Patents Examined by James Rogers
  • Morphine polymer release system
    Patent number: 8609143
    Abstract: A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: December 17, 2013
    Assignee: Egalet Ltd.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Method of preventing biofouling using an anti-fouling bio-hydrogel composition
    Patent number: 8603452
    Abstract: The invention comprises a biological hydrogel that is chemically stabilized with non-covalent or covalent cross-links. The biological hydrogel is used to coat surfaces of materials for submersion in marine water. Molecular dissolution at the marine water-hydrogel surface prevents attachment of fouling organisms. The rate of dissolution can be controlled by both the concentration of the biopolymer in the hydrogel and the nature and concentration of cross-linker used. Additional components, either molecular or particulate, can be added to the biological hydrogel before or after cross-linking for enhanced properties.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: December 10, 2013
    Assignee: University of South Florida
    Inventor: Thomas J. Koob
  • Biocidal particles of methylated polystyrene
    Patent number: 8598246
    Abstract: Methylated polystyrene having pendant N-halamine and N-halamine precursor groups. Biocidal particles have been prepared by reacting highly crosslinked methylated polystyrene beads as starting materials with various N-halamine precursor compounds. The resulting polymer beads are halogenated with chlorine or bromine. The porous beads will be useful in disinfection applications as well as for sanitization and controlling noxious odor when mixed with absorbent materials in items such as disposable diapers, infant swimwear, incontinence pads, bandages, sanitary napkins, pantiliners, mattress covers, shoe inserts, sponges, animal litter, carpets, and fabrics.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: December 3, 2013
    Assignee: Auburn University
    Inventors: Shelby D. Worley, Yongjun Chen
  • Coatings of acrylamide-based copolymers
    Patent number: 8591934
    Abstract: An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: November 26, 2013
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Thierry Glauser, Mikael O. Trollsas
  • Thermosensitive nanostructure for hyperthermia treatment
    Patent number: 8586095
    Abstract: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: November 19, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Wen Hsiang Chang, Chao-Hung Kao, Chin-I Lin, Shian-Jy Wang
  • Microbicidal and antiseptic gel composition
    Patent number: 8586067
    Abstract: A microbicidal and antiseptic composition, which comprises the following (a), (b) and (c): (a) at least one kind of alcohols selected from the group consisting of ethanol and isopropanol; (b) at least one kind of carboxyvinyl polymers selected from the group consisting of polyacrylic acids, polyacrylates, copolymers of polyacrylic acids and polyacrylic acid alkyl esters, and copolymers of polyacrylates and polyacrylic acid alkyl esters; and (c) agar.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: November 19, 2013
    Assignee: Maruishi Pharmaceutical Co., Ltd.
    Inventors: Kazuki Okamoto, Tsuyoshi Miura, Manabu Soga, Yutaka Nishihara
  • Local complement inhibition for treatment of complement-mediated disorders
    Patent number: 8580735
    Abstract: The present invention features the local administration of complement inhibitors for treatment of complement-mediated disorders. In certain embodiments the invention features inhibiting activation of one or more locally produced complement proteins. The invention provides sustained release formulations and devices comprising a complement inhibitor and methods of use thereof.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: November 12, 2013
    Assignee: Apellis Pharmaceuticals, Inc.
    Inventors: Cedric Francois, Pascal Deschatelets, Paul Olson
  • Variable tangential flow filtration
    Patent number: 8580933
    Abstract: The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: November 12, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Hepbildikler, Wolfgang Kuhne, Eva Rosenberg, Gerhard Winter
  • High glass transition temperature absorbable microspheres
    Patent number: 8580307
    Abstract: Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(?)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: November 12, 2013
    Assignee: Ethicon, Inc.
    Inventors: Dennis D. Jamiolkowski, Modesto Erneta, Robert DiLuccio
  • Methods and compositions for the delivery of biologically active agents
    Patent number: 8574604
    Abstract: The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 5, 2013
    Assignee: Interface Biologics, Inc.
    Inventors: Roseita Esfand, Paul J. Santerre, Meilin Yang
  • Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthapaedic fixation devices
    Patent number: 8568765
    Abstract: The present invention is directed to a novel poly (diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: October 29, 2013
    Assignee: Northwestern University
    Inventors: Guillermo Ameer, Hongjin Qiu, Jian Yang
  • Purification of proteins
    Patent number: 8569464
    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: October 29, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Wilson Moya, Jad Jaber
  • Liquid preparation
    Patent number: 8557259
    Abstract: It is an object of the present invention to provide a liquid preparation which excels in stability with no occurrence of precipitates and lees even after long storage. The liquid preparation contains a lipophilic material, a sucrose fatty acid ester, a polyoxyethylene hydrogenated castor oil, a polyglycerin fatty acid ester, a polyol and water. Also provided are a pharmaceutical preparation, cosmetic preparation, food and drink which contain the liquid preparation.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: October 15, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Norio Goto, Koichi Shibusawa
  • Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
    Patent number: 8557286
    Abstract: The invention relates to a method for producing pharmaceutical forms or preliminary stages thereof by means of extrusion. The pharmaceutical form has a matrix which the active agent is contained essentially, and whose essential characteristics are determined by the extrusion process and which comprises a polysaccharide and/or derivative thereof and/or a complex thereof and/or any mixture of the aforementioned substances with other substances and/or saccharides and/or derivatives thereof as an essential constituent, and at least one pharmaceutically active substance.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: October 15, 2013
    Assignee: EuroCeltique, S.A.
    Inventors: Hubert Rein, Klaus-Jurgen Steffens
  • Film coating for tablets and caplets
    Patent number: 8557294
    Abstract: The present invention relates to novel coating compositions for application to solid dosage forms such as tablets or caplets, solid dosage forms coated with the composition, and methods of preparing said coating compositions.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: October 15, 2013
    Assignee: Capsugel Belgium NV
    Inventors: Robert Anthony Scott, Dominique Cade, Frederic Hoehn, Ewart Thomas Cole
  • Phase-separated biocompatible polymer compositions for medical uses
    Patent number: 8551511
    Abstract: A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: October 8, 2013
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Don K. Brandom, Durgadas Bolikal, Lioubov Kabalnova, James E. McGrath, Joachim Kohn
  • Method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
    Patent number: 8546548
    Abstract: The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: October 1, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Wolfgang Teschner, Harald Arno Butterweck, Azra Pljevljakovic, Theresa Friederike Bauer, Bernhard Koelbl, Hans-Peter Schwarz, Nebojsa Nikolic, Gerhard Poelsler, Johanna Kindermann
  • Medical devices having polymer brushes
    Patent number: 8545865
    Abstract: According to an aspect of the present invention, internal medical devices are provided, which contain at least one surface region that comprises a polymer brush. The polymer brush, in turn, contains one or more types of hydrophobic polymer chains and one or more types of hydrophilic polymer chains.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: October 1, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Mark Boden
  • Anti-sweat antigen monoclonal antibody
    Patent number: 8546542
    Abstract: The invention relates to an antibody that inhibits histamine releasing activity induced by an antigenic substance contained in sweat. The invention further relates to an antibody which can react with a sweat antigen composition and inhibit the histamine releasing activity of the composition on a sweat antigen stimulation-responsive cell.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: October 1, 2013
    Assignee: Hiroshima University
    Inventors: Michihiro Hide, Toshihiko Tanaka, Kaori Ishii, Hidenori Suzuki
  • Polymeric hydrogel
    Patent number: 8541020
    Abstract: The invention aims at providing a polymeric hydrogel which is highly resistant to water washing. The aim is attained by a polymeric hydrogel comprising a polymeric matrix formed by copolymerizing a nonionic polymerizable monomer with a crosslinking monomer, characterized in that the polymeric matrix contains a wetting agent and water, at least 50 wt % of the wetting agent is constituted of a polymer prepared by polymerizing a polyhydric alcohol monomer component containing a trihydric or more alcohol monomer, and the polymer is a water-soluble one which has an average molecular weight of 150 to 4000 and satisfies the relationship: {(number of ether groups in the polymer+number of hydroxyl groups in the polymer)/number of carbon atoms present in the polymer}?1/3.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: September 24, 2013
    Assignee: Seikisui Plastics Co., Ltd.
    Inventors: Shuichi Sasahara, Kazuhiro Yosikawa, Shinichi Wakamatsu, Takahiko Fujita