Abstract: A method for ventilating a patient with a ventilator includes consecutively delivering a plurality of substantially equal volume amounts into a closed ventilator circuit during a ventilator self-test, receiving a pressure measurement for each volume delivery, calculating a change in pressure for each volume delivery, consecutively releasing a plurality of substantially equal volume amounts from the closed ventilator circuit during the ventilator self-test, calculating a change in pressure for each volume release, fitting the calculated change in pressure data for volume delivery and volume release to an inhalation non-linear model equation and an exhalation non-linear model equation, respectively, deriving one or more inhalation tubing compliance compensation coefficients from the inhalation non-linear model equation, and deriving one or more exhalation tubing compliance compensation coefficients from the exhalation non-linear model equation.

Abstract: A drug delivery system for automatically dispensing a pre-set dosage of a drug agent or medication. The drug delivery system generally includes a housing including one or more reservoirs; each having a medical agent hermetically sealed therein. A membrane extends across each of the one or more reservoirs which is adapted to allow the medical agents to pass therethrough in response to external stimuli, such as physical puncturing, melting the membranes through use of heating elements or electrowetting in response to a voltage pulse. A wicking material extends across the membranes through which the medical agents are dispensed to a patient. Because the housing can be made flat, the overall dispensing device can be reduced in size, allowing the drug delivery device to be located and attached to broader areas of the patient's body for expanded medical applications and treatment.

Abstract: Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, an ultrasound catheter includes an elongate flexible catheter body with one or more lumens. An ultrasound transmission member or wire extends longitudinally through the catheter body lumen and, in many embodiments, a guide wire tube also extends through the same lumen. A distal head is fixed to or otherwise mechanically coupled with the distal end of the ultrasound transmission member or wire and is positioned adjacent the distal end of the catheter body. Although the distal end of the catheter body overlaps the distal head, the distal head is not directly affixed to the distal end of the catheter body. Thus, the distal tip may move freely, relative to the distal end of the catheter body when ultrasonic energy is applied through the ultrasound transmission member.

Abstract: A delivery device (10) includes a roller (12) rotatably mounted on an axle (14), a reservoir (40), and one or more hollow needles (16) positioned in the roller (12) in fluid communication with the reservoir (40). As the roller (12) rotates about the longitudinal axis (17) of the axle (14), a piston (30) pushes contents of the reservoir (40) through the needles (16). An actuator (36) is operatively connected to the piston (30) for increasing a pushing force of the piston (30).

Abstract: An indicator arrangement for a regulator removably connectable to a facemask in a breathing apparatus, the indicator arrangement including: at least one release button comprising a body operationally engaged with at least one component of the regulator and configured to be actuated by a user to detach the regulator from the facemask, wherein at least a portion of the body is configured to facilitate transmission of light from at least one light source; and wherein the light is visible on or through at least one external surface of the body of the at least one release button. A regulator release button and breathing apparatus are also disclosed.

Abstract: An electronic cigarette atomization device includes an atomization bushing, an electric heater coil and an atomization base located in the atomization bushing. The atomization device further includes a liquid supply component inserted into the atomization bushing; the liquid supply component is formed by high temperature resistant fiber free of glass fiber and, a through hole axially extended is defined in the middle portion of the liquid supply component; and the electric heater coil is positioned in the through hole of the liquid supply component and is pressed against an inner wall of the liquid supply component. The liquid supply component of the atomization device is made of high temperature resistant fiber material free of glass fiber, thus making the construction and process simplified, leading to low fabrication cost, and causing no damage to human body.

Abstract: A liquid detection system includes an absorbent article for personal wear having a liquid permeable liner, an outer cover, and an absorbent body disposed between the liner and the outer cover. The article also includes at least one graphic element, a conductive pattern at least partially superposed with the graphic element, and a barrier layer disposed between the graphic element and the conductive pattern. A non-invasive signaling device is selectively attachable to the outer cover of the absorbent article in overlying relationship with the conductive pattern. The signaling device is adapted to detect the presence of liquid within the absorbent article.

Abstract: A pressure-maintaining valve assembly can be coupled to the tubing of an infusion pump system. The valve assembly includes an element that regulates fluid flow through the tubing. This element may also act as a one way or check valve.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A medication injection pen (11) includes a housing (1) and a dose set knob (2) rotatable with respect to the housing (1). A brake assembly (68) is disposed in the housing (1) and has a ratchet member (43). A driver (21) includes at least one external tooth (57) engaging the ratchet member (43). The engagement between the ratchet member (43) and the at least one external tooth (57) substantially prevents the driver (21) from rotating with respect to the dose set knob (2) during dose setting and dose correcting. The engagement between the ratchet member (43) and the at least one external tooth (57) allows the driver (21) to rotate with the dose set knob (2) during an injection.

Abstract: The disclosure relates to a medical dispenser, comprising an outlet and a plurality of sealed compartments containing medicament to be sequentially aligned with and dispensed through said outlet. Movement of an actuator sequentially causes mechanical energy to be built up and then released and converted into an indexing movement of the compartments. The disclosure also relates to an indexing method for a medical dispenser.

Abstract: Disclosed is an electrical signal applicable multi-needle syringe. The present invention comprises: a hollow cylinder; a needle hub closely coupled to the rear end of the cylinder; a plurality of needles placed at regular intervals inside the cylinder in such a way that the front ends are further protruded compared with the front end of the cylinder and the drug which is injected through the needle hub is sucked through the rear ends; a first electrode stored inside the cylinder, and commonly connected to a part of the plurality of needles; and a second electrode stored inside the cylinder, and commonly connected with the rest of the plurality of needles. Therefore, it is possible to inject a drug and to simultaneously apply a high frequency directly into the skin through a multi-needle injected into the skin by applying a high frequency between the first electrode and the second electrode, thereby promoting the activation of the injected drug.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.

Abstract: Provided is a neural device including a nanowire and a support layer. Further, provided is a neural device including: a substrate, at least one nanowire which is fixed on the substrate at a lengthwise end thereof to extend vertically and inserted into nerves to obtain electrical signals from nerve fibers or apply electrical signals to the nerve fibers; and a support layer which is formed on the substrate and which surrounds and supports at least one portion of the nanowire.

Abstract: The present disclosure relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by use of an obstacle in a flow passage, The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The present disclosure also relates to a medical dispenser, for instance an inhaler, in which the method may be performed.

Abstract: A fluid delivery connection includes a cuff to engage a port. A finger extends away from the cuff, and the finger is configured to interact with the port. A locking sleeve is movably disposed at least partially about the cuff and the finger. The locking sleeve is selectively movable between an unlocked configuration wherein the finger is movable and a locked configuration wherein the finger is secured to the port. A method of connection to a gas port includes moving a locking sleeve of a connector into an unlocked configuration. A finger of the connector is translated along the gas port and the locking sleeve is moved into a locked configuration.

Abstract: In a disposable wearing article, a first waist region is elasticized and formed of an inner sheet and an outer sheet. The non-skin-facing side of the outer sheet is formed substantially over its entire area with a plurality of thermocompression-bonded spots regularly and intermittently arranged at predetermined intervals. The outer sheet has non-thermocompressed regions surrounded by a plurality of thermocompression-bonded spots. A fibrous layer lying at least on the outer surface of said outer sheet is formed of thermal adhesive crimped fibers which are bonded together by thermocompression-bonding treatment in the thermocompression-bonded spots. The outer sheet and the inner sheet are bonded to each other by adhesive applied on at least one of respective opposite surfaces thereof so that the crimped fibers in the non-thermocompressed regions may protrude outward in a thickness direction of the outer sheet as the inner sheet contracts in the direction of the transverse axis Q.

Abstract: A needle-free connector includes a hollow connector, an elastic block, and a switch assembly. The inner perimeter of the hollow connector forms a first annular wall and a second annular wall. The elastic block is disposed in the hollow connector. The switch assembly has a stop member and a guide tube connected to the stop member, the stop member being pressed between the annular block and the elastic block, the guide tube being disposed in the hollow connector, the external perimeter of the stop member forming a first annular portion against the first annular wall and a second annular portion against the second annular wall, a groove being disposed between the first annular portion and the second annular portion of the stop member, the groove being connected to the guide tube. Thus, the structure stability and closing performance are achieved such that the outside air cannot leak into the connector.

Abstract: A system for transferring solutions from a first cartridge into a second cartridge comprises a cartridge holder, a plunger driver, and a cartridge connector. The cartridge connector carries a transfer needle and an exhaust needle. The cartridge holder positions the first cartridge against the cartridge connector so that the transfer needle penetrates the first cartridge septum. The second cartridge is removably inserted into another end of the cartridge connector so that both the transfer needle and the exhaust needle penetrate the second cartridge septum. The plunger driver is disposed to advance a plunger on the first cartridge to transfer solution from the first cartridge into the second cartridge thus displacing solution from the second cartridge through the exhaust needle. The cartridge connector includes a sealed interior waste chamber for receiving the solution from the second cartridge.