Patents Examined by James Rogers
  • Methods and composition of extended delivery of water insoluble drugs
    Patent number: 8535716
    Abstract: A pharmaceutical composition is provided that includes an active ingredient in the form of a powder or granule, a water soluble high molecular weight excipient and a water insoluble hydrophilic amphiphilic excipient. These ingredients are solution mixed and dried to form a modified pharmaceutical ingredient in simultaneous contact with both the water soluble high molecular weight excipient and the water insoluble hydrophilic amphiphilic excipient. Adjuvants are compacted about the modified pharmaceutical ingredient as well as a release control agent. The release control agent being present at levels from 1 to 40 total weight percent of the pharmaceutical composition.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: September 17, 2013
    Assignee: TSRL, Inc.
    Inventors: John Hilfinger, Jae Seung Kim, Paul Kijek
  • Methods for purifying a target protein from one or more impurities in a sample
    Patent number: 8536316
    Abstract: The present invention relates, at least in part, to improved methods of protein purification. In particular, the present invention relates, at least in part, to methods for purifying an Fc region containing protein from a composition comprising the Fc region containing protein and one or more impurities, where the methods eliminate the need for a holding tank and/or a buffer exchange step.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: September 17, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Neil Soice, John Dana Hubbard, Yu Zhang, James Hamzik
  • Pharmaceutical compositions and related methods of delivery
    Patent number: 8535695
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: September 17, 2013
    Assignee: Chiasma Inc.
    Inventors: Paul Salama, Roni Mamluk, Karen Marom, Irina Weinstein, Moshe Tzabari
  • Enzymatic antibody processing
    Patent number: 8524470
    Abstract: The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment with defined glycostructure comprising the following steps: a) providing an affinity chromatography column eluate containing the immunoglobulin or immunoglobulin fragment, b) incubating the affinity chromatography column eluate with (?1,3)galactosidase of plant origin, e.g. from green coffee beans (EC 3.2.1.22), c) applying the incubated affinity chromatography column eluate to a protein A chromatography material and recovering the immunoglobulin or immunoglobulin fragment from the protein A chromatography material and thereby producing an immunoglobulin or immunoglobulin fragment with defined glycostructure.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: September 3, 2013
    Assignee: Hoffman-La Roche, Inc.
    Inventors: Markus Haberger, Christine Jung, Dietmar Reusch
  • Process for the purification of Fc-containing proteins
    Patent number: 8513393
    Abstract: The invention relates to a process for reducing the concentration of free Fc-moieties in a fluid comprising an Fc-containing protein comprising a cation exchange chromatography step.
    Type: Grant
    Filed: August 27, 2007
    Date of Patent: August 20, 2013
    Assignee: Ares Trading S.A.
    Inventors: Alex Eon-Duval, Alain Lamproye
  • Use of soluble CEACAM8 for diagnosing, treating or monitoring diseases, and a method for screening compounds that prevent apoptosis
    Patent number: 8501192
    Abstract: The invention relates to new uses of soluble CEACAM6 or CEACAM8, or substances that are specific to soluble CEACAM8. Another object of the invention concerns the use of CEACAM1-specific and/or CEACAM6-specific compounds for apoptosis prevention in-vitro. The invention also relates to a method for screening compounds, which prevent apoptosis and a method for preventing apoptosis in human granulocytes.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: August 6, 2013
    Assignee: Charite Universitaetsmedizin Berlin
    Inventor: Bernhard Singer
  • Biobeneficial coating compositions and methods of making and using thereof
    Patent number: 8501211
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: August 6, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Soft tablet containing high molecular weight cellulosics
    Patent number: 8496969
    Abstract: The invention relates to an immediate release tablet capable of being chewed or disintegrated in the oral cavity, which comprises a pharmaceutically active ingredient having an optional tastemasking coating, and a matrix comprising hydroxyalkylcellulose having a weight average molecular weight of from about 60,000 to about 5,000,000. The tablet possesses exceptionally good mouthfeel and stability.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: July 30, 2013
    Assignee: McNeil-PPC, Inc.
    Inventors: David Wynn, Nick Parikh
  • Conformable solvent-based bandage and coating material
    Patent number: 8491881
    Abstract: A biological coating material that includes a polymerizable polyacrylate monomer; a volatile liquid; a polymer selected from a synthetic rubber, a natural rubber, and a thermoplastic elastomer. The biological liquid coating material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: July 23, 2013
    Assignee: Rochal Industries, LLP
    Inventors: Ann Beal Salamone, Joseph C. Salamone
  • Purification of immunoconjugates
    Patent number: 8481694
    Abstract: The present invention provides methods of purifying immunoconjugates.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: July 9, 2013
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Mark Snyder
  • Synergistic mixed poloxamer systems for the solubilisation of drugs
    Patent number: 8460644
    Abstract: Drugs which are difficult to solubilize in water, and especially those which otherwise cause pain on injection, can be readily formulated and typically administered with substantially less pain when solubilized in synergistic, aqueous micellar preparations of poloxamers. Such preparations may also be prepared with less, or without, co-solvents.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: June 11, 2013
    Assignee: IS Pharmaceuticals Limited
    Inventors: John Meadows, Colum Martin Dwyer
  • Method for screening of cell-protecting agent
    Patent number: 8450070
    Abstract: The invention provides a screening method and screening kit for a cell protecting agent. Specifically, the invention provides a method for screening a cell protecting agent showing an Hsp90-binding activity and a heat shock protein expression-inducing activity but having no Hsp90 client protein degradation-promoting activity. The method comprises the following steps (1) to (3): (1) measuring the binding property of a test compound to Hsp90; (2) measuring the activity of a test compound to induce the expression of a heat shock protein, or measuring the activity of a test compound to disrupt an Hsp90/HSF-1 complex, by using a cell capable of expressing the heat shock protein; and (3) measuring the activity of a test compound to induce the degradation of an Hsp90 client protein by using a cell capable of expressing the Hsp90 client protein.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: May 28, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventor: Haruhide Kimura
  • Anti-IRC85 monoclonal antibody; and composition comprising the same for preventing and treating tuberculosis or enteritis disease; and the use thereof
    Patent number: 8445643
    Abstract: The present invention provides the novel anti-IRC85 monoclonal antibody specifically binding with IRC85 and it showed potent effect in removing the infected/phagocytosed bacteria from THP-I, a monocytic cell that expresses human IRC85 and is infected with Listeria monocytogenes or WR-tubercle bacillus. Accordingly, it can be useful as a medicament and health care food in the prevention and treatment of tuberculosis disease and enteritis disease.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: May 21, 2013
    Assignee: Bio-Support Co., Ltd.
    Inventor: Byoung Se Kwon
  • Methods of purifying anti A ? antibodies
    Patent number: 8440799
    Abstract: The present application provides methods of purifying A? binding proteins having a Fc region, for example, anti-A? antibodies or antibody fusions, by adsorbing the A? binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed A? binding protein. The present application also features methods of eluting the purified A? binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: May 14, 2013
    Assignees: Janssen Alzheimer Immunotherapy, Wyeth LLC
    Inventors: Ranganathan Godavarti, Timothy Iskra
  • Covalently grafted pharmaceutically active polymers
    Patent number: 8440176
    Abstract: The invention relates to graftable polymers comprising biologically active agents and the use of such polymers in the manufacture of shaped articles, such as implantable medical devices and catheters. The graftable polymers are covalently grafted to a surface via one or more grafting moieties incorporated into the pharmaceutically-active graftable polymer. The coated articles of the invention can further comprise tie-coats, and the ratio of polymer:tie coat can be used to adjust the rate of drug elution.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: May 14, 2013
    Assignee: Interface Biologics, Inc.
    Inventors: Frank Laronde, Fan Gu
  • Antibodies to IL-6 and their uses
    Patent number: 8436158
    Abstract: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: May 7, 2013
    Assignees: Pfizer Inc., Bristol-Myers Squibb Company
    Inventors: Arvind Rajpal, Madhav Narasimha Devalaraja, Kristopher Toy, Lan Yang, Haichun Huang, Jun Zhang, Peter Brams, Brigitte Devaux, David B. Passmore
  • Anti-properdin antibodies
    Patent number: 8435512
    Abstract: A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the N terminus end of properdin effective to the inhibit alternative complement pathway in the subject.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: May 7, 2013
    Assignee: Novelmed Therapeutics, Inc.
    Inventor: Rekha Bansal
  • Biobeneficial coating compositions and methods of making and using thereof
    Patent number: 8426476
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: April 23, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Amide dendrimer compositions
    Patent number: 8425887
    Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: April 23, 2013
    Assignee: Genzyme Corporation
    Inventors: Pradeep K. Dhal, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Vitaly Nivorozhkin, Bruce Shutts
  • Controlled releases of actives in skin
    Patent number: 8414871
    Abstract: Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C—R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH?CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: April 9, 2013
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joachim Kohn, Bozena Michniak, David Devore, Larisa Sheihet, Prafulla Chandra, Priya Batheja