Abstract: The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes, such as infarctions or traumatic injuries, and thus to prevent or reduce the consequent progressive necrosis of tissue associated with such ischemia. This effect is achieved by administering DHEA or DHEA derivatives to a patient as soon as possible after the injury. The present invention is further directed to methods for preventing or reducing bacterial translocation or adult respiratory distress syndrome in a patient. Similarly, bacterial translocation and adult respiratory distress syndrome are prevented or reduced by administering DHEA or DHEA derivatives to a patient. Suitable derivatives of DHEA include, among others, 16.alpha.
Abstract: The present invention provides a convenient, simple, safe and efficient one-pot method for the synthesis of a number of diarlyiodonium triflate salts which does not involve sulfuric acid and which eliminates the need for any counter-ion exchange processes.
Type:
Grant
Filed:
July 21, 1994
Date of Patent:
January 30, 1996
Assignee:
Minnesota Mining and Manufacturing Company
Abstract: A process for the preparation of SCMOS from sulfur trioxide, maleic anhydride, glycolic acid, and alkaline earth metal hydroxide or mixtures of alkaline earth metal and alkali metal hydroxides is disclosed which cooperatively control pH, temperature, time and ratio of reactants.
Type:
Grant
Filed:
December 22, 1994
Date of Patent:
January 30, 1996
Assignee:
Lever Brothers Company, Division of Conopco, Inc.
Abstract: Direct fiuorination of organics such as 1,8-dichlorooctane in tubular reactor. Inert liquid containing organic feed is circulated through tubular reactor with fluorine gas for a time and at a temperature sufficient to yield fluorinated organic. Preferably, liquid and gas phases are separated from reactor product stream containing inert liquid, fluorinated organic, and any unreacted organic is recycled to turbulent mixing zone upstream of reactor in which fresh organic feed is added; and fluorine is added to recycle stream at end of mixing zone. Flow in tubular reactor is turbulent. Rate of organic feed and fluorine addition to process are independent of each other. Among process advantages are: Freon solvents not required; good control of reaction exotherm; and HF scavengers not required. Process useful for partial or complete fluorination.
Type:
Grant
Filed:
October 4, 1993
Date of Patent:
January 30, 1996
Assignee:
Minnesota Mining and Manufacturing Company
Abstract: A process for sulfonating internal olefins wherein a dilute solution of the internal olefins in an inert hydrocarbon solvent is sulfonated to produce a reaction mixture containing intermediate sulfonated compounds, the intermediate sulfonated compounds in the reaction mixture being neutralized under conditions to form neutralized sulfonated compounds, the neutralized sulfonated compounds in the reaction mixture being hydrolyzed to form a product mixture containing hydroxy alkane sulfonates and alkene sulfonates that are then recovered.
Type:
Grant
Filed:
September 1, 1993
Date of Patent:
January 30, 1996
Assignee:
Vista Chemical Company
Inventors:
Upali Weerasooriya, John Lin, K. Lee Matheson, Donald T. Robertson, Janet L. Watson, LeAnn M. Rowe
Abstract: Using in vitro adhesion of recombinant rat L-selectin-Ig or rat neutrophils, it has been demonstrated that these materials bind to sulfatide that has been present in solid phase on a plastic surface. The binding activity appears to have structural requirements, with the sulfate group being critically present in position 3 on the pyranose ring of galactose. When used in vivo, it has been demonstrated that sulfated glycolipids such as brain sulfatide and ganglioside, have significantly protective effects in two models of lung inflammation, the first systemic activation of complement and the second occurring after intrapulmonary deposition of immune complexes. Both inflammatory reactions are complement, neutrophil and selectin-dependent. The protective effects of these compounds are linked to their ability to prevent the recruitment of neutrophils into lung tissue. On the basis of these findings, it is demonstrated by sulfatides and related compounds have significant in vivo anti-inflammatory activities.
Type:
Grant
Filed:
August 15, 1994
Date of Patent:
January 23, 1996
Assignee:
The Regents of the University of Michigan
Inventors:
Peter A. Ward, Masayuka Miyasaka, Yasuo Suzuki
Abstract: Compound of formula (I): ##STR1## in which: R.sub.1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group,R.sup.2 represents an unsubstituted or substituted alkyl group,X.sub.1 represents --NH--,X.sub.2 represents --0--,R.sub.3 represents a hydrogen atom or an alkyl or phenyl group,R.sub.4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different,R.sub.5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base,and medicinal products containing the same are useful as endothelin convertase inhibitor.
Type:
Grant
Filed:
June 29, 1994
Date of Patent:
January 2, 1996
Assignee:
Adir et Compagnie
Inventors:
Guillaume de Nanteuil, Georges Remond, Tony Verbeuren
Abstract: The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts, complexes, esters and amides thereof, represented by the formula ##STR1## which is defined herein. Said compounds find application as anti-thrombotic and anti-asthmatic medicines.
Abstract: The invention relates to a catalyst comprising a rare metal of Group VIII of the Periodic Table of Elements which has been deposited on an inert support and which has been used to dehalogenate .alpha.-halogenated carboxylic acids in the presence of hydrogen, and a rare metal of Group VIII of the Periodic Table of Elements which has been deposited on an inert support and which is such that the granulometry of b) is very much lower than that of a) to form a homogeneous mixture as a result of the action of currents of .alpha.-halogenated carboxylic acid and hydrogen wherein said invention is particularly useful for regenerating palladium catalyst used in the purification of crude monochloroacetic acid.
Type:
Grant
Filed:
June 24, 1994
Date of Patent:
December 12, 1995
Assignee:
Societe Elf Atochem S.A.
Inventors:
Yves Correia, Dominique Jourdain, Joseph Nowocien, Alexandre Salerno
Abstract: The invention is a hard surface abrasive scouring cleanser having no significant syneresis, undue viscosity or yield stress increase, stably suspends abrasives, and has excellent rinsing characteristics. Furthermore, the present invention provides a stably suspended abrasive scouring cleanser which uses relatively small amounts of surfactants, thus lowering the total cost of producing these cleansers. The lesser amount of surfactant also affords the cleanser a milder feel and lower unaesthetic surfactant odor, while also requiring lower levels of fragrance. The absence of solvents results in a less irritating product as well.In one aspect the invention comprises, in aqueous solution:(a) a cross-linked polyacrylate;(b) at least one nonionic surfactant;(c) a pH adjusting agent; and(d) a calcium carbonate abrasive.
Type:
Grant
Filed:
September 23, 1993
Date of Patent:
November 28, 1995
Assignee:
The Clorox Company
Inventors:
Clement K. Choy, Brian P. Argo, Kevin J. Brodbeck, Lynn M. Hearn
Abstract: A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described.The novel conjugate of the phenylalanine-glycine derivative and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered singly or as a mixture with phenylalanine.
Abstract: This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).
Type:
Grant
Filed:
June 2, 1994
Date of Patent:
November 28, 1995
Assignee:
SmithKline Beecham Corp.
Inventors:
James S. Dixon, Raplh F. Hall, Lisa A. Marshall, Floyd H. Chilton, III, Ruth J. Mayer, James D. Winkler
Abstract: A composition comprising a mixture of dialkylbenzene monosulfonic acids or salts thereof containing greater than about 60 weight percent of the para dialkylbenzene isomer and greater than about 80 weight percent of the combined di(2-alkyl)benzene and di(3-alkyl)benzene isomers. The composition exhibits improved properties as a mineral collector in ore flotation.
Type:
Grant
Filed:
November 3, 1994
Date of Patent:
November 21, 1995
Assignee:
The Dow Chemical Company
Inventors:
Kevin A. Frazier, Juan M. Garces, Guo-shuh J. Lee
Abstract: Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined herein. The novel compounds are useful for modulating gene expression of retinoic acid receptors, vitamin D receptors and thyroid receptors. Pharmaceutical compositions and methods for modulating gene expression are provided as well.
Type:
Grant
Filed:
November 25, 1992
Date of Patent:
November 14, 1995
Assignees:
SRI International, La Jolla Cancer Research Foundation
Inventors:
Marcia L. Dawson, James F. Cameron, Peter D. Hobbs, Ling Jong, Magnus Pfahl, Xiao-kun Zhang, Jurgen M. Lehmann
Abstract: The present invention relates to environmentally safe aqueous cleaning compositions comprising alkaline salts, organic adjuvants and a hydrotrope comprised of alkali metal salts of carboxylic acids having a chain length of 7-13 carbon atoms so as to maintain the organic adjuvant in solution.
Type:
Grant
Filed:
August 24, 1993
Date of Patent:
November 7, 1995
Assignee:
Church & Dwight Co., Inc.
Inventors:
Anthony E. Winston, Francis R. Cala, Steven E. Dunn, Alfredo Vinci, M. Stephen Lajoie
Abstract: An originally viscous, non-flowable and non-pumpable cleaning composition made less viscous, flowable and pumpable by the addition of psyllium husks to the composition. The cleaning composition includes an oil phase including at least one of a hydrocarbon oil and a hydrocarbon solvent and mixtures thereof, and at least one of a fatty acid and a non-fatty acid soap surfactant; and the water phase including water and a base. The addition of psyllium husks in various amounts relative to the amount of water in the composition makes the composition flowable. In particular, the addition of from about 2 to about 38 percent by weight of psyllium husks has been found to be suitable to provide a flowable composition containing between about 30 and 55 percent water. A method for the preparation of flowable cleaning compositions is also provided. The cleaning composition (13) forms a novel combination with a container (10) as a replacement element for dispensing apparatus.
Type:
Grant
Filed:
August 20, 1993
Date of Patent:
October 31, 1995
Assignee:
GOJO Industries, Inc.
Inventors:
Jerome Lippman, Michael J. Dolan, John J. Sullivan, Jr., John H. Viscovitz
Abstract: The invention relates to a process for the oxidative preparation of C.sub.5 -C.sub.8 aliphatic dibasic acids by(1) reacting(a) at least one saturated cycloaliphatic hydrocarbon having from 5 to 8 ring carbon atoms in the liquid phase and(b) an excess of an oxygen-containing gas in the presence of(c) a solvent comprising an organic acid containing only primary and/or secondary hydrogen atoms and(d) at least about 0.002 mole per 1000 grams of reaction mixture of a polyvalent heavy metal catalyst;(2) removing the aliphatic dibasic acid; and(3) recycling intermediates, post-oxidation components, and derivatives thereof remaining after removal of the aliphatic dibasic acid into the oxidation reaction.