Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Abstract: On the back sheet side, back-side recessed portions recessed toward the top sheet are provided in a surface of the absorber of the disposable diaper. The back-side recessed portions include multiple grooves, which are continuous in the longitudinal direction L of the absorber. The back-side recessed portions is visible from an outside of the back sheet in a state before the disposable diaper is used, and when the absorber absorbs liquid, the depth D of the back-side recessed portions is made smaller than that before the absorber absorbs liquid. When the hydrophilic fiber and the particulate SAP swells, and thereby the absorber expands in at least the thickness direction thereof, the back-side recessed portions seems to disappear from the outside.

Abstract: The invention relates to a closing system for a natural or an artificial anus, the system comprising an inflatable balloon having a generally toroidal structure, and composed of a plane tubular section folded in on itself, the ends of which extend coaxially within each other and are linked to a sleeve.

Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second ±0.02 seconds.

Abstract: A wound therapy method that results in improved wound healing for conditions including diabetic foot ulcers, pressure ulcers, and arterial and venous ulcers is described. The wound therapy method uses local anesthetic injections in an area surrounding the wound combined with electrical stimulation causing local and deep muscle contraction in the same area. The method leads to increased vasodilation, increased tissue oxygen levels at the target site, and increased blood flow to the target site. This causes local angiogenesis and tissue perfusion that increases wound healing rates and decreases future wound occurrences.

Abstract: A needle-based medical device and method of manufacturing the same are disclosed. A needle device includes a hub having a longitudinal axis; a needle having a sharp distal tip; and a needle shield assembly associated with the needle and moveable from a non-shielding position to a shielding position. In the shielding position, the sharp distal tip is covered by at least part of the needle shield assembly. A latch is further provided for engaging with the hub when the needle shield assembly is in the non-shielding position; as well as a locking member operably connected to the needle shield assembly, and located at least partially within the hub when the needle shield assembly is in the non-shielding position. The latch and locking member lock the latch to the hub, such that when the needle shield assembly moves into the shielding position, the locking member moves generally proximally, unlocking the latch.

Abstract: A disposable wearing article improved so that leakage of body waste can be prevented, a change in color which might develop in an unused state of the wearing article can be inhibited and actually discharged body exudates can immediately cause an indicator to develop a change of color. A disposable diaper includes a topsheet, a backsheet and a liquid-absorbent structure interposed between these top- and backsheets. The backsheet includes first and second backsheets and the first backsheet is formed on its side facing the liquid-absorbent structure with an indicator adapted to develop a color reaction when the indicator comes in contact with at least one of moisture and body exudates. A plurality of such indicators is arranged to extend in a longitudinal direction and to be spaced apart from each other in a transverse direction. The liquid-absorbent structure includes a liquid-absorbent core and a wrapping sheet adapted to wrap the core.

Abstract: A contrast media injection system includes detects the absolute position of the syringe ram using a non-contact sensor. A series of magnets and Hall-Effect sensors may be used or an opto-reflective system. Illuminated knobs that are connected to the drive mechanism for the syringe ram rotate with the drive and provide visual feedback on operation through the illumination. Analog Hall-Effect sensors are used to determine the presence or absence of magnets that identify the type of faceplate being used. The faceplates include control electronics, connected to the powerhead through connectors, which may be interchangeably used by the two faceplates. The faceplate electronics include detectors for automatically detecting the capacity of pre-filled syringes.

Abstract: A balloon catheter assembly for delivering nano-carriers to bifurcation lesions in one or more of a main branch and a side branch of a blood vessel bifurcation within 30 to 90 seconds is provided. The balloon catheter assembly includes two or more balloons designed for use in the blood vessel bifurcation. The balloon catheter assembly may also include one or more stents. A surface of one or more of the two or more balloons is coated with the nano-carriers. Stents, when included, may also be coated with the nano-carriers. The nano-carriers include one or more drugs encapsulated with one or more biological agents.

Abstract: A catheter capable of rapid inflation and deflation and operation by one individual.

Abstract: A balloon catheter includes an elongate support member defining first and second openings therein, open proximal and distal ends, and an axial lumen; and a balloon disposed on the elongate support member, the balloon defining a balloon interior through which the support member extends, where the balloon interior has a proximal end region, a middle region, and a distal end region, with the first opening located in the middle region, and the second opening located in the distal end region, such that the support member lumen is in communication with the balloon interior through each of the first and second openings, and such that a pressurized liquid introduced through the open proximal end of the support member will enter the balloon interior through the first opening, and subsequently exit the balloon interior through the second opening, back into the lumen, and out the open distal end of the support member.

Abstract: A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.

Abstract: A radio frequency (RF) identification tag including a substrate, a planar antenna, an RF chip, a plurality of signal conductors and a plurality of ground conductors is provided. The RF chip receives an RF signal from the planar antenna to generate an identification code. The signal conductors are coupled to the planar antenna. The ground conductors, interlaced on two opposite sides of the signal conductors, and the signal conductors are adjacent to each other and disposed on the substrate to form a coplanar waveguide structure which includes an impedance match portion and a transmission portion. The impedance match portion has an input end coupled to the signal conductors and a ground plane coupled to the ground conductors. The RF chip is disposed between the input end and the ground plane. The transmission portion is connected between the impedance match portion and the planar antenna.

Abstract: A system including a catheter and an expandable member. The catheter includes an independent inflation lumen and an separate independent deflation lumen capable of sequential inflation and deflation of an expandable member in rapid succession, such as less than five seconds.

Abstract: An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.

Abstract: An introducer sheath assembly comprises a tubular sheath member having a deflectable distal end portion and a sheath member lumen, a handle assembly including a steering mechanism for deflecting the distal end portion of the sheath member, and a hemostasis valve assembly. The hemostasis valve assembly includes a side port member configured to be connected to a fluid source for introducing fluid into the sheath member lumen. The side port member is axially rotatable relative to the handle assembly and the sheath member such that the side port member can remain rotationally fixed relative to the fluid source as the handle assembly and the sheath member are rotated relative to the fluid source. The side port member may also be made transparent to allow for easy visualization of air bubbles, and is also configured to allow for evacuation of any visualized air bubbles.

Abstract: A respiratory mask assembly is provided. The assembly includes at least one post having a nasal engaging portion on about a first end thereof for delivering treatment gases to the nasal cavity of a patient. A mask having an inlet for receiving treatment gases from a fluid source and at least one receptacle for being sealably engaged with a respective one of the at least one post for delivering treatment gases from the inlet through the receptacle and into the nasal cavity of the patient is provided. The mask is configured for selective sealable engagement with the patient's mouth, patient's nose, or both the patient's mouth and the patient's nose.

Abstract: Sheath assemblies incorporating slotted structures at one or more areas provide areas of different flexibility and bendability characteristics along the length of the sheath assembly. An inner tubular member has an arrangement of discontinuous slots along at least a portion of its length, with at least some of the slots terminating in an enlarged aperture at at least one terminus of the slot, and a flexible outer tubular member contacts and extends over at least a portion of the inner tubular member.

Abstract: A dose setting mechanism for a drug delivery device is provided comprising a dose setting member, a drive member, a clutch, a first clicker and second clicker. The first clutch and a second clutch are designed and adapted to each other such that at any time during operation either the first clutch rotationally couples the dose setting member and the drive member and/or the second clutch rotationally couples the drive member and the first clicker component. Further, the invention refers to an injection device with such a dose setting mechanism.

Abstract: An ophthalmic irrigator-aspirator has a handpiece with aspiration and irrigation openings through its distal end; and a narrow aspiration tip projecting distally. A flexible sleeve has an annular hub for watertight connection to the handpiece. The sleeve has an intermediate portion that forms a channel for an irrigation fluid along the exterior of the tip to an irrigation port in the sleeve. The distal end portion of the sleeve is sized for a watertight connection over the distal portion of the tip. Such distal end portion of the sleeve has an aspiration port in communication with the tip aspiration port. The sleeve proximate, intermediate, and distal portions are integral with each other and are formed of a resilient material that allows the sleeve to be tightly fitted on the handpiece and tip.