Patents Examined by John Peabody
  • Patent number: 5814612
    Abstract: The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C.sub.20 H.sub.32 O.sub.3. The present invention also provides a purified retinoid compound having the structure: ##STR1## wherein the configuration of the C7, C9, and C11 double bond independently is Z or E and the absolute configuration at C13 and C14 is independently R or S; wherein R1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acyl halide, amide, nitrile, or amine; R2 and R3 are independently hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R2 and R3, or R1 and R2 are replaced by a 13,14-oxirane or a 14,15-oxirane group, respectively.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: September 29, 1998
    Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia in the City of New York
    Inventors: Jochen Buck, Ulrich Hammerling, Fadila Derguini, Koji Nakanishi
  • Patent number: 5691387
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: November 25, 1997
    Assignee: CytRx Corporation
    Inventors: R. Martin Emanuele, Robert L. Hunter, Paula H. Culbreth
  • Patent number: 5675043
    Abstract: A process for the removal of nitrogen-containing compounds from a hydrocarbon blend using a solvent with a liquid-phase density at 25.degree. C. not less than 0.90 g/cm.sup.3, and a Hansen polar solubility parameter .delta..sub.P, and a Hansen hydrogen bonding parameter .delta..sub.H, such that at 25.degree. C.9.0(Cal/cm.sup.3).sup.1/2 <(.delta..sub.P +.delta..sub.H)<28.0(Cal/cm.sup.3).sup.1/2.The process is useful for purifying feedstocks to catalytic conversion processes, particularly etherification processes used in the production of ether-rich additives for gasoline.
    Type: Grant
    Filed: November 21, 1995
    Date of Patent: October 7, 1997
    Inventors: Christopher P. Eppig, E. T. Robinson, Paul Greenough
  • Patent number: 5674911
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: Cytrx Corporation
    Inventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Hameedsulthan S. Allaudeen
  • Patent number: 5670694
    Abstract: A mixture of 2,4-dichloro-5-fluorotoluene and 2,6-dichloro-3-fluorotoluene which cannot be separated in an economically efficient manner and can be reacted individually to give the corresponding benzonitriles is subjected according to the invention to ammoxidation in the form of this mixture and then separated at the stage of the benzonitriles by methods known to the person skilled in the art.
    Type: Grant
    Filed: March 4, 1996
    Date of Patent: September 23, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ferdinand Hagedorn, Helmut Fiege, Reinhard Lantzsch
  • Patent number: 5668132
    Abstract: Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, and R.sup.1 also forms a heterocycle or heterocycle-C.sub.1-4 alkyl, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: September 16, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Joseph P. Vacca, Bruce D. Dorsey, James P. Guare, M. Katharine Holloway, Randall W. Hungate, Rhonda B. Levin
  • Patent number: 5665755
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 9, 1997
    Assignee: Bioresearch Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5663369
    Abstract: A catalyst composition comprising a zero-valent nickel and a multidentate phosphite ligand in the presence of a Lewis acid promoter.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: September 2, 1997
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Kristina Ann Kreutzer, Wilson Tam
  • Patent number: 5663410
    Abstract: The present invention relates to the compounds cis-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and to a process for their preparation.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: September 2, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Matthias Beller, Ralf Pfirmann
  • Patent number: 5663392
    Abstract: Mixed oxide vanadium/antimony/titanium ammoxidation catalysts, particularly suited for the ammoxidation of alkanes and exhibiting X-ray diffraction spectra which are characteristic of a crystallographic phase of rutile TiO.sub.2, are prepared by (a) dissolving respective soluble compounds of vanadium, of antimony and of titanium in at least one saturated alcohol, (b) contacting the alcoholic solution thus obtained with water and precipitating the mixed oxide therefrom, and (c) separating and calcining the mixed oxide thus precipitated.
    Type: Grant
    Filed: January 24, 1996
    Date of Patent: September 2, 1997
    Assignee: R.P. Fiber & Resin Intermediates
    Inventors: Stefania Albonetti, Gilbert Blanchard, Paolo Burattin, Fabrizio Cavani, Ferruccio Trifiro
  • Patent number: 5661166
    Abstract: A Saishin N derivative represented by the following general formula: ##STR1## wherein X represents a carbonyl group or a >CH--ORx group, or X bonds to a carbon atom in Y or Z to represent a >C(ORx)--O-- group; Y and Z may be the same or different and each represents a carbonyl group or a >CH--ORy group, or each bonds to an oxygen atom in X to represent a >CH-- group; the broken line represents an optional bond; and Rx and Ry may be the same or different and each represents a hydrogen atom or an alkyl, alkenyl, aralkenyl, aralkyl, heterocyclic-alkyl or acyl group, is provided which is therapeutically usable as an antiulcer agent.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: August 26, 1997
    Assignee: Tokyo Tanabe Co. Ltd.
    Inventors: Susumu Yokura, Kiyokazu Murakami, Nobuo Takoi, Hiroyuki Iizuka, Eiji Ohtubo
  • Patent number: 5661174
    Abstract: Compounds of the tautomeric formula Ia, Ib or Ic, ##STR1## where R is a radical of the formula ##STR2## are effective compounds for the treatment and prophylaxis of degenerative bone disorders. They are used as pharmaceuticals.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: August 26, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christoph Naumann, Hans-Jochen Lang, Jurgen Sandow, Anne-Marie Moura
  • Patent number: 5654311
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 5, 1997
    Assignee: BioResearch Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5650403
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 22, 1997
    Assignee: Bioresearch, Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5650515
    Abstract: Salts of the formulaF.sub.n.Awherein F is an anion of a metal-free anionic dye having m acid groupswhereinm is 1 to 4, inclusive,A is a cation of an amine containing 1 to 6 sterically hindered amine groups, andn is 1 or 2,with the proviso that the salt contains 1 to n.times.m groups selected from ammonium and immonium groups, useful as pigments, particularly for the coloring of solvent-free and solvent-containing plastic materials, lacquers and printing inks.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 22, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Bansi Lal Kaul, Angelos-Elie Vougioukas
  • Patent number: 5646122
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 8, 1997
    Assignee: Bioresearch, Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5643945
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 1, 1997
    Assignee: Bioresearch, Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5643955
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 1, 1997
    Assignee: Bioresearch, Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5643894
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: Bioresearch, Inc.
    Inventors: Robert J. Kurtz, William D. Fuller
  • Patent number: 5643956
    Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: Bioresearch, Inc.
    Inventors: Robert J. Kurtz, William D. Fuller