Patents Examined by K. Weddington
  • Patent number: 5232706
    Abstract: The preparation comprises a nucleus formed by a mixture of omeprazol or an alkali salt of omeprazol with a first basic compound; the nucleus has two coatings, the first of which is formed by one or more layers formed by a basic water soluble excipient and by a second basic compound, while the second coating is formed by an enteric coating.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: August 3, 1993
    Assignees: Esteve Quimica, S.A., Centro Genesis para la Investigacion, S.L.
    Inventor: Alberto Palomo Coll
  • Patent number: 5232946
    Abstract: The invention relates to new phenylethanolamines of general formula ##STR1## wherein A represents a straight-chained or branched alkylene group,B represents a bond, an alkylene group, a carbonyl or hydroxymethylene group,R.sub.1 represents a hydrogen atom, a halogen atom or a trifluoromethyl group,R.sub.2 represents a hydrogen atom or an amino group,R.sub.3 represents a cyano group, a hydrogen, chlorine or bromine atom andR.sub.4 represents a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group substituted in the end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group,the optical isomers and diastereoisomers and acid addition salts thereof.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: August 3, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Rudolf Hurnaus, Manfred Reiffen, Robert Sauter, Wolfgang Grell, Eckhard Rupprecht
  • Patent number: 5230903
    Abstract: Chloroisocyanurate compositions for disinfection and sterilization comprise a dichloroisocynurate and at least one alkaline substance selected from the group consisting of magnesium oxide, magnesium hydroxide, calcium hydroxide and sodium carbonate. The chloroisocyanurate compositions can prevent an increase in hydrogen ion concentration often caused by continuous use of dichloroisocyanurates in closed water systems and have excellent stability in a wet state and stability during storage over long periods of time.
    Type: Grant
    Filed: December 6, 1991
    Date of Patent: July 27, 1993
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Masanori Ota, Masashi Nakamura, Kenichi Mizusawa
  • Patent number: 5229372
    Abstract: Post-hatch diseases in poultry caused by Dactylaria gallopava are prevented and treated by exposing the poultry environment to an effective quantity of natamycin.
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: July 20, 1993
    Assignee: Du Coa L.P.
    Inventor: Bruce D. King
  • Patent number: 5227395
    Abstract: The use of 1-phenoxycarbonyl-2-pyrrolidinone derivatives as an anti-platelet aggregating agent. The derivatives are of the formula ##STR1## wherein R is a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a nitro group or a halogen atom and n is 0, 1 or 2.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: July 13, 1993
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Hirohiko Komatsu, Einosuke Sakurai, Fumiko Hamaguchi, Tatsuo Nagasaka
  • Patent number: 5227373
    Abstract: Improved lyophilizate compositions of ifosfamide comprising urea as the primary excipient and, optionally, mesna, are produced in a modified freeze-drying process to give products with increased heat stability and extended shelf storage life.
    Type: Grant
    Filed: October 23, 1991
    Date of Patent: July 13, 1993
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Robert L. Alexander, Robert J. Behme, Joseph A. Scott, Dana Brooke
  • Patent number: 5221673
    Abstract: This invention relates to fodder compositions, particularly feed additives, premixes and ready-for-use fodders, and a method for increasing weight-gain and improving fodder utilization of dimestic animals.The compositions according to the invention comprise as active ingredient a compound of the general formula (I), ##STR1## wherein R.sup.1 represents methoxy or hydrogen andR stands for methyl; orR and R.sup.1 each denotes hydrogen; orR.sup.1 stands for hydrogen and R represents ethyl.The compounds of the general formula (I) known from the literature exhibit useful weight-gain increasing and fodder-utilization improving effects and can be used in animal husbandry.
    Type: Grant
    Filed: December 4, 1991
    Date of Patent: June 22, 1993
    Assignee: Egis Gyogyszergyar
    Inventors: Zoltan Budai, Tibor Mezei, Klara Reiter nee Esses, Lajos Fekete, Karoly Magyar, Attila Nagy, Laszlo Puskas
  • Patent number: 5221695
    Abstract: Aqueous formulations comprising [1R-[1.alpha.(Z),2.beta.,3.beta.,5.alpha.]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl) cyclopentyl]-4-heptenoic acid or its hydrochloride salt and an unsubstituted or substituted .alpha.-, .beta.- or .gamma.-cyclodextrin have been found which are particularly useful in the treatment or prophylaxis of conditions mediated by thromboxane A.sub.2. Suitable aqueous formulations include injections, oral preparations such as syrups and capsules and inhalation preparations.
    Type: Grant
    Filed: June 8, 1992
    Date of Patent: June 22, 1993
    Assignee: Glaxo Group Limited
    Inventors: Harry Finch, Anthony J. Phillips
  • Patent number: 5219552
    Abstract: The present invention relates to measurements by tomo-densitometry. It relates in particular to compositions usable in tomo-densitometry which are comprised of a solution consisting at least of a salt or a complex of a metal of which the atomic weight is comprised between 24 and 66 associated with an appropriate solvent or vehicle. Utilization in tomo-densitometry.
    Type: Grant
    Filed: January 4, 1988
    Date of Patent: June 15, 1993
    Inventors: Francois Dietlin, Fernand Heitz
  • Patent number: 5215978
    Abstract: The method of enhancing egg laying in the turkey which comprises administering to a turkey hen an amount of epostane sufficient to increase significantly the number of eggs laid during the egg laying cycle of said turkey hen is disclosed.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: June 1, 1993
    Assignee: The Upjohn Company
    Inventor: Don M. Keister
  • Patent number: 5215977
    Abstract: A method of treating poultry suffering from leg bone joint infection and/or leg weakness by administering to the poultry an effective amount of a non-steroidal anti-inflammatory drug and composition of such drug.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: June 1, 1993
    Assignee: Pedivet Ltd.
    Inventor: Daniel Yam
  • Patent number: 5215993
    Abstract: Compositions comprising a mixture of the antibiotic frenolicin B with halofuginone hydrobromide the anticoccidial agent, useful for the treatment and prevention of coccidiosis in animals and methods of treating coccidiosis are disclosed.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: June 1, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Eugene G. Schildknecht, Govind G. Untawale
  • Patent number: 5216029
    Abstract: This invention is directed to the use of the compound ractopamine for improved production of fish.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: June 1, 1993
    Assignee: Eli Lilly and Company
    Inventors: David B. Anderson, Edward L. Veenhuizen
  • Patent number: 5213794
    Abstract: The present invention relates to an antacid preparation having a prolonged gastric residence time, comprising an antacid active substance, calcium polycarbophil and a water-insoluble, anionic polymer.
    Type: Grant
    Filed: November 13, 1991
    Date of Patent: May 25, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christian Fritsch, Franz Hausler, Jurgen Seedig
  • Patent number: 5213806
    Abstract: A pharmaceutical composition capable of being disintegrated in an acidic environment, which comprises calcium polycarbophil and 1 to 80% by weight of a cellulose derivative such as carboxymethylcellulose or low substituted hydroxypropylcellulose based on the calcium polycarbophil. The pharmaceutical composition in a form of a tablet, a capsule, or granules is useful as a bulk-forming laxative or an antidiarrheic agent since it can be disintegrated readily in the stomach and form a complete dispersion of polycarbophil in the digestive tract.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: May 25, 1993
    Assignee: Hokuriku Pharmaceutical Co., Ltd.
    Inventors: Yasuo Ito, Hideo Kato, Osamu Nagata, Masaharu Yamazaki, Takeo Ishibashi, Masakazu Kitayama
  • Patent number: 5211961
    Abstract: A gel composition for cleaning and sanitizing the teats and udder of an agricultural animal for machine milking. Residual surface water, a source of milk contamination and mastitis, is eliminated from the teats and udder by use of the gel composition. The composition is constituted of water, a germicide added to the water in concentration sufficient to kill environmental bacteria which cause mastitis, and an aqueous gelling agent added to the water in concentration sufficient to form a palpable jelly-like mass, or gel. The composition preferably also includes a soap, detergent or other agent for the reduction of surface tension, and a skin softener and moisturizer. It preferably also contains a coloring agent. In application, the composition is applied to the teats and udder to soften and emulsify the particulate foreign matter, and kill the bacteria which cause environmental mastitis, without the separation therefrom of a separate liquid phase.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: May 18, 1993
    Assignee: Louisiana State University Board of Supervisors
    Inventor: Robert W. Adkinson
  • Patent number: 5212204
    Abstract: This invention concerns antihypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein J is an organic or inorganic moiety, M.sup.+x is a pharmaceutically acceptable cation and the compound decomposes under physiological conditions to release nitric oxide (NO).
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: May 18, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Larry K. Keefer, David A. Wink, Tambra M. Dunams, Joseph A. Hrabie
  • Patent number: 5206243
    Abstract: A method of controlling fungal infections of animals in aquaculture caused by the genus Fusarium spp. involves applying as a fungicidal or fungistatic agent a compound of formula ##STR1## wherein n signifies 0 or 1 and either X signifies oxygen and R methyl or X signifies methylene and R hydrogen, or a salt thereof to the animals in aquaculture. The invention also concerns a fungicidal or fungistatic feed usable in such method.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: April 27, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dieter Hofmann, Walter Rehm
  • Patent number: 5206264
    Abstract: A method is disclosed for reducing cardiovascular damage caused by hypoxic or ischemic events such as heart attack and cardiac arrest. This method involves the administration of disulfiram, or a suitable salt or analog of disulfiram, to a mammal in need of such treatment. Disulfiram can inhibit enzymes such as xanthine oxidase which would otherwise generate oxygenated free radicals, which are highly reactive chemical compounds that non-specifically attack and damage essential molecules and cells. It can also chelate copper and iron, thereby suppressing lipid peroxidation and protecting cell membranes from destruction. It also generates metabolites such as tryptophol which reduce the rate of metabolic activity in neurons and affected tissue, which can be useful during cytotoxic events. This invention also discloses injectable formulations that rapidly release disulfiram into the circulating blood.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: April 27, 1993
    Assignee: Cypros Pharmaceutical Corporation
    Inventor: Paul J. Marangos
  • Patent number: 5200179
    Abstract: Sterile pharmaceutical compositions for use in therapy especially inactivated vaccines for use in prophylaxis, are prepared by inactivating a live virus or bacterium with ascorbic acid and/or a salt thereof in the presence of oxygen and a source of heavy metal ions. Methods of treating animals, including humans, with such compositions are also disclosed.
    Type: Grant
    Filed: February 13, 1991
    Date of Patent: April 6, 1993
    Assignee: Beecham Group p.l.c.
    Inventors: Dale Bordt, Hans Draayer