Patents Examined by Jean F Vollano
  • Patent number: 6794328
    Abstract: The present invention provides a novel phosphine compound, specifically to provide a novel phosphine compound useful as a ligand for the above catalysts, in particular, a novel catalyst having an excellent performance (chemical selectivity, enantio-selectivity, catalytic activity) as a catalyst for asymmetric synthetic reactions, particularly asymmetric hydrogenation. A diphosphine compound represented by the general formula (1): wherein R1 and R2 each independently represents a lower alkyl group, a cycloalkyl group, an unsubstituted or substituted phenyl group, or a five-membered heteroaromatic ring residue.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: September 21, 2004
    Assignee: Takasago International Corporation
    Inventors: Tohru Yokozawa, Takao Saito
  • Patent number: 6794529
    Abstract: The invention relates to a process for the preparation of an organic boronic acid derivative comprising reacting a penta- or hexa-substituted diboron derivative with an organic compound having a halogen or halogen-like substituent at a coupling position in the presence of a Group VIII metal catalyst, such that a direct carbon to boron bond is formed between said coupling position and a boron-containing residue of the penta- or hexa-substituted diboron derivative.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: September 21, 2004
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Sebastian Mario Marcuccio, Helmut Weigold
  • Patent number: 6790981
    Abstract: The invention relates to a process for the preparation of acyloxybenzenesulfonates starting from carbonyl halides and salts of phenolsulfonic acid which have a low water content. Surprisingly, it was discovered that acyloxybenzenesulfonates can be prepared in high yields and good grades, irrespective of the grade or reactivity of the phenolsulfonic acid derivative, if the reaction of the phenolsulfonic acid with an alkanecarboxylic acid derivative is carried out in an aliphatic or aromatic solvent in the presence of 0.5 to 25% by weight of a polyglycol ether.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: September 14, 2004
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Wolf-Dieter Mueller, Peter Naumann
  • Patent number: 6790974
    Abstract: A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. General Formula [I] (where R2 and R3 each denotes an unsubstituted aryl group; R1 and R4 each denotes an aryl group having a specific substituent such as methoxy group; and R5 and R6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino)benzaldehyde with diphosphonic ester or diphosphonium. The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 14, 2004
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6791001
    Abstract: A process in gaseous phase to obtain CFC 113a starting from CFC 113, wherein CFC 113, optionally diluted with a gas inert under the reaction conditions, is let flow on a catalyst formed by aluminum fluoride.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: September 14, 2004
    Assignee: Ausimont S.p.A.
    Inventors: Paolo Cuzzato, Letanzio Bragante
  • Patent number: 6790985
    Abstract: Phosphonium salts represented by the general formula (I) wherein R1 and R2 each represents a phenyl group which may be substituted by a lower alkyl group, R3 represents a phenylene group which may be substituted by a lower alkyl group, R7 and R8 each represents a hydrogen atom or a hydrocarbon group having 1 to 12 carbon atoms which may be substituted and R9 represents a hydrogen atom or a hydrocarbon group having 1 to 5 carbon atoms which may be substituted; processes for producing the same and uses for the same; phosphines providing the same, and processes for producing said phosphines.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: September 14, 2004
    Assignee: Kuraray Co., Ltd.
    Inventors: Kazuyuki Yada, Kenji Shimoyamada, Masahiro Muranaka, Junichi Fuji, Shigeaki Suzuki
  • Patent number: 6787667
    Abstract: (E)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, fluoro, chloro, iodo, bromo, C1-C6 alkyl, C1-C4 alkoxy, nitro, cyano and trifluoromethyl, with the proviso that (a) R1, R2 , and R3 not all hydrogen when R4 is 2-chloro or 4-chloro; (b) when R1 and R3 are hydrogen and R2 is 4-bromo or 4-chloro, then R4 may not be 4-chloro, 4-fluoro or 4-bromo; (c) when R1 and R3 are hydrogen and R2 is 4-fluoro, then R4 may not be 4-fluoro or 4-bromo, (d) when R1 is hydrogen, and R4 is 2-fluoro, the R2 and R3 may not be 4-fluoro; and (e) when R1 is hydrogen and R3 is 4-hydrogen, 4-chloro, 4-bromo, 4-methyl or 4-methoxy, and R4 is 2-hydrogen, 2-chloro, or 2-fluoro; then R2 may not be 4-hydrogen, 4-chloro, 4-fluoro, or 4-bromo.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: September 7, 2004
    Assignee: Temple University - of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Patent number: 6784321
    Abstract: There are disclosed a disulfone compound of formula (1): wherein Ar denotes an aryl group that may have a substituent, R1 denotes a hydrogen atom or a protective group of a hydroxyl group and the wavy line means that the disulfone compound is an E or Z geometrical isomer or a mixture thereof, a method for producing the same, intermediate compounds therefore and a process for producing retinol through the disulfone compound.
    Type: Grant
    Filed: October 20, 2003
    Date of Patent: August 31, 2004
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiya Takahashi, Shinzo Seko, Kazutaka Kimura, Noriyuki Doi, Naoto Konya
  • Patent number: 6781011
    Abstract: A novel class of compounds, i.e., 1,1-bis-H-phosphinates (or 1,1-bis-H-phosphinic acid derivatives) are provided. Also provided are novel methods for producing 1,1-bis-H-phosphinates and 1,1-bis-H-phosphinate conjugates. These compounds and conjugates are used are precursors of bisphosphonates and bisphosphonate conjugates, respectively, or as prodrugs directly for treating bone-related and various other diseases.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: August 24, 2004
    Assignee: Texas Christian University
    Inventors: Jean-Luc Montchamp, Sylvine Deprele
  • Patent number: 6774257
    Abstract: A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. General formula [I] (where R2 and R3 each denotes an unsubstituted aryl group; R1 and R4 each denotes an aryl group having a specific substituent such as methoxy group; and R5 and R6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino)benzaldehyde with diphosphonic ester or diphosphonium. The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: August 10, 2004
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6774265
    Abstract: A bis-phosphonium salt represented by the following formula (1) is provided: wherein R1, R2, R3, and R4 each represent a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group; A represents an alkylene group; Y represents an anion; R1 and R2 may form a ring; R3 and R4 may form a ring; and R1, R2, R3, and R4 may be the same or different. A process for producing such a bis-phosphonium salt includes a step of allowing a first secondary phosphine and second secondary phosphine to react with a compound in an alcohol solvent selected from a secondary alcohol and tertiary alcohol.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: August 10, 2004
    Assignee: Nippon Chemical Industrial Co., Ltd.
    Inventor: Sha Yaowu
  • Patent number: 6770774
    Abstract: The invention relates to a preparation process for making peroxy esters and peroxy carbonates, peroxy ester peroxy carbonates, mixed diperoxides, mixed diperoxy esters, and mixed diperoxy carbonates, and to specific monoperoxy esters, monoperoxy carbonates, mixed peroxides, mixed diperoxy esters, mixed diperoxy carbonates, peroxy ester peroxy carbonates, and mixtures thereof. The process involves the reaction of a type-3 ketone peroxide with a reactive carbonyl compound and optional subsequent reaction with an alkyl vinyl ether, acetal, halogen formate, or carboxylic acid anhydride.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: August 3, 2004
    Assignee: Akzo Nobel N.V.
    Inventors: Anna Gerdine Van De Bovenkamp-Bouwman, Joachim Willem J. Van Gendt, John Meijer, Bart Fischer, Andreas Herman Hogt
  • Patent number: 6767989
    Abstract: Compounds of formula (I), wherein each of R and R′ are independently selected from hydrogen, a hydroxyl group, a carboxyl group, an alkyl, aryl or alkaryl group or a hydroxy or carboxy substituted alkyl, aryl or alkaryl group, provided that R and R′, together have a total of less than 23 carbon atoms, R″ may either be hydrogen or a CHR═CR1 group or be selected from the same categories as R′″; R′″ is a group, or polymeric chain comprising from 1 to 100,000 groups, said group or groups being derived form at least one ethylenically unsaturated compound wherein the double bond is activated by an adjacent electron withdrawing group, and n is greater than 1 are novel, are useful corrosion inhibitors and are valuable intermediates in preparing telomers for use in water treatment.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: July 27, 2004
    Assignee: Rhodia Consumer Specialties Limited
    Inventors: Keith Philip Davis, Graham Philip Otter, Gary Woodward
  • Patent number: 6764673
    Abstract: The present invention is directed to labeled compounds, [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfones and [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfoxides, wherein the 13C methyl group attached to the sulfur of the sulfone or sulfoxide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure: wherein R1, R2, R3, R4 and R5 are each independently, hydrogen, a C1-C4 lower alkyl, a halogen, an amino group from the group consisting of NH2, NHR and NRR′ where R and R′ are each a C1-C4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing methyl aryl sulfones and methyl aryl sulfoxides.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: July 20, 2004
    Assignee: The Regents of the University of California
    Inventors: Rodolfo A. Martinez, Marc A. Alvarez, Louis A. Silks, III, Clifford J. Unkefer, Jurgen G. Schmidt
  • Patent number: 6765108
    Abstract: A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. General formula [I] (where R2 and R3 each denotes an unsubstituted aryl group; R1 and R4 each denotes an aryl group having a specific substituent such as methoxy group; and R5 and R6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino)benzaldehyde with diphosphonic ester or diphosphonium. The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: July 20, 2004
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6765112
    Abstract: A process that can be used for manufacturing a tetraalkylonium perfluoroalkylsulfonate is provided. The process comprises contacting a tetraalkylonium halide with a metal perfluoroalkyl sulfonate to produce a mixture; allowing the second mixture to produce an aqueous upper layer and a separate lower liquid layer; separating the lower liquid layer from the upper aqueous layers to produce a product layer; optionally washing the product layer with 1 to 10 volumes of water, based on the volume of the product layer at a temperature of about 50° C. to about 100° C. to produce a washed product layer; and drying the product layer or washed product.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: July 20, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: James A. Schultz
  • Patent number: 6762317
    Abstract: An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxidizing gas in the presence of a catalyst to form a reaction product mixture containing a formylphosphonic acid derivative and the conditions under which said contacting is carried out are controlled so that no more than 50% of the formylphosphonic acid derivative formed in the reaction product mixture is consumed by reaction with the reagent.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: July 13, 2004
    Assignee: Monsanto Company
    Inventor: Thaddeus S. Franczyk, II
  • Patent number: 6762326
    Abstract: Embodiments of the invention relate to C2-substituted indan-1-ones and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: July 13, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
  • Patent number: 6762207
    Abstract: (E)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, fluoro, chloro, iodo, bromo, C1-C6 alkyl, C1-C4 alkoxy, nitro, cyano and trifluoromethyl, with the proviso that (a) R1, R2, and R3 not all hydrogen when R4 is 2-chloro or 4-chloro; (b) when R1 and R3 are hydrogen and R2 is 4-bromo or 4-chloro, then R4 may not be 4-chloro, 4-fluoro or 4-bromo; (c) when R1 and R3 are hydrogen and R2 is 4-fluoro, then R4 may not be 4-fluoro or 4-bromo; (d) when R1 is hydrogen, and R4 is 2-fluoro, the R2 and R3 may not be 4-fluoro; and (e) when R1 is hydrogen and R3 is 4-hydrogen, 4-chloro, 4-bromo, 4-methyl or 4-methoxy, and R4 is 2-hydrogen, 2-chloro, or 2-fluoro; then R2 may not be 4-hydrogen, 4-chloro, 4-fluoro, or 4-bromo.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 13, 2004
    Assignee: Temple University - of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Patent number: 6759545
    Abstract: Organosilicon compounds having an organooxysilyl group at one end and a monovalent hydrocarbon group at the other end of the molecule and containing a polysulfide group and organosilicon compounds having organooxysilyl groups at both ends of the molecule and containing a divalent hydrocarbon group flanked with polysulfide groups at a center thereof are useful as a compounding additive to inorganic-organic composite materials and a surface treating agent for fillers, Processes capable of effective preparation of these organosilicon compounds are also provided.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: July 6, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Hideyoshi Yanagisawa, Masaaki Yamaya