the user; communication circuitry configured to transmit the data related to heart activity of the user according to a Bluetooth standard on a 2.4 GHz band; and an antenna coupled with the communication circuitry, and configured to access a radio interface to transmit the data related to heart activity of the user.
Abstract: Embodiments of the disclosure are directed to methods, apparatuses, and computer program products for determining a hemodynamic parameter. An exemplary method comprises: receiving data associated with at least one heart beat; calculating a first standard deviation for at least a portion of the data; interpolating a second standard deviation for at least a second portion of the data; and determining the hemodynamic parameter based on the first standard deviation and the second standard deviation.
Type:
Grant
Filed:
July 8, 2014
Date of Patent:
April 7, 2020
Assignee:
Edwards Lifesciences Corporation
Inventors:
Zhongping Jian, Jacobus J. G. M. Settels, Feras Al Hatib
Abstract: Methods and systems for encouraging interactions with a glucose monitoring system include incrementing a score and/or providing a reward based on a variety of different interactions with the glucose monitoring system. The interactions which improve the score may include initiating or changing displays, downloading data, setting operational parameters and other interactions that are independent of a user's glucose measurements. Encouraging these interactions can enhance success in maintaining healthy glucose concentrations.
Type:
Grant
Filed:
December 30, 2013
Date of Patent:
April 7, 2020
Assignee:
DexCom, Inc.
Inventors:
Apurv Ullas Kamath, Jack Pryor, Alexandra Lynn Carlton, Kristin Koenekamp Cote, Leif N. Bowman, Michael Robert Mensinger
Abstract: This invention is an arcuate wearable device with a circumferential or annular array of spectroscopic sensors which measures a person's body hydration. In an example, this invention can be embodied in a modular smart watch band, a specialized hydration-monitoring band, or a finger ring. A circumferential or annular array of spectroscopic sensors helps to ensure continuous measurement of body hydration, even if a wearable device shifts and/or rotates on a person's wrist, arm, or finger.
Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
Type:
Grant
Filed:
September 10, 2014
Date of Patent:
March 31, 2020
Assignee:
DexCom, Inc.
Inventors:
Apurv Ullas Kamath, Peter C. Simpson, Mark Brister
Abstract: A sphygmomanometer cuff for a wearable sphygmomanometer includes a cuff body for wrapping around a predetermined portion of a body. The cuff body includes an air bag, a retaining plate, and an air tube. The air bag includes a top layer, a bottom layer, and an intermediate layer disposed between and spacing apart the top layer and the bottom layer. A sealed cavity is defined between the top layer and the bottom layer. The intermediate layer has a rough surface. The retaining plate is attached to an outer surface of the top layer of the air bag. The air tube extends through the retaining plate and connects with the sealed cavity of the air bag.
Abstract: Medical device systems and methods for making and using medical device systems are disclosed. An example medical device system may include a guidewire. A pressure sensor assembly may be disposed within the guidewire. The pressure sensor assembly may include a pressure sensor and a first optical fiber coupled to the pressure sensor. The first optical fiber may have a first outer diameter. A cable may be coupled to the guidewire. The cable may include a second optical fiber. The second optical fiber may have a second outer diameter greater than the first outer diameter.
Type:
Grant
Filed:
August 27, 2013
Date of Patent:
March 10, 2020
Assignee:
BOSTON SCIENTIFIC SCIMED, INC.
Inventors:
Daniel J. Gregorich, Roger W. McGowan, Michael J. Tierney
Abstract: A method and apparatus is disclosed herein for erythema grading for psoriasis. In one embodiment, the method comprises generating Skellam distribution statistics related to differences between readout voltages for one or more psoriasis regions for a patient and a normal skin region for the patient; and generating an erythema grading classification for erythema regions in psoriasis using the Skellam distribution statistics as feature vectors.
Abstract: A handheld diabetes management device for managing blood glucose test data and continuous glucose monitoring data includes a port configured to receive a test strip, a wireless transceiver, a communications processor, and a user interface processor. The communications processor communicates with the wireless transceiver to periodically collect glucose measurement data from a continuous glucose monitoring device and to store the glucose measurement data in a first data storage module. The communications processor is operable to consume electrical power at a first rate. The user interface processor communicates with the communication processor to receive the glucose measurement data and operable to display the glucose measurement data on the device. The communications processor operates asynchronously from operation of the user interface processor to collect the glucose measurement data and the user interface processor operates to consume electrical power at a second rate that is higher than the first rate.
Type:
Grant
Filed:
August 31, 2016
Date of Patent:
February 25, 2020
Assignee:
Roche Diabetes Care, Inc.
Inventors:
Timothy P. Engelhardt, Gerhard Frisch, Robert E. Reinke, Wilfried Schmidt, Michael Schoemaker, Uwe Wittmann
Abstract: Embodiments of the present invention are related to a method and device for the determination and calculation of the depth of chest compressions during the administration of cardiopulmonary resuscitation (CPR). Embodiments use an optical sensor to monitor the distance that a victim's chest is displaced during each compression throughout the administration of CPR. The optical sensor is most commonly an image sensor such as a CMOS or CCD sensor, and more specifically a CMOS image sensor capable of three-dimensional imaging based on the time-of-flight principle. An infrared emitter may illuminate the victim's body and any visible piece of ground beside the victim. As the infrared light interacts with any surfaces it encounters, it is reflected and returns to the image sensor where the time of flight of the infrared light is calculated for every pixel in the image sensor. The distance data is used to gauge the effective displacement of the victim's chest.
Abstract: Methods and systems for encouraging interactions with a glucose monitoring system include incrementing a score and/or providing a reward based on a variety of different interactions with the glucose monitoring system. The interactions which improve the score may include initiating or changing displays, downloading data, setting operational parameters and other interactions that are independent of a user's glucose measurements. Encouraging these interactions can enhance success in maintaining healthy glucose concentrations.
Type:
Grant
Filed:
December 16, 2015
Date of Patent:
January 21, 2020
Assignee:
DexCom, Inc.
Inventors:
Apurv Ullas Kamath, Jack Pryor, Alexandra Lynn Carlton, Kristin Koenekamp Cote, Leif N. Bowman, Michael Robert Mensinger
Abstract: Various examples are provided for brain state advisory systems using calibrated metrics and optimal time-series decompositions. In one embodiment, a method includes monitoring brainwave activity of a subject and classifying a brain state of the subject based upon the brainwave activity and a model of the brainwave activity. In another embodiment, brain states of the subject are modeled based upon the brainwave activity of the subject.
Type:
Grant
Filed:
December 17, 2014
Date of Patent:
January 14, 2020
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Systems, devices, and methods are provided for a non-rigid wearable device comprising electrical circuitry and a support structure supporting the electrical circuitry. The support structure having rigid sections that rigidly support components of the electrical circuitry to protect components and/or solder joints from stress due to deflection and having non-rigid or flexible sections where there are no solder connections present on the electrical circuitry and/or where there are interconnecting traces present on the electrical circuitry that can tolerate stress due to deflection.
Abstract: A biosensor for monitoring nitric oxide (NO) of a patient in vivo, includes a PPG circuit configured to obtain a first spectral response for light reflected at a first wavelength from skin tissue of the patient, wherein the first wavelength has a high absorption coefficient for nitric oxide in arterial blood flow and obtain a second spectral response for light reflected at a second wavelength from skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for nitric oxide in arterial blood flow. The biosensor further includes a processing circuit configured to determine an NO measurement value for nitric oxide using the first spectral response and the second spectral response and obtain an adjusted measurement value of nitric oxide by compensating the NO measurement value using a measurement value for at least a first species of hemoglobin.
Abstract: Devices and methods for assessing ulceration risk in a tissue. Some embodiments include a device having a scan head on an extension neck extending from housing and having range of motion relative to the housing. The scan head includes light-emitting system that alternately emits light at different selected wavelengths into the tissue, and a photodetector that generates an electrical signal based on the receive light. A processor calculates regional-perfusion-index (RPI) data based on the electrical signal. Some embodiments provide a tissue-vibration mechanism to help measure mechano-transduction induced recovery from vibratory stimulation for determining short-term metabolic deficit. In some embodiments, the scan head has a topological feature (such as one or more grooves, holes, bumps and/or ridges) that provides pressure-change stimulation for measuring vascular recovery from pressure changes.
Abstract: The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. Preferably, the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity yielding a seizure index directly related to the current presence of ictal activity in the signal. Additionally, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. These indexes can be used in the context of emergency and/or clinical situations to assess the status and well-being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
December 10, 2019
Assignee:
NeuroWave Systems inc.
Inventors:
Stéphane Bibian, Tatjana Zikov, Mo Modarres