Abstract: An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.

Abstract: The invention relates to a method of navigation of a tool to be used in a surgical operation for treating a target region within the body of a patient.

Abstract: The invention relates to a method for objectively measuring skin phototype by reflectance spectrophotometry. The improved method correlates well with clinician-based assessments and is non-invasive, rapid and accurate.

Abstract: A method and system for co-registration of angiography data and intra vascular ultrasound (IVUS) data is disclosed. A vessel branch is detected in an angiogram image. A sequence of IVUS images is received from an IVUS transducer while the IVUS transducer is being pulled back through the vessel branch. A fluoroscopic image sequence is received while the IVUS transducer is being pulled back through the vessel branch. The IVUS transducer and a guiding catheter tip are detected in each frame of the fluoroscopic image sequence. The IVUS transducer detected in each frame of the fluoroscopic image sequence is mapped to a respective location in the detected vessel branch of the angiogram image. Each of the IVUS images is registered to a respective location in the detected vessel branch of the angiogram image based on the mapped location of the IVUS transducer detected in a corresponding frame of the fluoroscopic image sequence.

Abstract: A method to create magnetic resonance images of a predetermined imaging volume within an examination subject with a magnetic resonance system includes the following steps: Localize an inflow that supplies the imaging volume. Form a specific volume that at least partially includes the predetermined imaging volume and that is adapted to the inflow such that the specific volume has a recess into the specific volume at the inflow, via which recess at least a partial segment of the inflow is removed from the specific volume. Saturate or invert the magnetization of the specific volume by means of the magnetic resonance system. Detect measurement signals from the imaging volume. Create the MR images of the imaging volume by means of the measurement signals.

Abstract: Systems and methods which determine the position of an instrument internal to an object using an opto-mechanical sensor are shown. Embodiments utilize an opto-mechanical sensor system in which a mechanical instrument interface provides instrument movement information to a corresponding optical sensor system to determine instrument movement. Determinations of instrument movement preferably provide information regarding movement direction and speed. Such information, when used in combination with other information such as starting position or starting position offset, insertion angle or angle of attack, and/or insertion plane, is utilized by embodiments of the invention to determine the position of an instrument or portion thereof. Embodiments are adapted to accommodate different instrument configurations. Position information may be utilized in combination with an ultrasound image to display a visual representation of the instrument, or portion thereof, within a object being imaged.

Abstract: A method and system for detecting abnormalities in the properties of the walls of a subject's blood vessels by observing the characteristics of blood flow in vessels which are optically accessible, such as the retinal vasculature. A time sequenced series of images is taken, and the images are processed to eliminate the background and render erythrocyte motion visible. Information about the state of the inner wall of the blood vessel which has been imaged is obtained from the characteristics of this blood flow. This information can be extrapolated to provide information about the state of the blood vessels elsewhere in the subject. In addition, a system and method is described for detecting arteriosclerotic plaque on the walls of blood vessels by labeling the plaque with a molecular label having desired optical or radioactive properties, and directly imaging the plaque either in an optically accessible blood vessel, or by imaging radioactive label in the plaque in a blood vessel anywhere in the body.

Abstract: An in vivo source of compression is used to cause a bodily structure of interest to expand and contract. Ultrasound signals are incident and their echoes are processed by a strain processor. Resulting strain images are freed from noise caused by external sources of compression. A tissue stiffness index is calculated to obtain quantitative measure of stiffness.

Abstract: Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence.

Abstract: A viscoelastic property of tissue is measured in vivo. To collect more information and/or estimate viscosity, shear modulus, and/or other shear characteristics, an amplitude and phase modulated waveform is transmitted to the tissue. The displacement caused by the waveform over time includes displacements associated with response to different frequencies. By examining the displacement in the frequency domain, one or more viscoelastic properties may be calculated for different frequencies. The frequency response may indicate the health of the tissue.

Abstract: A method and apparatus to perform a procedure that can include a processor assisted surgical procedure. During the procedure patient space and image space can be registered to allow for tracking of various tracking sensors. A dynamic reference frame can be used to maintain localization of the patient space with the image space. The dynamic reference frame can be fixedly interconnected with a bone portion of the anatomy.

Abstract: Light is collected from a sample that is to be imaged, such as tissue or the like, and made to undergo self-interference, e.g., on a detector. An imaging system may include a low coherence light source arranged for illuminating the sample, and an interferometer arranged to receive the light collected from the sample and to pass it to a detector. The interferometer includes a beam divider that directs the radiation collected from the sample along two paths, phase-delaying one beam relative to another and then recombining the beams on a detector. A processor may be coordinated with the phase delay and in some embodiments with spatial scanning or detector array addresses, and operates on the signal from the detector to form a tomographic image of the sample illuminated tissue.

Abstract: The invention relates to a simplified fronto-sagittal and two-dimensional ultrasound apparatus exclusively intended for the exploration of the two right and left temporo-mandibular articulations (ATM) at rest or during mandibular movement, in the case of stomatology and traumatology exams. The calculation and the adjustment of the parameters for obtaining a displayed image of the region of the temporo-mandibular articulations is already done during the design step. Accordingly, the invention provides an apparatus with small dimensions and a lower cost relative to traditional ultrasound apparatuses, which will promote its use in medical practices both from a logistic and financial point of view. This exploration method has a low cost, does not require any particular preparation or hospitalisation for the patient, does not include any risks due to X-rays, and has no known side effects. The apparatus includes a quadruple hinged ultrasound probe (right and left) (FIG.

Abstract: This invention discloses a method and apparatus for ultrasonic color imaging applicable in medical diagnoses and industrial inspections. Multiple color parameters calculated via evaluating a plurality of characterizing properties of the ultrasonic signal attributable to an image point are employed to specify the color of the image point. The produced color image simultaneously exhibits the interior distributions of multiple physical properties of the target under ultrasound inspection, provides much richer interior information of the target than what traditional, single imaging parameter based ultrasonic imaging can provide. The invention enables far more and easier-to-perceive information to be communicated to image viewer's brain, significantly improves the efficiency of image reading, the capability of abnormality discrimination, and the accuracy and reliability of ultrasound inspection.

Abstract: A two-stage control system is disclosed being made of a first control means for providing command and control of a robotic arm, and a second control means for the control and movement of a therapy device, such as an ultrasound transducer. The therapy device is positioned within a therapy head. The therapy head is attached to the distal end of the robotic arm. The two-stage control system provides for a macro and micro level of control for the therapy device during a therapy procedure.

Abstract: An ultrasonic scanhead including an encoder, a pivot, a voice coil motor, and a transducer is provided. The encoder includes a fixed element and a rotary element. The rotary element is disposed at the fixed element and capable of rotating about a first axis. The pivot is through the encoder and capable of rotating with the rotary element. The pivot extends along a second axis and has a first end and a second end opposite to the first end. The voice coil motor includes a stator and a mover. The first end of the pivot is connected to the mover. The mover is capable of moving linearly along a third axis. The first axis, the second axis, and the third axis are substantially perpendicular to each other. The transducer is disposed at the second end of the pivot and capable of emitting an ultrasonic wave.

Abstract: A method and system for managing at least one animal is disclosed. The method can include imaging, such as ultrasound imaging, a lung of a live animal, such as a ruminant or bovine. The imaging can be performed to determine a degree of respiratory damage from past respiratory illness. After imaging, information regarding respiratory damage can be used to select at least one aspect of the treatment, care or disposition of the animal. For example, the information can be used to select the amount or type of feed provided to the animal at a feedlot. The information also can be used to select how long the animal should be housed at the feedlot prior to slaughter. If an animal is diagnosed with a respiratory illness, information about its degree of respiratory damage from past respiratory illness also can be used to select the appropriate medical treatment or lack of treatment.

Abstract: A wave generating device including a reflective surface adapted to reflect energy waves to a focus, and an energy wave transducer positioned at least partially around and outwards from the reflective surface, and adapted to generate an energy wave inwards towards the reflective surface through a wave propagating medium disposed between the reflective surface and the energy wave transducer.

Abstract: A method is disclosed for determining and displaying perfusion parameters. In at least one embodiment, the method includes measuring an arterial contrast agent profile; measuring a contrast agent profile in a tissue of an organ; temporally synchronizing measured values of the arterial contrast agent profile and the contrast agent profile by interpolation; fitting a theoretical parameterized contrast agent profile to the measured contrast agent profile in the tissue by minimizing the differences between the theoretical and measured contrast agent profiles over a multiplicity of times in a measurement interval by fitting function parameters; and determining at least one perfusion parameter from the function parameters in the case of minimal deviation between the theoretical and measured contrast agent profiles.

Abstract: In one aspect, in general, a method is provided for detecting temperature and protein denaturation of a tissue during thermal therapy. The method includes generating a plurality of MR pulse sequences that include a first group of pulse sequences and a second group of pulse sequences, and receiving a plurality of response signals that include a first and second group of response signals in response to the first and second groups of pulse sequences, respectively. A first information associated with a degree of protein denaturation of the tissue is determined based on the first and second groups of response signals. A second information associated with a temperature of the tissue is determined based on at least some of the plurality of response signals.