Abstract: Ruminal lactic acidosis develops in ruminant animals following the ingestion of large amounts of unaccustomed feeds that are rich in readily fermentable carbohydrates. Characteristics symptoms of this disease include systemic acidosis, ruminal acidosis, forestomach stasis or forestomach hypomotility, inappetence, depression and hemoconcentration. Alpha-2 adrenoceptor antagonists have been found to be capable of re-establishing forestomach motility that has been lost or severely diminished in ruminants suffering from ruminal lactic acidosis. These antagonist compounds have also been found to be effective in the treatment of ruminants experiencing ruminal lactic acidosis.
Abstract: The use is described of acetyl L-carnitine and some of its pharmacologically acceptable salts in the therapeutic treatment of coma. 2000-4000 mg/day of acetyl L-carnitine or an equivalent quantity of one of its pharmacologically acceptable salts is administered, preferably by the parenteral route.
Abstract: A method of relieving stress in fish and increasing resistance to pathogenic agents comprising orally administering to the fish an amount of a compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms and X is acyl of an organic carboxylic acid of 1 to 18 carbon atoms sufficient to relieve stress and increase resistance to pathogenic agents and novel fish feed containing an effective amount of a compound of formula I.
Abstract: Compounds are described which are useful for lowering the activity of .alpha..sub.2 -PI, for the treatment of myocardial infarctions and cerebral infarctions, as urokinase secretion accelerators, as antithrombotic agents and to accelerate the fibrinolysis accelerating effect.
Type:
Grant
Filed:
August 12, 1991
Date of Patent:
March 9, 1993
Assignee:
Nippon Shinyaku Co. Ltd.
Inventors:
Yoshiaki Yoshikuni, Nobutoshi Ojima, Kazuya Mori
Abstract: A pharmaceutically acceptable composition comprising a biologically active acid compound or its salt and from one to five molar excess of a bicarbonate or carbonate.
Abstract: Female prenatal, neonatal and postnatal animals are treated with compositions containing steroid biosynthesis inhibitors or antagonists which prevents the conversion of androgens to estrogens. The compositions are useful for improving growth and feed efficiency.
Type:
Grant
Filed:
October 5, 1990
Date of Patent:
November 10, 1992
Assignee:
Merck & Co., Inc.
Inventors:
Alexander Elbrecht, Yi-Tien Yang, Roy G. Smith
Abstract: An emulsifiable concentrate comprising an agriculturally active chemical, a surfactant, an organic diluent and a solvent having a component capable of solubilizing the agriculturally active chemical and, in conjunction with the surfactant, being effective to disperse the agriculturally active chemical. The inventive concentrate allows for high concentrations of the active ingredient, exhibits excellent stability and produces highly stable compositions upon dilution with water.
Type:
Grant
Filed:
April 5, 1990
Date of Patent:
November 3, 1992
Assignee:
ISP Investments Inc.
Inventors:
Ratan K. Chaudhuri, Kolazi S. Narayanan, Manilal Dahanayake
Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
Abstract: An emulsifiable concentrate comprising an agriculturally active chemical, a surfactant, and a solvent selected from the group consisting of a first component capable of solubilizing the agriculturally active chemical, a second component capable, in conjnction with the surfactant, to disperse the agriculturally active chemical, and combinations thereof, said first and second being biodegradeable. The inventive concentrate allows for high concentrations of the active ingredient, exhibits excellent stability and produces highly stable compositions upon dilution with water.
Type:
Grant
Filed:
June 28, 1990
Date of Patent:
October 20, 1992
Assignee:
ISP Investments Inc.
Inventors:
Kolazi S. Narayanan, Ratan K. Chaudhuri, Manilal Dahanayake
Abstract: Acid-sensitive antibiotic esters for oral administration to livestock are stabilized by incorporation in premix formulations comprising a carrier, a base, a protective coating, and optionally a sealant film.
Type:
Grant
Filed:
October 12, 1989
Date of Patent:
October 6, 1992
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Richard A. Runkel, Stephen A. Berry, Mahmood M. Ghani
Abstract: S-substituted beta-thioacrylamide compounds have been discovered to be useful as biocides and fungicides. Compositions comprising the compound and isothiazolin-3-ones and/or carriers, methods of preparation of the compounds and methods of using the compounds and compositions are also disclosed.
Abstract: Novel therapeutic antibody conjugates comprising amine derivatives of folic acid analogs covalently attached via a reactive amine group to an oxidized carbohydrate moiety of an antibody or antibody fragment are disclosed. The conjugates retain substantially the same immunorespecificity and immunoreactivity of the unconjugated antibody molecule. The immunospecificity and immunoreactivity of the antibody conjugates permits targeted delivery of the attached therapeutically effective amine derivative of folic acid analogs in vivo. The conjugates are therapeutically effective against a variety of neoplastic and non-neoplastic cellular disorders when administered in vivo. Methods for synthesizing the amine derivatives of folic acid analogs, methods for preparing the antibody conjugates, and methods for use of the conjugates in vivo are also disclosed.
Abstract: Described is a method of decreasing the weight in mammals to a desired amount comprising the steps of ingesting an effective weight reducing amount of a cholestyramine for a desired period of time to achieve a desired weight reduction. Compositions useful for reducing weight in patients contain cholestyramine, bran and optionally, artificial sweeteners and flavors.
Abstract: A method for transplanting fertilized ova comprising administering a parasympatholytic agent such as prifinium bromide or scopolamine butylbromide to a recipient animal and then transplanting fertilized ova in the animal.
Abstract: Substituted propanamines having anticoagulant or antifungal activity are disclosed. Also disclosed are methods of use involving the substituted propanamines as well as pharmaceutical compositions containing them.
Type:
Grant
Filed:
February 22, 1989
Date of Patent:
August 4, 1992
Assignee:
Eli Lilly and Company
Inventors:
Jack B. Campbell, Gerald F. Smith, William W. Turner
Abstract: The present invention provides a method for treating or preventing certain metabolic disorders comprising the systemic administration of 3-guanidinopropionic acid.
Abstract: Compositions and methods for treating the symptoms of certain allergy-related conditions using capsaicin in solution or suspension combined with a selected local anesthetic, topical steroid or antihistamine. The same methods and compositions may be used to treat headaches.
Abstract: A method for increasing the concentration of Omega-3 polyunsaturated fatty acids in poultry products is provided. The method includes adding to ordinary poultry feed an excess of Omega-3 polyunsaturated fatty acids and Vitamin E and feeding this supplemented feed to poultry simultaneously with enriched water to produce commercially valuable quantities of poultry products high in Omega-3 polyunsaturated fatty acids.
Abstract: The present invention provides a method for treating or preventing certain metabolic disorders comprising the systemic administration of 3-guanidinopropionic acid.
Abstract: The present invention relates to a composition for regulating hair growth comprising a safe and effective amount of a supernatant derived from a culture of epithelial cells which comprises a growth stimulating factor with characteristics of mitogenicity to dermal papilla cells, mitogenicity to 3T3 cells, lack of mitogenicity to epidermal cells, and a molecular weight of greater than about 3,000D; and a pharmaceutically-acceptable carrier.