Patents Examined by Kiet T. Nguyen
  • Patent number: 11518680
    Abstract: A method for producing a body obtained by processing a solid carbon-containing material, the method includes: preparing the solid carbon-containing material composed of a material having at least a surface containing solid carbon; forming a gas phase fluid containing at least one of an active gas or an active plasma which are active against the solid carbon; and processing the solid carbon-containing material by injecting the gas phase fluid onto at least a part of the surface of the solid carbon-containing material.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: December 6, 2022
    Assignee: Sumitomo Electric Industries, Ltd.
    Inventors: Yoshiki Nishibayashi, Natsuo Tatsumi, Kensei Hamaki
  • Patent number: 11521844
    Abstract: An ion confinement device (2) comprising: a plurality of electrodes arranged and configured for confining ions when an AC or RF voltage is applied thereto; and at least one inductive ballast (10a,10b), each ballast connected to at least some of said electrodes so as to form a resonator circuit therewith.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 6, 2022
    Assignee: Micromass UK Limited
    Inventors: John Garside, Kenneth Worthington
  • Patent number: 11501960
    Abstract: A method of removing nuclear isobars from a mass spectrometric technique comprising directing ions, decelerating the ions, neutralizing a first portion of the ions, creating residual ions and a second portion of the ions, reionizing a selective portion of the ions, re-accelerating the selective reionized portion of ions, and directing the reionized portion of ions to a detector. An apparatus to remove nuclear isobars comprising a deceleration lens, an equipotential surface, an electron source to neutralize a portion of the ion beam, a deflector pair, a tunable resonance ionization laser for selective resonant reionization, and an acceleration lens.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: November 15, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Evan E. Groopman, David G. Willingham
  • Patent number: 11501948
    Abstract: A method of operating a particle beam device for imaging, analyzing and/or processing an object may be carried out, for example, by a particle beam device. The method may include: identifying at least one region of interest on the object; defining: (i) an analyzing sequence for analyzing the object, (ii) a processing sequence for processing the object by deformation and (iii) an adapting sequence for adapting the at least one region of interest depending on the processing sequence and/or on the analyzing sequence; processing the object by deformation according to the processing sequence and/or analyzing the object according to the analyzing sequence; adapting the at least one region of interest according to the adapting sequence; and after or while adapting the at least one region of interest, imaging and/or analyzing the at least one region of interest using a primary particle beam being generated by a particle beam generator.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 15, 2022
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Luyang Han, Martin Edelmann, Josef Biberger
  • Patent number: 11495323
    Abstract: Techniques for determining a microbial classification based on a mass spectrum are disclosed. A mass spectrometer generates a mass spectrum for a biological sample. A binning function is applied to the mass spectrum to generate a binned mass spectrum. As an example, a binned mass spectrum is associated with a set of bins having mass errors of the same value. A classification algorithm is applied to the binned mass spectrum to determine a microbial classification.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: November 8, 2022
    Assignee: Thermo Finnigan LLC
    Inventor: Michael J. Athanas
  • Patent number: 11491236
    Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: November 8, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Harmut Duefel, Uwe Kobold, Andreas Leinenbach
  • Patent number: 11486864
    Abstract: Methods and system for identifying and quantifying antibody fragments and identifying the site of fragmentation on an antibody are provided herein.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: November 1, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Yuetian Yan, Shunhai Wang
  • Patent number: 11488818
    Abstract: The present disclosure relates to a device for filtering at least one selected ion from an ion beam includes a unit for creating an electric field for accelerating the ions of the ion beam along a flight path of predefinable length, and a controllable ion optical system, which delimits the flight path in one direction, and which is used to deflect the selected ion from a flight path of the ion beam. The device is further designed to control the ion optical system subject to a flight time of the selected ion along the flight path. The present disclosure also relates to a mass spectrometer having a device according to the present disclosure, and to a method for filtering at least one selected ion from an ion beam.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: November 1, 2022
    Assignee: Analytik Jena AG
    Inventor: Roland Lehmann
  • Patent number: 11480580
    Abstract: Disclosed herein is a chemo-proteomic probe for labelling and monitoring a live microbe interacting with a host cell and for qualitative and quantitative analyses of those proteins involved during a microbe infects the host cell. This probe comprises a functional group for conjugating to a surface protein of a live microbe under a physiological condition; a photo-reactive group for covalent cross-linking to an interacting cell protein of a host; and a tag for isolating the cross-linked complex of the surface protein of said live microbe and the interacting protein of a host cell for qualitative and quantitative proteomics analyses. The probe may further comprise a visualization tag. This technology takes advantage of the high throughput feature of mass spectrometry analysis and combines it with a uniquely designed chemistry to achieve high efficient isolation and analysis of host cell proteins interacting with a pathogen at different stages of an infection.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: October 25, 2022
    Assignee: Purdue Research Foundation
    Inventors: Weiguo Andy Tao, Ying Zhang, Mayank Srivastava
  • Patent number: 11480544
    Abstract: Apparatus comprise an electrode arrangement comprising a plurality of electrodes defining a volume, an ion entrance, and an ion exit, and a voltage source coupled to the plurality of electrodes and configured to apply a nonlinear DC voltage sequence to the electrodes between the ion entrance and the ion exit that directs ions through the volume with the volume at a pressure of at least 1 Torr. Ions can be focused using nonlinear DC voltage sequences, including at atmospheric pressure. Related methods are also disclosed.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: October 25, 2022
    Assignee: Battelle Memorial Institute
    Inventors: Adam L. Hollerbach, Yehia M. Ibrahim, Sandilya V. B. Garimella
  • Patent number: 11480581
    Abstract: The present disclosure provides methods of identifying or certifying an animal that consumed a traceable diet comprising a C1 metabolizing microorganism.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: October 25, 2022
    Assignee: CALYSTA, INC.
    Inventors: Sungwon Lee, Allan LeBlanc
  • Patent number: 11483917
    Abstract: A chamber device may include a concentrating mirror, a central gas supply port, an inner wall, an exhaust port, a recessed portion, and a lateral gas supply port. The recessed portion may be on a side lateral to the focal line and recessed outward from the inner wall when viewed from a direction perpendicular to the focal line. The lateral gas supply port is formed at the recessed portion and may supply gas toward gas supplied from the central gas supply port so that a flow direction of the gas supplied from the central gas supply port is bent from a direction along the focal line toward the exhaust port and an internal space of the recessed portion.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: October 25, 2022
    Assignee: Gigaphoton Inc.
    Inventors: Atsushi Ueda, Takayuki Osanai, Koichiro Koge
  • Patent number: 11476104
    Abstract: An ion detection system is disclosed that comprises one or more first devices 11 configured to produce secondary electrons in response to incident ions. The one or more first devices 11 comprise a first ion collection region and a second ion collection region and are configured to produce first secondary electrons in response to one or more ions incident at the first ion collection region and to produce second secondary electrons in response to one or more ions incident at the second ion collection region. The ion detection system also comprises a first output device 14 configured to output a first signal in response to first secondary electrons produced by the one or more first devices 11 and a second output device 15 configured to output a second signal in response to second secondary electrons produced by the one or more first devices 11.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: October 18, 2022
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jason Lee Wildgoose
  • Patent number: 11469091
    Abstract: A mass spectrometry apparatus includes an ion detector and a control circuit coupled to the ion detector. The ion detector includes a pulse counting stage and an analog stage configured to generate a pulse counting signal and an analog signal, respectively, responsive to incident ions. The a control circuit is configured to output the pulse counting signal in a pulse counting output mode and to output the analog signal in an analog output mode. The control circuit is configured to switch from the pulse counting output mode to the analog output mode responsive to the pulse counting signal exceeding a first threshold within a range of about 10 million counts per second to about 200 million counts per second. Related devices and operating methods are also discussed.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: October 11, 2022
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: William Fisher, Bohdan Atamanchuk, Hamid R. Badiei
  • Patent number: 11458513
    Abstract: To provide a charged particle beam apparatus. The charged particle beam apparatus includes: a stage on which a sample is placed; a cleaner configured to remove a contaminant on the sample; and a stage control unit configured to adjust a relative positional relationship between the cleaner and the sample by moving the stage during use of the cleaner.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: October 4, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Akinari Morikawa, Kotaro Hosoya
  • Patent number: 11454626
    Abstract: The present invention relates to a method for single-cell imaging mass spectrometry (MS) by correlating an optical image of a cell sample with an MS image. The method of the invention is in particular useful in research to test concomitantly optical and molecular phenotypes at a single-cell resolution.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: September 27, 2022
    Inventors: Theodore Alexandrov, Luca Rappez
  • Patent number: 11448624
    Abstract: An ionization probe connection jig used to connect an outlet-side flow path of a column 113 and an inlet-side flow path of an ionization probe 211 in a liquid chromatograph, the ionization probe connection jig includes: a first element fixture 10 fixed to a first element 113 that is one of the column 113 and the ionization probe 211; a second element fixture 20 fixed to a second element 211 that is the other; and a movement regulating tool 30 that permits the first element fixture 10 to advance in an axial direction of the first element 113 while regulating the first element 113 or the first element fixture 10 and the second element 211 or the second element fixture 20 such that flow paths of the first element 113 and the second element 211 are matched with each other, and regulates the second element fixture 20 such that the second element fixture 20 does not retreat beyond a predetermined position in a axial direction of the second element 211.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: September 20, 2022
    Inventor: Wataru Fukui
  • Patent number: 11448607
    Abstract: Systems and methods are provided for dynamically compensating position errors of a sample. The system can comprise one or more sensing units configured to generate a signal based on a position of a sample and a controller. The controller can be configured to determine the position of the sample based on the signal and in response to the determined position, provide information associated with the determined position for control of one of a first handling unit in a first chamber, a second handling unit in a second chamber, and a beam location unit in the second chamber.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: September 20, 2022
    Assignee: ASML Netherlands B.V.
    Inventor: Chiyan Kuan
  • Patent number: 11442067
    Abstract: The invention relates to peptide mass fingerprinting technique for the proteins such as Human insulin and insulin analogs. The insulin analogues can vary at least by one amino acid, which is elusive to distinguish by currently available analytical methods. The invention further allows sequence confirmation of the peptide wherein the run time of the method is forty minutes. This method could be applied for molecules up to 50 kDa.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: September 13, 2022
    Inventors: Phanichand Kodali, Krishnappa Mane, Srivatsa Koduru, Ashutosh Sudhir Naik, Laxmi Adhikary
  • Patent number: 11435303
    Abstract: The present invention provides an X-ray analysis device and a peak search method capable of realizing highly accurate peak searches without significantly increasing a processing time. Peak search processing includes: a step (S220) for acquiring a profile of a spectrum; a step (S240) for narrowing down a wavelength range where a true value of a peak wavelength (peak intensity) may be present, taking into account statistical fluctuation of a measured value; a step (S250) for measuring the intensity of the X-rays at the long wavelength end, the short wavelength end, and the intermediate wavelength in the narrowed wavelength range; a step (S255) for calculating a quadratic function passing through the respective measured values in the above-described three wavelengths; and a step (S260) for calculating the wavelength of the vertex of the calculated quadratic function as the peak wavelength.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: September 6, 2022
    Assignee: Shimadzu Corporation
    Inventor: Hiroshi Sakamae