Patents Examined by K. Weddington
  • Patent number: 5122518
    Abstract: Insects are combatted by treating the insects with a pyrogenically produced and hydrophobic silica. The insects can be sprayed with an aqueous dispersion of the pyrogenically produced and hydrophobic silica. Alternatively, the insects can be dusted with the silica in powdery form.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: June 16, 1992
    Inventor: Cenek H. Vrba
  • Patent number: 5120710
    Abstract: To improve the absorption of actve ingredients, which are not adequately bio-available on oral administration, an oral lipid medicinal composition is formed by combining a semi-solid, lipophilic component with a solid, water-soluble component. The semi-solid component is a homogeneous lipid mixture that exists as a hard fat with thermally reversible fat/liquid melting property, at least 95% of which is present in the liquid aggregate state below the body temperature of 37.degree. C. and comprises monoacyl-, diacyl-, and triacylglycerides of saturated vegetable fatty acids with chain lengths ranging from 6 to 18 carbon atoms, preferably comprising a mixture of 40 to 60% monoacyl- and diacylglycerides and 40 to 60% triacylglycerides, in which the active ingredients are either dissolved, suspended or emulsified.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: June 9, 1992
    Assignee: Pharmed GmbH
    Inventor: Rainer K. Liedtke
  • Patent number: 5120760
    Abstract: Method of, and preparations of medicaments for, treating schizophrenia and/or associated tardive dyskinesia by combining an essential fatty acid selected from GLA and higher n-6 series acides with an essential fatty acid selected from stearidonic acid and higher n-3 series acids in effective daily amounts of 10 mg and 50 g of each acid.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: June 9, 1992
    Assignee: Efamol Holdings PLC
    Inventor: David F. Horrobin
  • Patent number: 5116857
    Abstract: The present invention relates to the use of substituted benzamides of formula (1): ##STR1## in which: A is linear or branched C.sub.1 -C.sub.3 alkyl; allyl or diethylaminoethyl;R.sub.1 is hydrogen or methyl, andZ-- is --NH--, --O-- or --S--,and of their pharmacologically acceptable salts for modifying gastric motility.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: May 26, 1992
    Assignee: Laboratoires Delagrange Div. Societe d'Applications Pharmacodynamiques
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Brenda Costall, Robert Naylor, Renee Gardaix-Luthereau
  • Patent number: 5116844
    Abstract: The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).
    Type: Grant
    Filed: August 11, 1989
    Date of Patent: May 26, 1992
    Assignee: Pfizer Inc.
    Inventors: Roger P. Dickinson, Kenneth Richardson
  • Patent number: 5114713
    Abstract: The present invention relates to the use of a peptide from the circumsporozoite (CS) protein of Plasmodium falciparum (P. falciparum) and the derivatives thereof as a universally recognized T-cell epitope i.e. an epitope which is recognized in association with many different human and mouse major histocompatibility complex (MHC) haplotypes e.g. in the context of the human MHC class II molecules such as DR1, DR2, DR4, DR5, DRw6, DR7 or DR9. Furthermore the present invention relates to the above-mentioned peptide per se and to immunogenic compositions comprising such a peptide or a derivative thereof. These immunogenic compositions can be used as vaccines to elicit a durable immune response against a pathogenic agent in humans and animals irrespective of the MHC haplotype of the host.
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: May 19, 1992
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Francesco Sinigaglia
  • Patent number: 5100878
    Abstract: By administration of sulfated cyclodextrin on a pregnant mother, the effect of a teratogen on a developing fetus is blocked. Blocking the effect of the teratogen reduces congenital defects in a developing fetus. The sulfated cyclodextrin has also been found to reduce the effect of the teratogen on a host. The sulfated cyclodextrin is administered either before or after onset of organogenesis and either before or after exposure to the teratogen. Teratogens include radiation, temperature extremes, chemicals, drugs, bacteria, viruses, hormones, stress, injury, pregnancy, and fatigue.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: March 31, 1992
    Assignee: American Maize-Products Company
    Inventor: William F. Geber
  • Patent number: 5096908
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: March 17, 1992
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • Patent number: 5096887
    Abstract: A method of applying a drug selected from the benzo-pyrone group of drugs to an animal to treat high-protein oedemas.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: March 17, 1992
    Assignee: Lamorna Investments Proprietary Limited
    Inventor: John R. Casley-Smith
  • Patent number: 5093315
    Abstract: A dieting agent is disclosed which comprises an aqueous solution or a solid substance of a concentration .alpha.-amylase inhibiting substance which is produced by a process which comprises heat treating a supernatant fraction of an aqueous extract of wheat or wheat flour to modify unnecessary protein contaminants in the supernatant fraction, removing a modified protein from said fraction, subjecting a resulting aqueous solution containing an .alpha.-amylase inhibiting substance to a concentration treatment using an ultrafiltration membrane to form an aqueous solution of a concentrated .alpha.-amylase inhibiting substance or drying the aqueous solution. The dieting agent exhibits a body weight gain-inhibiting effect.
    Type: Grant
    Filed: April 26, 1991
    Date of Patent: March 3, 1992
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Koji Maeda, Yoshikuni Suzuki, Hidehiko Takahashi
  • Patent number: 5093132
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: March 3, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-ichiro Hirai
  • Patent number: 5089483
    Abstract: The antidecay and antitermite agent for timber of the invention contains alkyldimethylamine tetraborate as an effective component; the compound can be applied as it is or in a form of preparation to the sites where termites are generated, termitoria, construction members such as pillars, buildings and soils surrounding the buildings, waterproof sheets, paving materials and covering materials for wires or cables or the like by such means as painting, blowing, soaking, injecting, spraying, mixing and kneading.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: February 18, 1992
    Assignees: Daicel Chemical Industries Ltd., Shokusan Jutaku Sogo Co., Ltd.
    Inventors: Kenji Tsuda, Shoichi Ono
  • Patent number: 5087626
    Abstract: A method for increasing the weight gain and/or improving the feed utilization of efficiency of livestock which comprises administering to livestock in need thereof an effective amount of a compound of formula (XXII): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1Z is hydrogen, halogen, or trifluoromethyl; R.sup.2Z is hydrogen or halogen; R.sup.3Z is hydrogen or methyl; R.sup.4Z is --O(CH.sub.2).sup.6 CO.sub.2 H or an ester or amide thereof, O(CH.sub.2).sup..epsilon. M.sup.4 or --CO.sub.2 H or an ester or amide thereof, wherein .delta. is an integer from 1 to 6, .epsilon. is an integer from 2 to 7, and M.sup.4 is hydroxy, alkoxy of 1 to 6 carbon atoms or ##STR2## wherein R.sup.6Z and R.sup.7Z are each hydrogen or alkyl of 1 to 6 carbons or ##STR3## is a 5- or 6-membered ring; R.sup.
    Type: Grant
    Filed: September 7, 1989
    Date of Patent: February 11, 1992
    Assignee: Beecham Group p.l.c
    Inventor: Jonathan R. Arch
  • Patent number: 5086066
    Abstract: The present invention relates to the application of substituted benzamides of formula (I): ##STR1## in which: A is diethylaminoethyl, 1-ethyl-2-pyrrolidinylmethyl or 1-allyl-2-pyrrolidinylmethyl;R.sub.1 is hydrogen or methyl;X is chlorine or bromine;Z is --NH-- or --O-- except when Z is --NH--,R.sub.1 is hydrogen and X is chlorine, and of their pharmacologically acceptable addition salts, as anxiolytics and antipsychotics.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: February 4, 1992
    Assignee: Laboratoires Delagrange Societe d'Applications Pharmacodnymiques
    Inventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Robert Naylor, Brenda Costall
  • Patent number: 5057510
    Abstract: A method for improving the growth response in poultry comprising administering to said poultry a growth-promoting amount of at least one pyridine-2-thione-N-oxide compound selected from the group consisting of(a) a metallic salt of pyridine-2-thione-N-oxide;(b) 2,2'-dithiobispyridine-1,1'-dioxide; and(c) adducts of 2,2'-dithiobispyridine-1,1'-dioxide, the adducts having the formula(C.sub.5 H.sub.4 NOS).sub.2 MY.sub.twherein M is an alkaline earth metal selected from the group consisting of calcium, magnesium, barium and strontium, Y is an anion selected from the group consisting of halides, sulfates, nitrates, chlorates and acetates, and t is either 1 or 2.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: October 15, 1991
    Assignee: Olin Corporation
    Inventors: Jeffrey N. Davidson, John H. Wedig, John G. Babish, Richard A. McMillan
  • Patent number: 5013755
    Abstract: A germicidal composition is disclosed which includes:a first ingredient which is tribromoacetoxypropane of the formula: ##STR1## a second ingredient selected from the group consisting of (a) an alcohol of the general formula: ##STR2## wherein R.sup.1 and R.sup.2 stand independently from each other for hydrogen, a halogen, an alkyl or a substituted alkyl and X stands for a halogen and (b) dibromocyanoacetamide of the formula: ##STR3## .
    Type: Grant
    Filed: October 25, 1989
    Date of Patent: May 7, 1991
    Assignee: Somar Corporation
    Inventors: Susumu Mitsui, Ryoji Funatsu, Shigeru Kurose
  • Patent number: 4929758
    Abstract: Amines are prepared from an olefin and ammonia or a primary and/or secondary amine in the presence of a zeolite catalyst of the pentasil type. Iron silicate zeolites of the pentasil type having an SiO.sub.2 /Fe.sub.2 O.sub.3 ratio greater than or equal to 10 are preferably used.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: May 29, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Volker Taglieber, Wolfgang Hoelderich, Rudolf Kummer, Wolf D. Mross, Guenter Saladin