Abstract: A dispensing tip holder is used when a dispensing tip is attached to a tip of a pipette, and includes a peripheral wall having a shape surrounding an outer peripheral surface of the dispensing tip, and an insertion portion having an insertion opening into which the dispensing tip is to be inserted. The peripheral wall has a first end into which the dispensing tip is to be inserted, and has a second end provided at a position opposite to the first end. The insertion portion is formed in the peripheral wall such that an outer peripheral surface of the dispensing tip abuts against an edge of the insertion opening, and is formed in the peripheral wall such that a tip of the dispensing tip does not project from the second end of the peripheral wall, when the dispensing tip is inserted into the insertion opening from the first end.

Abstract: Methods for quantifying the amount of drug present in a crosslinked hyaluronic acid-linker-peptide (xHA-L-P) prodrug composition are provided. Disclosed are steps of contacting a sample of the xHA-L-P prodrug formulation with a hyaluronoglucosidase to generate oligomeric hyaluronic acid-linker-peptide drug (oHA-L-P), contacting the oHA-L-P with a second enzyme to generate peptide digest products of the drug, and detecting the peptide digest products to determine the amount of the drug present in the xHA-L-P prodrug formulation.

Abstract: A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.

Abstract: The present disclosure relates to a method for detecting a prostate cancer related biomarker, including contacting the diluted sample with a modulating agent selected from a group consisting of sodium; 3-hydroxy-4-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate, sodium; 3-hydroxy-4-[(1-hydroxynaphthalen-2-yl)diazenyl]-7-nitronaphthalene-1-sulfonate, triisopropylsilane, and iron(III) chloride, and a luminescent label to obtain a measurement sample. Then, the measurement sample is incubated for a period of time and excited thereafter. Time-resolved luminescence signal of the label in the measurement sample is measured, leading to an increased likelihood of prostate cancer of the human subject if the luminescence signal is at least 50% higher than for a control sample from a human subject without prostate cancer.

Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.

Abstract: A respiratory droplet suction device includes an air inlet end and an exhaust end. A plurality of filtering devices are arranged between the air inlet end and the exhaust end. The filtering device is provided with a bacteria filtering screen for adsorbing bacteria and an ultraviolet sterilization lamp for inactivating the bacteria. The filtering device includes a first side wall and a second side wall. The first side wall is connected to the air inlet end, and the second side wall is connected to the exhaust end. The air entering from the first side wall is filtered by the bacteria filtering screen and discharged through the second side wall. The ultraviolet sterilization lamp is arranged corresponding to the bacteria filtering screen. A respiratory droplet filtering apparatus includes the respiratory droplet suction device, and a respiratory droplet electric suction system includes the respiratory droplet filtering apparatus are further provided.

Abstract: A blood component collection cassette of a blood component collection system, which is a biological component transfer system, includes a sheet-shaped cassette main body in which a blood line is formed. The blood line includes a second applied load measurement unit and line main body portions. A separation device includes a second load measurement unit that measures a load applied to a wall portion of the second applied load measurement unit in a cassette mounted state. The second applied load measurement unit is more easily deformed than the line main body portions, and is disposed at a location within the blood line on which only a positive pressure acts.

Abstract: A system includes a fluid transfer device and a lateral flow assay device. The fluid transfer device has an inlet fluidically coupleable to a bodily fluid source, an outlet fluidically coupleable to a sample reservoir, and a sequestration chamber configured to receive an initial volume of bodily fluid. The fluid transfer device can be transitioned between (1) a first state with the sequestration chamber in fluid communication with the inlet to receive the initial volume, (2) a second state with the outlet in fluid communication with the inlet to receive a subsequent flow of bodily fluid, and (3) a third state with the lateral flow assay device in fluid communication with the sequestration chamber to receive a portion of the initial volume of bodily fluid. The lateral flow assay device configured to provide an indication associated with a presence of a target analyte in the bodily fluid.

Abstract: Disclosed herein are solvent reservoir systems for steady flow delivery and simultaneous monitoring of solvent level and solvent density within the solvent reservoir systems and methods for monitoring the solvent reservoir systems and providing feedback to a user or adjusting the systems in response to the monitored characteristics.

Abstract: A hydrogen-free carbon film polymer lubricating material and a preparation method and use thereof are disclosed. In the method, a graphite target is used as the target material, and a magnetron sputtering deposition is performed on a surface of the polymer substrate, thereby physically depositing and forming a hydrogen-free carbon film on the surface of the polymer substrate, thereby obtaining a hydrogen-free carbon film polymer lubricating material.

Abstract: A magnetic shape memory (MSM) microfluidic device may include a flexible membrane positioned between a channel and an MSM element. The MSM element may engage the flexible membrane to deform the channel at portions of the flexible membrane that are adjacent to non-contracted portions of the MSM element. The flexible membrane may prevent contact between a fluid within the channel and the MSM element. Magnetic field components may be applied to the MSM element and moved along the MSM element enable fluidic flow within the channel while. The device may include an upper portion including the flexible membrane and a lower portion including the MSM element. The upper portion may be interchangeable with additional upper portions.

Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.

Abstract: Disclosed is a test strip for detecting microalbumin in urine, and more particularly a test strip for detecting microalbumin in urine that contains a synthetic albumin indicator, a buffer solution, a surfactant and a polymer (sensitizer) and thus exhibits high sensitivity. The albumin detection test strip has accuracy sufficient to enable clear observation of color change from colorless to blue through the albumin indicator, and improves the detection limit (increases sensitivity) to thereby enable detection of microalbuminuria at a concentration of 20 mg/L or less. The albumin test detection strip contains a surfactant and a polymer in addition to a synthetic albumin indicator, thereby incorporating separate first and second processes into a single process and having effects of reducing costs, improving processing convenience, and increasing solubility and miscibility.

Abstract: The disclosure describes a method for disinfecting an aircraft cabin that includes injecting a non-peroxide disinfectant into an environmental control system of an aircraft and discharging cabin supply air through the environmental control system to discharge the non-peroxide disinfectant into the aircraft cabin. In some instances, the method includes aerosolizing the disinfectant into a plurality of liquid droplets while injecting the disinfectant into the environmental control system. In some instances, the injected disinfectant includes a non-corrosive, non-toxic disinfectant, such that the disinfectant may be discharged into the aircraft cabin in the presence of personnel in the aircraft cabin.

Abstract: A flow stabilized chip includes a chip mainbody, a buffering chamber and two fluid delivery ports. The chip mainbody has a pipe-connection surface. The buffering chamber is disposed in the chip mainbody. The two fluid delivery ports are disposed on the pipe connection surface and connected to the buffering chamber. The chip mainbody includes, in order from the pipe-connection surface to a bottom of the chip mainbody, a first base plate, a first elastic membrane, a second base plate, a second elastic membrane and a third base plate. The first base plate includes a first opening. The second base plate includes a second opening. The third base plate includes a third opening. The first elastic membrane, the second base plate and the second elastic membrane are stacked in sequence to form the buffering chamber.

Abstract: The present disclosure relates to a novel probe compound, i.e., 1-(ortho-benzophenylaminoalkyl)-phenylboronic acid, or its derivative for a fluorescence and/or circular dichroism (CD) sensor for amine compounds containing aminoalcohols. Also, the present disclosure relates to a simultaneous fluorescence and CD analysis method of of amine compounds containing aminoalcohols using the novel probe compound to obtain concentration and optical purity of the amine compounds.

Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

Abstract: Disclosed is a real-time method for detecting copper and silver in water in parts per billion. Total silver is detected by adding a nitric acid solution to the sample; after the silver is digested, adding a buffer solution comprising water, sodium bicarbonate, sodium carbonate and EDTA to the sample; adding an indicator comprising Cadion 2B, EtOH, and Triton X-100 to the sample; then reading the absorbance of the sample after light with an approximate target peak of 515 nm is sent through the sample; and determining the silver concentration by comparing the absorbance of the sample to the absorbances of known silver standards.

Abstract: Disclosed herein are sterilized medical coiled tubing and process for producing the same. One process comprises: helically winding a length of the medical tubing along a mandrel such that adjacent turns of the medical tubing are in contact with each other; applying solvent where the turns of the medical tubing contact each other to produce coiled medical tubing; allowing the solvent to dry; removing the medical tubing from the mandrel after the solvent has dried; and subjecting the medical tubing to a sterilization process using ethylene oxide with in-chamber aeration.

Abstract: An apparatus includes a bill feeder, a housing for holding a bill that is received from the bill feeder, sensors coupled to the housing, an ultraviolet (UV) lamp that emits ultraviolet light to illuminate a portion of the bill, a UV shutter to control a power of the ultraviolet light on the bill, a memory and a processor. The processor configured to determine at a property of the bill from a first output of a first sensor, to determine a bill contaminant on the bill from a second output from a second sensor, to retrieve a UV dose rate to be applied by the ultraviolet light needed to sterilize the bill based on the type of bill contaminant on the bill, the property of the bill, an illumination area or any combination thereof, and to apply the UV dose rate to the bill.