Abstract: A method for providing blood glucose data is provided. In response to a suspension of a continuous basal insulin delivery, by an insulin delivery pump, the method identifies a condition indicating continuing hypoglycemia that continues when basal insulin delivery is suspended; and performs an action, by the insulin delivery pump, based on identifying the condition.

Abstract: Computerized oral prescription administration (COPA) devices, systems, and methods are provided. In one embodiment, a method of dispensing a substance to an intended user is provided. The method comprises identifying an intended user based on a biological marker of the intended user; determining whether a unique dentition of the intended user is positioned within a recess of a mouthpiece based on a comparison to data associated with the intended user's unique dentition being positioned within the recess; and dispensing a substance from a reservoir coupled to the mouthpiece in response to identifying the intended user and determining that the intended user's unique dentition is positioned within the recess of the mouthpiece.

Abstract: An automatic jet injector for administering tissue is provided with a housing including a grip and a pushbutton; a syringe positioning device on a top of the housing and including an intermediate support and a rear pushing board having a lower through hole and a threaded hole under the through hole; a power source in the housing and including a power supply configured to supply power to the power source by pressing the pushbutton; a fastening member in the housing and being adjacent to a rear end of the housing; a positioning member being adjacent to the power source; a reciprocating screw having a front end operatively connected to the power source and a rear end fastened in the fastening member; a rod having a front end fastened in the positioning member and a rear end fastened in the fastening member; and a control device.

Abstract: An infusion arrangement for administering a medical fluid includes a pump apparatus with an elastomeric membrane which forms a pump volume. The elastomeric membrane is elastically extended in a fill state, filled at least partially with medical fluid, of the pump volume and produces a delivery pressure on the pump volume. An infusion line is connected to the pump volume and provided with a patient access for fluid-conducting connection. A main fluid channel transfers medical fluid from the pump volume to the patient access. A monitoring device is connected to the infusion line and configured for monitoring the pump apparatus. The monitoring device has a differential pressure-measuring element connected to the main fluid channel and designed such that differential pressure formed along a channel portion of the main fluid channel can be detected by the differential pressure-measuring element and a delivery rate of the medical fluid can be indicated.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: A wearable infusion pump assembly includes a reusable housing assembly, and a disposable housing assembly including a reservoir for receiving an infusible fluid. The wearable infusion pump assembly also includes a releasable engagement assembly configured to allow the reusable housing assembly to releasably engage the disposable housing assembly. A switch assembly of the wearable infusion pump assembly is configured to effectuate a functionality of the infusion pump assembly.

Abstract: Provided herein are devices, systems, and methods for providing controlled delivery of a therapeutic substance during a surgical procedure, the devices and systems including a base, a frame having a proximal end and a distal end attached to the base, an injection subassembly including a plunger shaft, a relative motion subassembly including a lever plate, and a fastener configured to connect the plunger shaft of the injection subassembly and the lever plate of the relative motion subassembly.

Abstract: A fluid replacement method including: determining the amount of urine expelled by a patient; infusing via a pump fluid from a first fluid source into a patient; determining an amount of fluid infused into the patient from the first fluid source; adjusting the operating of the pump based on the determined amount of urine expelled and the amount of fluid infused into the patient; setting a desired fluid balance for the patient; setting an amount of at least one additional fluid delivered to the patient, wherein the at least one additional fluid is not pumped into the patient; calculating an actual fluid balance based on the determined urine output, the determined amount of fluid infused into the patient from the first fluid source, and the set amount of said at least one additional fluid delivered to the patient; and automatically controlling the pump based on the actual fluid balance and the set desired fluid balance so the actual fluid balance conforms to the desired fluid balance.

Abstract: A method of providing and/or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 ?g/mL. The method further includes providing, on the injector, a plurality of indicia only at prescribed doses of 50 ?g, 100 ?g, 150 ?g and 200 ?g settable via the dose setter without indicia between said prescribed doses; and permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter, wherein the injector is configured to provide at least one audible feedback during the rotation.

Abstract: A sensor assembly comprising a first rotary sensor part with a plurality of individual electrically conducting axial position sensor segments arranged in a circumferential pattern, and a second rotary sensor part arranged rotationally relative to the first portion and comprising a plurality of circumferentially arranged electrically interconnected axial position contacts adapted to be arranged in contact with the axial position sensor segments. The assembly further comprises actuator means for axially moving the axial position contacts between a connected and a dis-connected position, wherein the axial position contacts and the axial position sensor segments are arranged such that for a given rotational position at least two axial position contacts each are in contact with a different axial position sensor segment.

Abstract: Systems and methods are provided for anesthetizing a tympanic membrane of an ear. The systems are personalizable to ensure proper anesthetizing solution administration. The systems and methods may also be useful for administering a solution to the ear canal of a human patient and for maintaining the solution therein.

Abstract: A medical puncture needle comprising includes: a rod-shaped body portion; and a blade surface formed at a distal end portion of the rod-shaped body portion. The blade surface includes: a first blade surface portion that is inclined with respect to a central axis of the body portion and extends to a tip, and a second blade surface portion that is formed on a back side of the first blade surface portion. A blade edge extending to the tip is formed by a ridgeline at which the first blade surface portion intersects the second blade surface portion. The second blade surface portion comprises a first plane and a second plane having different angles with respect to a virtual plane including the central axis passing through the tip at an orthogonal cross-section that is orthogonal to the central axis.

Abstract: A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

Abstract: An injection needle assembly is presented having an injection needle; a tubular needle holder having distal engagement means and proximal engagement means; a tubular cap having proximal outer engagement means and proximal inner engagement means; a tubular needle cover having first engagement means arranged to cooperate with the proximal engagement means, and second engagement means arranged to cooperate with the proximal outer engagement means of the cap. A needle cover is arranged to be displaced from a first position wherein the second engagement means and the proximal outer engagement means prevents the needle cover and the needle holder to be axially displaced by a linear displacement, to a second position wherein the needle cover and the needle holder are distally displaced where the needle holder can be displaced distally, but not proximally.

Abstract: The disclosure relates to a device for treatment of skin, mucous membranes or body parts with a cold atmospheric pressure plasma by generating a dielectric barrier surface discharge, including a flexible insulating material, a flexible high-voltage electrode, a flexible dielectric, a flexible grounded electrode, a gas supply, wherein the flexible high-voltage electrode is embedded between the flexible insulating material and the flexible dielectric, wherein the grounded electrode is applied on a surface of the flexible dielectric that is configured to face a curved surface of a body part to be treated, wherein the flexible high-voltage electrode, the flexible dielectric and the flexible grounded electrode of the device form a flexible layered arrangement for providing the cold atmospheric pressure plasma, wherein the arrangement forms a hollow spherical body with a closed volume and wherein a plasma can be ignited for treating the curved surface with the cold atmospheric pressure plasma.

Abstract: A balloon catheter for use with a guidewire includes an elongated, tubular shaft extending in a longitudinal direction, said shaft having a proximal end and a distal end. An inflatable balloon is connected to the distal end of the shaft, the balloon including a working surface. A radiopaque identifier is provided for identifying the working surface. A receiver adjacent the proximal end of the shaft is adapted for allowing the shaft to move relative to the receiver in at least the longitudinal direction.

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Abstract: A multi-modal medicine delivery system in which some embodiments can be configured to control dispensation of medicine according to any of a plurality of delivery modes, such as by closed-loop delivery modes and open-loop delivery modes, and according to a secondary feedback loop to determine user-specific settings related to dosage delivery.

Abstract: An apparatus includes a catheter having a balloon including at least one first radiopaque marking. A guidewire guides the balloon to the treatment area, and includes at least one second radiopaque marking adapted for corresponding to the at least one first radiopaque marking of the balloon when positioned at the treatment area. Related aspects and methods are disclosed.

Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate formed from a first material and a second material. At least one of the first and second materials includes a hemostatic agent. Kits, systems and methods are disclosed.