Patents Examined by James W. Rogers
  • Metal-containing semiconducting polymer dots and methods of making and using the same
    Patent number: 11249073
    Abstract: The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Daniel T. Chiu, Wei Sun, Jiangbo Yu, Changfeng Wu
  • Aqueous emulsions of carbamato-functionalized organopolysiloxanes
    Patent number: 11197818
    Abstract: Aqueous nanoemulsions of carbamato-functional organopolysiloxanes prepared using a polyoxyethylene emulsifier having an HLB greater than 15 and at least 40 oxyethylene moieties and having a D50 particle size ?100 nm are transparent, stable, and useful in cosmetic compositions, particularly hair care compositions.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: December 14, 2021
    Assignee: WACKER CHEMIE AG
    Inventors: Christof Brehm, Gerhard Beer, Werner Limmer
  • Robust sunscreen compositions
    Patent number: 11191714
    Abstract: A robust sunscreen composition is disclosed herein comprising a water soluble polymer and a water insoluble film former providing a synergistic effect in SPF retention and critical wavelength after immersion in water, salt water, and chlorinated water. The water soluble polymer comprises poloxamer 338 (and) PPG-12/SMDI copolymer, poloxamer 407 (and) PPG-12/SMDI copolymer, or a combination thereof.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: December 7, 2021
    Assignee: EDGEWELL PERSONAL CARE BRANDS, LLC
    Inventors: Geng Li, James SaNogueira
  • Compositions and methods for controlled moisturizing and release of active ingredients
    Patent number: 11191704
    Abstract: The subject matter of the present invention is a cosmetic or pharmaceutical composition for controlled moisturizing and release of active molecule(s), comprising at least one emulsifier having an enzyme cleavable bound, at least one emollient, at least one polar solvent, and water, forming together a macroscopically homogenous liquid crystals emulsion. In some embodiments of the invention, the composition also includes at least one ingredient having a cosmetic or pharmaceutical activity.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: December 7, 2021
    Assignee: AMANTIN EXPERTS
    Inventors: Elisabeth Briand, Jean-Baptiste Dumas Milne Edwards, Jacques Delort
  • Metal complex formulations
    Patent number: 11186553
    Abstract: The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: November 30, 2021
    Assignee: GE HEALTHCARE AS
    Inventors: Mikkel Jacob Thaning, Andreas Richard Meijer
  • Method of using hydrophilized bactericidal polymers
    Patent number: 11134684
    Abstract: A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and/or wound dressings.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: October 5, 2021
    Assignee: Purdue Research Foundation
    Inventors: Jeffrey P. Youngblood, Philippe H. Sellenet
  • Prolonged release pharmaceutical composition comprising cysteamine or salt thereof
    Patent number: 11135173
    Abstract: A prolonged release multiple unit dosage form, preferably pellets, of cysteamine, cystamine or a pharmaceutically acceptable salt thereof, preferably cysteamine bitartrate, with a non gastro-resistant coating is described. The dosage form is particularly indicated for the administration to patients once or twice a day and it can be used also for pediatric administration.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: October 5, 2021
    Assignee: RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A.
    Inventors: Andrea Gazzaniga, Matteo Cerea, Alessandra Maroni, Marco Barchielli
  • Radiopaque monomers, polymers, microspheres, and methods related thereto
    Patent number: 11116855
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: September 14, 2021
    Assignee: Biosphere Medical, Inc.
    Inventor: Philippe Reb
  • Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
    Patent number: 11111254
    Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: September 7, 2021
    Assignee: The University of Melbourne
    Inventors: Paul Stephen Donnelly, Michelle Therese Ma, Denis Bernard Scanlon
  • Risperidone sustained release microsphere composition
    Patent number: 11110094
    Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: September 7, 2021
    Assignees: Shandong Luye Pharmaceutical Co., Ltd., Nanjing Luye Pharmaceutical Co., Ltd.
    Inventors: Kaoxiang Sun, Rongcai Liang, Oilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
  • Polyacrylate salt, methods of preparation and applications for employing the same
    Patent number: 11111339
    Abstract: The present invention relates to a crosslinked polyacrylate salt, which has been neutralized by two types of amines: (1) amine groups attached to the polymer backbone of an aminosilicone and (2) water soluble organic amines. The compositions of the present invention can readily swell in water, displaying enhanced thickening, emulsifying, dispersing and producing film with water resistance compared to acrylate based thickener alone. The compositions can be used to formulate a wide variety of ingredients, such as, for example, fatty substances, humectants, solid particles, silicones, organic or inorganic sunscreens, without the need of further neutralizing agents, dispersants or emulsifiers.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 7, 2021
    Assignee: Momentive Performance Materials Inc.
    Inventors: Anne Dussaud, Ning Lu, Bhavna Rana, Sigfredo Gonzalez
  • Sustained release small molecule drug formulation
    Patent number: 11110093
    Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having a Cmax to Cmin ratio of less than 200 and a lag time less than 0.2.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: September 7, 2021
    Assignee: INDIVIOR UK LIMITED
    Inventors: Andrew S. Luk, Gunjan H. Junnarkar, Guohua Chen
  • Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (SNAP)-doped nitric oxide release polymers with enhanced stability
    Patent number: 11103622
    Abstract: A polymeric film includes a polymer matrix having at least one of a discrete RSNO adduct or a polymeric RSNO adduct associated therewith, by: covalent attachment to the polymer matrix; dispersion within the polymer matrix; or both, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, or a copolymer matrix of polyurethane and silicone rubber. The polymeric film is to exhibit stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to moisture or light capable of photolyzing an RSNO bond, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: August 31, 2021
    Assignee: The Regents of the University of Michigan
    Inventors: Elizabeth J. Brisbois, Hitesh Handa, Mark E. Meyerhoff
  • Block copolymer and micelle compositions and methods of use thereof
    Patent number: 11098150
    Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: August 24, 2021
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jinming Gao, David Boothman, Kejin Zhou, Xiaonan Huang, Yiguang Wang
  • Formulation for soft anticholinergic analogs
    Patent number: 11084788
    Abstract: Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: August 10, 2021
    Assignee: BODOR LABORATORIES, INC.
    Inventors: Nicholas S. Bodor, John J. Koleng, David Angulo
  • Triazole conjugated ureas, thioureas, carbamates, and reversed carbamates for PSMA-targeted imaging agents and uses thereof
    Patent number: 11078166
    Abstract: Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 3, 2021
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Ying Chen, Xing Yang, Ronnie C. Mease, Sangeeta Ray
  • Topical glycopyrrolate formulations
    Patent number: 11071694
    Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 27, 2021
    Assignee: Rose U, LLC
    Inventors: Michael Johnston, Robert James Houlden
  • Formulation for soft anticholinergic analogs
    Patent number: 11052067
    Abstract: Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: July 6, 2021
    Assignee: Bodor Laboratories, Inc.
    Inventors: Nicholas S. Bodor, John J. Koleng, David Angulo
  • Radiopaque polymers
    Patent number: 11040104
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: June 22, 2021
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Formulation for soft anticholinergic analogs
    Patent number: 11034652
    Abstract: Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: June 15, 2021
    Assignee: BODOR LABORATORIES, INC.
    Inventors: Nicholas S. Bodor, John J. Koleng, David Angulo