Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.

Abstract: [Problem] An object of the invention is to provide a novel complex that can be used as an emulsifier. [Solving means] A complex in which an amide alcohol and a carboxyl group-containing polymer exerts an excellent emulsifying power for oil having a wide range of required HLB.

Abstract: The present disclosure relates to compositions that are useful in the delivery of various materials. In particular, the compositions comprise a suspension wherein an internal phase material is surrounded by an external phase material. The internal phase specifically can be a hydrophilic material, and the external phase specifically can be a hydrophobic material. The materials are combined so that the internal phase is substantially encapsulated by the external phase such that release can be controlled in relation to osmotic pressure differentials. The suspension can be combined with a carrier, and various systems and products can be formed with the suspension and optional carrier, such as oral strips, spray delivery systems, smokeless tobacco products, aerosol delivery devices, cigarettes, and packaging.

Abstract: A deodorant composition comprising ethylhexylglycerol, triethyl citrate and BHT, wherein the ratio of ethylhexylglycerol to triethyl citrate is from 1:6 to 1:1 by weight and wherein the ratio of BHT to the sum of ethylhexylglycerol and triethyl citrate is from 1:40 to 1:5 by weight.

Abstract: In one aspect, the present disclosure relates to click-functional antimicrobial molecules (including small molecules or, in some cases, macromolecules) and the construction of antimicrobial polymers such as polyurethanes, polyesters, and polyacrylates, including through the use of such molecules. In some cases, the antimicrobial click-functional molecules are based on 1,2-benzisothiazolin-3-one (BIT), trimethylguanidine or tetramethylguanidine (TMG), polyhexamethylene guanidine (PHMG), fluorine-containing molecules, or a combination thereof. For example, 1,2-benzisothiazolin-3-one (BIT) functionalized with an alkyne (BIT-Al), trimethylguanidine or tetramethylguanidine (TMG) functioned with an alkyne (TMG-Al) or dual alkynes (TMG-dAl), and/or polyhexamethylene guanidine (PHMG) functionalized with an alkyne (PHMG-Al) are described herein. Clickable antimicrobial polymers can be used to form coatings or films.

Abstract: The present invention relates to a gastric retention active delivery system in the form of a coated capsule, which, in contrast to prior art delivery systems exhibiting relatively poor floating-properties, and thus requiring size expansion capability in order to securely delay passage through the pylorus, reliably stay afloat for several hours. This is achieved by combining pore forming components and flexible polymer components in the coating in suitable proportions. The present invention, further, relates to the use of gastric retention active delivery systems of the invention for the delivery of one or more water soluble active components A to a mammal.

Abstract: A controlled release system includes surfactant protein D (SPD) and a carrier suitable for controlled release that can be polylactic-co-glycolic acid (PLGA). The system can be in the form of a nanoparticle. A pharmaceutical composition includes the system and a pharmaceutically acceptable carrier. Methods of treatment of a disease, disorder or condition associated with a decreased level of SPD in a subject, or for pulmonary delivery of SPD, include administering the pharmaceutical composition to a subject in need of such treatment.

Abstract: Emulsions of carbamato-functional organopolysiloxanes emulsified with the aid of cationic emulsifiers are useful for treating textiles to provide good haptic properties, and also in hair care products.

Abstract: The present invention relates to materials having antimicrobial properties, said materials comprising a polymer having incorporated therein a synergistic combination of at least two metal oxide powders, comprising a mixed oxidation state oxide of a first metal and a single oxidation state oxide of a second metal, the powders being incorporated substantially uniformly within said polymer, wherein the powders have substantially different specific gravities and substantially similar bulk densities and wherein the ions of the metal powders are in ionic contact upon exposure of said material to moisture. There are further provided methods for the preparation of said materials and uses thereof, including in combating or inhibiting the activity of microbes or microorganisms.

Abstract: The present invention relates to treating malignancies such as tumors or cancers by orally administering lyophilized compositions comprising arsenic to a subject in such need. Malignancies include various hematological malignancies, such as acute myeloid leukemia (AML) including acute promyelocytic leukemia (APL), myelodysplastic syndrome (MDS), multiple myeloma (MM) and lymphomas and solid tumors including glioblastoma multiforme and breast cancer. Arsenic treatment has shown great promise in the treatment of several cancers but requires daily intravenous (IV) administration. This invention relates to a novel formulation comprising a lyophilized compositions comprising arsenic. As a result, the formulation facilitates a systemic bioavailability comparable to that of intravenous (IV) administration of arsenic trioxide currently practiced.

Abstract: Provided are formulations and dosage forms of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide, alternatively named (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide, or a pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.

Abstract: The present invention relates to a cosmetic product having an excellent UV-blocking effect and a manufacturing method thereof, in which the cosmetic product has an excellent UV-blocking effect, shows reduced whitening, has a good feeling in use, and good adhesion to the skin, and is not glossy and sticky after application to the skin, and to a manufacturing method thereof. The cosmetic product having an excellent UV-blocking effect according to the present invention includes: a cosmetic composition; and a hollow pearlescent pigment added to the cosmetic composition in an amount of 1 to 15 parts by weight based on 100 parts by weight of the cosmetic composition.

Abstract: A method of forming an erodible sustained release tablet comprising the steps of:—a. mixing one or more therapeutic agents, one or more disintegrant and one or more molten wax, whilst retaining the wax in molten form; b. solidifying and granulating the mixture; c. forming a tablet by compression of the granules. The invention also relates to a sustained release tablet made according to the method.

Abstract: Norlimbanol in general and particularly its isomer mixture Timberol®, an amber-woody fragrance, is able to specifically inhibit the trimethylamine-induced h TAAR5 activation up to 96%. Moreover, human psychophysical data showed that the presence of Timberol® increases the olfactory detection threshold for the characteristic fishy odor of trimethylamine by almost one order of magnitude.

Abstract: Compositions containing (1) water, (2) at least one hydrophilic sunscreen active agent having a sulfonic acid group, (3) at least one surfactant selected from the group consisting of alkoxylated fatty alcohols, sorbitan esters, alkoxylated silicones, and mixtures thereof, and (4) at least one copolymer comprising at least one monomer comprising a carboxylic acid containing ?,?-unsaturation, at least one monomer containing an ester of a carboxylic acid containing ?,?-unsaturation, and at least one monomer containing an oxyalkylenated fatty alcohol are provided.

Abstract: Disclosed a pregabalin-containing, high swellable, oral sustained-release triple layer tablet suitable for administration once daily.

Abstract: A hydrophobic hybrid organosiloxane nano latex is provided as the copolymerizate of: (a) organosiloxane monomer of the general formula MaMvbDcDvdTeTvfQg wherein: M=R1R2R3SiO1/2, Mv=R4R5RuSiO1/2, D=R6R7SiO2/2, Dv=R8RuSiO2/2, T=R9SiO3/2, Tv=RuSiO3/2, and Q=SiO4/2 in which R1, R2, R3, R4, R5, R6, R7, R8 and R9 each independently is hydrogen, a hydroxyl group, a hydrocarbyl group having up to 100 carbon atoms and optionally containing at least one hetroatom; Ru is a free-radical polymerizable group; subscripts a, b, c, d, e, f and g each independently range from 0 to 10,000 subject to the limitation that b+d+f is at least 1, p, q and r are integers independently selected from 0 to 100 and subscript h is 0 or 1; and, (b) monomer possessing a group which is free-radical copolymerizable with group Ru of organosiloxane monomer (a).

Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Abstract: The present invention relates to a process for preparing an antiseptic product, an antiseptic product obtainable by the process, an antiseptic inorganic powder composition, an antiseptic polymer product as well as the use of one or more source of lithium ions in combination with one or more source of sodium ions for the preparation of an antiseptic product being effective against microbial contamination.