Patents Examined by James A. Patten
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Patent number: 3957861Abstract: In accordance with this invention, there are disclosed compounds of the formula ##SPC1##Wherein X is selected from the group consisting of nitro and amino with the proviso that when y is hydrogen, X is nitro; Y is selected from the group consisting of hydrogen and fluoro; R is selected from the group consisting of hydrogen and alkyl of from one to six carbon atoms, inclusive.These compounds are compounded into pharmaceutical compositions and administered to mammals for purposes of relieving inflammation and to mammals in need of prophylactic anti-thrombotic treatment.Type: GrantFiled: November 7, 1973Date of Patent: May 18, 1976Assignee: The Upjohn CompanyInventors: Milton E. Herr, Roy A. Johnson
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Patent number: 3956363Abstract: New substituted indenyl acetic acids and nontoxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indenyl acetic acids disclosed herein have anit-inflammatory, anti-pyretic and analgesic activity.Type: GrantFiled: August 23, 1974Date of Patent: May 11, 1976Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Richard B. Greenwald, Howard Jones, Bruce O. Linn, Bruce E. Witzel
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Patent number: 3956377Abstract: Coated catalysts having an inert support material with an outer surface and a coating of active catalyst containing tungsten, vanadium and molybdenum plus optionally one or more of Fe, Mn, Cu, Sn, Sb, Cr, Ce, U, Co, Ni, Zn, Mg or mixture thereof have been found to be especially effective catalysts for the production of unsaturated acids from the corresponding unsaturated aldehydes, for example, acrolein is oxidized to acrylic acid using these catalysts. The catalysts give a very low exotherm, very high single pass yields of the desired acid and reduce the undesirable by-products.Type: GrantFiled: June 17, 1974Date of Patent: May 11, 1976Assignee: The Standard Oil Company (Ohio)Inventors: Serge R. Dolhyj, Ernest C. Milberger
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Patent number: 3956378Abstract: A process for the catalytic oxidation of olefins to unsaturated aldehydes and acids and the ammoxidation of olefins to unsaturated nitriles in which the catalyst comprises a promoted, reduced, antimony oxide-molybdenum oxide-containing catalyst.Type: GrantFiled: August 20, 1973Date of Patent: May 11, 1976Assignee: The Standard Oil Company (Ohio)Inventors: Robert K. Grasselli, Dev D. Suresh, Ernest C. Milberger
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Patent number: 3956373Abstract: Process of reducing the bromine content of spent sulfuric acid bromination liquor containing organic impurities by blowing an oxygen containing gas through said sulfuric acid liquor at an elevated temperature at least until substantially all of the organic material in said liquor is oxidized.Type: GrantFiled: August 20, 1973Date of Patent: May 11, 1976Assignee: Standard Oil CompanyInventor: James O. Knobloch
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Patent number: 3956360Abstract: A process for the manufacture of urethanes and the optional co-production of amines by reacting at elevated temperatures and pressures an organic compound containing at least one hydroxyl group with carbon monoxide and a nitrogenous organic compound containing at least one non-cyclic group, in which a nitrogen atom is directly attached to a single carbon atom and is also attached through a double bond to an oxygen or another nitrogen atom, in the presence of an active amount of a catalyst selected from the group consisting of selenium, sulfur, selenium compounds, tellurium compounds, sulfur compounds and mixtures thereof and a base and/or water.Type: GrantFiled: April 11, 1974Date of Patent: May 11, 1976Assignee: Atlantic Richfield CompanyInventors: John G. Zajacek, John J. McCoy, Karl E. Fuger
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Patent number: 3956376Abstract: An improved process for the production of acrolein from propylene and of acrylic acid from propylene or acrolein or mixtures of propylene and acrolein which essentially comprises catalytic oxidation of propylene and/or acrolein with oxygen or a gas containing molecular oxygen in the presence of an oxidation catalyst and of methanol in a quantity of from 0.01 to 1% by volume with respect to the total gaseous mixture of the reactants. Acrolein and acrylic acid are formed in the process at high conversion rates and selectivities.Type: GrantFiled: November 29, 1973Date of Patent: May 11, 1976Assignee: Societa Italiana Resine S.p.A.Inventors: Natale Ferlazzo, Gian Fausto Buzzi, Marcello Ghirga
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Patent number: 3956364Abstract: This invention relates to novel N-alkyl-N-cyanoformyl carbamates and N-alkyl-N-cyanoformyl thiolcarbamates and their use as namatocides.Type: GrantFiled: May 15, 1974Date of Patent: May 11, 1976Assignee: Chevron Research CompanyInventor: Malcolm S. Singer
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Patent number: 3954852Abstract: 4, 5, 6 or 7 Aryl substituted indenyl acetic acids and pharmaceutically acceptable salts, amides and esters thereof. The 4, 5, 6 or 7 aryl substituted indenyl acetic acids have anti-inflammatory, anti-pyretic and analgesic activity. The invention also includes methods for the preparation of these compounds, pharmaceutical compositions and methods of treating inflammation by administering these particular compounds to patients.Type: GrantFiled: October 19, 1973Date of Patent: May 4, 1976Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones
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Patent number: 3954808Abstract: Novel compounds, useful as intermediates in the preparation of lubricant additives, are described by specified general formulae and as condensation products of (i) an alkyl-substituted monohydric phenol, phenol sulphide or alkylene bis-phenol in which the alkyl substituent contains at least 8 carbon atoms and (ii) a carbonyl-substituted compound selected from the group consisting of glyoxylic acid, pyruvic acid, levulinic acid, 3-oxoglutaric acid, 2-oxoglutaric acid and esters of such acids.Type: GrantFiled: November 1, 1973Date of Patent: May 4, 1976Assignee: Edwin Cooper & Company LimitedInventors: John Scotchford Elliott, Bryan Terence Davis, Richard Martin Howlett
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Patent number: 3954841Abstract: Curable compositions are provided by the interaction of bis(2-hydroxyethyl) terephthalate with unsaturated epoxy derivatives such as allyl glycidyl ether to form unsaturated poly(ester-ethers).Type: GrantFiled: June 24, 1974Date of Patent: May 4, 1976Assignee: Celanese CorporationInventor: Robert W. Stackman
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Patent number: 3954806Abstract: A process for preparing dl-strigol, a potent seed germination agent, which comprises preparing the 2-bromomethyl-substituted methyl ester of 2,6,6-trimethylcyclohex-1-en-3-one-1-carboxylic acid, alkylating and cyclizing the said compound with an excess of dimethyl sodiomalonate to obtain methyl 1,4-diketo-7,7-dimethyl-4,5,6,7-tetrahydroindane-2-carboxylate and its enol, subjecting the said keto and enol forms of the compound, in admixture, to alkylation with methyl bromoacetate followed by acidic hydrolysis and spontaneous decarboxylation to obtain methyl 1,4-diketo-7,7-dimethyl-4,5,6,7-tetrahydroindane-2-acetic acid, reducing the said acetic acid with a hydride reducing agent and recovering and separating the resulting 1,4-cis and trans-dihydroxy-7,7-dimethyl-4,5,6,7-tetrahydroindane-2-acetic acid lactones, formylating each of the cis and trans .gamma.Type: GrantFiled: December 13, 1974Date of Patent: May 4, 1976Assignee: Wisconsin Alumni Research FoundationInventor: Charles J. Sih
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Patent number: 3954837Abstract: Allophanates of the formula: ##EQU1## wherein: THE X's are oxygen or sulfur;R.sub.1 is hydrogen, certain organic radicals, or halogen; andR.sub.2 and R.sub.3 are certain organic radicals,Are useful for the control of flowering and plant sexual reproduction. A preferred use of the compounds of the present invention is to prevent corn inbreeding by applying the allophanate to the plant at or shortly before tassel emergence.Exempliary of such compounds is: ethyl 4-[1-(4-chlorophenylcarbamoylimino)-1-(methoxy-methyl)]allophanate.Type: GrantFiled: October 12, 1973Date of Patent: May 4, 1976Assignee: E. I. Du Pont de Nemours and CompanyInventor: Russell F. Bellina
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Patent number: 3953496Abstract: A bis(benzamido)-benzoic acid derivative represented by the formula ##SPC1##Wherein R.sup.1, R.sup.2 and R.sup.3 are as defined hereinbelow and a process for preparing the same is disclosed.The compounds of the invention inhibit hemolysis of sheep red blood cell and cutaneous anaphylactic reaction, and also have an antipyretic sedative, anti-inflammatory and anti-allergic effect and are especially useful for treatment of rheumatic arthritis, bronchial asthma and nephritis.Type: GrantFiled: March 13, 1974Date of Patent: April 27, 1976Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Mori, Sakae Takaku, Yoshiyuki Osugi, Takashi Matsuno, Shogo Tomizawa
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Patent number: 3953500Abstract: Compounds of the formula: ##SPC1##Wherein R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.Type: GrantFiled: August 12, 1974Date of Patent: April 27, 1976Assignee: Takeda Chemical Industries, Ltd.Inventors: Shunsaku Noguchi, Tetsuya Aono, Yoshiaki Araki, Kiyohisa Kawai
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Patent number: 3953472Abstract: Lactones are separated from a mixture of (a) at least one member selected from the group consisting of hydroxy acids wherein the OH group and the COOH group are bonded through 3 or 4 carbon atoms, lactones derived therefrom, lower polymers of said hydroxy acids and/or said lactones and esters of said hydroxy acids and/or said lactones and (b) at least one member selected from the group consisting of hydroxy acids wherein the OH group and the COOH group are bonded through 5 carbon atoms, lactones derived therefrom, lower polymers of said hydroxy acids and/or said lactones and esters of said hydroxy acids and/or said lactones, by heating said mixture in the presence of one or more monovalent or bivalent aliphatic or alicyclic alcohols under the conditions so as to remove the lactones from said (a) by distillation.Type: GrantFiled: March 15, 1974Date of Patent: April 27, 1976Assignees: Teijin Limited, Sumitomo Chemical Company, LimitedInventors: Yutaka Fujita, Toru Sawaki, Tadahisa Sasano, Masao Sada
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Patent number: 3952019Abstract: The disclosure relates to a series of novel prostaglandin intermediates, the preparation of which in sequence constitutes a novel process for the manufacture of known diol intermediates, for example 2,3,3a.beta.,6a.beta.-tetrahydro-5.alpha.-hydroxy-4.beta.-(3-hydroxyoct-1- trans-enyl)-2-oxocyclopenteno[b]furan, from the readily available norbornadiene, said process comprising fewer and more easily operable stages than previously known processes for the manufacture of said diol intermediates.Type: GrantFiled: April 30, 1974Date of Patent: April 20, 1976Assignee: Imperial Chemical Industries LimitedInventors: Richard Philip Peel, James Kenneth Sutherland
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Patent number: 3950395Abstract: Benzoylphenylguanidines of the formula ##SPC1##WhereinR.sup.1 is alkyl of 1 to 4 carbon atoms;R.sup.2 is hydrogen; alkyl of 1 to 18 carbon atoms unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, cyano, alkoxy of 1 to 4 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, phenoxy, halophenoxy, alkylphenoxy and alkoxyphenoxy; cycloalkyl of 5 to 8 carbon atoms; aralkyl unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms; aryl unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms;Z is OR.sup.1 wherein R.sup.1 is as above defined orR.sup.3 wherein R.sup.Type: GrantFiled: January 28, 1974Date of Patent: April 13, 1976Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Arno Widdig, Herbert Thomas, Hans Peter Schulz
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Patent number: 3950407Abstract: The maleic acid adduct of anthracene is used as a starting material for 11-amino-12-carboalkoxy-9,10-dihydro-9,10-ethanoanthracene, which through reaction with nitrous acid in a protic solvent provides an 11-substituted-12-carboalkoxy-10,11-dihydro-5,10-methano-5H-dibenzo[a,d]cy cloheptene which is then converted into the useful intermediate 12-carboxy-10,11-dihydro-5,10-methano-5H-dibenzo[a,d]cycloheptene.Type: GrantFiled: June 18, 1973Date of Patent: April 13, 1976Assignee: Riker Laboratories, IncorporatedInventor: Walton J. Hammar
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Patent number: 3950413Abstract: A process for the preparation of phosphonic acid dihalides of the formula ##EQU1## IN WHICH R is .alpha., .beta.-unsaturated alkyl, .alpha., .beta.-unsaturated alkyl, phenyl or benzyl and may be further substituted, which comprises reacting corresponding phosphonic or pyrophosphonic acids or their functional derivatives with acid halides of the formula (CO).sub.n Hal.sub.2 where n is 1 or 2.Type: GrantFiled: May 23, 1974Date of Patent: April 13, 1976Assignee: Hoechst AktiengesellschaftInventors: Manfred Finke, Hans-Jerg Kleiner