Patents Examined by K. Weddington
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Patent number: 5122518Abstract: Insects are combatted by treating the insects with a pyrogenically produced and hydrophobic silica. The insects can be sprayed with an aqueous dispersion of the pyrogenically produced and hydrophobic silica. Alternatively, the insects can be dusted with the silica in powdery form.Type: GrantFiled: October 17, 1989Date of Patent: June 16, 1992Inventor: Cenek H. Vrba
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Patent number: 5120710Abstract: To improve the absorption of actve ingredients, which are not adequately bio-available on oral administration, an oral lipid medicinal composition is formed by combining a semi-solid, lipophilic component with a solid, water-soluble component. The semi-solid component is a homogeneous lipid mixture that exists as a hard fat with thermally reversible fat/liquid melting property, at least 95% of which is present in the liquid aggregate state below the body temperature of 37.degree. C. and comprises monoacyl-, diacyl-, and triacylglycerides of saturated vegetable fatty acids with chain lengths ranging from 6 to 18 carbon atoms, preferably comprising a mixture of 40 to 60% monoacyl- and diacylglycerides and 40 to 60% triacylglycerides, in which the active ingredients are either dissolved, suspended or emulsified.Type: GrantFiled: May 17, 1990Date of Patent: June 9, 1992Assignee: Pharmed GmbHInventor: Rainer K. Liedtke
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Patent number: 5120760Abstract: Method of, and preparations of medicaments for, treating schizophrenia and/or associated tardive dyskinesia by combining an essential fatty acid selected from GLA and higher n-6 series acides with an essential fatty acid selected from stearidonic acid and higher n-3 series acids in effective daily amounts of 10 mg and 50 g of each acid.Type: GrantFiled: September 25, 1990Date of Patent: June 9, 1992Assignee: Efamol Holdings PLCInventor: David F. Horrobin
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Patent number: 5116857Abstract: The present invention relates to the use of substituted benzamides of formula (1): ##STR1## in which: A is linear or branched C.sub.1 -C.sub.3 alkyl; allyl or diethylaminoethyl;R.sub.1 is hydrogen or methyl, andZ-- is --NH--, --O-- or --S--,and of their pharmacologically acceptable salts for modifying gastric motility.Type: GrantFiled: December 14, 1989Date of Patent: May 26, 1992Assignee: Laboratoires Delagrange Div. Societe d'Applications PharmacodynamiquesInventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Brenda Costall, Robert Naylor, Renee Gardaix-Luthereau
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Patent number: 5116844Abstract: The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).Type: GrantFiled: August 11, 1989Date of Patent: May 26, 1992Assignee: Pfizer Inc.Inventors: Roger P. Dickinson, Kenneth Richardson
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Patent number: 5114713Abstract: The present invention relates to the use of a peptide from the circumsporozoite (CS) protein of Plasmodium falciparum (P. falciparum) and the derivatives thereof as a universally recognized T-cell epitope i.e. an epitope which is recognized in association with many different human and mouse major histocompatibility complex (MHC) haplotypes e.g. in the context of the human MHC class II molecules such as DR1, DR2, DR4, DR5, DRw6, DR7 or DR9. Furthermore the present invention relates to the above-mentioned peptide per se and to immunogenic compositions comprising such a peptide or a derivative thereof. These immunogenic compositions can be used as vaccines to elicit a durable immune response against a pathogenic agent in humans and animals irrespective of the MHC haplotype of the host.Type: GrantFiled: May 18, 1989Date of Patent: May 19, 1992Assignee: Hoffmann-La Roche Inc.Inventor: Francesco Sinigaglia
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Patent number: 5100878Abstract: By administration of sulfated cyclodextrin on a pregnant mother, the effect of a teratogen on a developing fetus is blocked. Blocking the effect of the teratogen reduces congenital defects in a developing fetus. The sulfated cyclodextrin has also been found to reduce the effect of the teratogen on a host. The sulfated cyclodextrin is administered either before or after onset of organogenesis and either before or after exposure to the teratogen. Teratogens include radiation, temperature extremes, chemicals, drugs, bacteria, viruses, hormones, stress, injury, pregnancy, and fatigue.Type: GrantFiled: May 7, 1990Date of Patent: March 31, 1992Assignee: American Maize-Products CompanyInventor: William F. Geber
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Patent number: 5096908Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 4, 1990Date of Patent: March 17, 1992Assignee: Eli Lilly and CompanyInventors: Jaswant S. Gidda, John M. Schaus
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Patent number: 5096887Abstract: A method of applying a drug selected from the benzo-pyrone group of drugs to an animal to treat high-protein oedemas.Type: GrantFiled: October 28, 1985Date of Patent: March 17, 1992Assignee: Lamorna Investments Proprietary LimitedInventor: John R. Casley-Smith
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Patent number: 5093315Abstract: A dieting agent is disclosed which comprises an aqueous solution or a solid substance of a concentration .alpha.-amylase inhibiting substance which is produced by a process which comprises heat treating a supernatant fraction of an aqueous extract of wheat or wheat flour to modify unnecessary protein contaminants in the supernatant fraction, removing a modified protein from said fraction, subjecting a resulting aqueous solution containing an .alpha.-amylase inhibiting substance to a concentration treatment using an ultrafiltration membrane to form an aqueous solution of a concentrated .alpha.-amylase inhibiting substance or drying the aqueous solution. The dieting agent exhibits a body weight gain-inhibiting effect.Type: GrantFiled: April 26, 1991Date of Patent: March 3, 1992Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Koji Maeda, Yoshikuni Suzuki, Hidehiko Takahashi
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Patent number: 5093132Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.Type: GrantFiled: August 31, 1990Date of Patent: March 3, 1992Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadashi Makino, Tetsuro Tabata, Shin-ichiro Hirai
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Patent number: 5089483Abstract: The antidecay and antitermite agent for timber of the invention contains alkyldimethylamine tetraborate as an effective component; the compound can be applied as it is or in a form of preparation to the sites where termites are generated, termitoria, construction members such as pillars, buildings and soils surrounding the buildings, waterproof sheets, paving materials and covering materials for wires or cables or the like by such means as painting, blowing, soaking, injecting, spraying, mixing and kneading.Type: GrantFiled: January 22, 1990Date of Patent: February 18, 1992Assignees: Daicel Chemical Industries Ltd., Shokusan Jutaku Sogo Co., Ltd.Inventors: Kenji Tsuda, Shoichi Ono
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Patent number: 5087626Abstract: A method for increasing the weight gain and/or improving the feed utilization of efficiency of livestock which comprises administering to livestock in need thereof an effective amount of a compound of formula (XXII): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1Z is hydrogen, halogen, or trifluoromethyl; R.sup.2Z is hydrogen or halogen; R.sup.3Z is hydrogen or methyl; R.sup.4Z is --O(CH.sub.2).sup.6 CO.sub.2 H or an ester or amide thereof, O(CH.sub.2).sup..epsilon. M.sup.4 or --CO.sub.2 H or an ester or amide thereof, wherein .delta. is an integer from 1 to 6, .epsilon. is an integer from 2 to 7, and M.sup.4 is hydroxy, alkoxy of 1 to 6 carbon atoms or ##STR2## wherein R.sup.6Z and R.sup.7Z are each hydrogen or alkyl of 1 to 6 carbons or ##STR3## is a 5- or 6-membered ring; R.sup.Type: GrantFiled: September 7, 1989Date of Patent: February 11, 1992Assignee: Beecham Group p.l.cInventor: Jonathan R. Arch
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Patent number: 5086066Abstract: The present invention relates to the application of substituted benzamides of formula (I): ##STR1## in which: A is diethylaminoethyl, 1-ethyl-2-pyrrolidinylmethyl or 1-allyl-2-pyrrolidinylmethyl;R.sub.1 is hydrogen or methyl;X is chlorine or bromine;Z is --NH-- or --O-- except when Z is --NH--,R.sub.1 is hydrogen and X is chlorine, and of their pharmacologically acceptable addition salts, as anxiolytics and antipsychotics.Type: GrantFiled: December 20, 1989Date of Patent: February 4, 1992Assignee: Laboratoires Delagrange Societe d'Applications PharmacodnymiquesInventors: Jacques Acher, Jean-Claude Monier, Jean-Paul Schmitt, Renee Gardaix-Luthereau, Robert Naylor, Brenda Costall
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Patent number: 5057510Abstract: A method for improving the growth response in poultry comprising administering to said poultry a growth-promoting amount of at least one pyridine-2-thione-N-oxide compound selected from the group consisting of(a) a metallic salt of pyridine-2-thione-N-oxide;(b) 2,2'-dithiobispyridine-1,1'-dioxide; and(c) adducts of 2,2'-dithiobispyridine-1,1'-dioxide, the adducts having the formula(C.sub.5 H.sub.4 NOS).sub.2 MY.sub.twherein M is an alkaline earth metal selected from the group consisting of calcium, magnesium, barium and strontium, Y is an anion selected from the group consisting of halides, sulfates, nitrates, chlorates and acetates, and t is either 1 or 2.Type: GrantFiled: December 3, 1984Date of Patent: October 15, 1991Assignee: Olin CorporationInventors: Jeffrey N. Davidson, John H. Wedig, John G. Babish, Richard A. McMillan
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Patent number: 5013755Abstract: A germicidal composition is disclosed which includes:a first ingredient which is tribromoacetoxypropane of the formula: ##STR1## a second ingredient selected from the group consisting of (a) an alcohol of the general formula: ##STR2## wherein R.sup.1 and R.sup.2 stand independently from each other for hydrogen, a halogen, an alkyl or a substituted alkyl and X stands for a halogen and (b) dibromocyanoacetamide of the formula: ##STR3## .Type: GrantFiled: October 25, 1989Date of Patent: May 7, 1991Assignee: Somar CorporationInventors: Susumu Mitsui, Ryoji Funatsu, Shigeru Kurose
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Patent number: 4929758Abstract: Amines are prepared from an olefin and ammonia or a primary and/or secondary amine in the presence of a zeolite catalyst of the pentasil type. Iron silicate zeolites of the pentasil type having an SiO.sub.2 /Fe.sub.2 O.sub.3 ratio greater than or equal to 10 are preferably used.Type: GrantFiled: June 13, 1988Date of Patent: May 29, 1990Assignee: BASF AktiengesellschaftInventors: Volker Taglieber, Wolfgang Hoelderich, Rudolf Kummer, Wolf D. Mross, Guenter Saladin