Abstract: A process for hydrocyanation of an aliphatic monoethylenically unsaturated compound, in which the ethylenic double bond is not conjugated to any other unsaturated group in the molecule, or a monoethylenically unsaturated compound in which the ethylenic double bond is conjugated to an ester group, which process uses a catalyst composition comprising a zero-valent nickel and a multidentate phosphite ligand in the presence of a Lewis acid promoter.
Type:
Grant
Filed:
July 23, 1998
Date of Patent:
October 3, 2000
Assignee:
E. I. du Pont de Nemours and Company
Inventors:
James Michael Garner, Kristina Ann Kruetzer, Wilson Tam
Abstract: An improved catalyst for the production of unsaturated nitriles from their corresponding olefins, the catalyst having the atomic ratios described by the empirical formula Bi.sub.a Mo.sub.b V.sub.c Sb.sub.d Nb.sub.e A.sub.f B.sub.g O.sub.x and methods of using the same.
Abstract: The invention concerns a method for the production of unsymmetrically substituted cyanobiphenyls by the slow addition of an aryl Grignard compound to an optionally substituted bromobenzonitrile in the presence of a palladium complex catalyst.
Type:
Grant
Filed:
August 7, 1998
Date of Patent:
September 19, 2000
Assignee:
Great Lakes Chemical Konstanz GmbH
Inventors:
Bernd Kohler, Manfred Langer, Thomas Mosandl
Abstract: The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;R.sub.1, R.sub.5 and R.sub.6 are independently a C.sub.1 -C.sub.6 alkyl group;R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or a C.sub.1 -C.sub.6 alkyl group;Z is thio, oxy or a methylene group;A is a C.sub.1 -C.sub.4 alkylene group;X is thio or oxy; andG.sub.1 and G.sub.2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl or --C(O)--(CH.sub.2).sub.n --CH.sub.3 and n is an integer 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.
Type:
Grant
Filed:
June 23, 1998
Date of Patent:
September 19, 2000
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Roger A. Parker, Michael L. Edwards, Mark J. Vaal, James E. Matt, Kim S. Chen, Mark T. Yates, Paul S. Wright, Steven J. Busch
Abstract: Improved liquid phase process useful in the hydrocyanation of diolefinic compounds to produce nonconjugated acyclic nitriles and to the liquid phase process of isomerization of the nitrites to, among other things, 3- and/or 4-monoalkene linear nitriles. The improvement involves conducting the process in the presence of zero-valent nickel and a multidentate phosphite ligand. Novel multidentate phosphite ligands and catalyst precursor compositions made therefrom are also disclosed.
Type:
Grant
Filed:
August 12, 1999
Date of Patent:
September 19, 2000
Assignee:
E. I. du Pont de Nemours and Company
Inventors:
Thomas Foo, James Michael Garner, Wilson Tam
Abstract: The invention concerns a process for the preparation of 6-aminocapronitrile or 6-aminocapronitrile-hexamethylene diamine mixtures by: a) reacting 5-formylvaleronitrile with ammonia and hydrogen in the presence of hydrogenation catalysts selected from the group consisting of metals or metal compounds rhenium, copper and elements of group VIII of the periodic table of elements, a hydrogenation discharge product being obtained; and b) extracting from the hydrogenation discharge product 6-aminocapronitrile and optionally hexamethylene diamine, provided that the hydrogenation catalyst does not contain copper, nickel or copper and nickel as it's only components.
Type:
Grant
Filed:
February 1, 1999
Date of Patent:
September 19, 2000
Assignee:
BASF Aktiengesellschaft
Inventors:
Rolf Fischer, Rocco Paciello, Michael Roper, Werner Schnurr
Abstract: The invention concerns Diels-Alder reactions between non-activated aldehydes RCHO in which R is a C1-C10 aliphatic group or phenyl group, which is unsubstituted or substituted with one or more C1-C5 alkyl groups or one other functional group, with simple aliphatic dienes R.sub.1 CH.dbd.CR.sub.2 --CR.sub.3 .dbd.CHR.sub.4 in which R.sub.1 -R.sub.4 are H or C1-C5 alkyl groups using as a catalyst a perfluorinated organic sulphonic acid or a Bronsted acid derivative thereof. The reaction leads to dihydropyrans of the structure below in which R1-R4 have the meaning indicated above.The preferred perfluorinated organic sulfonic acids are perfluorooctanesulphonic acid, triflic acid, Nafion or a Bronsted acid derivative of triflic acid. ##STR1## The preferred aldehydes are those wherein R is a C2-C6 aliphatic group or a phenyl group which is unsubstituted or mono-substituted with C1-C3 alkyl or with 4-Cl, 4-nitro or 3-methoxy. The preferred dienes are those wherein the groups R.sub.1 -R.sub.4 are H or methyl.
Type:
Grant
Filed:
January 19, 1998
Date of Patent:
September 5, 2000
Assignee:
Quest International B.V.
Inventors:
Christopher Paul Newman, Varinder Kumar Aggarwal, Graham Patrick Vennall
Abstract: A process for obtaining a nitrile represented by formula RCN, comprising contacting a corresponding aldehyde represented by formula RCHO with (i) ammonia or ammonium hydroxide, and (ii) hydrogen peroxide, in the presence of a transition metal or a transition metal compound.
Type:
Grant
Filed:
September 3, 1999
Date of Patent:
September 5, 2000
Assignee:
Millennium Specialty Chemicals
Inventors:
Mark B. Erman, Joe W. Snow, Melissa J. Williams
Abstract: The object of the invention is to provide a process for preparing a cyano group-containing methylamine, comprising hydrogenating only one of the two nitrile groups of a aromatic dinitrile, wherein the aromatic dinitrile is reacted a a high conversion ratio using a small amount of a catalyst under the conditions of a low temperature and a low pressure to prepare a cyano group-containing aromatic methylamine in a high yield.
Abstract: The compounds of the formula (I) wherein R is as defined in the disclosure, are prepared by bromination of compounds of the formula (II) by means of Br.sub.2 or HBr in the presence of H.sub.2 O.sub.2.
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Type:
Grant
Filed:
December 29, 1998
Date of Patent:
August 29, 2000
Assignee:
Abbott Laboratories
Inventors:
James Link, Gang Liu, Zhonghua Pei, Tom von Geldern, Martin Winn, Zhili Xin
Abstract: In the presence of a metal catalyst such as a samarium compound, an enol ester compound shown by the formula (1) is reacted with a carbonyl compound shown by the formula (3) and a cyanogenation agent to produce an .alpha.-cyanohydrin ester shown by the formula (4): ##STR1## wherein R.sup.1, R.sup.7, and R.sup.8 are the same or different from each other, each representing a non-reactive atom or a non-reactive organic group; R.sup.2, R.sup.3, and R.sup.4 are the same or different from each other, each representing a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.By hydrolyzing the obtained compound, the corresponding .alpha.-hydroxy acid or a salt thereof can be obtained. According to the above processes, an .alpha.-cyanohydrin ester and an .alpha.-hydroxy acid can be obtained in high yields.
Abstract: Compounds of formula I, N-oxides or salts, thereof ##STR1## in which q is 0, 1 or 2A is CH and D is N.sup.+ R.times.1/n Q.sup.n- or A is N and D is N.sup.+ R.times.1/n Q.sup.n- or A is CH or N and D is Nor A is N.sup.+ R.times.1/n Q.sup.n- and D is N, R is CR.sup.6 R.sup.7 D.sup.a R.sup.8,Q.sup.n- is an inorganic or organic anion, n being 1, 2, 3 or 4;X is NH, O or S(O).sub.q, (q is 0, 1 or 2); and the R groups have various meanings as defined in the claims are useful pesticidal, especially insecticidal activity.
Type:
Grant
Filed:
May 18, 1999
Date of Patent:
August 22, 2000
Assignee:
Hoechst Schering AgrEvo GmbH
Inventors:
Harald Jakobi, Matthias Eckhardt, Wolfgang Schaper, Ralf Braun, Gerhard Krautstrunk, Oswald Ort, Ulrich Sanft, Maria-Theresia Thonessen, Werner Bonin
Abstract: There are disclosed a process for producing a nitrile compound which comprises catalytically reacting an alkyl group-substituted aromatic compound or an alkyl group-substituted heterocyclic compound with a mixed gas containing ammonia and oxygen in the presence of 1 a catalyst comprising a vanadium oxide, a chromium oxide, a boron oxide, a molybdenum oxide, and an oxide of an alkali metal or an alkaline earth metal or 2 a catalyst comprising a vanadium oxide, a chromium oxide, a boron oxide, an alkali metal oxide, and a heteropolyacid. According to the above process and by virtue of the specific catalyst, it is made possible to produce a nitrile compound having an aromatic ring or a heterocyclic ring in an extremely advantageous manner, that is, in high yield at high selectivity to the objective product.
Abstract: The process of manufacturing an unsaturated mononitrile selected from the group consisting of acrylonitrile and methacrylonitrile comprising transporting a reactor effluent containing the unsaturated mononitrile to a first column where the reactor effluent is cooled with at least one aqueous stream, transporting the cooled effluent containing the unsaturated mononitrile into a second column where the cooled effluent is contacted with at least one second aqueous stream to absorb the unsaturated mononitrile into at least one second aqueous stream, transporting the second aqueous stream containing the unsaturated mononitrile from the second column to a first distillation column for separation of the crude unsaturated mononitrile from the second aqueous stream, and transporting the separated crude unsaturated mononitrile to a second distillation column to remove at least some impurities from the crude mononitrile, and transporting the partially purified crude unsaturated mononitrile to a third distillation column
Type:
Grant
Filed:
March 31, 1999
Date of Patent:
August 22, 2000
Assignee:
The Standard Oil Company
Inventors:
Michael Keith Hagans, Sanjay Purushottam Godbole, Patrick Michael Conrath, Donald Eugene Meihls
Abstract: Described are novel photochromic pyrano-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted "S" pyran ring, the 3,4 positions of which are fused to the f side of the naphtho portion of the naphthopyran, and certain substituents at the 2-position of the "T" pyran ring. Certain substituents may also be present at the number 5, 7, 8, 9, 10, 11 or 12 carbon atoms of the compounds. These compounds may be represented by the following graphic formula: ##STR1## Also described are polymeric organic host materials that contain or that are coated with such compounds or combinations thereof with complementary photochromic compounds, e.g., certain other naphthopyrans, benzopyrans, and spiro(indoline)type compounds.
Type:
Grant
Filed:
December 3, 1997
Date of Patent:
August 22, 2000
Assignee:
PPG Industries Ohio, Inc.
Inventors:
Barry Van Gemert, Christopher D. Selvig
Abstract: The present invention provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject a photosensitizer formulated in a liposome carrier, and exposing the subject to light at a wavelength 20-40 nm greater than the maximum absorption of the photosensitizer at a sufficient dose and duration to treat the viral infection in the subject. The present invention also provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject (i) a photosensitizer formulated in a liposome carrier and (ii) at least one quencher, and exposing the subject to light at a sufficient wavelength, dose and duration to treat the viral infection in the subject.
Abstract: Catalyst for halogen-fluorine exchange reactions on aromatics, consisting essentially of a mixture of one or more compounds of the component a) plus at least one compound of the components b), c) and/or d), whereina) is an amidophosphonium salt of the formula (I) ##STR1## where A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, A.sup.8 are, independently of one another, identical or different and are each a straight-chain or branched alkyl or alkenyl having from 1 to 12 carbon atoms, cycloalkyl having from 4 to 8 carbon atoms, an aryl having from 6 to 12 carbon atoms, an aralkyl having from 7 to 12 carbon atoms, or A.sup.1 A.sup.2, A.sup.3 A.sup.4, A.sup.5 A.sup.6, A.sup.7 A.sup.8 are, independently of one another, identical or different and are in each case connected to one another either directly or via O or N--A.sup.9 to form a ring having from 3 to 7 ring atoms, A.sup.9 is an alkyl having from 1 to 4 carbon atoms and B.sup..crclbar.
Type:
Grant
Filed:
July 21, 1999
Date of Patent:
August 15, 2000
Assignee:
Aventis Research & Technologies GmbH & Co. KG
Inventors:
Sergej Pasenok, Wolfgang Appel, Ralf Pfirmann, Thomas Wessel, Thomas Schach, Hans Schubert
Abstract: Compounds consisting of indan derivatives of the formula: ##STR1## Wherein X or Y represents an aldehyde or an acetal group and the other represents a hydrogen, and R represents a hydrogen or a methyl group and the t-butyl group is at the 5 or 6 position of the phenyl ring. Where these compounds are useful as perfuming ingredients for the preparation of perfuming compositions and perfumed articles to which they impart floral odor notes.