Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.

Abstract: The present invention relates to quinolone carboxylic acid derivatives having useful antibacterial activities of formula (I): ##STR1## wherein, R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group optionally substituted with an amino or a hydroxy group;R.sub.4 is hydrogen atom, a lower alkyl, benzyl, t-butoxycarbonyl or ethoxycarbonyl group;R.sub.5 is hydrogen, chlorine atom, methyl or an amino group;R.sub.6 is a lower alkyl group, or a cyclopropyl or a phenyl group optionally substituted with a halogen atom; andX is nitrogen atom, or a methyne group optionally substituted with a lower alkyl or a lower alkoxy group or a halogen atom, and pharmaceutically acceptable salts thereof, and processes for preparing these compounds. The present invention also relates to novel intermediates which are useful for preparing the quinolone compounds of the invention.

Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.

Abstract: A process for purifying crude acetonitrile comprising: (1) a step of contacting crude acetonitrile with nascent oxygen, (2) a step of contacting the acetonitrile from step (1) with a solid base, and (3) a step of removing low-boiling compounds and high-boiling compounds from the acetonitrile from step (2), wherein the step (3) may be effected after the step (1) and before the step (2).

Abstract: The present invention relates to analogues of 2,7-diaminomitosene, a mitomycin C metabolite, useful as antitumor, antimicrobial and/or antiviral agents. These analogues involve functionalization of the N-2 nitrogen with organic groups.

Abstract: The present invention relates to a highly selective method for the deacetylation and deacylation of taxol and taxanes compounds. Specifically, the present invention relates to a one step process wherein acyl groups located at the carbon 2', 10, and 7 positions of taxol and other taxane compounds may be selectively removed.

Abstract: A process for the recovery of acrylonitrile or methacrylonitrile obtained from the reactor effluent of an ammoxidation reaction of propylene or isobutylene comprising passing the reactor effluent through an absorber column, a first decanter, recovery column, a second decanter and stripper column wherein the improvement comprises maintaining inside temperature of the first and second decanter at between about 32.degree. F. to 75.degree. F.

Abstract: A process is disclosed to produce an .alpha.-hydroxyiminophenylacetonitrile of the general formula [II]: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and Z are each as defined in the specification, characterized in that a crude nitrile containing a phenylacetonitrile of the general formula [I]: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and Z are each as defined in the specification, is reacted with an alkyl nitrite in the presence of a base, after which the reaction mixture is extracted with water and then the separated aqueous layer is neutralized with an acid. According to this production process, the desired .alpha.-hydroxyiminophenylacetonitrile can be produced with high purity, in high yield and with ease by extracting the reaction mass with water and then neutralizing the separated aqueous layer with an acid.

Abstract: A higher alcohol synthesis catalyst precursor comprises a homogeneous, highly crystalline, hydroxycarbonate compound containing copper, zinc and at least one element selected from the group consisting of aluminium, manganese and chromium. It also comprises at least one element from at least one of the followng groups of the Periodic Table of Elements: Group IIIA, Group IIIB, Group IVB and Group VIIB.

Abstract: A method for producing 4'-bromomethyl-2-cyanobiphenyl by the step of treating 4'-methyl-2-cyanobiphenyl with Br.sub.2 in a halogenated hydrocarbon solvent or an alkane solvent having 5 to 7 carbon atoms.

Abstract: Preparation of 5-cyanovalerates (I) by the carbonylation of a 1-cyanobutene with carbon monoxide and an alkanol (II) corresponding to the ester radical at an elevated temperature and under superatmospheric pressure in the presence of a cobalt catalyst as well as in the presence of an activating solvent, in which the activating solvent used is an effective amount of a urea of the formula IIIcR.sub.2 N--CO--NR.sub.2 (IIIc)where R is, C.sub.1 -C.sub.6 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl or where 2R groups together form 5-membered to 7-membered rings. The end products I serve as intermediates, chiefly for the preparation of .epsilon.-caprolactam.

Abstract: The present invention relates a method of making to 2-debenzoyl-2-acyl taxol derivatives, and analogues thereof.

Abstract: The present invention is directed to the use of disulfonyl methane compounds for the control off parasites in vertebrate animals.

Abstract: New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the same or different and are hydrogen, alkyl or hydroxyalkyl.Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups. Preferred hydroxyalkyl groups include: ##STR4## R.sub.3 and R.sub.4 are the same or different and are hydrogen, methyl or --CH.sub.2 CH.sub.2 OH; R.sub.5 is hydrogen, alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH or OH and R.sub.6 is alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH, OH or hydrogen and may be the same or different than R.sub.5 and m is zero or one, with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond, m is not zero.

Abstract: The present invention is directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic chemotherapeutic agents or hyperthermia. In a specific example, administration of cell free hemoglobin, a nitric oxide scavenger, in conjunction with mitomycin C, a hypoxic cytotoxin, results in a significant delay in tumor growth of a human tumor xenograft in a mouse compared to mitomycin C alone.

Abstract: Angiotensin II receptor antagonists for the treatment and prophylaxis of coronary heart disease.Antagonists for angiotensin II receptors of the AT.sub.1 subtype can be employed for the prophylaxis and combating of coronary heart disease.Furthermore these compounds, such as, for example, azoles of the formula (I) ##STR1## can also be used for the therapy of cognitive and erectile dysfunction.

Abstract: The invention discloses a process for the preparation of azo dyes using an aminodiphenylamine as diazo component. The process comprises reacting the amine, an alkali metal nitrite and a mineral acid continuously in the temperature range from 35.degree. to 65.degree. C. to give the diazo compound, using a 3 to 15% excess of alkali metal nitrite, and thereafter coupling the diazo compound to a coupling component. Azo dyes of superior quality constancy and in high yield are obtained by the novel process.

Abstract: Taxoids having a 1,3-oxazole containing moiety at the 13-position of the taxane nucleus.

Abstract: Compounds of the formula ##STR1## salts thereof, and mixtures of such compounds and salts, wherein D.sub.1 is ##STR2## wherein R.sub.1 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --SO.sub.3 H or --COOH,R.sub.2 is --COOH, --CONR.sub.6 R.sub.7, --SO.sub.2 NR.sub.6 R.sub.7 or --SO.sub.2 --X, wherein each of R.sub.6 and R.sub.7 is independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 -hydroxyalkyl or C.sub.2-4 sulfatoalkyl, or--NR.sub.6 R.sub.7 is a saturated 5- or 6-membered heterocyclic ring containing no hetero atom in addition to the nitrogen atom to which R.sub.6 and R.sub.7 are attached or containing one hetero atom selected from nitrogen and oxygen in addition to said nitrogen atom, which ring is unsubstituted or substituted by 1 to 3 C.sub.1-4 alkyl groups, andm is 0, 1 or 2, andD.sub.2 is ##STR3## wherein R.sub.3 is hydrogen, --SO.sub.3 H or --COOH,R.sub.4 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, halo, cyano, --SO.sub.3 H, --OSO.sub.

Abstract: The process for producing 5-amino-3-methylpyrazole includes the steps of reacting 2,3-dichloropropene with a cyanogenating agent in the presence of a cuprous salt and water at a pH of 3-8 to obtain at least one intermediate selected from the group consisting of 3-chloro-3-butenonitrile and 2,3-butadienenitrile; reacting the at least one intermediate with a base in the presence of water at a pH of 12.5 or above to obtain 2-butynenitrile; and reacting the 2-butynenitrile with hydrazine. This process is advantageous in that it enables the production of 5-amino-3-methylpyrazole in high yield without using any reagent which may produce fire. 5-Amino-3-methylpyrazole is a useful intermediate for medicines, agricultural chemicals, photographic chemicals, etc.