Abstract: Trigger based analytics database synchronization is described. In one example case, a trigger is invoked based on an operation issued for a record in a transactional database. According to the trigger, one or more data values for synchronization from the transactional database to an analytics database are determined. A message including the data values is formed and added to a message queue through a message infrastructure service including a message broker. In turn, the values from the message are stored in a suitable memory space, such as a staging table, for forwarding to an analytics computing system. Using the trigger and the message infrastructure service, execution of the transactional database operation can be detached in execution from the addition of the value to the staging table and synchronization with the analytics computing system.

Abstract: Certain aspects of the present disclosure provide techniques for determining query intent and complexity based on text input. One example method generally includes receiving, from a user device, a text query and preprocessing the text query to generate a query vector. The method further includes providing the query vector to an intent model configured to output a user intent of the text query and providing the query vector to a complexity model configured to output a complexity of the text query. The method further includes receiving the user intent of the text query from the intent model and receiving the complexity of the text query from the complexity model. The method further includes determining, based on the user intent and the complexity of the query, a routing target for the text query and routing the text query to the routing target.

Abstract: Contemplated systems and methods use high-accuracy in silico HLA analysis of omics data of donor tissue samples to so establish a transplant match database suitable for transplantation, and particularly stem cell and solid organ transplant, including identification of a donor tissue sample as being compatible with a recipient having a matching HLA type.

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

Abstract: According to various embodiments, a validation device may be provided. The validation device may include: a source information identification circuit configured to determine information relating to a source file; a source information transmitter configured to transmit the information relating to the source file to a server; a validation program receiver configured to receive a validation program from the server; a validation circuit configured to execute the validation program to validate the source file; and a source transmitter configured to transmit the source file if the validation circuit validates the source file.

Abstract: A method for processing sequencing data, including: (i) generating, by a sequencing platform, a plurality of sequencing signals from a sequencing operation, each of the plurality of sequencing signals representing a genetic sequence; (ii) sampling, by a controller, each of the plurality of sequencing signals at a Nyquist rate of the sequencing platform to generate an upsampled signal; (iii) receiving, for each of the plurality of sequencing signals, the respective upsampled signal and information associated with the respective sequencing signal, comprising a base pair read number and a time stamp for the respective sequencing signal; (iv) packaging, by the controller for each sequencing signal, the received upsampled signal, base pair read number, and time stamp into a data packet; (v) organizing the packaged data packets into a multiplexed single data stream; and (vi) transmitting the multiplexed single data stream to a remote system.

Abstract: Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients.

Abstract: A database platform authenticates a system user for access via an application to a database that is associated with a customer account of the database platform. The system user is a first object in a first account-level namespace of the customer account, and the first account-level namespace is distinct from a default account-level namespace of the customer account. The database platform sends, as the system user, a query to the database via the application. The database platform receives, as the system user, results of the query from the database, and stores, as the system user, the results of the query in a first-namespace stage, which is a second object in the first account-level namespace.

Abstract: An apparatus and methods are provided to cross-check the reliability of data. Referring to one of the methods, the cross-checking includes receiving a client request containing data in the form of geographic-related information associated with a location. The method also includes determining one or more knowledge providers to determine one or more confidence levels for the data of the client request based on a type of the geographic-related information at the specific location. The method further includes causing the transmission of at least some of the geographic-related information the client request to the one or more knowledge providers. The method still further includes determining one or more confidence levels of the geographic-related information based on a comparison of the geographic-related information and a known resource associated the specific location. A corresponding apparatus and additional method are also provided.

Abstract: A method includes automatically determining a component of a security label for each first record in a first table of a database having multiple tables, including: identifying a second record related to the first record according to a foreign key relationship; identifying a component of the security label for the second record; and assigning a value for the component of the security label for the first record based on the identified component of the security label for the second record. The method includes storing the determined security label in the record.

Abstract: A method of treating a subject having been diagnosed as having cancer with an immunotherapy is described. The method comprises targeting one or more clonal neoantigens selected using a method comprising determining whether a tumour-specific mutation is likely to be clonal in a subject. The method comprises providing sequence data from one or more samples from the subject comprising tumour genetic material, the sequence data comprising for each of the one or more samples, and determining the likelihood that the tumour-specific mutation is clonal as a posterior probability depending on: a prior probability of the mutation being clonal, and the probabilities of observing the sequence data if the tumour-specific mutation is (i) clonal and (ii) non-clonal, in view of a tumour fraction for each of the one or more samples and one or more candidate joint genotypes.

Abstract: Systems and methods for generating a data map based on a dynamically updated data set. The system includes a client-side device. The client-side device includes a controller and is operably connected to a communication network. The controller includes a processor and a non-transitory computer readable data storage medium, the processor is configured to retrieve from the medium and execute computer readable instructions to receive a data set including one or more data assets and generate the data map based on the received data set. Each data asset includes four or more attributes. The data map includes one or more segments, and the one or more segments illustrate each of the four or more attributes of the one or more data assets.

Abstract: Systems and methods for provisioning a customized software stack are disclosed. A user inquiry for a technical issue is received from an inquiring user and at least one response to the user inquiry is received. A customized software stack is established for a virtual computing environment based on one or more characteristics similar to one or more user characteristics of a user computing environment of the inquiring user and the at least one response.

Abstract: Provided are methods, systems, and computer products for genotyping polyploid organisms, as well as diploid organisms. The provided methods use an allele-intensity model to generate cluster definitions. The allele-intensity model relates allele counts of different genotypes to signal intensities generated by the genotyping platform. The model also includes a capability to update cluster positions obtained from a maximum likelihood model using a Bayesian method.

Abstract: Described herein are systems and methods for designing and testing custom biologic molecules in silico which are useful, for example, for the treatment, prevention, and diagnosis of disease. In particular, in certain embodiments, the biomolecule engineering technologies described herein employ artificial intelligence (AI) software modules to accurately predict performance of candidate biomolecules and/or portions thereof with respect to particular design criteria. In certain embodiments, the AI-powered modules described herein determine performance scores with respect to design criteria such as binding to a particular target. AI-computed performance scores may, for example, be used as objective functions for computer implemented optimization routines that efficiently search a landscape of potential protein backbone orientations and binding interface amino-acid sequences.

Abstract: Various methods, systems, computer readable media, and graphical user interfaces (GUIs) are presented and described that enable a subject, doctor, or user to characterize or classify various types of cancer precisely. Additionally, described herein are methods, systems, computer readable media, and GUIs that enable more effective specification of treatment and improved outcomes for patients with identified types of cancer. Some embodiments of the methods, systems, computer readable media, and GUIs described herein comprise obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample; determining a molecular-functional (MF) profile for the subject at least in part by determining first and second visual characteristics for first and second GUI elements using the data; generating a personalized GUI personalized to the subject using the first and second visual characteristics; and presenting the generated personalized GUI to a user.

Abstract: A method for controlling the quality of traditional Chinese patent medicines is based on metagenomics. The method includes extracting genomic DNA of a sample of the traditional Chinese patent medicine, constructing a library of the genomic DNA based on a high-throughput sequencing platform, and performing metagenomic sequencing. The data obtained from the metagenomic sequencing is processed to obtain the ITS2 sequence of the traditional Chinese patent medicine sample A BLAST alignment is performed on the ITS2 sequence in the DNA Barcoding System for Identifying Herbal Medicine, to obtain species identification results. The obtained identification results are compared with the labeled species of the traditional Chinese patent medicine to obtain a conclusion about the quality of the traditional Chinese patent medicine sample.

Abstract: Various methods, systems, computer readable media, and graphical user interfaces (GUIs) are presented and described that enable a subject, doctor, or user to characterize or classify various types of cancer precisely. Additionally, described herein are methods, systems, computer readable media, and GUIs that enable more effective specification of treatment and improved outcomes for patients with identified types of cancer. Some embodiments of the methods, systems, computer readable media, and GUIs described herein comprise obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample from a subject; determining a molecular-functional (MF) profile for the subject; identifying an MF profile cluster with which to associate the MF profile for the subject; and clustering the plurality of MF profiles to obtain the MF profile clusters.

Abstract: The present invention relates to a method and system for dynamically analyzing, determining, predicting and displaying ranked suitable heterologous biosynthesis pathways for a specified host. The present invention addresses the problem of finding suitable pathways for the endogenous metabolism of a host organism because the efficacy of heterologous biosynthesis is affected by competing endogenous pathways. The present invention is called MRE (Metabolic Route Explorer), and it was conceived and developed to systematically and dynamically search for, determine, analyze, and display promising heterologous pathways while considering competing endogenous reactions in a given host organism.

Abstract: Various methods, systems, computer readable media, and graphical user interfaces (GUIs) are presented and described that enable a subject, doctor, or user to characterize or classify various types of cancer precisely. Additionally, described herein are methods, systems, computer readable media, and GUIs that enable more effective specification of treatment and improved outcomes for patients with identified types of cancer. Some embodiments of the methods, systems, computer readable media, and GUIs described herein comprise obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample from a subject; determining a molecular-functional (MF) profile for the subject; identifying an MF profile cluster with which to associate the MF profile for the subject; and clustering the plurality of MF profiles to obtain the MF profile clusters.