Abstract: Described herein are bioaerosol detection systems and methods of use. In embodiments of bioaerosol detection systems and methods of use as described herein, systems and methods detect one or more coronaviruses and/or one or more influenza strains. In embodiments, coronaviruses according to systems and methods as described herein are SARS-CoV-2 coronavirus. In embodiments, influenza strains and/or particles according to the present disclosure are H1N1 influenza.

Abstract: A structure, apparatus, and method are disclosed. A silicon substrate with a microfluidic system that receives a sample fluid and prepares an analyte solution received by a reservoir containing a sensing surface is electrically connected to a semiconductor device. The structure includes a component for receiving a sample fluid, a component for preparing the sample fluid, a CRISPR system for cleaving a reporter species when the sample fluid contains a target sequence, a sorting component for separating the cleaved reporter species from the sample fluid and the CRISPR products, a cavity for receiving an analyte solution containing the cleaved reporter species, and a sensing surface in the cavity. The sensing surface detects electrical signals induced by reaction events in the analyte solution.

Abstract: According to the present teachings, systems, compositions, kits and methods for protein melt analysis are provided that utilizing a dye that is a dipyrrometheneboron difluoride compound. In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating, while recording the fluorescence emission of the sample.

Abstract: An automation apparatus of an analysis laboratory, for handling support devices able to support containers of biological samples. The automation apparatus includes two main automatic belt conveyors arranged in positions spaced from one another on a floor, and at least one auxiliary automatic belt conveyor. The auxiliary belt conveyor is spaced at a different height with respect to the main conveyors, and is operatively connected to the main conveyors by means of lift devices.

Abstract: Temperature measurement is an important part of many potential applications in process industry. Conventional temperature measurement methods require manual intervention for process monitoring and fail to provide accurate and precise measurement of temperature of an enclosed mixed fluid chamber. The present disclosure provides artificial intelligence based temperature measurement in mixed fluid chamber. A plurality of inputs pertaining to the mixed fluid chamber are received to build a fluid based model. The fluid based model is used to generate one or more fluid parameters. The one or more fluid parameters are used along with a ground truth temperature data and the received plurality of inputs for training an artificial intelligence (AI) based model. However, the AI based model is trained with and without knowledge of fluid flow. The trained AI based model is further used to accurately estimate temperature of the mixed fluid chamber for a plurality of test input data.

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.

Abstract: Provided are valveless microfluidic flowchips comprising fluid flow barrier structures or configurations. Further provided are systems and methods having increased fluid transfer control in a valveless microfluidic flowchip. The systems and methods can be used in the present valveless microfluidic flowchips as well as in currently available valveless microfluidic flowchips.

Abstract: A film deposition system according to the present embodiment includes a film deposition apparatus, and a computer, in which the film deposition apparatus includes a film deposition chamber in which a plurality of deposition species are installable, and the computer includes a calculation region that calculates based on a calculation model having an Ising model or QUBO, and predict a time required for film deposition when a disposition of the deposition species is set.

Abstract: Methods and devices for single cell analysis using fluorescence lifetime imaging microscopy (FLIM) are disclosed. The methods utilize microfluidic devices which use traps to immobilize cells for FLIM analysis. The analysed cells may be sorted before or after imaging and may be plant, animal, or bacterial cells. Analysis of the FLIM data may use a phasor plot and may be used to identify a metabolic pattern of the single cells.

Abstract: The present disclosure generally pertains to a biomimetic array device and methods of using the device to expose biological samples to an array of fluids. The device includes a cassette and an inlet region, where the cassette comprises at least one microchamber array and at least one microchannel. Each microchamber within a microchamber array has a top interface that is open to the external environment, so that a biological sample placed at the top interface is positioned to draw fluid from the microchambers. The inlet region comprises at least one well and at least one inlet channel, each well in fluid communication with one inlet channel. Fluid deposited into wells flows through each inlet channel and microchannel in fluid communication with each well containing fluid, so that each microchamber within one microchamber array provides an approximately equal volume of fluid to the biological sample.

Abstract: Digital microfluidic (DMF) apparatuses, systems, devices and associated fluid manipulation and extraction devices, and methods of using them are presented. The devices may be useful for analysis of clinical, laboratory, chemical, or biological samples. A fluid application and extraction interface device may include a waste reservoir with a fluid trap and a transfer conduit extending through the waste reservoir so that fluid may pass from the transfer conduit into the waste reservoir and be trapped within the waste chamber. A transfer conduit may be configured to double back on itself and to hold a fluid sample. A DMF apparatus may be configured to hold and process large sample volumes.

Abstract: This disclosure relates to compositions and methods for analyzing a tissue section from a biological sample.

Abstract: Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.

Abstract: A sputtering system is suitable for sputtering a surface to be sputtered having sections. Each section has a projection height. The sputtering system includes a supporting plate, a sputtering array, and a controller. The sputtering array is arranged on the supporting plate. The sputtering array includes sputtering units. Each section corresponds to at least one of the sputtering units. Each sputtering unit has a driving shaft and a target. The target faces the surface to be sputtered. The controller is electrically connected the driving shaft. The driving shaft drives the target to move relative to the surface to be sputtered. The controller controls a distance between each sputtering unit and the corresponding section of the sections in the direction of the projection height to satisfy a given condition.

Abstract: One object of the present invention is to provide a method or apparatus for purifying target particles from high-concentration particles in a short time. The above problem can be solved by a method for purifying target particles, characterized in that the method comprises a step of sorting the target particles from a high concentration of non-target particles, wherein the sorting step is repeated for three times or more.

Abstract: A deposition apparatus, which forms a film on a substrate, includes a rotation unit configured to rotate a target about a rotating axis; a striker configured to generate an arc discharge; a driving unit configured to drive the striker so as to make a close state which the striker closes to a side surface around the rotating axis of the target to generate the arc discharge; and a control unit configured to control rotation of the target by the rotation unit so as to change a facing position on the side surface of the target facing the striker in the close state.

Abstract: There is provided a film formation apparatus which forms a film on a substrate by sputtering. The apparatus comprises: a substrate holder configured to hold the substrate; and a plurality of cathodes configured to hold targets that emit sputtered particles, and connected to a power supply. At least one of the plurality of cathodes holds the targets of a plurality of types.

Abstract: A fluid handling device includes a sample channel configured to carry a sample; a dispersion medium channel configured to carry dispersion medium; a dispersion liquid generation part connected to the sample channel and the dispersion medium channel, and configured to generate dispersion liquid by dividing the sample by the dispersion medium, the dispersion liquid being liquid in which droplets of the sample are dispersed in the dispersion medium; and a dispersion liquid channel connected to the dispersion liquid generation part. The dispersion liquid generation part includes a protrusion.

Abstract: A sample vessel includes a biological sample container and a sample stabilizer container. The biological sample container is configured to receive a biological sample and to store the biological sample. The sample stabilizer container is configured to contain a stabilizer associated with the biological sample. The sample stabilizer container is assembled from a stabilizer vial, an adaptor, and a fluid channel. The stabilizer vial is configured to store an amount of the stabilizer. The adaptor is configured to secure the biological sample container and the stabilizer vial such that the biological sample container and the stabilizer vial form the sample vessel. The fluid channel extends through the adaptor from the stabilizer vial to the biological sample container, the biological sample moving from the biological sample container into the stabilizer vial through the fluid channel.

Abstract: This application relates to a movable apparatus for collecting and analyzing specimens. In one aspect, the movable apparatus includes a transport means configured to be moved independently and to maintain negative pressure therein by a negative pressure module, and a specimen collecting device arranged in the transport means and configured to collect a specimen under remote control by inserting a specimen collecting member into the nasal cavity of a testee who enters the transport means. The apparatus may also include a specimen transport device arranged in the transport means and configured to transport the specimen collecting member under remote control that has collected the specimen in one direction, and a specimen analysis device arranged in the transport means and configured to extract the specimen from the specimen collecting member that has been transported by the specimen transport device under remote control and to analyze the specimen.