Abstract: Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to release the active ingredient into an external environment based on the activation of the stimuli responsive actuator.

Abstract: A peritoneal dialysis device includes a disposable tubing set that includes a fill line with a patient access connector at one end and a dialysis fluid receiving end opposite the patient access connector end. The device also includes a fill-side pressure measuring sensor attached at the fill end and forming a disposable component of the tubing set and a patient-side pressure measuring sensor located at the fluid receiving end. The patient-side and fill-side pressure measuring sensors are adapted for measuring pressure in the fill line at the respective ends thereof. The device also includes a controller configured to regulate a rate of flow in the fill line responsively to a signal from the at least the patient-side pressure measuring sensor.

Abstract: A disinfecting and pre-opening device is disclosed for use with a female needleless connector. The disinfecting and pre-opening device includes a housing comprising a chamber having a distal opening and configured to fit over the female needleless connector, and an elongated finger attached to the housing and disposed within the chamber such that the elongated finger opens the fluid path through the female needleless connector when the distal opening of the disinfecting and pre-opening device is placed proximally adjacent to the septum and the disinfecting and pre-opening device is advanced in the distal direction.

Abstract: A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

Abstract: The set for the electrical stimulation of a patient, comprises a backing, at least one electrically active zone and a wire connected to said electrically active zone for connection to a stimulator. Said backing has the shape of a bandage or of a plaster.

Abstract: A neurovascular catheter has enhanced tensile strength to resist distal tip detachment during proximal retraction past an obstruction. The catheter includes an elongated flexible tubular body, having a proximal end, a distal end and a side wall defining a central lumen. A radiopaque marker is provided adjacent to the distal end. The tensile support extends axially inside the side wall and is attached to the radiopaque marker, to tether the marker to the catheter body. In one implementation, the tensile support may at least partially wrap around the marker. The marker may have a tubular sidewall with a feature to increase compressibility, such as at least one compression gap in a proximal portion of the side wall.

Abstract: A device and a method for adjustable quantitative injection of high-pressure gas are provided, wherein the gas may have a pressure of 5 MPa or more than 5 MPa. The gas may be directly communicated with a gas tank in the mechanism or an external gas source, flows through corresponding valves, and is charged into a predetermined or adjustable reservoir. Alternatively, the valve may be time-controllable, and does not need the reservoir. The gas is ejected through a nozzle selected based on depth or range of injection, wherein a one-way valve is disposed between the nozzle and the body to prevent contamination due to backflow. The manipulator can exert an appropriate force onto a target portion of a human for gas injection, and when the injection is done, a biasing member can automatically return the mechanism to its original state, ready for the next injection.

Abstract: A plunger head to measure fluid in a drug cartridge includes a transducer coupled to emit ultrasonic signals, and a power source. A controller is coupled to the transducer and the power source, and the controller includes logic that when executed by the controller causes the plunger head to perform operations. For example the plunger head may emit the ultrasonic signals along a length of the drug cartridge, when the plunger head is disposed in the drug cartridge, and receive the ultrasonic signals after the ultrasonic signals are reflected from a dispensing end of the drug cartridge. The plunger head may then determine when the ultrasonic signals received by the transducer have an absolute value of amplitude greater than a first threshold value, and associate a timestamp with the ultrasonic signals received that have the absolute value of amplitude greater than the first threshold value.

Abstract: The application provides a unipolar cannula that can have a metal cannula tube, a body part made of an electrically insulating plastic, attached to the proximal end of the cannula tube, a connector disposed on the body part for the introduction of a liquid into the cannula tube, and a stimulation cable, an electroconductive wire of which electrically contacts the cannula tube in the region of the body part. The stimulation cable can be mounted laterally on the body part by a mounting part made of an electrically insulating plastic, where the mounting part has an electroconductive contact element which is connected conductively to the wire, and where the contact element engages into a recess of the body part and contacts the cannula tube when the mounting part is mounted on the body part.

Abstract: An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a subject. The present disclosure comprises apparatus for the controlled administration of the therapeutic agent through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

Abstract: The present invention relates to a breast pump (1) comprising a first pump (6) and second pump (6?), at least one expression kit (2, 2?), a valve assembly (13), and a control unit (8) for controlling the valve assembly (13) and/or the pumps (6, 6?), wherein the control unit (8) is configured to control the valve assembly (13) and/or the pumps (6, 6?) for alternate operation of the first and second pumps (6, 6?) in dependency of the operation times of the first and second pumps (6, 6?).

Abstract: The present invention is directed to a device for expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the reservoir between the bellows, a plunger and the expression port, and a spring is disposed within the reservoir between the air pump and the plunger. The powder is disposed within the reservoir between the porous filter and the expression port, and the pump is in a fluid communication with the expression port through the porous filter and through the powder.

Abstract: A non-occlusive intravascular device for local application of a therapeutic agent to a selected segment of a lumenal wall of a blood vessel without applying radial force on the wall. The device comprises a radially expandable/collapsible flexible scaffold of an open-skeletal structure and a flexible outer surface capable of conforming to the lumenal wall without applying radial force thereon and a controllable mechanism for expanding and collapsing the scaffold. The therapeutic agent is loaded and carried on the outer surface of the scaffold. Also provided are a method and a system for delivering a therapeutic agent to a selected segment within a blood vessel.

Abstract: An automated peritoneal dialysis system provides both cycler-assisted peritoneal dialysis treatment and also continuous ambulatory peritoneal dialysis (CAPD). The system includes a fluid preparation and treatment device with a concentrate dilution components connected to a source of purified water and medicament concentrate. The treatment device has at least one mixing container connected via a pump and valves to the sources, the valves and the pump mixing and diluting the concentrate to form a medicament. An auxiliary port is provided for attaching a CAPD container and for receiving medicament. A controller is programmed to control the fluid preparation and treatment device to implement one or more cycler-assisted peritoneal dialysis treatment cycles using medicament from the mixing container and also to control the preparation of additional dialysate at the end of the cycler-assisted peritoneal dialysis treatment cycles to dispense additional dialysate through the auxiliary port for use in CAPD.

Abstract: A control assembly for implantation in a patient comprises a first unit adapted for subcutaneous implantation at a first side of a body tissue of said patient, a second unit adapted for implantation in a body cavity of said patient at a second side of said body tissue, wherein at least one of the first and the second unit is adapted to control an implanted powered medical device, and an interconnecting device adapted for mechanical interconnection of the first and second units to keep the assembly in place by the body tissue, the interconnecting device having a cross-sectional area which is smaller than the cross-sectional area of the first unit and the second unit in a plane parallel to the extension of the body tissue.

Abstract: A visual insufflation obturator is provided. The obturator includes seals, valves, screens and/or various other tip features to eliminate the ingress of fluids, matter and/or gas that can disrupt the visual field of the laparoscope disposed within the obturator. The obturator provides additional features such as lens and anti-fog features to further increase visibility of the scope, efficiently insufflate the patient and ultimately provide an access channel into the insufflated abdomen once the visual insufflation obturator is removed.

Abstract: Drug delivery devices having integrated non-luer connectors are described. An exemplary drug delivery device includes a container with a non-luer connector that prevents connection of a standard female luer connector to the container. One or more embodiments pertain to a container with a non-luer connector that prevents the formation of a fluid-tight seal between a standard female luer connector and the container. A non-luer connector for attachment to a container having a non-luer element is also described.