Patents Examined by Jesse P Frumkin
  • Patent number: 11398294
    Abstract: A method for controlling the quality of traditional Chinese patent medicines is based on metagenomics. The method includes extracting genomic DNA of a sample of the traditional Chinese patent medicine, constructing a library of the genomic DNA based on a high-throughput sequencing platform, and performing metagenomic sequencing. The data obtained from the metagenomic sequencing is processed to obtain the ITS2 sequence of the traditional Chinese patent medicine sample A BLAST alignment is performed on the ITS2 sequence in the DNA Barcoding System for Identifying Herbal Medicine, to obtain species identification results. The obtained identification results are compared with the labeled species of the traditional Chinese patent medicine to obtain a conclusion about the quality of the traditional Chinese patent medicine sample.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 26, 2022
    Assignee: Institute of Medicinal Plant Development, Chinese Academy of Medical Science
    Inventors: Jingyuan Song, Tianyi Xin, Zhichao Xu, Jing Jia
  • Patent number: 11367509
    Abstract: Various methods, systems, computer readable media, and graphical user interfaces (GUIs) are presented and described that enable a subject, doctor, or user to characterize or classify various types of cancer precisely. Additionally, described herein are methods, systems, computer readable media, and GUIs that enable more effective specification of treatment and improved outcomes for patients with identified types of cancer. Some embodiments of the methods, systems, computer readable media, and GUIs described herein comprise obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample from a subject; determining a molecular-functional (MF) profile for the subject; identifying an MF profile cluster with which to associate the MF profile for the subject; and clustering the plurality of MF profiles to obtain the MF profile clusters.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: June 21, 2022
    Assignee: BostonGene Corporation
    Inventors: Alexander Bagaev, Feliks Frenkel, Nikita Kotlov, Ravshan Ataullakhanov, Olga Isaeva
  • Patent number: 11342045
    Abstract: The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 24, 2022
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xin Gao, Hiroyuki Kuwahara, Meshari Saud Alazmi, Xuefeng Cui
  • Patent number: 11335439
    Abstract: Various methods, systems, computer readable media, and graphical user interfaces (GUIs) are presented and described that enable a subject, doctor, or user to characterize or classify various types of cancer precisely. Additionally, described herein are methods, systems, computer readable media, and GUIs that enable more effective specification of treatment and improved outcomes for patients with identified types of cancer. Some embodiments of the methods, systems, computer readable media, and GUIs described herein comprise obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample from a subject; determining a molecular-functional (MF) profile for the subject; identifying an MF profile cluster with which to associate the MF profile for the subject; and clustering the plurality of MF profiles to obtain the MF profile clusters.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: May 17, 2022
    Assignee: BostonGene Corporation
    Inventors: Alexander Bagaev, Feliks Frenkel, Nikita Kotlov, Ravshan Ataullakhanov, Olga Isaeva
  • Patent number: 11328010
    Abstract: Aspects of the technology described herein use acoustic features of a music track to capture information for a recommendation system. The recommendation can work without analyzing label data (e.g., genre, artist) or usage data for a track. For each audio track, a descriptor is generated that can be used to compare the track to other tracks. The comparisons between track descriptors result in a similarity measure that can be used to make a recommendation. In this process, the audio descriptors are used directly to form a track-to-track similarity measure between tracks. By measuring the similarity between a track that a user is known to like and an unknown track, a decision can be made whether to recommend the unknown track to the user.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: May 10, 2022
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Oren Barkan, Noam Koenigstein, Nir Nice
  • Patent number: 11315661
    Abstract: Aspects of the present disclosure include systems for use in preparing an epitope tagged biomolecule reagent. A reagent preparatory apparatus for preparing the epitope tagged biomolecule reagent from an activated biomolecule and activated epitope tag is also described. Methods for communicating and receiving an epitope tagged biomolecule reagent request and preparing the subject epitope tagged biomolecule reagents are also provided.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: April 26, 2022
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Jody Martin, Adam Wright, Paul Waterman, James Ghadiali
  • Patent number: 11313862
    Abstract: The method for aiding ALS detection provided by the present invention includes determining a profile of signal peptides contained in a bodily fluid from a test subject, and comparing the signal peptide profile thus determined for the test subject with a previously-determined profile of signal peptides in a bodily fluid from a healthy subject. The presence of a difference between the signal peptide profile of the test subject and the signal peptide profile of the healthy subject at a specific molecular weight is then associated with the test subject's suffering from or developing ALS.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 26, 2022
    Assignees: Toagosei Co., Ltd., National University Corporation Nagoya University
    Inventors: Nahoko Baileykobayashi, Makoto Sawada, Tetsuhiko Yoshida
  • Patent number: 11309058
    Abstract: Techniques are described for determining the strain on a cell wall using two models: 1) a short timescale model, describing the relationship between physical properties assumed to be fixed and 2) a long timescale model, describing the dynamic chemical composition of a cell wall. Short term modeling of the physical properties in a cell wall is used to properly understand how physical factors such as osmotic pressure affects the strain on the cell wall, which is in turn used to identify conditions under which a cell wall will cease to function properly or lyse entirely. Although temporally the physical properties which cause cell walls to underperform/lyse can be evaluated under a short time frame, the chemical properties that lead to the physical properties which cause that behavior themselves change over much longer timescales, in a relative sense.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: April 19, 2022
    Assignee: X Development LLC
    Inventor: Nicholas Casavant
  • Patent number: 11308101
    Abstract: An activity of interest is modeled by a non-stationary discrete stochastic process, such as a pattern of mutations across a cancer genome. Initially, input genomic data is used to train a model to predict rate parameters and their associated uncertainty estimation for each of a set of process regions. For any arbitrary set of indexed positions of the stochastic process that are identified in an information query, the rate parameters and their associated estimation uncertainties are scaled using the model to obtain a distribution of the events of interest and their associated estimation uncertainties for the set of indexed positions. In one practical application, and in response to a search query associated with one or more base-pairs, a result is then returned. The result, which represents deviations between the estimated and observed mutation rates, is used to identify genomic elements that have more mutations than expected and therefore constitute previously unknown driver mutations.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: April 19, 2022
    Inventors: Bonnie Berger Leighton, Maxwell Aaron Sherman, Adam Uri Yaari
  • Patent number: 11299555
    Abstract: This method for aiding Alzheimer's detection provided by the present invention includes: determining a profile of signal peptides contained in a bodily fluid from a test subject, and comparing the signal peptide profile thus determined for the test subject with a previously-determined profile of signal peptides in a bodily fluid from a healthy subject. A difference between the signal peptide profile of the test subject and the signal peptide profile of the healthy subject at a specific molecular weight is then associated with the test subject's suffering from or developing Alzheimer's.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 12, 2022
    Assignees: Toagosei Co., LTD, National University Corporation Nagoya University
    Inventors: Nahoko Baileykobayashi, Makoto Sawada, Tetsuhiko Yoshida
  • Patent number: 11294954
    Abstract: An unidentified media content item may be received by a processing device. A set of features of the unidentified media content item may be determined. Metadata associated with the unidentified media content item may be determined. A first similarity between the metadata associated with the unidentified media content item and additional metadata associated with a known media content item from a media content repository may be determined. A second similarity between the set of features of the unidentified media content item and an additional set of features associated with the known media content item may be determined. The unidentified media content item may be identified as a cover of the known media content item based on the first similarity and the second similarity by the processing device.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: April 5, 2022
    Assignee: Audible Magic Corporation
    Inventors: Erling Wold, Jay Friedman, Richard Boulderstone
  • Patent number: 11250043
    Abstract: This disclosure relates to analyzing log data of a system. This comprises evaluating a first graph model with multiple log events in the log data. The first graph model comprises a first set of nodes connected by a first set of edges representing a first behaviour. A processor determines a first correspondence value based on the first graph model and indicative of a correspondence between the multiple log events and the first behaviour. The processor repeats the steps of evaluating the first graph model for one or more further graph models representing one or more further behaviors and determining the first correspondence value to determine one or more further correspondence values. The processor finally determines a classification of the multiple log events as representing one of the behaviors based on the correspondence values. The use of multiple graph models allows a more granular classification than binary intrusion detection.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: February 15, 2022
    Assignee: National ICT Australia Limited
    Inventors: Nick Van Beest, Ingo Weber
  • Patent number: 11249988
    Abstract: A database platform receives an object identifier from a client in association with a database session. The client is associated with a customer account of the database platform, and the database session is associated with the client. In response to receiving the object identifier, the database platform identifies a resolution namespace for the object identifier, where the resolution namespace for the object identifier is a namespace that is specified in the object identifier if the object identifier includes a specified namespace, and where the resolution namespace is otherwise a current account-level namespace of the database session. The database platform resolves the object identifier with reference to the identified resolution namespace for the object identifier, including identifying an object corresponding to the object identifier in the customer account.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: February 15, 2022
    Assignee: Snowflake Inc.
    Inventors: Damien Carru, Thierry Cruanes, Istvan Cseri, Benoit Dageville, Zheng Mi, Subramanian Muralidhar
  • Patent number: 11244742
    Abstract: Techniques for generating output genomics data. The techniques include: receiving a genome sequence read comprising at least one sequence of bases and associated quality scores; and processing the genome sequence read to generate the output genomics data at least in part by: performing a search of the at least one sequence of bases in a reference genome corpus comprising n-mers from a reference genome, based upon a similarity criterion; calculating an adjustment for one or more of the associated quality scores, based upon results of the search, the adjustment calculation for a quality score associated with a base in the genome sequence read utilising a Bayesian estimation of a likelihood of a sequencing error at the base given the sequence of the read, the Bayesian estimation utilising the results of the search; and adjusting one or more of the associated quality scores according to the calculated adjustment.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: February 8, 2022
    Assignee: Petagene Ltd.
    Inventors: Daniel Leo Greenfield, Alban Rrustemi
  • Patent number: 11243915
    Abstract: A current file is obtained in the data. It is determined whether a similar historical file exists based on a sampled data block from at least one predetermined location in the current file. In response to non-existence of the similar historical file, the current file and corresponding metadata are stored on a file basis. In response to existence of the similar historical file, a deduplication operation is applied on the current file on a block basis.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: February 8, 2022
    Assignee: International Business Machines Corporation
    Inventors: Min Fang, JiaYang Zheng, GuoFeng Zhu
  • Patent number: 11226939
    Abstract: The present disclosure is directed toward systems, methods, and non-transitory computer readable media for generating and providing a collaborative content management interface for a group of users. For example, the systems described herein can detect user input to add a header within the collaborative content management interface. The systems can cause a file management system to generate a subfolder that corresponds with the new header in the collaborative content management interface. Conversely, the systems can analyze a file database maintained by a file management system and, in response to user input to initiate a collaborative content management system, generate a collaborative content management interface with graphical elements to represent files and headers to represent subfolders.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: January 18, 2022
    Assignee: DROPBOX, INC.
    Inventor: Evan Tana
  • Patent number: 11215840
    Abstract: A computer-implemented method includes: receiving, by a computing device, data corresponding to a dynamic speckle spectrum image associated with a biological sample; comparing, by the computing device, the dynamic speckle spectrum image with a plurality of training images; classifying, by the computing device, a contaminant present in the biological sample, based on the comparing; and providing, by the computing device, information regarding the classification of the contaminant.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: January 4, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ginés Carrascal De Las Heras, Sumit Patel, David Bacarella
  • Patent number: 11216514
    Abstract: A secure DNS query may be made by establishing a secure connection with a specific DNS server to determine an address for a hostname. A client device may have a database that may contain a record of a secure DNS server for one or more hostnames. When a DNS request contains one of the specified hostnames, an authenticated session may be created with the designated secure DNS server and a network address for the hostname is returned using the session. The authenticated session may authenticate a client device to the server as well as authenticate the server to the client. In some embodiments, the secure DNS server may accept connections from authenticated clients and may disregard connection requests from non authenticated clients.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: January 4, 2022
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Jeromy S. Statia, Christopher J. Engdahl, Lee Walker, William Dixon
  • Patent number: 11204949
    Abstract: Disclosed are systems, methods, and computer-readable storage media to present content on an electronic display. In one aspect, a method includes identifying a first candidate content and a second candidate content for presentation on an electronic display, determining a first probability and a second probability that the first candidate content and the second candidate content respectively will elicit a particular type of input response, determining a first weight and a second weight based on the first probability and the second probability respectively, selecting either the first content or the second content based on the first weight and the second weight; and presenting the selected content on the electronic display.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: December 21, 2021
    Assignee: Snap Inc.
    Inventors: Jason Brewer, Rodrigo B. Farnham, Nima Khajehnouri, David B. Lue, Zhuo Xu
  • Patent number: 11205502
    Abstract: Provided are a processing method and a processing apparatus for efficacy of a combined drug. The processing method includes: obtaining dose-effect curve band of expected additive effect of the combined drug; obtaining actual dose-effect relationship curve formed by actual effect value of the combined drug with a dose change of one target component drug in the combined drug; comparing a positional relationship between the actual dose-effect relationship curve and the dose-effect curve band; and outputting the efficacy of the combined drug as a synergistic effect when the actual dose-effect relationship curve is located above the dose-effect curve band, outputting the efficacy of the combined drug as an antagonistic effect when the actual dose-effect relationship curve is located below the dose-effect curve band, and outputting the efficacy of the combined drug as an additive effect when the actual dose-effect relationship curve is located within a range of the dose-effect curve band.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: December 21, 2021
    Assignee: Institute of radiation medicine, academy of military medical sciences, PLA.
    Inventors: Shoujun Yuan, Linna Li, Dexuan Yang