Patents Examined by Kiet T. Nguyen
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Patent number: 12389522Abstract: A linear accelerator system according to an embodiment is for generating an MeV electron beam. The linear accelerator system includes a linear accelerator cavity having an enclosure, wherein the enclosure is open at one end to provide an exit port for the MeV electron beam; and a switchable magnet unit designed to, in a deflection mode, generate a magnetic field within the linear accelerator cavity to enable at least one electron, emitted within the linear accelerator cavity, to interact with the enclosure due to deflection away from the exit port caused by the magnetic field. Accordingly, in an embodiment, in the deflection mode, an intensity of the MeV electron beam passing through the exit port is relatively lower than an intensity of the MeV electron beam passing through the exit port in a beam generation mode of the switchable magnet unit.Type: GrantFiled: September 20, 2021Date of Patent: August 12, 2025Assignee: SIEMENS HEALTHINEERS AGInventors: Sven Mueller, Stefan Willing, Martin Koschmieder, Claudia Noak, Marvin Moeller
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Patent number: 12381073Abstract: A mass spectrometry system that includes an ion source that produces ions, an ion transfer device, and a mass analyzer. The ion transfer device includes a first ion transfer device that receives ions from an inlet and transfers ions to an outlet, and includes a plurality of first plate electrodes that are stacked, each plate electrode having a hole with a same diameter, and separated by a first inter-electrode spacing such that the hole diameter is between 1 to 100 times the first inter-electrode spacing; a second ion transfer device receives and transfers the ions, and includes a plurality of second plate electrodes with holes having a same diameter, separated by a second inter-electrode spacing such that the hole diameter is between 3 to 100 times the second inter-electrode spacing; and a third ion transfer device includes a plurality of third plate electrodes with holes having a plurality of diameters.Type: GrantFiled: March 19, 2025Date of Patent: August 5, 2025Assignee: Trace Matters Scientific LLCInventor: Mazdak Taghioskoui
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Patent number: 12370374Abstract: The present disclosure relates to the field of radiotherapy, in particular, methods of and apparatus for treating cancer using ultra-high dose rate radiotherapy (FLASH). The apparatus may comprise a device configured to administer to the subject no more than five fractions of proton ultra-high dose rate radiotherapy (FLASH), said fractions having a range of radiation from 1.5 Gy to 60 Gy, collectively. The device may be configured such that the treatment is sufficient to prevent further growth of the tumor for at least 10% longer than standard of care radiotherapy, induce at least 10% more tumor regression than standard of care radiotherapy and/or delay tumor regrowth by at least about 2 months longer than standard of care radiotherapy.Type: GrantFiled: October 18, 2022Date of Patent: July 29, 2025Assignees: Varian Medical Systems, Inc., Aarhus University, Central Denmark RegionInventors: Ricky Anupam Sharma, Sophia Pfister, Marta Vilalta, Brita Singers Sørensen, Per Rugaard Poulsen, Gael Luis Boivin
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Patent number: 12368017Abstract: A technique that enables automatic focus adjustment even for a sample having regions with different heights is proposed. A charged particle beam device according to the disclosure includes: a sample holder configured to hold a sample; a sample stage configured to move the sample; a charged particle gun and a charged particle beam column configured to irradiate the sample with a charged particle beam; an objective lens configured to perform focus adjustment by changing an intensity of a focusing effect on the charged particle beam; a detector configured to detect electrons from the sample and output a signal forming an electron image; an optical imaging device configured to capture an optical image of the sample; and a control device configured to calculate height information of the sample based on the optical image obtained by imaging the sample by the optical imaging device, and automatically set a focus adjustment value of an observation site based on the height information (see FIG. 5).Type: GrantFiled: June 8, 2020Date of Patent: July 22, 2025Assignee: Hitachi High-Tech CorporationInventors: Keisuke Igarashi, Wei Chean Tan, Mai Yoshihara, Hiroyuki Chiba
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Patent number: 12368040Abstract: The embodiments relate to a method and an apparatus for the molecular atomic analysis of a fluid in the gaseous state, in particular the method includes introducing a fluid in the gaseous state into a collection chamber having a predetermined internal volume V and generating a laser beam through a laser device. The method may also include focusing the beam onto the fluid sited in the collection chamber, in order to create an electric field in at least a portion V? of the internal volume V, so as to excite the electrons residing on the atoms and molecules present in said fluid in the gaseous state, causing an atomic/molecular alteration of the fluid itself in said portion V?. The method provides detecting the elements emitted after focusing the beam on the fluid, through detection devices and analyzing the elements detected by the detection devices using a processing unit.Type: GrantFiled: April 1, 2021Date of Patent: July 22, 2025Assignee: ISTITUTO NAZIONALE DI FISICA NUCLEAREInventor: Giovanni Carugno
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Patent number: 12364448Abstract: Disclosed is a radiation protection screen for protecting an operator against emissions of ionizing radiation of the X-ray type or other types. This radiation protection screen includes a front wall provided with a transparent panel and with an airlock structure adapted to the passage of equipment and/or the arms of the operator. The airlock structure includes an airlock opening associated with a flexible closing structure, which airlock opening includes a horizontal or approximately horizontal lower opening edge. And the screen further includes a support device suitable for supporting material and/or an arm of the operator, which support device is arranged at the level of the lower opening edge of the airlock structure, on the side of the inner face of the front wall.Type: GrantFiled: January 13, 2021Date of Patent: July 22, 2025Assignee: LEMER PAXInventor: Pierre-Marie Lemer
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Patent number: 12362161Abstract: Methods and systems for identifying or classifying charge states of detected ions. An example method for classifying a charge state of detected ions may include generating a pulse for each ion in a plurality of ions detected by a detector, wherein each pulse has a pulse characteristic; generating a pulse-characteristic distribution of the generated pulses; and based on the pulse-characteristic distribution, generating an identification of the charge state of one or more ions in the plurality of ions.Type: GrantFiled: May 14, 2021Date of Patent: July 15, 2025Assignee: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.Inventor: Pavel Ryumin
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Patent number: 12360078Abstract: An analytical device for analysing ions is provided comprising a separator 2 for separating ions according to a physico-chemical property and an interface 3 comprising one or more ion guides. A quadrupole rod set mass filter 4 is arranged downstream of the interface 3. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator 2 through the interface 3 with a first transit time t1 and (ii) to transmit a second group of ions which subsequently emerges from the separator 2 through the interface 3 with a second different transit time t2.Type: GrantFiled: January 7, 2022Date of Patent: July 15, 2025Assignee: Micromass UK LimitedInventors: Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose
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Patent number: 12358817Abstract: Water disinfecting modules, water supply systems, methods of assembling a water supply system as well as method of disinfecting water are provided. The water disinfecting module includes a frame, hot and cold water flow switches and hot and cold UV treatment modules is provided. The frame supports a hot and cold water inlets and hot and cold water outlets. Hot and cold water flow switches are fluidly interposed between the respective inlets and outlets for sensing water flow. Hot and cold water UV treatment modules are fluidly interposed between corresponding inlets and outlets and are coupled to flow switches for activation upon sensing of water flow. All of the components are supported by the frame to form a complete unit. The systems and methods incorporate the use of such a water disinfecting module.Type: GrantFiled: January 12, 2021Date of Patent: July 15, 2025Assignee: AQUISENSE INC.Inventors: Steven Franklin Pugh, John Krause
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Patent number: 12354830Abstract: A sample image display system 150 displays, on a screen, a plurality of images 203 of a sample S and a symbol 205 corresponding to each of the images. The sample image display system 150 displays each symbol 205 in a different mode according to information related to the corresponding image 203.Type: GrantFiled: September 4, 2019Date of Patent: July 8, 2025Assignee: Hitachi High-Tech CorporationInventors: Wei Chean Tan, Hiroyuki Chiba, Ryo Komatsuzaki, Hirofumi Sato
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Patent number: 12354834Abstract: A cathode apparatus for an ion source has a cathode with a positioning feature and a blind hole. A cathode holder has an aperture defined by a thru-hole and a locating feature defined along an aperture axis. The thru-hole receives the cathode along the aperture axis in first and second alignment positions based on a rotational orientation of the positioning feature with respect to the locating feature. The first alignment position locates the cathode at a first axial position along the aperture axis. The second alignment position locates the cathode at a second axial position along the axial axis. A filament device has a filament clamp, a filament rod defining a filament axis, and a filament coupled to the filament rod. The filament clamp is in selective engagement with the filament rod to selectively position the filament along the filament axis within the blind hole.Type: GrantFiled: July 29, 2022Date of Patent: July 8, 2025Assignee: Axcelis Technologies, Inc.Inventors: Steven T. Drummond, Joshua Max Abeshaus
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Patent number: 12345698Abstract: The present invention discloses a method for authentication of animal species origin of leather products, which includes the following steps: Step 1: Model establishment: (1) Collect leather samples from different animal species origins, set mass spectrometric parameters, cut the surface of leather samples using a preheated electric soldering iron, and detect the resulting sample ions using the mass spectrometer; (2) Create a multivariate statistical model based on principal component analysis and linear discriminant analysis of rapid evaporative ionization mass spectrometric data and evaluate the model with cross-validation tests; Step 2: Analysis of real leather samples: detect and authenticate the identity of real leather samples based on the multivariate statistical model. The authentication method disclosed in present invention is a rapid analytical method that requires no sample pretreatment and can identify the animal species origin of leather products rapidly and accurately.Type: GrantFiled: February 8, 2022Date of Patent: July 1, 2025Assignee: CHINESE ACADEMY OF INSPECTION AND QUARANTINEInventor: Qiang Ma
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Patent number: 12340999Abstract: A method for correcting mass spectral data obtained for a sample is described, where the mass spectral data is a time-of-flight mass spectral data. The method includes receiving mass spectral data obtained from a sample, the mass spectral data being indicative of an ion abundance. The method further includes applying a correction function to the mass spectral data based on the ion abundance indicated by the mass spectral data and on one or more trapping parameters associated with the mass spectral data. The correction function defines correction values for the mass spectral data for a range of ion abundances and for a range of trapping parameters.Type: GrantFiled: October 25, 2022Date of Patent: June 24, 2025Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Hamish Stewart, Bernd Hagedorn, Dmitry Grinfeld
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Patent number: 12339261Abstract: The invention relates to a method for mass analysing a sample by ionising the sample to first sample ions and to second sample ions and by obtaining mass spectra from the first sample ions and the second sample ions with a mass analyser (5). Thereby, repeatedly, a first assay is obtained from the sample and transferred past any chromatography column to a first ion source (2) and ionised by the first ion source (2) to the first sample ions, wherein the first sample ions obtained from the respective first assay are transferred to the mass analyser (5), wherein at least one first mass spectrum is obtained with the mass analyser (5) from the first sample ions obtained from the respective first assay and ionised by and transferred from the first ion source (2).Type: GrantFiled: April 20, 2022Date of Patent: June 24, 2025Assignee: TOFWERK AGInventors: Sonja Klee, Steffen Bräkling, Marc Gonin, Urs Rohner, Carsten Stoermer
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Patent number: 12334327Abstract: A mass spectrometer includes an ion source, an ion guide, a quadrupole mass filter, a detector, DC and RF power sources, and a voltage control device for controlling an acceleration voltage by controlling the power source. The voltage controller controls the acceleration voltage such that it is increased as the mass-to-charge ratio of ions to be measured is increased within a control region. The control region is surrounded, having one coordinate axis representing the mass-to-charge ratio of the ions passing the ion guide and another axis representing the acceleration voltage applied to the ion guide, by a line representing a lower limit of a stable region where the ions pass the ion guide stably, a line representing an ion mobility of the ions, an upper side representing an upper limit of the acceleration voltage, and a lower side representing a value at which the acceleration voltage is zero.Type: GrantFiled: March 23, 2021Date of Patent: June 17, 2025Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Masuyuki Sugiyama, Hideki Hasegawa, Yuki Nagaya, Yuichiro Hashimoto, Hiroyuki Yasuda
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Patent number: 12330157Abstract: An optoelectronic tweezer device includes a transparent substrate, a semiconductor layer, a first electrode and a dielectric layer. The semiconductor layer is located above the transparent substrate and includes a first doping region, a second doping region and a transition region, wherein the transition region is located between the first doping region and the second doping region. The first electrode is located on the first doping region and is electrically connected to the first doping region. The dielectric layer is located above the semiconductor layer and has a first through hole overlapping the first electrode.Type: GrantFiled: May 23, 2022Date of Patent: June 17, 2025Assignee: Au Optronics CorporationInventors: Shih-Hua Hsu, Wei-Han Chen, Ching-Wen Chen, Ying-Hui Lai
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Patent number: 12327717Abstract: Systems and methods for analyzing samples are provided. In some embodiments, a mass spectrometer may include a source configured to output a plurality of particles, a tube having a central axis, and a skimmer. In some embodiments, the skimmer may include an aperture arranged to receive the one or more charged particles deflected by a deflector and a contact surface comprising an intersection point that intersects the central axis of the tube. The intersection point may be spaced from the aperture by a distance of at least 5 mm.Type: GrantFiled: October 20, 2022Date of Patent: June 10, 2025Assignee: CMP Scientific CorpInventors: Paul Nurmi, Joshua Wiley, Qiangwei Xia
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Patent number: 12320765Abstract: Evaluating the quality of cyanate ester matrix resin material includes inserting a small piece of a deposit extracted from a composite laminate into an epoxy for cross-sectional analysis, and performing cross-sectional polishing on the small piece of the deposit. Evaluating the quality of the cyanate ester matrix resin material also includes performing resolution imaging to study a plurality of plies in the small piece of the deposit to evaluate each ply without causing destruction to each of the plurality of plies.Type: GrantFiled: December 5, 2022Date of Patent: June 3, 2025Assignee: THE AEROSPACE CORPORATIONInventors: Rafael J. Zaldivar, Hyun I. Kim, Geena L. Ferrelli
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Patent number: 12315653Abstract: An atom chip for an ultracold-atom sensor, the chip includes an XY-plane normal to a Z-axis, the atom chip comprising: first and second coplanar waveguides suitable for propagating microwaves at respective angular frequencies ?a and ?b, the waveguides being placed symmetrically on either side of the X-axis and being referred to as X-wise guides, first and second coplanar waveguides suitable for propagating microwaves at respective angular frequencies ??a and ??b, the waveguides being placed symmetrically on either side of an axis the projection of which in the XY-plane is along an axis Y? that is different from the X-axis and that is contained in the XY-plane, and being referred to as Y?-wise guides, the X-wise guides being electrically insulated from the Y?-wise guides, an intersection of the guides forming a parallelogram of center O defining an origin of the reference frame XYZ, at least a first conductive wire and a second conductive wire the respective projections of which in the XY-plane are secant at OType: GrantFiled: May 7, 2021Date of Patent: May 27, 2025Assignee: THALESInventors: Matthieu Dupont-Nivet, Benjamin Wirtschafter
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Patent number: 12298226Abstract: A sensing rack includes a base, a plurality of sensing mechanisms, and a plurality of displaying elements. The base includes a plurality of accommodating spaces. The sensing mechanisms are disposed in the base, and each of the sensing mechanisms correspond to each of the accommodating spaces and includes a light sensing component and a light blocking element. A light sensing component includes a light emitting element and a light receiving element. The light blocking element is drivable to move between the light emitting element and the light receiving element so as to control a light of the light emitting element to enter the light receiving element or not. Each of the displaying elements is electrically connected with the light receiving element of each of the sensing mechanisms and is for displaying the light of each of the light emitting elements entering the light receiving element or not.Type: GrantFiled: May 18, 2022Date of Patent: May 13, 2025Assignee: RHYMEBUS CORPORATIONInventors: Hsuan-Yu Huang, Chiu-Hsiung Chen, Shun-Han Ko, Yu-Hung Lin, Hsien-Tang Jao