Patents Examined by James A. Patten
-
Patent number: 4014920Abstract: Amines of the formula ##SPC1##Wherein R.sub.1 is lower alkyl, lower alkoxy or amino, R.sub.2 is hydrogen or lower alkyl, R.sub.3 is hydrogen, lower alkyl, carboxyl or lower alkoxycarbonyl, R.sub.4 is hydrogen or lower alkyl, R.sub.5 is lower alkyl, aryl-lower alkyl or optionally functionally modified carboxy-lower alkyl and R.sub.6 denotes halogen, trifluoromethyl, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, lower alkoxymethyl, carbamoyl, N-lower alkylcarbamoyl, nitrile, lower alkinyloxy or hydrogen, and their salts block cardiac and vascular .beta.-receptors the are useful in the treatment of arrhythenias and angina pectoris and as intermediates for, especially for pharmaceutically active substances.Type: GrantFiled: June 4, 1973Date of Patent: March 29, 1977Assignee: Ciba-Geigy CorporationInventors: Knut Alfred Jaeggi, Franz Ostermayer, Herbert Schroter
-
Patent number: 4014923Abstract: N-carboxylated N-methylcarbamic acid aryl esters of the general formula ##EQU1## in which Ar is phenyl, naphthyl, dihydrobenzofuranyl or indanyl optionally substituted by alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, alkylmercapto, alkenylmercapto, alkynylmercapto, dialkylamino, trihalomethyl, halogen, nitro, cyano, cycloalkyl, formamidino, dioxolanyl, dioxanyl or dialkoxymethyl, andR is OAr or optionally substituted alkoxy, alkenoxy, alkynoxy, cycloalkyloxy, amino, alkylmercapto or arylmercapto,Which possess insecticidal and acaricidal properties.Type: GrantFiled: June 27, 1974Date of Patent: March 29, 1977Assignee: Bayer AktiengesellschaftInventors: Engelbert Kuhle, Peter Siegle, Wolfgang Behrenz, Ingeborg Hammann
-
Patent number: 4013714Abstract: Compounds represented by the formula ##EQU1## wherein Rx is ##EQU2## AND A is hydrogen, methyl, ethyl, CH.sub.2 OH or RxOH; M being alkali metal, ammonium, alkyl ammonium, or alkanol ammonium and Rz being hydrogen, alkyl, phenyl, phenyl alkyl, alkoxy alkyl, alkoxy phenyl or alkoxy phenyl alkyl are useful as complexing agents and/or detergency builders. The ester and acid forms of these compounds are useful as intermediates for their preparation.Type: GrantFiled: December 19, 1973Date of Patent: March 22, 1977Assignee: Monsanto CompanyInventor: Kent P. Lannert
-
Patent number: 3993665Abstract: 3-Amidocoumaranones which may be substituted in the benzene ring by halo or alkyl; the compounds are obtained by treating an appropriate 2-hydroxyphenylacetic acid lactone with nitrous acid or with an ester, salt or chloride of nitrous acid in an acid medium to afford a coumaranedione-3-monoxime which is subjected to catalytic hydrogenation in the presence of an acid anhydride. The resulting 3-amidocoumaranone is an intermediate in the preparation of .alpha.-amino-2-hydroxyphenylacetic acid which can be used to synthesize antibiotics such as cephalosporin and penicillin derivatives.Type: GrantFiled: August 8, 1974Date of Patent: November 23, 1976Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Rudolf Braden
-
Patent number: 3993666Abstract: Coumaranedione-3-monoximes which may be substituted in the benzene ring by halo or alkyl. The compounds are obtained by treating the corresponding 2-hydroxyphenylacetic acid lactone with nitrous acid or with an ester, salt or chloride of nitrous acid in an acid medium. The coumaranedione-3-monoxime thus obtained is an intermediate which undergoes hydrogenation in the presence of a suitable acid anhydride to afford the corresponding 3-amidocoumaranone, which compound, upon hydrolysis in the presence of dilute acid, affords the corresponding .alpha.-amino-2-hydroxyphenylacetic acid. That product is also an intermediate which has utility in the synthesis of antibiotics, including cephalosporin and penicillin derivatives.Type: GrantFiled: August 8, 1974Date of Patent: November 23, 1976Assignee: Bayer AktiengesellschaftInventors: Hermann Oediger, Rudolf Braden
-
Patent number: 3989841Abstract: Novel fluorene-2-acetic acid derivatives and methods for preparing these derivatives are provided. Inflammatory conditions may be treated by administering these novel compounds. Additionally, it has been found that the treatment of inflammatory conditions is a new use for certain known compounds; specifically, fluorene-2-acetic acid and its 7-halo, 7-amino, and 7-nitro derivatives.Type: GrantFiled: September 30, 1974Date of Patent: November 2, 1976Assignee: E. R. Squibb & Sons, Inc.Inventors: Eric T. Stiller, Seymour D. Levine, Pacifico A. Principe, Patrick A. Diassi
-
Patent number: 3988335Abstract: The disclosure is directed to 1,6-bis-(substituted oxy)-xanthen-9-ones which have the formula ##SPC1##Where R.sub.1 is morpholino(lower)alkyl, di(lower)alkylamino(lower)-alkyl, or pyrrolidinyl(lower)alkyl; and R.sub.2 is lower alkylamino (lower)alkyl or hydrogen. The compounds are active as immunoregulators or as intermediates in the preparation of immunoregulators. The intermediates also have trichomonacidal activity.Type: GrantFiled: May 8, 1974Date of Patent: October 26, 1976Assignee: American Home Products CorporationInventors: Arthur A. Santilli, Anthony C. Scotese, Stanley C. Bell, Marvin E. Rosenthale
-
Patent number: 3985790Abstract: A novel pharmaceutically useful compound, the p-chlorophenoxyisobutyrate salt of 4-(p-chlorophenoxyacetyl-amino)-benzene carboxylic acid diethylaminoethyl ester, is disclosed, which has superior antilipemic and anticholesteremic properties.Type: GrantFiled: July 23, 1974Date of Patent: October 12, 1976Assignee: Ludwig Merckle KGInventors: Gunter Metz, Manfred Specker
-
Patent number: 3985799Abstract: 2,6-halo and trifluoromethyl-substituted-benzoic acids, e.g., 2,3,4,6-tetrafluorobenzoic acid or 2-chloro-6-trifluoromethylbenzoic acid, are prepared from substituted 2,4-halo and trifluoromethyl-substituted benzene compounds and are useful as plant growth regulators.Type: GrantFiled: August 20, 1973Date of Patent: October 12, 1976Assignee: Sandoz, Inc.Inventor: William J. Houlihan
-
Patent number: 3985773Abstract: The disclosure herein pertains to the use of certain 3-[(naphthyl, or substituted-phenyl)imino]-phthalides, some of whose members are novel, to regulate the natural growth or development of plants.Type: GrantFiled: December 26, 1974Date of Patent: October 12, 1976Assignee: Monsanto CompanyInventors: Gerhard H. Alt, John E. Franz
-
Patent number: 3981892Abstract: New polycyclic lactones useful as perfuming and odor-modifying agents in the manufacture of perfumes and perfumed articles, and as flavoring and taste-modifying agents in the aromatization of foodstuffs in general and imitation flavors for foodstuffs, beverages, animal feeds, pharmaceutical preparations and tobacco products.Novel process for the preparation of said cycloaliphatic compounds and compositions of matter relating to mixtures containing same.Type: GrantFiled: July 23, 1974Date of Patent: September 21, 1976Assignee: Firmenich S.A.Inventor: Werner Skorianetz
-
Patent number: 3975381Abstract: A process for preparing a .gamma.-lactone derivative having the formula (I) ##EQU1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a phenyl group which may be substituted with a halogen atom, and R.sup.1 and R.sup.2, and R.sup.5 and R.sup.6 may, when taken together with the carbon atom to which they are attached, form a cycloalkyl group having 4 to 7 carbon atoms, and R.sup.7 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 4 to 6 carbon atoms or a phenyl group which may be substituted with an alkyl group having 1 to 3 carbon atoms, which comprises reacting an allylic diol with an orthocarboxylic acid ester in the presence of an acidic catalyst.Type: GrantFiled: December 27, 1974Date of Patent: August 17, 1976Assignee: Sagami Chemical Research CenterInventors: Kiyosi Kondo, Fumio Mori
-
Patent number: 3970673Abstract: A process for preparing a bicyclic .gamma.-lactone represented by the formula (I) ##SPC1##wherein R represents a hydrogen atom or a straight or branched chain alkyl group having 1 to 4 carbon atoms and n is an integer of 1 to 6, which comprises condensing a cycloalkene diol compound represented by the formula (II) ##SPC2##wherein n is as defined above, with an orthocarboxylic acid ester represented by the formula (III)r--ch.sub.2 --c(or.sup.1).sub.3 (iii)wherein R is as defined above and R.sup.1 represents a straight or branched chain alkyl group having 1 to 4 carbon atoms, in the presence of an acidic catalyst.Type: GrantFiled: May 29, 1975Date of Patent: July 20, 1976Assignee: Sagami Chemical Research CenterInventors: Kiyosi Kondo, Masakatsu Matsumoto, Fumio Mori
-
Patent number: 3970693Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl) benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid.This invention relates to new processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid, to intermediates thereof and processes for said intermediates.Type: GrantFiled: July 5, 1974Date of Patent: July 20, 1976Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
-
Patent number: 3969368Abstract: 2-Substituted benzodioxoles are useful as pharmaceuticals having e.g. anti-inflammatory, analgesic, antipyrretic, antitussive, C.N.S. depressant, local anaesthetic, antiarrythmic, antihistaminic action and hypolipidic action.Type: GrantFiled: February 1, 1973Date of Patent: July 13, 1976Assignee: Istituto Luso Farmaco d'Italia S.r.l.Inventors: Elso Manghisi, Aldo Salimbeni
-
Patent number: 3969468Abstract: 6,7-Benzomorphan derivatives, which are useful as unaddictive analgesics, are prepared from aromatic aminoketones through several steps of reactions. Most of the intermediates are new compounds. Process for preparing 2-benzyl-1,2,5,6-tetrahydropyridine derivatives which are known as intermediates for the preparation of 6,7-benzomorphan derivatives is also disclosed.Type: GrantFiled: October 29, 1973Date of Patent: July 13, 1976Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kentaro Tamaki, Kyoichi Fujii, Seiichi Yada, Shiro Kudo
-
Patent number: 3968142Abstract: Compounds of the formula ##EQU1## in which Ph represents an ortho-phenylene radical which contains in position 4 or 5 an unsubstituted or substituted hydrocarbon radical of aliphatic character, R represents a lower alkyl radical or especially a hydrogen atom, Z represents a free, esterified or amidated carboxyl group, A represents an ethylene radical and X stands for two hydrogen atoms or especially for an oxo group, are useful as chemotherapeutic and prophylactic agents against pain and inflammation.Type: GrantFiled: October 7, 1969Date of Patent: July 6, 1976Assignee: Ciba-Geigy CorporationInventors: Dieter Beck, Karl Schenker, Alberto Rossi
-
Patent number: 3968152Abstract: Aromatic mono- and polycarboxylic acids are produced by hydrolyzing the corresponding mono- and polynitriles in aqueous slurry containing a catalyst, removing ammonia from the hydrolysis mixture by countercurrent stripping with steam, and cooling the hydrolysis product to separate the carboxylic acid.Type: GrantFiled: January 31, 1975Date of Patent: July 6, 1976Assignee: The Lummus CompanyInventors: Morgan C. Sze, Daniel H. Gold, Richard T. Whitehead
-
Patent number: 3966801Abstract: Novel substituted phenyl butyric acids and their derivatives are described. Therapeutic compositions and method of treatment of inflammation is also disclosed.Type: GrantFiled: December 13, 1973Date of Patent: June 29, 1976Assignee: William H. Rorer, Inc.Inventor: Julius Diamond
-
Patent number: 3966793Abstract: Intermediates for preparing novel benzodiazepines having the formula ##SPC1##In which R.sub.1 is a hydrogen or halogen atom or a trifluoromethyl, loweralkyl, loweralkoxy, nitro or amino group; R.sub.2 is a furyl, a thienyl, cyclohexyl, a loweralkyl group or a phenyl group which may be substituted by a halogen atom or by a trifluoromethyl, nitro, loweralkoxy or loweralkyl group; and R.sub.3 is a hydrogen atom or a loweralkyl group; and R.sub.4 is lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)carbamoyl, a group having the formula --COOCat in which Cat is a cation of an alkali metal or a semication of an alkaline earth metal or COOCat.CatOH, said intermediates being ortho-aminoaryl ketimines having the formula ##SPC2##Wherein R is hydrogen or ##EQU1## R.sub.1, R.sub.2, and R.sub.3 are as defined above, R.sub.Type: GrantFiled: September 26, 1973Date of Patent: June 29, 1976Assignee: Clin MidyInventor: Josef Schmitt, deceased