Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent. Further, in some implementations devices, systems, and methods of the present disclosure are configured to normalize and/or temporally align pressure measurements from two different pressure sensing instruments. Further still, in some instances devices, systems, and methods of the present disclosure are configured to exclude outlier cardiac cycles from calculations utilized to evaluate a vessel, including providing visual indication to a user that the cardiac cycles have been excluded.

Abstract: The invention relates generally to a medical device wireless adapter, and more particularly, to a module that adapts an existing legacy or newly designed medical device to a healthcare provider's wireless infrastructure.

Abstract: The present disclosure generally relate s to blood pressure monitoring. In some embodiments, methods and devices for measuring a mean arterial pressure and/or for monitoring blood pressure changes of a user are provided. Blood pressure measured by one or more pressure sensors may be adjusted using one or more correction factors. The use of the one or more correction factors disclosed herein may allow for more compact, convenient, and/or accurate wearable blood pressure measurement devices and methods. In particular, wrist-worn devices may be provided which are less bulky than current devices and may facilitate more frequent and accurate blood pressure monitoring.

Abstract: A system and method for controlling and monitoring a diabetes-management system through the use of a model that predicts or estimates future dynamic states of glucose and insulin from variables such as insulin delivery or exogenous glucose appearance as well as inherent physiological parameters. The model predictive estimator can be used as an insulin bolus advisor to give an apriori estimate of postprandial glucose for a given insulin delivery profile administered with a known meal to optimize insulin delivery; as a supervisor to monitor the operation of the diabetes-management system; and as a model predictive controller to optimize the automated delivery of insulin into a user's body to achieve a desired blood glucose profile or concentration. Open loop, closed-loop, and semi-closed loop embodiments of the invention utilize a mathematical metabolic model that includes a Minimal Model, a Pump Delivery to Plasma Insulin Model, and a Meal Appearance Rate Model.

Abstract: A method for processing a quasi-periodic signal includes receiving a representation of a quasi-periodic signal and removing a DC component from the received signal to produce a purely time-varying signal. The time-varying signal is filtered to produce a pre-processed signal and at least a portion of a representation of the pre-processed signal is auto-correlated with itself. A corresponding auto-correlation output is stored in a memory device for the at least portion of the representation of the pre-processed signal. A biphasic tapering function is applied to the auto-correlation output, the tapering function including a time constant parameter that is a function of the quasi-periodic signal and producing a first maximum. A representation, based on the first maximum, is stored in the memory device as an indication of a rate or a frequency of the quasi-periodic signal.

Abstract: Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

Abstract: A method for measuring anatomical dead space in a lung, the method comprising: (a) providing, in a supply of inspired gas, at least one indicator gas for inhalation by a patient during a test, the concentration of the indicator gas being controlled such as to follow a sinewave pattern over successive breaths; (b) measuring, over successive breaths, the flow rate and concentration of the indicator gas during both inspiration and exhalation of the patient; (c) fitting sinewave envelopes to the measured concentration values of the indicator gas over the successive breaths and, from the fitted sinewave envelopes, determining the inspired concentration, the mixed expired concentration, and the end expired concentration in respect of the indicator gas for each breath; and (d) calculating the anatomical dead space for each of a plurality of inspirations based on a conservation-of-mass principle.

Abstract: The application relates to a method for analyzing continuously monitored physiological measurement values of a user, the method being performed in a data processing system and comprising: providing, by a data interface, a set of present physiological measurement values, determining whether a common pattern of values is contained in both the set of present physiological measurement values and a set of historical physiological measurement values, if the common pattern of values is found, requesting the user to provide contextualization for at least the present physiological measurement values of the common pattern of values, receiving contextualization and storing contextualized data. Furthermore, the application relates to a device for analyzing continuously monitored physiological measurement values of a user.

Abstract: A respiratory air measuring device is provided through which a measuring air stream flows for measuring at least one component of the respiratory air of a patient. The respiratory air measuring device includes a sensor device and a flow generator disposed downstream for generating a measuring air stream. A flow nozzle is disposed in a channel portion to affect flow, wherein a generator air stream coming from the flow nozzle creates the measuring air stream. The respiratory air measuring device may be partially disassembled for effective cleaning.

Abstract: A lactate sensor arrangement includes a catheter for withdrawing a test fluid sample, a sensor module for measuring an analyte such as lactate in the sample, and a pumping mechanism. A single uninterrupted flow path extends between the pumping mechanism and the catheter and within the flow path resides a sensor module containing a test chamber. The sensor arrangement also includes a control unit or controller that interfaces with a pumping mechanism driver. The sensor arrangement also includes a source of sensor calibration and anticoagulant solution, such as a reservoir, which has a silicone rubber fill septum, a non-woven Teflon air vent, and a check valve sub-assembly.

Abstract: There is provided a respiratory waveform drawing system. The system includes: load detectors configured to detect loads of the subjects and output them as a load signal; a subject number determination unit configured to determine a number of the subjects on the bed based on a frequency spectrum of the load signal; a waveform separation unit configured to separate a load component of each of the subjects from the load signal outputted from each of the plurality of load detectors; a center of gravity position calculation unit configured to calculate a position of a center of gravity of each of the subjects based on the separated load component of each of the subjects; and a waveform drawing unit configured to draw a respiratory waveform of each of the subjects based on a temporal variation of the position of the center of gravity of each of the subjects.

Abstract: An apparatus includes a needle, a cutter, a medication fluid path, and a filter assembly. The needle defines a tissue receiving feature. The cutter is movable relative to the needle to sever tissue protruding into the tissue receiving feature. The medication fluid path includes a first portion and a second portion. The first portion is configured to couple with a source of medication fluid. The tissue receiving feature is in fluid communication with the medication fluid path such that the first portion is upstream of the tissue receiving feature. The filter assembly is located in the second portion of the medication fluid path. The filter assembly is configured to permit air to pass through the filter assembly. The filter assembly is further configured to prevent medication fluid from passing through the filter assembly.

Abstract: A detection device, for placement under or on a mattress, configured for the movements of a person lying on the mattress, includes a sensing portion having an inflatable chamber intended to be positioned under the individual, an electronic unit arranged at a distance from the sensing portion and having a pressure sensor, intended to be positioned outside of the bedding, a transmitting portion interposed between the sensing portion and the electronic unit, including a channel establishing a fluid connection between the inflatable chamber and the sensor, the channel having a transverse dimension (T) that is much smaller than the width (L1) of the chamber.

Abstract: The present invention relates generally to systems and methods for processing, transmitting, and displaying data received from continuous analyte sensor, such as a glucose sensor. In some embodiments, the continuous analyte sensor system comprises a sensor electronics module that includes power saving features. One feature includes a low power measurement circuit that can be switched between a measurement mode and a low power mode, in which charging circuitry continues to apply power to electrodes of a sensor during the low power mode. In addition, the sensor electronics module can be switched between in a low power storage mode higher power operational mode via a switch. The switch can include a reed switch or optical switch, for example. A validation routine can also be implemented to ensure an interrupt signal sent from the switch is valid.

Abstract: A coaxial dual lumen pigtail catheter utilizes coaxial construction incorporating a thin wall guiding catheter technology for the outer lumen and using a strong braided diagnostic technology for the central lumen to accommodate high-pressure injections. The catheter includes a manifold body to provide for connection to each of the dual lumens. The distal end of the coaxial dual lumen pigtail catheter tapers to a more flexible portion that is perforated by spiral side holes to provide for more undistorted pressure readings in the left ventricle. The coaxial dual lumen pigtail catheter also utilizes proximal straight sideholes at the end of the dual lumen portion and a taper between the dual lumen portion and the single lumen portion.

Abstract: An apparatus including a main processing unit. The apparatus further including a precordial patch coupled to the main processing unit, the precordial patch having a plurality of sensors for detecting heart sounds and cardiac electrical signals (ECG). The apparatus further including a probe coupled to the main processing unit, the probe having a sensor for detecting oxygen saturation of blood circulating through a human. A method is further described including simultaneously measuring and analyzing heart sounds, cardiac electrical signals (ECG) and oxygen saturation of blood circulating through a human. The method further includes performing an algorithm to determine the presence of a significant congenital heart disease and displaying management recommendations based on results of the algorithm.

Abstract: An apparatus for guiding a biomedical electrode is provided, which guides a biomedical electrode to be brought into close contact with a living body surface of a voluntary muscle into optimum close contact positions on the basis of positions of the voluntary muscle and a neuromuscular junction of the voluntary muscle inside the living body surface. The relative positions of the voluntary muscle and the neuromuscular junction of the voluntary muscle to the living body surface are detected from muscle action potentials detected by myoelectric detection electrodes put into close contact with a large number of positions on the living body surface. On the basis of the relative position information, a close contact position of the biomedical electrode to be brought into close contact with the living body surface of the voluntary muscle is guided to an optimum position.

Abstract: A breathing support system is provided. The system may include a breathing support device configured to deliver gas to a patient and a display device associated with the breathing support device. The display device may be configured to display a work of breathing graphic indicating one or more work of breathing measures regarding the patient's breathing.

Abstract: Methods and systems are disclosed for the detecting of whether a subject has a lung disorder such as asthma, tuberculosis or lung cancer. Monitoring the subject's health and prognosis is also disclosed.

Abstract: A blood pressure measurement cuff is worn on a measurement site that extends in longitudinal direction in substantial round bar shape and gradually becomes thinner from one side to another side in longitudinal direction. A band-shaped body is included which is configured to contain an air bladder between an inner cloth that is to come into contact with the measurement site and an outer cloth that opposes the inner cloth, the band-shaped body being configured to be wrapped in a circumferential direction around the measurement site. A plate member is included which is provided between the outer cloth and the air bladder in a thickness direction and in a region that corresponds to at least a portion in the circumferential direction of the band-shaped body. The thickness of the plate member gradually becomes thinner from the one side to the other side in the longitudinal direction.