Patents Examined by José G. Dees
  • Broad spectrum microbicidal and spermicidal compositions, devices, and methods
    Patent number: 6458346
    Abstract: Microbicidal and spermicidal devices, methods, and compositions containing sodium dodecyl sulfate or related anionic surfactants as active ingredients for the prevention and control of pregnancy and sexually transmitted disease, including conditions caused by non-enveloped viruses such as human papilloma virus.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: October 1, 2002
    Assignee: The Pennsylvania State University
    Inventors: Mary K. Howett, John W. Krieder
  • Bone sialoprotein-based compositions for enhancing connective tissue repair
    Patent number: 6458763
    Abstract: The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: October 1, 2002
    Assignee: DePuy Orthopeadics
    Inventors: Dale R. Peterson, Nancy Nousek-Goebl, Todd P. Glancy
  • Hydrogels containing absorbable polyoxaamides
    Patent number: 6458385
    Abstract: The present invention describes a crosslinked aliphatic polyoxaamide polymer and blends thereof that may be used to produce hydrogels, surgical devices such as catheters, molded devices, and the like. The crosslinked aliphatic polyoxaamide of the present invention are formed by crosslinking an aliphatic polyoxaamide having a first divalent repeating unit of formula I: [X—C(O)—C(R1)(R2)—O—(R3)—O—C(R1)(R2)—C(O)—]  I and a second repeating unit selected from the group of formulas consisting of: [—Y—R17—]T,  II [—O—R5—C(O)—]B, and  III ([—O—R9—C(O)]P—O—)LG  XI and combinations thereof, wherein X and Y are selected from the group consisting of —C— and —N(R)—, provided both X and Y are not both —O— and may be blended with a second polymer that is preferably biocompatable.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: October 1, 2002
    Assignee: Ethicon, Inc.
    Inventors: Dennis D. Jamiolkowski, Rao S. Bezwada
  • Sheet for whitening cosmetics and method for using the same
    Patent number: 6458379
    Abstract: A sheet for whitening cosmetics comprises a sheet-like substrate and an adhesive layer which comprises a wet pressure-sensitive adhesive composition formed on the substrate. The whitening component includes vitamin C or its derivatives such as magnesium L-ascorbyl-2-phosphate, vitamin E nicotinate, kojic acid, hydroquinone, ellagic acid, albumin, galenical extracts, and rice bran extracts. Kojic acid and magnesium L-ascorbyl-2-phosphate are preferred. By contacting the adhesive layer with water and/or a hydrophilic medium such as alcohols, e.g., methanol, ethanol, etc., the wet pressure-sensitive adhesive composition exhibits excellent stickiness and excellent applicability to skin as well as excellent whitening effect with alleviating or eliminating stains, freckles, non-transparency, etc. on the skin.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: October 1, 2002
    Assignee: Nitto Denko Corporation
    Inventors: Masayuki Konno, Takashi Kawasaki
  • Gel powder composition
    Patent number: 6458372
    Abstract: The invention relates to liquid powder compositions that are applied as liquid and dry to a powder on the skin. The compositions comprise a cosmetically acceptable liquid base and a powder component comprising at least one type of cosmetically acceptable microparticle.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: October 1, 2002
    Assignee: Color Access, Inc.
    Inventors: Barbara A. Scordamaglia-Crockett, Timothy W. Hackford
  • Treating skin afflictions/conditions with 2-amino-4-alkylaminopyrimidine 3-oxide compounds
    Patent number: 6455054
    Abstract: Skin-soothing, -calmant and/or anti-inflammatory amounts of at least one 2-amino-4-alkylaminopyrimidine 3-oxide are well suited for therapeutically treating such afflictions/conditions of human skin as sensitive skin, skin discomfort, tautness, itchiness or swelling of the skin, blotchy red skin, or sensations of warming or burning of the skin.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: September 24, 2002
    Assignee: Societe l'Oreal S.A.
    Inventors: Yann Mahe, Jean-François Michelet, Lionel Breton
  • Cosmetic compositions
    Patent number: 6455056
    Abstract: A cosmetic composition contains a water-immiscible carrier liquid and a structurant therefor which is effective to gel the composition upon cooling from a temperature at which the structurant is a mobile solution in the carrier liquid. The carrier liquid may serve as a continuous phase in which a solid or liquid disperse phase is suspended. The structurant is a fully or partially esterified saccharide which contains no more than eight monosaccharide residues and has an enthalpy of gelation in the carrier liquid with a magnitude of at least 45 kJ/mole. This minimum enthalpy of gelation facilitates processing at conveniently accessible temperatures and promotes stability.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: September 24, 2002
    Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.
    Inventors: Kevin Ronald Franklin, Andrew Hopkinson
  • Method of applying an adhesive composition over a bioactive polymerization initiator or accelerator
    Patent number: 6455064
    Abstract: A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 24, 2002
    Assignee: Closure Medical Corporation
    Inventors: Upvan Narang, Daniel L. Hedgpeth, Gabriel N. Szabo, Ibraheem T. Badejo, Joe B. Barefoot
  • Skin care composition
    Patent number: 6455057
    Abstract: A topical composition comprising: (a) petroselinic acid and/or derivatives thereof; (b) a phenolic compound and/or mixtures thereof; and (c) a dermatologically acceptable vehicle. The product is particularly useful for treating wrinkles and soothing sensitive skin.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: September 24, 2002
    Assignee: Elizabeth Arden Co., div. of Conopco, Inc.
    Inventors: Karen Elizabeth Barrett, Martin Richard Green, Heng-Long Hu, Preyesh Parmar, Jonathan Richard Powell, Anthony Vincent Rawlings
  • Ipratropium formulation for pulmonary inhalation
    Patent number: 6455028
    Abstract: Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically acceptable salts, solvates, hydrates, esters and isomers thereof. The described formulations include a propellant selected from the group consisting of a fluorocarbon propellant, a hydrogen-containing fluorocarbon propellant, and mixtures thereof. The formulations are substantially free of both surfactant and solvent. Methods of use and drug delivery devices are also provided.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: September 24, 2002
    Assignee: Pharmascience
    Inventors: Harold Wulffhart, Khaldoun Ayoub, Rosemary Logiudice, Hanna Piskorz
  • Formable tubular product
    Patent number: 6455117
    Abstract: A formable plastic product which may be manually shaped into various ornamental devices includes a tubular plastic sheath normally having a predetermined orientation and configuration and tending to retain that orientation and configuration absent external force varying such orientation and configuration. Received in the interior passageway of the sheath is a forming member which extends essentially the length of said sheath, the forming member including an outer surface portion which is unbonded to the sheath and spaced from intimate contact with the internal passageway of the sheath. The forming member is further characterized as being manually formable to a desired conformational shape and for retaining said desired conformational shape whereby said sheath assumes the conformational shape of said forming member as contrasted to the predetermined orientation and configuration of said tubular sheath.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: September 24, 2002
    Inventor: Mike A. Margucci
  • Method for inhibiting skin lesion formation using histamine as the active ingredient
    Patent number: 6455565
    Abstract: A pharmaceutical composition of water, water soluble vinyl polymer gel, amine alcohol dispersant and IEP is used topically to treat herpes labialis and aphthous stomatitis lesions, and also to treat herpes genitalis, chicken pox, allergic conjunctivitis, giant papillary conjunctivitis, stomatitis secondary to chemotherapy, thermal burn, sunburn, and decubitus ulcers and shingles.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: September 24, 2002
    Assignee: Professional Pharmaceutical, Inc.
    Inventors: Bruce A. Jack, B. Thomas White
  • Fluorinated copolymer surfactants and use thereof in aerosol compositions
    Patent number: 6451287
    Abstract: Amphiphilic fluorinated block copolymers are disclosed which are useful for increasing the dispersability of particles, preferably drug particles, in a fluorine-containing propellant.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: September 17, 2002
    Assignee: Smithkline Beecham Corporation
    Inventors: Joseph M. Desimone, Terri Johnson Carson, John F. Miller, Sharon Wells
  • Albuterol formulations
    Patent number: 6451289
    Abstract: Albuterol formulations packaged in an oxygen-permeable plastic container have a long shelf life at room temperature. The formulations consist essentially of albuterol or a pharmaceutically acceptable salt thereof, sodium chloride, and water, have a pH of about 4, and contain less than 0.08% by weight of albuterol aldehyde and less than 1 ppm dissolved oxygen.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: September 17, 2002
    Assignee: Sepracor Inc.
    Inventors: Robert J. Wherry, III, Stewart H. Mueller
  • Spray-drying process for the preparation of microparticles
    Patent number: 6451349
    Abstract: Microparticles, obtainable by spray-drying a substantially pure solution of a therapeutic agent, consist essentially of the agent having its therapeutic activity when administered to the lung. In a preferred embodiment the agent is insulin.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: September 17, 2002
    Assignee: Quadrant Healthcare (UK) Limited
    Inventors: Stuart Robinson, Susan Stewart Smith
  • Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
    Patent number: 6451286
    Abstract: Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: September 17, 2002
    Assignee: Generex Pharmaceuticals Incorporated
    Inventor: Pankaj Modi
  • Method of manufacturing porous matrix-type controlled release systems using emulsion technique
    Patent number: 6451348
    Abstract: A method of manufacturing a porous matrix-type drug delivery system is provided. It comprises the steps of: dispersing, stirring, and emulsifying an aqueous solution of a drug in an organic solvent having a polymer compound and a surface active agent solved therein; thereafter forming it into a desirable matrix shape; lyophilizing or drying it at a low temperature or room temperature until the matrix surface is hardened; and drying it again in order to remove the water and the organic solvent.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: September 17, 2002
    Assignee: Korea Institute of Science and Technology
    Inventors: Seo Young Jeong, Kuiwon Choi, Ick-Chan Kwon, Yong-Hee Kim, Jae Bong Choi, Kyu Back Lee
  • Combination of erythrulose and a reducing sugar with self-tanning properties
    Patent number: 6451293
    Abstract: The invention relates to an active ingredient combination containing erythrulose and a further reducing sugar with self-tanning properties, for example, dihydroxyacetone, which combination is used for artificially tanning the skin. Compared with compounds containing, for example, only dihydroxyacetone, said active ingredient combination and cosmetic compounds based thereon result in an even and longer-lasting colouring of the skin and prevent skin dehydration and uneven flaking.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: September 17, 2002
    Assignee: Pentapharm AG
    Inventors: Thomas Schreier, Roland Jermann
  • Composition and method for contraception and treatment of tumors of the mammary glands
    Patent number: 6451779
    Abstract: A composition with three hormone components is administered to a mammal to cause the suppression or cessation of the menstruation cycle. Alternatively, it can be administered for treatment of tumors of the mammary gland. The composition contains at least a synthetic estrogen, a biogenetic estrogen, and a gestagen. Alternatively, the composition can include hormones which upon ingestion are metabolized to the above-mentioned hormones.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: September 17, 2002
    Inventor: Rolf-Dieter Hesch
  • Implantation composition comprising glass particles
    Patent number: 6447805
    Abstract: A composition suitable for implantation in soft tissue (for example at or around a body orifice) in order to augment the volume of soft tissue is produced. The particles, which are desirably irregularly shaped, are formed from a biodegradable phosphate glass, and may have an average particle diameter of 50 &mgr;m to 2000 &mgr;m, preferably 50 &mgr;m to 300 &mgr;m. The particles are used with a carrier medium for injection into soft tissue such as the bladder submucosa. This procedure can be applied to treat conditions such as vesicoureteric reflux. Additionally the procedure could be used cosmetically.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: September 10, 2002
    Assignee: Giltech Limited
    Inventor: David Michael Healy