Abstract: The invention relates to a production method, wherein, with 1 equivalent of pentafluorobenzene of the formula C.sub.6 HF.sub.5 M, 0.5 to 1.5 equivalents of an organometallic compound of the formula RM, wherein R is a hydrocarbon group of 1 to 10 carbon atoms and m is an alkali metal ion, are reacted at -120.degree. to 80.degree. C. in an ether type solvent, a hydrocarbon type solvent or a mixed solvent of the ether type solvent with the hydrocarbon type solvent to generate a pentafluorophenyl alkali metal salt of the formula C.sub.6 F.sub.5 M. Next, 1 equivalent of a boron compound of the formula BX.sub.3, where X is halogen, OR or NR'R" is reacted with 2.1 to 3.9 equivalents of a pentafluorophenyl alkali metal salt of the formula C.sub.6 F.sub.5 M within a temperature range from -120.degree. to 80.degree. C. to produce tris(pentafluorophenyl)borane of the formula (C.sub.6 F.sub.5).sub.3 B or a complex of tris(pentafluorophenyl)borane coordinated with the ether type solvent.
Abstract: Ion-sensitive compounds are provided comprising a quaternary polypyridinium receptor designed to bind anionic species by the formation of a receptor-substrate complex. The receptor comprises one or more quaternary 2,2'-bipyridyl moieties. The compounds are of use in applications requiring anion detection or removal.
Type:
Grant
Filed:
May 12, 1995
Date of Patent:
July 30, 1996
Assignee:
Eastman Kodak Company
Inventors:
Trevor J. Wear, Christopher P. Moore, Paul D. Beer, John W. Wheeler
Abstract: Dyestuffs of the formula ##STR1## in which D is the radical of an aromatic or heterocyclic diazo component andK is the radical of an aromatic or heterocyclic coupling component, or is the radical of an active methylene compound,are obtained in an ecologically advantageous manner by reacting an aromatic or heterocyclic diazo components of the formulaD--NH.sub.2and a coupling component of the formulaH--Kwith a nitrite, for example NaNO.sub.2, in the presence of CO.sub.2 at a pressure of 5-100 at. The process is suitable in particular for the preparation of concentrated dye-stuff solutions, because expensive operations, such as, for example, pressure permeation and reverse osmosis, can be omitted.
Type:
Grant
Filed:
September 23, 1994
Date of Patent:
July 30, 1996
Assignee:
Bayer Aktiengesellschaft
Inventors:
Roderich Raue, Alfred Brack, Karl-Heinrich Lange
Abstract: The invention relates to compounds of the formula ##STR1## having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, in which A--B indicates an optional 1(2) or 6(1) double bond, X is carboxy, carbalkoxy, or carboxamido, linked to the ring directly or through an alkylene linkage, G is halogen, alkyl, or oxy, and Y is alkyl, oxy, or oxyalkylene. The invention further relates to the synthesis of such compounds, and to pharmaceutical compositions and therapeutic methods in which such compounds may be employed.
Type:
Grant
Filed:
February 7, 1994
Date of Patent:
July 23, 1996
Assignee:
Yissum Research Development Company
Inventors:
Raphael Mechoulam, Aviva Breuer, William Devane, Sumner H. Burstein
Abstract: Disclosed herein is a process for making perfluoro(alkyl vinyl ethers) by fluorination with elemental fluorine of selected novel partially fluorinated (di) chloroethyl ethers, followed by dehalogenation to the corresponding perfluoro(alkyl vinyl ether). The perfluoro(alkyl vinyl ethers) are useful as monomers for molding resins and elastomers.
Abstract: Disclosed are novel polyether compounds obtained by the reaction or polymerization of 3,4-epoxy-1-butene in the presence of an acidic catalyst and a nucleophilic initiator compound. The polyether compounds comprise n units of residue (1) and m units of residue (2), wherein the total value of n+m is 2 to 70, n/(n+m) is a value in the range of 0.70 to 0.
Type:
Grant
Filed:
March 3, 1995
Date of Patent:
July 16, 1996
Assignee:
Eastman Chemical Company
Inventors:
James C. Matayabas, Jr., Stephen N. Falling
Abstract: Process for the preparation of 5,6-dihydroxyindole, wherein the compound of formula: ##STR1## in which R' denotes a hydrogen atom or an optionally substituted benzyl radical, is subjected either to the action of hydrogen under pressure or to a hydrogen transfer operation, in a solvent medium and in the presence of a hydrogenation catalyst.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
July 16, 1996
Assignee:
L'Oreal
Inventors:
Alex Junino, Jean J. Vandenbossche, Gerard Lang
Abstract: There are disclosed novel hydroquinone derivatives of the formulas: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments, and the derivatives of the formula (II) are intermediates for the production thereof.
Abstract: Hydrocarbon derivatives are produced by contacting a hydrocarbon with oxygen obtained from an air separation unit in the presence of a partial oxidation reaction catalyst. After separation of the hydrocarbon derivative from the reactor effluent, unreacted hydrocarbon is recovered from the effluent by adsorbing the unreacted hydrocarbon onto an adsorbent at superatmospheric pressure and removing the adsorbed hydrocarbon from the adsorbent by depressurizing said adsorbent and purging the adsorbent with nitrogen obtained from the air separation unit. The recovered unreacted hydrocarbon is recycled to the partial oxidation reactor.
Type:
Grant
Filed:
May 9, 1994
Date of Patent:
July 2, 1996
Assignee:
The BOC Group, Inc.
Inventors:
Arthur Shirley, Ramakrishnan Ramachandran
Abstract: Process for the highly stereoselective production of trans-3,3 5-trimethylcyclohexyl ethyl ether which comprises contacting 3,3,5-trimethycyclohexenyl ethyl ether with hydrogen in the presence of an effective amount of a palladium catalyst at from about 20.degree. C. to about 100.degree. C.
Type:
Grant
Filed:
March 3, 1995
Date of Patent:
June 25, 1996
Assignee:
Henkel Kommanditgesellschaft auf Aktien
Inventors:
Arno Behr, Christoph Lohr, Hans-Peter Handwerk, Thomas Gerke
Abstract: Compounds having the formula ##STR1## wherein --OR.sup.1 comprises the C-13 side-chain of taxol and R.sup.3 comprises hydrogen, as well as a method for the preparation thereof.
Type:
Grant
Filed:
October 4, 1994
Date of Patent:
June 25, 1996
Assignee:
Abbott Laboratories
Inventors:
Geewananda P. Gunawardana, Larry L. Klein, James B. McAlpine
Abstract: Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, or R.sup.1 and R.sup.2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Type:
Grant
Filed:
March 21, 1995
Date of Patent:
June 18, 1996
Assignee:
Merck & Co., Inc.
Inventors:
Joseph P. Vacca, Bruce D. Dorsey, James P. Guare, M. Katharine Holloway, Randall W. Hungate, Rhonda B. Levin
Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
Type:
Grant
Filed:
July 2, 1993
Date of Patent:
June 4, 1996
Assignee:
CYTRX Corporation
Inventors:
R. Martin Emanuele, Robert L. Hunter, Paula H. Culbreth
Abstract: A method of production of an ether compound from an acetal compound or a ketal compound which is excellent in conversion and selectivity and does not cause corrosion of apparatuses and a novel useful polyvinyl ether compound as lubricating oil for compression-type refrigerators, electric insulation oil and the like are disclosed. The method of production of the present invention comprises reaction of an acetal compound or a ketal compound with hydrogen in the presence of a solid catalyst having acidic property and hydrogenation ability to produce the corresponding ether compound.
Abstract: The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, hydrogen in the presence of the catalysts ruthenium black or ruthenium on alumina, diphenyl-silane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
Type:
Grant
Filed:
November 4, 1994
Date of Patent:
May 14, 1996
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Janak Singh, Gregory S. Bisacchi, Richard H. Mueller
Abstract: The present invention relates to 7-[carboxyalkyl or alkenyl]-6-[alkyl or alkenyl]-3-oxo-2,4-dioxobicyclo[3.2.1]octanes and derivatives thereof. In particular, hydroxyl, nitro, amino, amido, azido, oxime, thiol, ether and thiol ether derivatives of said carboxy group are contemplated. In particular, 7-[6-carboxy-2-hexenyl]-6-[3-hydroxy-1-octenyl] of 3-oxo-2,4-dioxobicyclo-[3.2.1 ]octane and derivatives thereof are disclosed. These compounds are useful as ocular hypotensives and as (a) thromboxane mimetics for the prevention of hemorrhaging as follows:, during surgery; tooth extraction; hemorrhaging associated with gastro-intestinal diseases and conditions such as hemorrhoids, inflammatory bowel diseases and gastric and peptic ulcers; as a result of stroke; as a complication in retinal diseases resulting in impaired vision and associated with-menstruation, childbirth and uterine dysfunction and (b) selective vasoconstrictors for treating systemic hypotension, e.g.
Type:
Grant
Filed:
January 26, 1995
Date of Patent:
May 14, 1996
Assignee:
Allergan
Inventors:
Robert M. Burk, Achim H. Krauss, David F. Woodward
Abstract: Salts of the formulaF.sub.n .multidot.A,wherein F is an anion of a metal-free anionic dye having m acid groupswherein m is 1 to 4, inclusive,A is a cation of an amine containing 1 to 4 sterically hindered amine groups, andn is 1 or 2,with the proviso that the salt contains 1 to n.times.m groups selected from ammonium and immonium groups, useful as pigments, particularly for the coloring of solvent-free and solvent-containing plastic materials, lacquers and printing inks.
Abstract: There is disclosed a process for producing an alkoxyiminoacetamide compound which is useful as agricultural fungicides. Also dislclosed are novel intermediate compounds for the above process and their production.
Abstract: Anthraquinone dyes of formula ##STR1## wherein R.sub.2 and R.sub.2 are each independently of the other hydrogen or C.sub.1 -C.sub.4 alkyl,X is a C.sub.2 -C.sub.22 alkylene radical which is interrupted by 1, 2 or 3 members selected from the group consisting of --NH--, --N(CH.sub.3)-- or --O-- and which is unsubstituted or substituted by hydroxyl, sulfo or sulfato; ora C.sub.1 -C.sub.4 alkylene-phenylene-C.sub.1 -C.sub.4 alkylene radical which is unsubstituted or substituted in the phenylene ring by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.
Abstract: Several Fischer-Tropsch reaction schemes using a promoted iron catalyst in a slurry reactor produce oxygenated naphtha and diesel fractions on distillation that reduce particulate emissions in diesel engines. High carbon conversion efficiencies and optimum chain growth are characteristics of the processes.
Type:
Grant
Filed:
March 14, 1994
Date of Patent:
April 2, 1996
Assignee:
Rentech, Inc.
Inventors:
Charles B. Benham, Mark S. Bohn, Dennis L. Yakobson