Patents Examined by José G. Dees
  • Non-chlorofluorocarbon aerosol formulations
    Patent number: 6503482
    Abstract: Aerosol formulations substantially free of chlorofluorocarbons, for oral and/or nasal administration, are described. The formulations comprise 1,1,1,2-tetrafluoroethane, a medicament, optionally an excipient and optionally a surfactant. Methods of treatment using the formulations also are described.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: January 7, 2003
    Assignee: Schering Corporation
    Inventors: Julianne Fassberg, Joel A. Sequeira, Imtiaz A. Chaudry, Michael Kopcha
  • Method of preventing development of severe metabolic derangement in inborn errors of metabolism
    Patent number: 6503530
    Abstract: The present invention provides a method of avoiding rapid development of extreme hyperammonemia and metabolic acidosis in undiagnosed metabolically abnormal infants having an inherited metabolic disorder.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: January 7, 2003
    Inventors: Chunghee Kimberly Kang, David S. Kang
  • Use of borate-polyol complexes in ophthalmic compositions
    Patent number: 6503497
    Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: January 7, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Masood Chowhan, Nissanke L. Dassanayake
  • Method of reducing or preventing malodour
    Patent number: 6503489
    Abstract: A method for reducing or preventing body malodour by topically applying to human skin a perfume component capable of selectively increasing the population of naturally occurring deodorising micro-organisms on the surface of the skin. The perfume component is preferably capable of inhibiting lysozyme.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: January 7, 2003
    Assignee: Quest International B.V.
    Inventors: Craig S. Wilson, Tony Minhas, John M. Behan
  • Cosmetic aerosol composition for fixing and sheen of keratin substances, and processes
    Patent number: 6503479
    Abstract: The present invention relates to a cosmetic aerosol-pressurized composition for treating keratin substances, in particular the hair, comprising (a) a fluid comprising at least one fixing polymer and at least 5% by weight, relative to the total weight of the pressurized composition, of a non-volatile aryl silicone and (b) at least one propellant, as well as to a process for treating keratin substances using this composition.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: January 7, 2003
    Assignee: L'Oreal
    Inventors: Claire-Marie LesAulnier, Jean-Michel Sturla
  • Sustained release ranolazine formulations
    Patent number: 6503911
    Abstract: A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is suitable for twice daily administration of ranolazine and is useful for controlling the rate of dissolution of ranolazine, and to maintain human plasma ranolazine levels at between 550 and 7500 ng base/mL.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: January 7, 2003
    Assignees: CV Therapeutics, Inc., Syntex USA, Inc.
    Inventors: Andrew A. Wolff, Fiona Baker, John Langridge
  • Topical compositions including deodorant compositions
    Patent number: 6503488
    Abstract: A topical composition for use in a variety of environments includes an active component, e.g., acetylsalicylic acid, a solvent mixture for the active components and, optionally, a silicone additive. The topical compositions according to the invention include nail hardeners, deodorants and sunscreen products.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: January 7, 2003
    Assignee: Tend Skin International, Inc.
    Inventors: Steven E. Rosen, Robert Lee Brown
  • Single-phase transparent aqueous cosmetic composition
    Patent number: 6500441
    Abstract: A single-phase transparent aqueous liquid cosmetic composition comprising at least 90% of water, at least one alkyl para-hydroxybenzoate (paraben), preferably methyl para-hydroxybenzoate (methylparaben), and at least one metabisulfite, preferably sodium metabisulfite. This composition is preferably devoid of primary alcohol. The inventive composition may be in the form of a stable transparent lotion and may be used, in particular, for gently cleaning and/or removing make-up from the skin and/or eyes. The present invention also relates to a process for dissolving an alkyl para-hydroxybenzoate in an aqueous cosmetic composition which by adding at least one metabisulfite thereto.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: December 31, 2002
    Assignee: L'Oreal
    Inventors: Lien Bui-Bertrand, Marie-Laure Carrel
  • Stable microemulsions for the administration of fatty acids to humans or to animals, and use of these microemulsions
    Patent number: 6500862
    Abstract: The present invention relates to a stable, nondetergent composition based on fatty acids, in microemulsion form, for administration to humans or animals, comprising: from 5 to 30% by weight of one or more fatty acids with a free carboxylic acid function, as active ingredient; from 5 to 35% by weight of one or more surfactants; from 5 to 30% by weight of one or more C1-C12 alcohols, as cosurfactant; from 5 to 35% by weight of one or more water-soluble compounds with a carbonyl or hydroxyl function; and from 0 to 35% by weight of one or more water-immiscible compounds; the said composition having a pH of less than 6.5.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: December 31, 2002
    Assignee: Ceva Sante Animale
    Inventor: Philippe Zanello
  • Sun-protection formulations active against herpes simplex viruses
    Patent number: 6500869
    Abstract: The invention relates to sun-protection formulations in solid or liquid form, containing organic and/or inorganic sunscreen filters having a prophylactic action against herpetic diseases of the skin, and to the use of said sun-screen formulations.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: December 31, 2002
    Assignee: Merck Patent Gesellschaft
    Inventors: Hansjürgen Driller, Sabine Hitzel
  • High performance color-depositing shampoo
    Patent number: 6500413
    Abstract: The present invention relates to cosmetic compositions, particularly foaming cleansing compositions, comprising a cationic component and an anionic alkyl glucoester surfactant. These compositions are particularly useful as color-depositing shampoos containing cationic dyes.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: December 31, 2002
    Assignee: Aveda Corporation
    Inventors: Timothy Roland Kapsner, Peter Matravers
  • Topical preparation of alprostadil for the treatment of erectile dysfunction
    Patent number: 6500440
    Abstract: The present invention relates to a composition of topical preparation containing alprostadil, which has excellent skin permeation rate with little skin irritation, which is prepared by dissolving alprostadil or a solid dispersion thereof prepared using poloxamer, into a mixture of an oily vehicle, a pyrrolidone and an anti-irritant agent.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: December 31, 2002
    Assignee: Whan In Pharm Co., Ltd.
    Inventors: Sang-Cheol Chi, Dong Soo Lee, Kye Kwan Lee
  • Condensate of SAR abolisher, producing method thereof, and SAR abolisher powder
    Patent number: 6500458
    Abstract: Condensate of superoxide anion radical (SAR) abolisher exhibiting strong and stable SAR abolishing activity is provided. Hydrogen adsorbent is introduced into a solution obtained by dissolving electrolyte into purified water. The solution containing hydrogen adsorbent is introduced into both cathode and anode chambers separated by a diaphragm. With a cathode immersed in the cathode chamber and with an anode immersed in the anode chamber, electricity is applied between the cathode and the anode to electrolyze the solution. Electrolytic reduced water produced in the cathode chamber is derived, and water included in the electrolytic reduced water is evaporated.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: December 31, 2002
    Inventors: Sanetaka Shirahata, Kazumichi Otsubo
  • Surfactant, and an emulsion-type cosmetic composition and a lipsome containing said surfactant
    Patent number: 6497898
    Abstract: The invention provides a surfactant comprising at least one trehalose-6-fatty acid ester selected from those represented by the following formula: wherein R represents a saturated or unsaturated acyl group having 8-22 carbon atoms, and may have a hydroxyl group or other substituents, and an emulsion-type cosmetic composition comprising said surfactant and a water-soluble polymer. The surfactant of the invention has excellent surface activity and safety. Also, the emulsion-type cosmetic composition has excellent long-term storage stability and sensory properties, has no irritation to skin, and gives beautiful appearance with fine surface texture. Further, the invention is a liposome having a membrane wall composed of trehalose fatty acid ester. Said liposome has excellent chemical and physical stabilities such as long-term storage stability.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: December 24, 2002
    Assignee: Kanebo LTD
    Inventors: Takeshi Ikemoto, Hiromi Minamino, Yasushi Sumida, Yoh-ichi Inoue
  • Rapidly disintegrating and fast-dissolving solid dosage form
    Patent number: 6497899
    Abstract: Described are non-friable, rapidly disintegrating, fast-dissolving solid dosage forms that are produced from pharmaceutically acceptable steam extruded polymers. The solid dosage forms dissolve in the mouth and are particularly useful for subjects that require or desire oral medication but have difficulty swallowing standard oral dosage forms such as tablets or in subjects suffering from emesis. The solid dosage forms are also useful for rapid drug delivery as vaginal or rectal suppositories or for oral delivery of veterinary drugs.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: December 24, 2002
    Assignee: Pfizer, Inc.
    Inventors: Avinash G. Thombre, Larry S. Wigman
  • Composition for inhibiting body odor and uses thereof
    Patent number: 6497862
    Abstract: Disclosed are a composition for inhibiting body odor which comprises trehalose and/or maltitol as an effective ingredient, a method for inhibiting body odor by using the composition, and an article incorporated with the composition.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: December 24, 2002
    Assignees: Kabushiki Kaisha Hayashibara, Seibutsu Kagaku Kenkyujo
    Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Membrane delivery system
    Patent number: 6497887
    Abstract: The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent. The membrane can be used to deliver biologically active agents to the skin.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: December 24, 2002
    Assignee: Color Access, Inc.
    Inventors: Jules Zecchino, E. Althea Knight, Carmen Castillo-Bucci
  • Topical leave-on compositions containing selected pantothenic acid derivatives
    Patent number: 6495149
    Abstract: Disclosed are topical leave-on compositions such as antiperspirant and deodorant compositions comprising (b) from about 0.01% to about 10% by weight of selected pantothenic acid derivatives, (b) from about 10% to about 99.89% by weight of a liquid carrier, wherein the composition has a pH of from about 2.0 to about 5.0, or otherwise comprises an acidic skin active agent or other similar material such as an aluminum-containing antiperspirant active. The selected pantothenic acid derivatives remain stable within the antiperspirant or acidic compositions and provide improved skin feel and cosmetics benefits.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: December 17, 2002
    Assignee: The Procter & Gamble Company
    Inventors: Timothy Alan Scavone, Benjamin Scott Schlagheck, Lisa Ann Runtz
  • Formulation and system for intra-oral delivery of pharmaceutical agents
    Patent number: 6495120
    Abstract: A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption enhancer is adapted to modify the surface membrane such that absorption through the surface membrane is initiated or increased. The oral-absorption enhancer may comprise hydroxypropyl-beta-cyclodextrin and surfactants including benzalkonium chloride, benzethonium chloride, polysorbate 80, sodium lauryl sulfate, Brij surfactants, Tween and Pluronic surfactants. Also disclosed is a system for delivering the formulation including a mechanism for dispensing predetermined doses of the inventive formulation intra-orally as with an aerosol or spray pump or propellant device.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: December 17, 2002
    Inventors: Randall McCoy, Robert O. Williams, III, Miles A. Libbey, III
  • Topical compositions comprising protected functional thiols
    Patent number: 6495125
    Abstract: This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: December 17, 2002
    Assignee: The Procter & Gamble Company
    Inventors: Robert Wayne Glenn, Jr., Alan Roy Katritzky, Eric Block, Matthew David Shair, Thomas Ehlis, Joseph Anthony Lupia