Abstract: Hydroxyaromatic compounds such as phenol are carbonylated with oxygen and carbon monoxide in the presence of a catalyst system comprising a Group VIIIB metal, preferably palladium; at least one bromide or chloride salt, preferably sodium bromide or a tetraalkylammonium bromide; at least one organic bisphosphine such as 1,3-bis(diphenylphosphino)propane or 1,4-bis(diphenylphosphino)butane; and a compound of a metal other than a Group VIII metal having an atomic number of at least 44, preferably a lead bromophenoxide. There may also be present a polar organic liquid as a cosolvent.
Type:
Grant
Filed:
December 20, 1999
Date of Patent:
June 12, 2001
Assignee:
General Electric Company
Inventors:
Grigorii Lev Soloveichik, Ben Purushatom Patel, John Yaw Ofori, Kirill Vladimirovich Shalyaev
Abstract: A process for using sludge formed in the preparation of a high BN overbased alkylaryl sulfonate or overbased sulfurized alkylphenate, wherein the sludge is treated with an acidic reactant to convert large particles of the alkaline earth metal salt in the sludge into calcium sulfonate, then is reacted with an excess of alkaline earth base and either alkylaryl sulfonic acid or alkylphenol to produce a reaction product, which could be a low or high overbased alkylaryl sulfonate or overbased sulfurized alkylphenate.
Abstract: A process for preparing endothelin receptor antagonists of the sulfanyl type of the general formula I
by nucleophilic reaction of a carboxylic acid derivative of the formula II with a sulfide of the formula III
to give endothelin receptor antagonists of the formula I.
Type:
Grant
Filed:
August 23, 2000
Date of Patent:
May 22, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Wilhelm Amberg, Rolf Jansen, Dagmar Klinge
Abstract: The present invention provides a continuous series of at least 3 esterification reactions, each of which yields highly pure esters derived from benzoic and at least one alcohol selected from monohydric alcohols containing from 6 to 12 carbon atoms and dihydric alcohols containing from 2 to 8 carbon atoms. At least a portion of the esterification catalyst and high boiling impurities remaining following distillation of the desired ester are used in the reaction mixture for the next reaction of the series.
Type:
Grant
Filed:
August 7, 2000
Date of Patent:
May 22, 2001
Assignee:
Velsicol Chemical Corporation
Inventors:
Wesley Wayne McConnell, Bruce Edward Stanhope, Franz Josef Luxem
Abstract: The present invention relates to a process for the hydrogenation of aliphatic dinitriles at least partly into corresponding aminonitriles. More specifically, the invention consists of a continuous process for the hydrogenation of dinitrile, at least partly into corresponding aminonitrile, in the presence of a hydrogenation catalyst which is not dissolved in the reaction medium, characterized in that it is carried out in apparatus comprising means for the continuous separation of the hydrogenate and of the catalyst in a zone in which the gas-liquid transfer is limited or zero, the said separation and the recycling of the catalyst being carried out in a period of time less than or equal to 30 minutes.
Type:
Grant
Filed:
September 19, 2000
Date of Patent:
May 15, 2001
Assignee:
Rhodia Fiber and Resin Intermediates
Inventors:
Vincent Boschat, Philippe Leconte, Daniel Rochette, Lionel Sever
Abstract: The invention involves a method of preparation of omeprazole by a reaction of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimidazole with peroxyacetic acid in a two-phase water and chlorinated organic solvent medium, in alkaline pH, subsequent separation of water and organic phases after the reaction and isolation of omeprazole from organic phase.
Type:
Grant
Filed:
March 5, 1999
Date of Patent:
May 8, 2001
Assignee:
Slovakofarma, A.S.
Inventors:
Vendel {haeck over (S)}mahovský, Vladimir Oremus, Katarina Heleyová, Pavol Zlatoidský, Ond{haeck over (r)}ej Gattnar, Ivan Varga, Valdemar {haeck over (S)}talmach, Ladislav Je{haeck over (z)}ek
Abstract: Pyrazole derivatives are prepared by reacting carbonyl compounds R1—C(O)—CH(R2)—CH2R3 with hydrazine, its hydrate or its salts in 30 to 100% by weight sulfuric acid in the presence of catalytic amounts of iodine or of an iodine compound.
Abstract: To form a mixture of anhydrides suitable for use as a curing agent for epoxy resins, a mixture formed from maleic anhydride and a liquid monoolefin is heated to produce a reaction mass containing a liquid phase comprised of alkenyl succinic anhydride, maleic anhydride, and monoolefin. Then a conjugated diene hydrocarbon is mixed with this reaction mass and the temperature of the resultant mixture is such as to form a reaction mass comprising tetrahydrophthalic anhydride and/or alkyl-substituted tetrahydrophthalic anhydride and alkenyl succinic anhydride.
Abstract: This invention relates to the purification of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester by resolving a mixture of the alpha- and beta-isomers of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester using metal ions.
Type:
Grant
Filed:
August 21, 2000
Date of Patent:
May 1, 2001
Assignee:
The Nutrasweet Company
Inventors:
Indra Prakash, Joseph P. Haar, Jr., Robert Y. Zhao
Abstract: The invention relates to method for separating tocotrienol from a first tocol admixture by heating the first tocol admixture composed of a tocotrienol, at least one tocopherol, a fatty acid, and an esterifying compound to esterify the fatty acid to produce a second tocol admixture composed of the tocotrienol, the tocopherol, the esterified fatty acid, and the unesterified fatty acid; distilling the second tocol admixture with the esterified fatty acid to remove the unesterified fatty acid from the second tocol admixture to produce a third tocol admixture composed of the tocotrienol and the tocopherol, with substantially removed unesterified fatty acid; distilling the third tocol admixture for a sufficient time and temperature to substantially remove the tocotrienol and tocopherol from the third tocol admixture to produce a fourth tocol admixture composed of the removed tocotrienol, tocopherol, and a non-tocol component; and extracting the tocotrienol from the fourth tocol admixture with an extraction solvent
Type:
Grant
Filed:
January 26, 1999
Date of Patent:
May 1, 2001
Assignee:
Eastman Chemical Company
Inventors:
Charles E. Sumner, Jr., John D. Moncier, Jeffrey S. Kanel, Mary K. Foster
Abstract: 1,5-naphthylenediisocyanate is industrially advantageously produced at high yields by pyrolyzing methyl 1,5-naphthylenecarbamate synthesized by providing 1,5-naphthylenedinitrile as a raw material and carrying out amidation, chlorination and Hofmann rearrangement.
Abstract: Disclosed is a process for the production of cyclopropanecarbonitrile (CPCN) by feeding concurently cyclopropanecarboxaldehyde (CPCA) and hydroxylamine aqueous solution to a reaction zone which contains formic acid. The process avoids the formation and accumulation of large amounts CPCA oxime intermediates which exhibit a very high energy release upon thermal decomposition. Additional embodiments of the invention comprise the steps of (1) synthesizing CPCN by feeding concurrently CPCA and hydroxylamine aqueous solution to a reaction zone containing formic acid to form a reaction product mixture comprising CPCN and (2) isolating and recovering the CPCN by contacting the reaction product mixture with a base to obtain a mixture comprising an organic phase containing CPCN and an aqueous phase.
Abstract: The present invention relates to a process for the preparation of 4′-bromomethyl-biphenyl derivatives of the formula:
by reacting a 4′-methyl-biphenyl derivative of the formula:
with a brominating agent a in a hydrobromic acid/alkali metal bromate system in a two-phase medium, and under photo-iradiation, where R is as defined in the specification.
Abstract: Preparation of cyclopropane carboxylic acids usable as intermediates and of formula (II), wherein R1 represents halogen, preferably Cl or Br, or haloalkyl, preferably CF3, and X2 represents halogen, preferably Cl or Br, where R1 or X2 may be the same or different, and wherein the configuration of (II) is predominantly Z for R1=CF3 and X2=Cl; by reacting, in the presence of a catalyst, a compound of formula (I), wherein R1 and X2 are as defined, and X1 represents halogen, preferably Cl or Br, where R1, X1 and X2 may be the same or different, with a compound which is a hydrogen donor.
Type:
Grant
Filed:
August 17, 2000
Date of Patent:
April 10, 2001
Assignee:
Cheminova Agro A/S
Inventors:
Per Dausell Klemmensen, Hans Kolind-Andersen, Ib Winckelmann
Abstract: The present invention provides intermediate for the preparation of indane-like compounds which are useful for the modulation of a muscarinic receptor.
Type:
Grant
Filed:
June 10, 1999
Date of Patent:
April 3, 2001
Assignee:
Eli Lilly and Company
Inventors:
Bret E Huff, Michael A Staszak, John S Ward
Abstract: A process for coproduction of 6-aminocapronitrile and hexamethylenediamine starting from adiponitrile comprises
(1) partially hydrogenating adiponitrile in the presence of a catalyst to obtain a mixture comprising 6-aminocapronitrile, hexamethylenediamine and adiponitrile,
(2) removing 6-aminocapronitrile and hexamethylenediamine from the mixture,
(3) adding to the portion comprising essentially adiponitrile from 0.01 to 10% by weight of an acid, based on adiponitrile, or an acidic ion exchanger and removing the adiponitrile from the mixture, and
(4) recycling the adiponitrile into step (1).
Type:
Grant
Filed:
March 10, 1999
Date of Patent:
March 27, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Hermann Luyken, Guido Voit, Peter Bassler, Alwin Rehfinger, Rolf Fischer
Abstract: A process for distillative removal of 6-aminocapronitrile from mixtures (I) comprising 6-aminocapronitrile and an imine (II) comprises conducting the distillation in the presence of carbon dioxide.
Type:
Grant
Filed:
July 21, 1999
Date of Patent:
March 20, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter Bassler, Hermann Luyken, Alwin Rehfinger, Harald Rust
Abstract: A process for increasing the yield of one or both co-products HCN and acetonitrile produced during the manufacture of acrylonitrile comprising introducing a hydrocarbon selected from the group consisting of propylene and propane, a mixture comprising one or more alcohols selected from crude methanol, crude ethanol or crude propanol, ammonia and air into a reaction zone containing an ammoxidation catalyst, reacting the hydrocarbon, alcohol, ammonia and oxygen over said catalyst at an elevated temperature to produce acrylonitrile, hydrogen cyanide and acetonitrile, and recovering the acrylonitrile, hydrogen cyanide and acetonitrile from the reactor.
Type:
Grant
Filed:
March 2, 2000
Date of Patent:
March 20, 2001
Assignee:
The Standard Oil Company
Inventors:
Sanjay P. Godbole, Michael J. Seely, Dev D. Suresh
Abstract: The present invention provides a safer and more efficient process for producing [2-(arylsulfonyl)ethenyl]benzene derivatives of the formula (3):
wherein R1, R2, R3 and R4 are the same or different and each independently represent a hydrogen, fluorine, or chlorine atom, a lower alkyl group, or the like, and two adjacent R3 and R4 may bond each other at their terminals to form a ring, which the process is characterized in that a 2-(arylsulfonyl)ethanol of formula (1):
wherein R1 and R2 are as defined above, and an acid anhydride are reacted in the presence of a base, and the reaction liquid obtained is supplied to a reaction with an aromatic halide of formula (2):
wherein X represents a chlorine, bromine, or iodine atom, and R3 and R4 are the same as defined above, in the presence of a palladium catalyst and a base.