Abstract: A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.

Abstract: The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that does not result in muscle toxicity.

Abstract: This invention relates to an anhydrous cosmetic composition comprising: (a) 15-33% of an external phase (also called the oil phase) which is made with at least one selected naphthalate organic ester; a volatile silicone based emulsifier; and a volatile silicone; and (b) 85-67% of an internal phase which is made with an active ingredient, such as an antiperspirant active, in a glycol solvent. For the external phase all or a major portion of what would have been a non-volatile silicone component has been replaced by the naphthalate ester. While a dimethicone copolyol is still included, the use of this particular naphthalate ester obviates the need for the use of any other non-ionic emulsifiers.

Abstract: Acetyldinaline in combination with gemcitabine, a pharmaceutically acceptable salt thereof, capecitabine, or cisplatin is synergistic for treating cancer.

Abstract: The present invention relates generally to the preparation and use of novel enhanced biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen component in the presence of various critical biological and non-biological agents. The invention further relates to a novel method of using said enhanced fibrin sealant whereby the sealant and accompanying agent are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant resulting in enhanced therapeutic value derived by the prolonged presence, and optionally time-released delivery, of said accompanying agent at the critical site.

Abstract: The invention discloses an extract containing puccoon and Chinese angelica, and a formula and preparation method of an ointment containing the extract. The extract is used for treating burns and scalds and is characterized by superior shelf-life. The puccoon and Chinese angelica are extracted with an organic solvent having a polarity of between 0.35 and 0.95, which are then filtrated, concentrated and mixed with a physiologically acceptable carrier or excipient.

Abstract: The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces.

Abstract: The present invention relates to a composition (e.g., a cosmetic composition) comprising, (a) an oxygen labile active agent, (b) erythorbic acid or a cosmetically acceptable salt or ester thereof, (c) optionally, a tocopherol derivative, (d) optionally, a pantothenic acid derivative, and (e) optionally, an extract of green tea, provided that said composition comprises a compound selected from both (c) and (d), both (c) and (e), or both (d) and (e).

Abstract: The invention provides novel mixtures of quaternary ammonium salts having plant growth-regulating properties. The salts, as well as other active ingredients used to regulate plant growth, are dissolved in solvents having either formula II(a) or II(b), as depicted below: wherein “R” is Hydrogen or a C1-C16 alkyl, “n” is 0, 1, 2 or 3, “A” is a C1-C6 alkene or a C1-C6 oxyalkylene, “m” is 1, 2, 3, 4 or 5, and “B” is a straight-chain or branched C2-C8 alkylene.

Abstract: A solid preparation for dialysis for preparing a double preparation type sodium bicarbonate solid preparation for dialysis in which there is no fear that a sugar is decomposed or colored, and which can maintain stability and also is excellent in content homogeneity and a process for producing the same. The solid preparation for dialysis is a mixture of a first composition composed of core particles including sodium chloride that are coated with a coating layer containing one or more electrolytes, a second composition composed of core particles including a sugar that are covered with a coating layer containing one or more electrolytes, and an acid.

Abstract: Inclusion complexes of glipizide and a nonionic surfactant with cyclodextrin and cyclodextrin derivatives. A method of preparing the inclusion complexes of glipizide and a nonionic surfactant with cyclodextrin and cyclodextrin derivatives, by wetting cyclodextrin or a derivative thereof with a nonionic surfactant, and mixing the resulting mixture with glipizide. A pharmaceutical composition containing an inclusion complex of glipizide and a nonionic surfactant with cyclodextrin and cyclodextrin derivatives, in combination with pharmaceutically acceptable excipients.

Abstract: The invention is directed to a process for the preparation of suspensions of drug particles for inhalation delivery, said process providing particles of optimized particle size and distribution homogeneously dispersed in the carrier. The process, which is also suitable for the preparation of sterile suspensions, includes the step of homogenizing and micronizing the formulation in a turboemulsifier provided with a high-potency turbine, optionally followed by a treatment in a high-pressure homogenizer. A further aspect of the invention is directed to a process for preparing micronized sterile beclomethasone dipropionate by gamma-irradiation.

Abstract: Disclosed are sunscreen compositions comprising zinc oxide and at least one of an effective amount of carbomer and an effective amount of C10 to C30 alkyl acrylate crosspolymers. The compositions most preferably utilize an oil in water emulsion. Also disclosed are related processes for producing and using such compositions.

Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of cystic fibrosis.

Abstract: Tungsten and molybdenum oxide, and oxides of other metals and bronzes derived from such oxides, constitute a broad class of materials having applications as photochromic sunblock/cosmetics. These materials are well known in the prior art in the context of photochromic optical data storage media and they offer an excellent match with the very properties needed for cosmetic applications. The invention relates to the adaptation of the class of tungsten and molybdenum oxide photochromics to sunblocking/dosimetry, energy storage, and cosmetic coloration. In addition, certain naturally occurring proteins which exhibit the necessary photochromism can also be used alone for the same purpose or with the oxide systems described above.

Abstract: The present invention refers to a cosmetic composition in the powder form comprising a basic portion and a specific portion, wherein the basic portion comprises a first load of mois-touch lamellar particles of coated mica and a second load of dry-touch spherical particles with statistical size distribution of substantially up to 16 micra consisting of hollow silica microspheres, a binding compound and a carrier comprising a lamellar mineral load with particles below 10 micra, preferably micronized talcum powder.

Abstract: The present invention relates to a protective composition for skin, which protects against bacterial, viral and fungal infections. The compositions comprise a C8-C20 fatty acid, one or more parabens or a combination of these. The compositions of the invention are particularly effective in controlling infections by Methicillin Resistant Staphylococcus aureus (MRSA) as well as other organisms. The invention includes protective hand creams such as barrier hand creams, as well as body lotions, liquid soaps, shampoos, soap bars and creams generally, which are all protective.

Abstract: The invention relates to a process for conditioning and cleaning hair, which comprises contacting the hair with an effective conditioning amount of a series of novel salt complexes. These complexes provide outstanding conditioning effects to the hair and are very mild to the eye. The complexes are made by neutralizing a fatty ammonium compound that is cationic with an anionic compound, producing a salt complex. Optionally, the complex can be combined with dimethicone copolyol to produce extremely mild products suitable for use in shampoos, body washes, and cleanser. The mildness makes these compounds of particular interest in baby shampoos.

Abstract: A pressure-liquefied propellant mixture for aerosols, comprising a fluorinated alkane, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, and carbon dioxide, makes possible an improvement of the wetting properties of pharmaceutically active compounds, with which the formulation problems existing with hydrofluoroalkanes in relation to suspension as well as solution aerosols can be overcome and thus improved medicinal aerosol formulations can be obtained. With the aid of carbon dioxide, it is also possible to specifically influence the pressure and thus the particle size distribution and also by displacement of oxygen from the hydrofluoroalkanes to improve the storage stability of oxidation-sensitive active compounds.

Abstract: The invention provides a pharmaceutical composition for preventing and/or curing digestive disorders such as digestive ulcers, gastritis, etc. The pharmaceutical composition contains, as the active ingredient, an aluminosilicate having silver and zinc ions, and it has an excellent effect for protecting gastric mucous membrane and an excellent effect of promoting the curing of a gastric ulcer.