Patents Examined by José G. Dees
  • Medicinal aerosol formulation
    Patent number: 6447750
    Abstract: This invention relates to a medical aerosol formulation and more particularly, to a medicinal aerosol formulation containing a rosiglitazone maleate and a fluid carrier.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: September 10, 2002
    Assignee: Aeropharm Technology Incorporated
    Inventors: Anthony J. Cutie, Akwete L. Adjei, Frederick A. Sexton
  • Ultraviolet absorbent
    Patent number: 6447759
    Abstract: To provide an ultraviolet absorbent having high UV shieldability, especially UV-A shieldability, high transparency and good dispersibility. An ultraviolet absorbent, which comprises a flaky substrate coated with ultra-fin zinc oxide particles having a mean particle size of not larger than 100 nm, and which is optionally treated with an organic silicone compound; and a method for producing the ultraviolet absorbent, which comprises calcining particles as coated with basic zinc carbonate in the presence of a complex-forming agent.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: September 10, 2002
    Assignee: Merck Patent Gesellschaft
    Inventors: Tamio Noguchi, Yukitaka Watanabe
  • Water soluble, broad spectrum preservative system
    Patent number: 6447793
    Abstract: An effective broad spectrum system useful in an extended range of physical factors and/or composition elements in a cosmetic or personal care product for preservation is described by the present invention. The broad spectrum, water soluble preservative system of the present invention includes an acid or acid derivative, chlorphenesin and a solvent mixed with phenoxyethanol.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: September 10, 2002
    Assignee: The Collaborative Group, Ltd.
    Inventors: Duncan Aust, Stephen Spiegelman, Michael Ross
  • Porous particles for deep lung delivery
    Patent number: 6447753
    Abstract: Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: September 10, 2002
    Assignees: The Penn Research Foundation, Inc., Massachusetts Institute of Technology
    Inventors: David A. Edwards, Giovanni Caponetti, Jeffrey S. Hrkach, Noah Lotan, Justin Hanes, Robert S. Langer, Abdellaziz Ben-Jebria
  • Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus
    Patent number: 6447751
    Abstract: A dispensing container which incorporates an aerosolizable topical insulin preparation, at least one oral hypoglycemic agent, and indicia and instructions for their coordinated use as a single therapeutic regimen for the treatment of diabetes mellitus in a human, and a method for treating diabetes mellitus which employs such a device.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: September 10, 2002
    Inventors: Robert E. Weinstein, Allan M. Weinstein
  • Facial cleanser and method of treating skin conditions
    Patent number: 6447789
    Abstract: A formulation comprising a phosphate salt, particularly sodium tripolyphosphate for cleansing and treating human skin is disclosed. The formulation provides exfoliating properties useful in gently peeling the skin, as well as sequestering properties for removing harmful metals from the skin. The preferred method for the formulations use is also disclosed.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: September 10, 2002
    Inventor: Terrie E. Banks
  • Use in cosmetics of a rigid gel, and cosmetic or dermatological compositions used
    Patent number: 6447792
    Abstract: The present invention relates to the use in cosmetics of rigid gels containing at least 20% by weight of one or more water-soluble or hydrophilic gelling agent(s) which may be obtained from the said water-soluble or hydrophilic gelling agent in the presence of water by mixing, blending, compression and extrusion in a twin-screw extruder. These gels constitute novel pharmaceutical forms for cosmetic or dermatological use. These gels are generally in the form of sticks, pencils or cakes. They may be aqueous with a matrix consisting of an aqueous gelled network. They may be in anhydrous form with a matrix consisting of a dehydrated gelled network. They may constitute many products in solid form applied to making up, to care of and/or to treatment of the skin, the scalp, the hair or the mucous membranes, or alternatively applied to the hygiene of the body, the skin, the scalp, the hair or the mucous membranes.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: September 10, 2002
    Assignee: Loreal S.A.
    Inventors: Veronique Roulier, Myriam Mellul, Therese Daubige, Katrin Holz
  • Amorphous porous particles for deep lung delivery
    Patent number: 6447752
    Abstract: Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: September 10, 2002
    Assignees: The Penn State Research Foundation, Massachusetts Institute of Technology
    Inventors: David A. Edwards, Giovanni Caponetti, Jeffrey S. Hrkach, Noah Lotan, Justin Hanes, Robert S. Langer, Abdellaziz Ben-Jebria
  • Method and compositions for changing the contour of skin
    Patent number: 6444220
    Abstract: Compositions containing insulin formulated for topical application and a method for using the compositions for the cosmetic treatment of wrinkles. The formulation is useful for contouring the skin for the reduction of wrinkles, furrows and the like. Insulin, delivered transdermally by means of topical application to a portion of skin having wrinkles and/or furrows therein, permeates the epidermis and accumulates in the dermis and subcutaneous tissue underlying the portion of skin. The elevated insulin concentration in the dermis and subcutaneous tissue, relative to the concentration of insulin in other analogous, remotely located tissue, typically in the range of about 25-50 &mgr;U/gm, stimulates the formation of a layer of adipose tissue in the insulin-rich tissue underlying the portion of skin.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: September 3, 2002
    Inventor: Teresa S. Wiley
  • Use of mixtures of active substances, containing phytostenols and/or phytostenol esters and potentiators, for the production of hypocholesterolemic agents
    Patent number: 6444659
    Abstract: A hypocholesterolemic composition containing: (a) an active ingredient selected from the group consisting of a phytostenol, a phytostenol ester, and mixtures thereof; and (b) a potentiating agent selected from the group consisting of a chitosan, a phytostenol sulfate, a (deoxy)ribonucleic acid, and mixtures thereof.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: September 3, 2002
    Assignee: Cognis Deutschland GmbH
    Inventors: Norbert Weitkemper, Bernd Fabry
  • Synergistic composition of peracetic acid and amine oxide
    Patent number: 6444230
    Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1)(R2)(R3)N→O  (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: September 3, 2002
    Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques Seppic
    Inventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
  • Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same
    Patent number: 6444709
    Abstract: The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: September 3, 2002
    Assignee: Galderma Research & Development S.N.C.
    Inventors: Philippe Diaz, Jean-Michel Bernardon
  • Cosmetics with hydrofluoroether (HFE)
    Patent number: 6444213
    Abstract: A cosmetic containing at least 1% by weight of hydrofluoroether having a viscosity of less than 5 mPa·s at 25° C., which is represented by the general formula (1): CnHmFl—O—CxHyFz  (1) wherein n is a number of 1 to 12, m is a number of 0 to 25, l is a number of 0 to 11, m+l=2n+1, x is a number of 1 to 12, y is a number of 0 to 25, z is a number of 0 to 11, and y+z=2x+1, provided that m and y are not be simultaneously zero, and l and z are not be simultaneously zero, gives no environment disruption, is highly safe for the skin and improves the feeling in use.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: September 3, 2002
    Assignee: Daikin Industries Ltd.
    Inventors: Masamichi Morita, Motonobu Kubo
  • Method for treatment of aging or damage skin
    Patent number: 6444699
    Abstract: An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and/or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: September 3, 2002
    Assignee: Bioderm, Inc.
    Inventor: Lorraine Faxon Meisner
  • Ion-sensitive, water-dispersible polymers, a method of making same and items using same
    Patent number: 6444214
    Abstract: The present invention is directed to ion-sensitive, water-dispersible polymers. The present invention is also directed to a method of making ion-sensitive, water-dispersible polymers and their applicability as binder compositions. The present invention is further directed to fiber-containing fabrics and webs comprising ion-sensitive, water-dispersible binder compositions and their applicability in water-dispersible personal care products.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: September 3, 2002
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Douglas Bryan Cole, Varsha K. Shah, Kurt J. Bevernitz, Franklin M. Chen, Eric D. Johnson, Frederick J. Lang, Jeffrey D. Lindsay, Ligia A. Rivera, Kim G. Schick, Katherine Denise Stahl
  • Nasal calcitonin formulations
    Patent number: 6440392
    Abstract: A liquid pharmaceutical composition is disclosed comprising calcitonin or an acid addition salt thereof and citric acid or salt thereof in a concentration from about to about 50 mM, said composition being in a form table for nasal administration.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: August 27, 2002
    Assignee: Unigene Laboratories, Inc.
    Inventor: William Stern
  • Skin cosmetic compositions containing dextran or maltodextrin and a weak carboxylic acid
    Patent number: 6440432
    Abstract: Cosmetic skin compositions containing a dextran or maltodextrin and a weak carboxylic acid. Dextran enhances the anti-aging activity of the weak acids and reduces skin irritation that is sometimes caused by the weak acid active.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: August 27, 2002
    Assignee: Unilever Home & Personal Care USA, a division of Conopco, Inc.
    Inventors: Surajit Mukherjee, Donald Rick, Stephan Samuel Habif, Ronni Lynn Weinkauf
  • Disinfectant composition
    Patent number: 6441045
    Abstract: A disinfectant composition containing more than 0.05% and less than 9.4% by volume of dimethyl benzyl lauryl ammonium bromide, substantially pure, substantially de-ionized, substantially bacteria free water if the pH of the water is between 5.0 and 6.8, a first stabilizer structured to adjust a pH level of the disinfectant composition to approximately 7, ammonium Bulfate structured to increase a strength of the composition and a stabilizer structured to lower the pH level of the disinfectant composition back to approximately 7.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: August 27, 2002
    Inventor: Bernardo Birnbaum
  • Carbon dioxide enhancement of inhalation therapy
    Patent number: 6440393
    Abstract: The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: August 27, 2002
    Assignee: Research Development Foundation
    Inventors: J. Clifford Waldrep, J. Vernon Knight, Nadezhda Koshkina
  • Cosmetic composition
    Patent number: 6440431
    Abstract: In order to provide a cosmetic composition which is excellent in stability of viscosity and usability, the cosmetic composition of the present invention comprises an associative thickener, which is composed of a compound shown in Formula (1), and the cosmetic composition is an oil-in-water emulsion composition, which further comprises a water-soluble polymer: R1—{(O—R2)k—OCONH—R3[—NHCOO—(R4—O)n—R5]h}m  (1) wherein R1, R2, and R4 each is a hydrocarbon group, which may be the same or different each other; R3 is a hydrocarbon group, which may have urethane bond; R5 is a straight chain, branched chain or secondary hydrocarbon group; m is an integer of 2 or more; h is an integer of 1 or more; and k and n each is an integer within the range of 0 to 1000, respectively.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: August 27, 2002
    Assignee: Shiseido Co., Ltd.
    Inventors: Katsunori Yoshida, Toshio Yanaki, Isamu Kaneda