Abstract: Particles with a spatial and/or temporal release profile for delivery of different agents at different times to the same cells of a subject have been developed. The particles include a core polymeric particle containing a polymer and a first agent, a tethering moiety, covalent linker or covalent linkage attached to the core particle, and a tethered particle attached to the particle via the tethering moiety, covalent linker or covalent linkage and containing a second agent, where the agents are released at different times within or to the same cells. The first and second agents may be a therapeutic or prophylactic agent, such as an antigen, an immunomodulator, an anti-neoplastic agent, a hormone, an inhibitor, etc. The particles may form compositions for treating diseases with a spatial and/or temporal treatment regimen.
Type:
Grant
Filed:
May 8, 2019
Date of Patent:
December 6, 2022
Assignee:
YALE UNIVERSITY
Inventors:
Tarek Fahmy, Philip Kong, Sean Bickerton, Michael D. McHugh, Jung Seok Lee
Abstract: The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions comprising the nanoparticle compositions for use in treating patients with various disease states.
Type:
Grant
Filed:
January 28, 2021
Date of Patent:
November 22, 2022
Assignee:
THE TEXAS A&M UNIVERSITY SYSTEM
Inventors:
Naga Venkata Ravi Kumar Majeti, Raghu Ganugula, Meenakshi Arora, Dianxiong Zou
Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
Type:
Grant
Filed:
October 25, 2018
Date of Patent:
October 11, 2022
Assignee:
Massachusetts Institute of Technology
Inventors:
Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
Abstract: A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and/or wound dressings.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
October 4, 2022
Assignee:
Purdue Research Foundation
Inventors:
Jeffrey P. Youngblood, Philippe H. Sellenet
Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
Type:
Grant
Filed:
March 10, 2020
Date of Patent:
September 20, 2022
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Jinming Gao, David Boothman, Kejin Zhou, Xiaonan Huang, Yiguang Wang
Abstract: Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.
Type:
Grant
Filed:
October 14, 2016
Date of Patent:
September 6, 2022
Assignee:
Purdue Research Foundation
Inventors:
David H. Thompson, Seok-Hee Hyun, Yawo Mondjinou, Christopher Collins
Abstract: The present invention is related to a mesoscale colloidal particle including a hydrophobe-rich core surrounded by hydrogen bonded outer shell. The outer shell includes water and at least one hydrotrope wherein the hydrotrope molecules form hydrogen bonds with water molecules. The invention is also related to an aqueous solution including at least one mesoscale colloidal particle as well as methods of making and using such mesoscale colloidal particles and their solutions.
Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
Abstract: The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.
Type:
Grant
Filed:
January 24, 2020
Date of Patent:
August 2, 2022
Assignee:
GE HEALTHCARE AS
Inventors:
Mikkel Jacob Thaning, Andreas Richard Meijer
Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
Type:
Grant
Filed:
April 15, 2020
Date of Patent:
July 19, 2022
Assignee:
GE HEALTHCARE LIMITED
Inventors:
Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
Abstract: The present invention relates to compounds that are useful as radiopharmaceuticals and radioimaging agents which bear a radionuclide-chelating agent. These coordinated compounds are useful in radiotherapy and diagnostic imaging. The invention also relates to methods of diagnosis, prognosis and therapy utilising the non-coordinated and radiolabelled compounds of the invention.
Type:
Grant
Filed:
March 10, 2021
Date of Patent:
July 12, 2022
Assignee:
Clarity Pharmaceuticals Ltd
Inventors:
Nicholas Alan Zia, Paul Stephen Donnelly
Abstract: Imaging based detection of changes in extracellular neurotransmitter concentration in living tissue is achieved using novel nanotube-based sensors. The sensors are functionalized, neurocompatible single-walled carbon nanotubes (SWNT) comprising an adsorbed neurotransmitter analyte selective polynucleotide.
Type:
Grant
Filed:
July 1, 2020
Date of Patent:
June 14, 2022
Assignee:
The Regents of the University of California
Inventors:
Markita P. Del Carpio Landry, Linda A. Wilbrecht, Jackson Travis Del Bonis-O'Donnell, Abraham G. Beyene
Abstract: The present disclosure discloses preparation and application of a novel multifunctional nanocomposite material with new photosensitizer, and belongs to the technical field of photodynamic therapy and the field of biomedicine. The photosensitizer multifunctional nanocomposite material provided by the present disclosure is prepared by self-assembly of cercosporin and an acid-sensitive copolymer multifunctional material with liver tumor cell targeting ability and traceability, wherein the acid-sensitive copolymer multifunctional material can be a copolymer of poly(N,N-dimethylaminoethyl methacrylate) and poly-3-azido-2-hydroxypropyl methacrylate covalently linked by galactose-modified rhodamine B.
Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
May 17, 2022
Assignee:
DFB SORIA, LLC
Inventors:
Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
May 10, 2022
Assignee:
MEDTRONIC VASCULAR, INC.
Inventors:
Craig Wiltsey, Nikhita Mansukhani, Jeffrey Groom, II, Kate Rielly, Changcheng You, Danny Concagh
Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
April 26, 2022
Assignee:
MEDTRONIC VASCULAR, INC.
Inventors:
Craig Wiltsey, Nikhita Mansukhani, Jeffrey Groom, II, Kate Rielly, Changcheng You, Danny Concagh
Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering HIV active drugs into animal or human brain.
Type:
Grant
Filed:
July 10, 2014
Date of Patent:
April 19, 2022
Assignee:
Lauren Sciences LLC
Inventors:
Charles Linder, Sarina Grinberg, Eliahu Heldman
Abstract: The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR?) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.
Type:
Grant
Filed:
November 7, 2019
Date of Patent:
March 29, 2022
Assignees:
Daegu-Gyeongbuk Medical Innovation Foundation, KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL, Kyungpook National University Industry-Academic Cooperation Foundation
Inventors:
Sung Yeoun Hwang, Sung Jin Cho, Jina Kim, Jungwook Chin, Hayoung Hwang, In-Kyu Lee, Yong-Hyun Jeon, Jaetae Lee, Jae-Han Jeon, Sang Wook Kim
Abstract: The present disclosure provides purified forms of iobenguane and preparations of a precursor to iobenguane, such as a polymer, the polymer comprising a monomer of formula (I) or a pharmaceutically acceptable salt thereof, the preparation comprising leachable tin at a level of 0 ppm to 850 ppm.