Patents Examined by James A. Patten
  • Patent number: 3948892
    Abstract: The compounds are 2-alkoxy(and 2-amino)-3-amino-2-heterocyclic-thiopropanamides, for example 2-methoxy-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide, which are inhibitors of gastric acid secretion.
    Type: Grant
    Filed: October 15, 1974
    Date of Patent: April 6, 1976
    Assignee: SmithKline Corporation
    Inventor: Bernard Loev
  • Patent number: 3948975
    Abstract: Hydroxyalkyl esters of N-phosphonomethyl glycine and their salts and a process for their preparation are described. These esters and salts are useful as contact herbicides.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: April 6, 1976
    Assignee: Monsanto Company
    Inventor: John E. Franz
  • Patent number: 3947488
    Abstract: Thallous salts of .beta.-dicarbonyl compounds, prepared by reaction of the .beta.-dicarbonyl compounds with a thallous alkoxide, are treated with alkyl halides to give C-alkyl products in high yield, with acyl halides at room temperature to give C-acyl products, and with acyl halides at low temperatures to give O-acyl products. Thallous phenolates are esterified with acyl or aroyl halides. Anhydrides are also prepared, as are biaryls and bi-sec-alkyls. N-Heterocyclics, including purines and pyrimidines, are N-alkylated. Lactams are O-acylated or N-alkylated.
    Type: Grant
    Filed: May 21, 1974
    Date of Patent: March 30, 1976
    Inventors: Edward C. Taylor, Alexander McKillop
  • Patent number: 3947495
    Abstract: The selective preparation of acrylic or methacrylic acids by a single step vapor phase oxidation of propylene or isobutylene, respectively, at temperatures up to 300.degree. C. in the presence of a catalyst containing palladium metal and phosphoric acid is improved by the use of a sulfur modifier.
    Type: Grant
    Filed: July 1, 1974
    Date of Patent: March 30, 1976
    Assignee: National Distillers and Chemical Corporation
    Inventors: Jawad H. Murib, Charles E. Frank, Ben Seeskin
  • Patent number: 3946071
    Abstract: Substituted alpha-chloro-methane-sulfenyl chlorides, intermediary chlorinated benzyl sulfides and chlorinated mercaptans useful as herbicides and chemical intermediates for herbicides are prepared by the chlorination of substituted methyl benzyl sulfides and substituted methyl mercaptans.
    Type: Grant
    Filed: December 7, 1973
    Date of Patent: March 23, 1976
    Assignee: Monsanto Company
    Inventor: Wendell Gary Phillips
  • Patent number: 3944583
    Abstract: The invention is concerned with dianhydrides derived from phenolphthalein and from bisphenol fluorenone by a process which can include the reaction of an N-methyl-nitrophthalimide with the dialkali metal salt of either of the aforementioned two dihydroxy compounds.
    Type: Grant
    Filed: February 27, 1975
    Date of Patent: March 16, 1976
    Assignee: General Electric Company
    Inventor: Clayton B. Quinn
  • Patent number: 3944600
    Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.
    Type: Grant
    Filed: September 30, 1974
    Date of Patent: March 16, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
  • Patent number: 3944603
    Abstract: Production of propionic acid and propionic anhydride with the repression of polyketone formation by carboxylating ethylene utilizing a catalyst system essentially composed of an iridium compound in the substantial absence of added halide components.
    Type: Grant
    Filed: May 7, 1974
    Date of Patent: March 16, 1976
    Assignee: Monsanto Company
    Inventor: Donald E. Morris
  • Patent number: 3944571
    Abstract: Pharmaceutical compositions having anti-arthritic activity comprising an ester derivative of pulvinic acid and methods of producing anti-arthritic activity by administering internally said compositions. Certain of the pulvinic acid derivatives are novel compounds per se.
    Type: Grant
    Filed: May 6, 1974
    Date of Patent: March 16, 1976
    Assignee: SmithKline Corporation
    Inventors: Blaine M. Sutton, Donald T. Walz, James W. Wilson
  • Patent number: 3944570
    Abstract: Phthalanols disubstituted in the 3-position, e.g. 3-(4-chlorophenyl)-3-(2-dimethylaminomethyl phenyl)-1-methyl-1-phthalanol, prepared by alkylating corresponding phthalides, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: June 27, 1974
    Date of Patent: March 16, 1976
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Patent number: 3943257
    Abstract: The compounds are 4-naphthyl-4-lower alkyl substituted-2-oxygenated-2-butenes, or butanes; the naphthyl position may be unsubstituted or 6-substituted, e.g., 2-(6-methoxynaphthyl)-2-penten-4-ol, and are useful as pharmaceuticals.
    Type: Grant
    Filed: August 20, 1973
    Date of Patent: March 9, 1976
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Darryl A. Brittain
  • Patent number: 3941816
    Abstract: Stabilized oxichromic compounds are disclosed, along with processes for stabilizing oxichromic compounds. In one aspect, the stabilized compounds are O-acylated compounds which contain a reduced azomethine linkage. In another aspect, the stabilized compounds are O-acylated compounds which can undergo base catalyzed chromogenic oxidation to produce a yellow dye.
    Type: Grant
    Filed: December 10, 1971
    Date of Patent: March 2, 1976
    Assignee: Eastman Kodak Company
    Inventor: Albert Edward Anderson, Jr.
  • Patent number: 3939182
    Abstract: 6 .alpha.-Carboxy-5.alpha. (1-hydroxyethyl)-2-cyclohexene-1-heptanoic acid, .gamma. - lactone, and lower alkyl and aralkyl esters thereof, are useful intermediates for the production of Prostaglandin E.sub.1.
    Type: Grant
    Filed: February 11, 1975
    Date of Patent: February 17, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Chan-Hwa Kuo, David Taub, Norman L. Wendler
  • Patent number: 3939199
    Abstract: An improved process for oxacylating olefins in the gaseous phase which comprises using a supported catalyst comprising palladium and a carrier having a total pore volume of from 0.4 to 1.2 ml/g, less than 10% of the total pore volume being attributable to micropores having a diameter of less than 30 A. Catalysts of this type are much more efficient than conventional catalysts.
    Type: Grant
    Filed: June 22, 1973
    Date of Patent: February 17, 1976
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Fernholz, Friedrich Wunder, Hans-Joachim Schmidt
  • Patent number: 3935240
    Abstract: The disclosure relates to novel intermediates, for use in the manufacture of known prostaglandins and prostaglandin-like compounds, for example aldehydes such as methyl 7-[2.beta.-formyl-3.alpha.-hydroxy-5.alpha.-(4-phenylbenzoyloxy)cyclopent- 1.alpha.-yl]hetp-5-cis-enoate and enones such as methyl 15-oxo-9.alpha.,11.alpha.-di(4-phenylbenzoyloxy)-5-cis,13-trans-prostadien oate, processes for their manufacture, and their conversion to prostaglandins or prostaglandin-like compounds.
    Type: Grant
    Filed: October 26, 1973
    Date of Patent: January 27, 1976
    Assignee: Imperial Chemical Industries Limited
    Inventor: Keith Blakeney Mallion
  • Patent number: 3935236
    Abstract: Aminopropanols with .beta.-blocking activity having the general formula ##SPC1##Wherein R is hydrogen, C.sub.1 -C.sub.4 alkyl or hydroxy-(C.sub.2 -C.sub.4) alkyl, R.sub.1 is C.sub.1 -C.sub.4 alkyl or hydroxy-(C.sub.2 -C.sub.4) alkyl; R.sub.2 and R.sub.3 each independently represent hydrogen or C.sub.1 -C.sub.2 alkyl, R.sub.4 is hydrogen or alkoxy of 1 to 4 C, n is the number 1 or 2; and their pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: May 24, 1974
    Date of Patent: January 27, 1976
    Assignee: Gruppo Lepetit, S.p.A.
    Inventor: Elvio Bellasio
  • Patent number: 3933859
    Abstract: Process for obtaining 5,6 or 6,7 or 7,8 dihydroxy coumarin or derivatives thereof, which are useful for lower blood pressure and for chemical sympathectomy by oxidizing 2,3 or 3,4 or 4,5 dihydroxyphenyl-propionic acid or derivatives thereof, and novel coumarin derivatives of the process.
    Type: Grant
    Filed: June 12, 1974
    Date of Patent: January 20, 1976
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Ado Kaiser, Wolfgang Koch, Marcel Scheer, Uwe Wolcke
  • Patent number: 3932498
    Abstract: New substituted indene acids and non-toxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indene acids disclosed herein have anti-inflammatory, anti-pyretic and analgesic activity. Also included herein are methods of preparing said indene acid compounds, pharmaceutical compositions having said indene acid compounds as an active ingredient and methods of treating inflammation by administering these particular compositions to patients.
    Type: Grant
    Filed: February 23, 1973
    Date of Patent: January 13, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Michael W. Fordice
  • Patent number: 3932480
    Abstract: Novel compounds are disclosed which release a silver halide solvent in the presence of alkali, which compounds may be defined as quinone-or naphthoquinone-methide precursors containing the silver halide solvent moiety. These novel compounds are useful in photographic products and processes.
    Type: Grant
    Filed: May 3, 1974
    Date of Patent: January 13, 1976
    Assignee: Polaroid Corporation
    Inventors: J. Michael Grasshoff, Lloyd D. Taylor
  • Patent number: 3932499
    Abstract: 2-(Substituted biphenylyl)propionic acids and salts and esters thereof, said substituents being selected from fluorine and bromine atoms, useful as anti-inflammatory agents, and their preparation.
    Type: Grant
    Filed: September 22, 1971
    Date of Patent: January 13, 1976
    Assignee: The Boots Company Limited
    Inventors: Stewart Sanders Adams, Bernard John Armitage, John Stuart Nicholson