Patents Examined by Jean F Vollano
  • Patent number: 6753324
    Abstract: Use of phosphorous organic compounds of general formula (I) wherein B represents either an ether group of the formula (II) or a keto group of the formula (III) or is a 5 or 6 membered cyclic compound, and their use for preparing pharmaceutical compositions for the therapeutic and prophylactic treatment of infections in humans and animals due to viruses, bacteria, fungi, and parasites as well as their use as a fungicide, bactericide and herbicide in plants.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: June 22, 2004
    Inventor: Hassan Jomaa
  • Patent number: 6750361
    Abstract: An aminofunctional organoalkoxysilane of formula I R2N—(CH2)y—Si(OR1)3−nR2n  (I), wherein the R groups bonded to nitrogen are identical or different and each individual R group is hydrogen, an alkyl radical having from 1 to 4 carbon atoms, an aryl radical or an arylalkyl radical, R1 is an alkyl radical having from 1 to 8 carbon atoms or an aryl radical, R2 is an alkyl radical having from 1 to 8 carbon atoms or an aryl radical, y is 2, 3 or 4 and n is 0, 1 or 2, is prepared by a process comprising: reacting a chlorofunctional organoalkoxysilane of formula II Cl—(CH2)y—Si(OR1)3−nR2n  (II), wherein R1, R2, y and n are as defined above, with ammonia or an organic amine of formula III HNR2  (III), wherein the two R groups are identical or different and each is defined as described above; separating organic amine hydrochloride or ammonium chloride by-product which is formed in the reaction; distilling the resulting crude product, thereby
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: June 15, 2004
    Assignee: Degussa AG
    Inventors: Frank Kropfgans, Hartwig Rauleder
  • Patent number: 6749778
    Abstract: A process for the preparation of organomagnesium compounds from organic halides and magnesium metal in the presence of transition metal catalysts using an activity-enhancing main group metal component. The latter is a compound of a metal of Periodic Table groups 1, 2 or 13 in which elements of Periodic Table groups 14-17 or hydrogen are bonded to the metal. Some of these additional components may also be formed in situ.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: June 15, 2004
    Assignee: Studiengesellschaft Kohle mbH
    Inventors: Borislav Bogdanović, Manfred Schwickardi
  • Patent number: 6750171
    Abstract: P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: June 15, 2004
    Assignee: Warner-Lambert Company LLC
    Inventors: Garrett Stewart Hoge, II, Om Prakash Goel
  • Patent number: 6743951
    Abstract: A composition based on dimethyl disulphide (DMDS) with a masked smell according to the invention comprises, by weight, at least 95% of DMDS, less than 500 ppm of methyl mercaptan, less than 100 ppm of dimethyl sulphide and up to 1% of at least one odor-masking agent.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: June 1, 2004
    Assignee: Elf Atochem S.A.
    Inventor: Georges Fremy
  • Patent number: 6740782
    Abstract: The invention aims at providing novel sulfur compounds, molecular compounds containing the same as the component compound, and so on. The above aim is achieved by using sulfur compounds of the general formula (I) wherein Rs are each independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl, chloro, or bromo; m is an integer of 0, 1, or 2; and Z is a group represented by any of the general formulae (II) to (V) (wherein R and m are each as defined above; W is hydrogen or C1-6 alkyl; and Y is a direct bond, C1-3 alkylene, or phenylene).
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: May 25, 2004
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Ryu Sato, Hiroshi Suzuki
  • Patent number: 6730812
    Abstract: The present invention provides a method of preparing a phosphonium salt of the formula [R1R2R3P—CR4R5R6]X, comprising ball-milling a phosphine of the formula R1R2R3P with a compound of the formula XCR4R5R6; a method of preparing a phosphorus ylide of the formula R1R2R3P═CR4R5, comprising ball-milling a phosphonium salt of the formula [R1R2R3P—HCR4R5]X in the presence of a base; and a method of preparing an olefin of the formula R4R5C═CR7H or R4R5C═CR7R8, comprising ball-milling a phosphorus ylide of the formula R1R2R3P═CR4R5 with a compound of the formula R7C(O)H or R7C(O)R8. The inventive method produces phosphonium salts and phosphorus ylides by mechanical processing solid reagents under solvent-free conditions.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: May 4, 2004
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Vitalij K. Pecharsky, Viktor P. Balema, Jerzy W. Wiench, Marek Pruski
  • Patent number: 6730805
    Abstract: The present invention is directed to labeled compounds, [2-13C]dithane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2-13C]dithane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e.g., [2H1-2, 13C]methanol (arylthio)-, acetates wherein the 13C atom is directly bonded to exactly one or two deuterium atoms.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: May 4, 2004
    Assignee: The Regents of the University of California
    Inventors: Rodolfo A. Martinez, Marc A. Alvarez, Louis A. Silks, III, Clifford J. Unkefer
  • Patent number: 6730629
    Abstract: A phosphine compound having excellent properties (chemical selectivity, enantioselectivity, catalytic activity) as a catalyst for asymmetric syntheses, especially asymmetric hydrogenations. A phosphine-phospholane compound represented by the following formula (1): a phosphine-primary phosphine intermediate; a transition metal complex including the phosphine-phospholane compound of formula (1) and a transition metal, and a catalyst including the transition metal complex.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: May 4, 2004
    Assignee: Takasago International Corporation
    Inventors: Kazuhiko Matsumura, Takao Saito
  • Patent number: 6730813
    Abstract: The invention relates to a method for producing N-(phosphonomethyl)glycine involving the following steps: (a) oxidizing N-(phosphonomethyl)iminodiacetic acid (PMIDA) with peroxides or oxygen in an aqueous medium and in the presence of a heterogeneous catalyst at a temperature ranging from 50 to 150° C.; (b) subsequently separating the solid catalyst out of the aqueous reaction suspension of step (a); (c) concentrating the clear reaction solution from step (b), especially by evaporation, and; (d) separating the N-(phosphonomethyl)glycine out of the concentrated reaction solution from step (c), especially by filtration. According to the invention, the aqueous reaction solution from step (d) (mother liquor) is returned with small amounts of N-(phosphonomethyl)glycine and byproducts to step (b) (catalyst separation) and/or to step (c) (concentration). This results in distinctly increasing the yield with a constant product purity and in noticeably reducing the amount of mother liquor.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: May 4, 2004
    Assignee: Monsanto Technology LLC
    Inventors: Martin Hitzler, Franz Thalhammer, Benedikt Hammer
  • Patent number: 6727378
    Abstract: A process for the production of an organic phosphorus-containing product, which comprises reacting a phosphorus-containing oxide with an unsaturated hydrocarbon in the presence of a boron-containing compound at a temperature of less than or equal to 50° C.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: April 27, 2004
    Assignee: Adisseo France S.A.S.
    Inventors: Georges Gros, Michel Garrait, Patrick Rey, Jacques Taillades
  • Patent number: 6727390
    Abstract: A method of increasing the fluorous nature of a compound includes the step of reacting the compound with or tagging the compound with at least one of a second compound having the formula: wherein R is an alkyl group or an aryl group, n is 1, 2 or 3 and Rs is a spacer group and Rf is a branched fluorous group. A chemical compound having the general formula: wherein n, Rs and Rf are defined above.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: April 27, 2004
    Assignee: University of Pittsburgh
    Inventors: Dennis P. Curran, Qisheng Zhang
  • Patent number: 6727379
    Abstract: A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. (where R2 and R3 each denotes an unsubstituted aryl group; R1 and R4 each denotes an aryl group having a specific substituent such as methoxy group; and R5 and R6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino)benzaldehyde with diphosphonic ester or diphosphonium. The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: April 27, 2004
    Assignee: Sony Corporation
    Inventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
  • Patent number: 6727375
    Abstract: An apparatus for continuously preparing substantially halogen-free, in particular chlorine-free, trialkoxysilanes of the general formula I (RO)3SiH  (I) in which R is an alkyl group having from 1 to 6 carbon atoms, has a main reactor unit (1), at least one metering unit (2, 3, 4) for liquids and/or suspensions, located upstream of the main reactor, and at least one metering unit (5) for gaseous and/or vaporous substances, and also a product workup unit (6) located downstream of the main reactor. A process for preparing substantially halogen-free trialkoxysilanes of the general formula I in which silicon is reacted with alcohols in an inert solvent utilizes at least one organocopper compound catalyst.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: April 27, 2004
    Assignee: Degussa AG
    Inventors: Frank Steding, Gerda Grund, Burkhard Standke, Frank Kropfgans, Michael Horn, Albert-Johannes Frings, Jaroslaw Monkiewicz, Hans-Günther Srebny, Claus-Dietrich Seiler, Hans-Joachim Kötzsch
  • Patent number: 6723710
    Abstract: Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart disease, gastrointestinal motility disorders, and penile erectile dysfunction in humans.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: April 20, 2004
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Christianson, Ricky Baggio, Daniel Elbaum
  • Patent number: 6723717
    Abstract: The present disclosure describes novel compounds of formula (A), wherein R1-R12, X and Y have the meanings given in the specification and compositions containing them which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds described herein are cardiac-sparing.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: April 20, 2004
    Assignee: The University of Texas Southwestern Medical Center
    Inventors: Robert Scott Youngquist, John McMillan McIver
  • Patent number: 6723875
    Abstract: The present invention relates to the preparation of alkyl-ureas, starting from O,S-dimethyl dithiocarbonate, which provides the following steps: A) causing the O,S-dimethyl dithiocarbonate to react with a primary amine of general formula R1NH2 in order to obtain an O-methyl thiocarbamate; B) isomerising the O-methyl thiocarbamate in order to obtain an S-methyl thiocarbamate; C) causing the S-methyl thiocarbamate with a compound of general formula R′R″NH, wherein R′ and R″ may be equal or different one in respect of the other and of R1 and may be H, R2 or R3, in order to obtain one of the alkyl-ureas of formula (4), (5) or (6).
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: April 20, 2004
    Assignee: Oxon Italia S.p.A.
    Inventors: Edoardo Pallucca, Jacopo Degani, Anna Maria Serri, Rita Fochi, Sonia Gazzetto, Claudia Fenoglio, Claudio Ornati, Mara Migliaccio, Silvano Cadamuro, Gianni Carvoli
  • Patent number: 6720281
    Abstract: The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula I wherein R1, R2, R3, R4, R5 are chiral or achiral organic residues which are derived from substituted or unsubstituted straight or branched chain or cyclic aliphatic or aromatic groups and which, in the case of the pairs R1/R2 and R4/R5, may be interconnected. Further, the invention relates to the use of chiral phosphorus compounds of general formula I as catalysts or catalyst components in processes for the preparation of optically active products.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: April 13, 2004
    Assignee: Studiengesellschaft Kohle mbH
    Inventors: Walter Leitner, Giancarlo Francio, Felice Faraone, Carmela G. Arena
  • Patent number: 6720442
    Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: April 13, 2004
    Assignee: SRI International
    Inventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Wolf Eilenberg
  • Patent number: 6717016
    Abstract: A phosphine compound of formula (1) and a phosphine compound of formula (2) a transition metal complex having the phosphine compound as a ligand and a catalyst for asymmetric hydrogenation including the transition metal complex.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: April 6, 2004
    Assignee: Takasago International Corporation
    Inventors: Hideo Shimizu, Takao Saito