Abstract: The compounds are 2-alkoxy(and 2-amino)-3-amino-2-heterocyclic-thiopropanamides, for example 2-methoxy-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide, which are inhibitors of gastric acid secretion.
Abstract: Hydroxyalkyl esters of N-phosphonomethyl glycine and their salts and a process for their preparation are described. These esters and salts are useful as contact herbicides.
Abstract: Thallous salts of .beta.-dicarbonyl compounds, prepared by reaction of the .beta.-dicarbonyl compounds with a thallous alkoxide, are treated with alkyl halides to give C-alkyl products in high yield, with acyl halides at room temperature to give C-acyl products, and with acyl halides at low temperatures to give O-acyl products. Thallous phenolates are esterified with acyl or aroyl halides. Anhydrides are also prepared, as are biaryls and bi-sec-alkyls. N-Heterocyclics, including purines and pyrimidines, are N-alkylated. Lactams are O-acylated or N-alkylated.
Abstract: The selective preparation of acrylic or methacrylic acids by a single step vapor phase oxidation of propylene or isobutylene, respectively, at temperatures up to 300.degree. C. in the presence of a catalyst containing palladium metal and phosphoric acid is improved by the use of a sulfur modifier.
Type:
Grant
Filed:
July 1, 1974
Date of Patent:
March 30, 1976
Assignee:
National Distillers and Chemical Corporation
Inventors:
Jawad H. Murib, Charles E. Frank, Ben Seeskin
Abstract: Substituted alpha-chloro-methane-sulfenyl chlorides, intermediary chlorinated benzyl sulfides and chlorinated mercaptans useful as herbicides and chemical intermediates for herbicides are prepared by the chlorination of substituted methyl benzyl sulfides and substituted methyl mercaptans.
Abstract: The invention is concerned with dianhydrides derived from phenolphthalein and from bisphenol fluorenone by a process which can include the reaction of an N-methyl-nitrophthalimide with the dialkali metal salt of either of the aforementioned two dihydroxy compounds.
Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.
Type:
Grant
Filed:
September 30, 1974
Date of Patent:
March 16, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
Abstract: Production of propionic acid and propionic anhydride with the repression of polyketone formation by carboxylating ethylene utilizing a catalyst system essentially composed of an iridium compound in the substantial absence of added halide components.
Abstract: Pharmaceutical compositions having anti-arthritic activity comprising an ester derivative of pulvinic acid and methods of producing anti-arthritic activity by administering internally said compositions. Certain of the pulvinic acid derivatives are novel compounds per se.
Type:
Grant
Filed:
May 6, 1974
Date of Patent:
March 16, 1976
Assignee:
SmithKline Corporation
Inventors:
Blaine M. Sutton, Donald T. Walz, James W. Wilson
Abstract: Phthalanols disubstituted in the 3-position, e.g. 3-(4-chlorophenyl)-3-(2-dimethylaminomethyl phenyl)-1-methyl-1-phthalanol, prepared by alkylating corresponding phthalides, are useful as anti-inflammatory agents.
Abstract: The compounds are 4-naphthyl-4-lower alkyl substituted-2-oxygenated-2-butenes, or butanes; the naphthyl position may be unsubstituted or 6-substituted, e.g., 2-(6-methoxynaphthyl)-2-penten-4-ol, and are useful as pharmaceuticals.
Abstract: Stabilized oxichromic compounds are disclosed, along with processes for stabilizing oxichromic compounds. In one aspect, the stabilized compounds are O-acylated compounds which contain a reduced azomethine linkage. In another aspect, the stabilized compounds are O-acylated compounds which can undergo base catalyzed chromogenic oxidation to produce a yellow dye.
Abstract: 6 .alpha.-Carboxy-5.alpha. (1-hydroxyethyl)-2-cyclohexene-1-heptanoic acid, .gamma. - lactone, and lower alkyl and aralkyl esters thereof, are useful intermediates for the production of Prostaglandin E.sub.1.
Type:
Grant
Filed:
February 11, 1975
Date of Patent:
February 17, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Chan-Hwa Kuo, David Taub, Norman L. Wendler
Abstract: An improved process for oxacylating olefins in the gaseous phase which comprises using a supported catalyst comprising palladium and a carrier having a total pore volume of from 0.4 to 1.2 ml/g, less than 10% of the total pore volume being attributable to micropores having a diameter of less than 30 A. Catalysts of this type are much more efficient than conventional catalysts.
Type:
Grant
Filed:
June 22, 1973
Date of Patent:
February 17, 1976
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Hans Fernholz, Friedrich Wunder, Hans-Joachim Schmidt
Abstract: The disclosure relates to novel intermediates, for use in the manufacture of known prostaglandins and prostaglandin-like compounds, for example aldehydes such as methyl 7-[2.beta.-formyl-3.alpha.-hydroxy-5.alpha.-(4-phenylbenzoyloxy)cyclopent- 1.alpha.-yl]hetp-5-cis-enoate and enones such as methyl 15-oxo-9.alpha.,11.alpha.-di(4-phenylbenzoyloxy)-5-cis,13-trans-prostadien oate, processes for their manufacture, and their conversion to prostaglandins or prostaglandin-like compounds.
Abstract: Aminopropanols with .beta.-blocking activity having the general formula ##SPC1##Wherein R is hydrogen, C.sub.1 -C.sub.4 alkyl or hydroxy-(C.sub.2 -C.sub.4) alkyl, R.sub.1 is C.sub.1 -C.sub.4 alkyl or hydroxy-(C.sub.2 -C.sub.4) alkyl; R.sub.2 and R.sub.3 each independently represent hydrogen or C.sub.1 -C.sub.2 alkyl, R.sub.4 is hydrogen or alkoxy of 1 to 4 C, n is the number 1 or 2; and their pharmaceutically acceptable acid addition salts.
Abstract: Process for obtaining 5,6 or 6,7 or 7,8 dihydroxy coumarin or derivatives thereof, which are useful for lower blood pressure and for chemical sympathectomy by oxidizing 2,3 or 3,4 or 4,5 dihydroxyphenyl-propionic acid or derivatives thereof, and novel coumarin derivatives of the process.
Type:
Grant
Filed:
June 12, 1974
Date of Patent:
January 20, 1976
Assignee:
Hoffmann-La Roche, Inc.
Inventors:
Ado Kaiser, Wolfgang Koch, Marcel Scheer, Uwe Wolcke
Abstract: New substituted indene acids and non-toxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indene acids disclosed herein have anti-inflammatory, anti-pyretic and analgesic activity. Also included herein are methods of preparing said indene acid compounds, pharmaceutical compositions having said indene acid compounds as an active ingredient and methods of treating inflammation by administering these particular compositions to patients.
Type:
Grant
Filed:
February 23, 1973
Date of Patent:
January 13, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Tsung-Ying Shen, Howard Jones, Michael W. Fordice
Abstract: Novel compounds are disclosed which release a silver halide solvent in the presence of alkali, which compounds may be defined as quinone-or naphthoquinone-methide precursors containing the silver halide solvent moiety. These novel compounds are useful in photographic products and processes.
Abstract: 2-(Substituted biphenylyl)propionic acids and salts and esters thereof, said substituents being selected from fluorine and bromine atoms, useful as anti-inflammatory agents, and their preparation.
Type:
Grant
Filed:
September 22, 1971
Date of Patent:
January 13, 1976
Assignee:
The Boots Company Limited
Inventors:
Stewart Sanders Adams, Bernard John Armitage, John Stuart Nicholson