Patents Examined by Kurt G. Briscoe
  • Patent number: 4874778
    Abstract: The invention relates to 1-carbamoyl-3-phenyl-4-benzyl-.DELTA..sup.2 -pyrazolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, methyl halogen, trifluoromethyl, C.sub.1 -C.sub.4 haloalkoxy containing 1 to 7 halogen atoms or C.sub.1 -C.sub.4 haloalkylthio containing 1 to 7 halogen atoms;R.sub.3 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl containing 1 to 7 halogen atoms, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy containing 1 to 7 halogen atoms or alkoxycarbonyl containing 1 to 4 carbon atoms in the alkyl moiety;R.sub.4 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl or trifluoromethyl;R.sub.5 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy; andR.sub.6 and R.sub.7 are each independently hydrogen, halogen or trifluoromethyl or R.sub.6 and R.sub.5 or R.sub.7 and R.sub.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: October 17, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Saleem Farooq
  • Patent number: 4845089
    Abstract: 1-Aralkylpyrazoles of the formula ##STR1## in which Ar represents optionally substituted aralkyl,R.sup.1 represents alkyl,R.sup.2 represents hydrogen, alkyl, halogenoalkyl, optionally substituted benzyl, or the --COR.sup.4, --COOR.sup.4, --NR.sup.5 R.sup.6 or --CONR.sup.5 R.sup.6 radicals,whereR.sup.4 represents hydrogen, alkyl, halogenoalkyl or alkoxyalkyl, andR.sup.5 and R.sup.6 represent hydrogen and/or alkyl,R.sup.3 represents hydrogen or alkyl, orR.sup.2 and R.sup.3 together represent the --Co--(CH.sub.2).sub.m --, --(CH.sub.2).sub.m --or --CH.dbd.CH--CH.dbd.CH-- groups, wherem represents the numbers 2, 3, 4 or 5, andn represents the numbers 0, 1 or 2, which possess pesticidal activity.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: July 4, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Markus Lindig, Benedikt Becker
  • Patent number: 4837333
    Abstract: This disclosure relates to a class of novel substituted alkylidene imidazole derivatives and pharmaceutically acceptable salts thereof. The disclosure further describes pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as agents for selectively inhibiting the action of the enzyme thromboxane synthetase.
    Type: Grant
    Filed: May 14, 1987
    Date of Patent: June 6, 1989
    Assignee: G. D. Searle & Co.
    Inventors: Paul W. Manley, Roderick A. Porter, Mun F. Lai
  • Patent number: 4816474
    Abstract: Disclosed are compounds of the formula ##STR1## wherein A represents the divalent radical --S--CR.sub.4 .dbd.CR.sub.5 -- in which R.sub.4 and R.sub.5 independently represent hydrogen or lower alkyl; R.sub.1 represents hydrogen, lower alkyl or aryl-lower alkyl; R.sub.2 represents hydrogen, lower alkyl or aryl-lower alkyl; or R.sub.1 and R.sub.2 combined represent alkylene of 4 to 6 carbon atoms; R.sub.3 represents hydrogen or lower alkyl; an S-oxide thereof; or a pharmaceutically acceptable salt thereof; which are useful as presynaptic dopamine receptor agonists for the treatment of central nervous system disorders; processes for preparing same; and pharmaceutical compositions comprising said compounds.
    Type: Grant
    Filed: February 27, 1987
    Date of Patent: March 28, 1989
    Assignee: Ciba-Geigy Corporation
    Inventor: Alan J. Hutchison
  • Patent number: 4808623
    Abstract: Novel insecticidally active compounds of the formula ##STR1## in which R.sup.1 represents halogenoalkyl,R.sup.2 represents cyano, hydroxycarbonyl, carbamoyl, thiocarbamoyl, alkoxycarbonyl, N-alkylcarbamoyl or N,N-dialkylcarbamoyl, or represents alkenyloxycarbonyl, N-alkenylcarbamoyl, N,N-dialkenylcarbamoyl, alkinyloxycarbonyl, N-alkinylcarbamoyl, N,N-dialkinylcarbamoyl or N-arylcarbamoyl andAr represents substituted phenyl, with the exception of the 4-nitrophenyl radical.
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: February 28, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Pieter Ooms, Benedikt Becker
  • Patent number: 4808210
    Abstract: A 5-pyrazolone of the formula ##STR1## wherein R is selected from the group consisting of mono- and polycyclic aromatic of 6 to 14 carbon atoms, heterocyclic optionally substituted with phenyl, ##STR2## and benzyl, all optionally substituted with at least one member of the group consisting of fluorine, chlorine, bromine, --CF.sub.3, optionally unsaturated alkyl of 1 to 8 carbon atoms and the radical OZ in which Z is an optionally unsaturated alkyl of 1 to 8 carbon atoms or an acyl of a carboxylic acid of 1 to 6 carbon atoms, A is selected from the group consisting of halogen, --CF.sub.3 and --CN, B and C are individually selected from the group consisting of hydrogen, halogen, --OH, --OR' and R' is optionally unsaturated alkyl of 1 to 8 carbon atoms, acyl of 1 to 6 carbon atoms, alkyl sulfonyl of 1 to 8 carbon atoms, aryl sulfonyl of 6 to 18 carbon atoms and benzyl optionally substituted with a member of the group consisting of fluorine, chlorine, bromine, --CF.sub.
    Type: Grant
    Filed: September 11, 1987
    Date of Patent: February 28, 1989
    Assignee: Roussel Uclaf
    Inventors: Jean Tessier, Pierre Girault
  • Patent number: 4804398
    Abstract: Herbicidally active novel 1-phenyl-4-cyano-5-halogenopyrazoles of the formula ##STR1## in which R is hydrogen or alkyl,Hal is halogen, andAr is phenyl substituted at least once by a radical other than halogen.Intermediates of the formulas ##STR2## are also new.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: February 14, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Uta Jensen-Korte, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4804675
    Abstract: A method of combating insects, sense animals and nematodes comprising applying to insects, arachnids and nematodes and/or their environment an effective amount of at least one 5-aminopyrazole of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, alkyl or halogenoalkyl,R.sup.2 represents alkyl, halogenoalkyl, unsubstituted or substituted aralkyl or unsubstituted or substituted aryl,R.sup.3 represents hydrogen, alkyl or a radical ##STR2## Ar represents unsubstituted or substituted phenyl or unsubstituted or substituted pyridyl andn represents the number 0, 1 or 2,whereinX represents oxygen or sulphur andR.sup.4 represents hydrogen, alkyl, alkenyl, alkinyl, halogenoalkyl, alkoxyalkyl, alkylthioalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, alkoxy, alkylthio, unsubstituted or substituted aryloxy, unsubstituted or substituted arylthio, alkylamino, dialkylamino or unsubstituted or substituted arylamino.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: February 14, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uta Jensen-Korte, Reinhold Gehring, Otto Schallner, Jorg Stetter, Heinz-Jurgen Wroblowsky, Benedikt Becker, Bernhard Homeyer, Wolfgang Behrenz, Wilhelm Stendel, Peter Andrews
  • Patent number: 4803215
    Abstract: Pesticidally active 5-heterocyclyl-1-aryl-pyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl or haloalkyl,R.sup.2 represents alkyl, alkenyl, alkinyl, cycloalkyl, haloalkyl, haloalkenyl, optionally substituted aralkyl or optionally substituted aryl,Ar represents in each case optionally substituted phenyl or pyridyl,Het represents a heterocycle of the formula ##STR2## n represents a number 0, 1 or 2, whereR.sup.3 and R.sup.4, independently of one another, represent in each case hydrogen, alkyl or phenyl.Intermediates of the formulas ##STR3## are provided, the former also being pesticidal.
    Type: Grant
    Filed: December 16, 1986
    Date of Patent: February 7, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uta Jensen-Korte, Reinhold Gehring, Otto Schallner, Jorg Stetter, Heinz-Jurgen Wroblowsky, Benedikt Becker, Bernhard Homeyer, Wolfgang Behrenz, Wilhelm Stendel
  • Patent number: 4803278
    Abstract: 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones are prepared in a three step process by(a) reducing 1-pyridyl-1,3-deketo-2-oximinoalkanes to produce 1-pyridyl-1-hydroxy-2-amine-3-ketoalkanes;(b) reacting the thus produced hydroxyaminoketone with cyanate ion to produce a 1,3-dihydro-4-hydroxy(pyridyl)methyl-2H-imidazol-2-one; and(c) oxidizing the thus produced hydroxymethyl compound to yield the desired product.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: February 7, 1989
    Assignee: Merrell Dow Pharmaceuticals, Inc.
    Inventors: Richard A. Schnettler, Chi-Hsin R. King
  • Patent number: 4801326
    Abstract: Pollen formation in cereal grain plants is inhibited by application of a 4,5-dicarboxy or 5-carboxamido-4-carboxy (or derivatized carboxy)-1-(3,5-disubstitutedphenyl)pyrazole. Use of the compounds facilitates the production of hybrid seed.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventors: Stephen A. Ackmann, James R. Beck, Fred L. Wright
  • Patent number: 4799951
    Abstract: Herbicidal 5-acylamino-pyrazole derivatives of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen or nitro,R.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl or optionally substituted cycloalkyl,R.sup.3 represents hydrogen or alkyl, or represents optionally substituted cycloalkyl, or represents optionally substituted aryl,Ar represents in each case optionally substituted phenyl or pyridyl,X.sup.1 represents oxygen or sulphur,A represents a straight-chain or branched optionally substituted alkylene bridge,n represents the number 0 to 1 andX.sup.2 represents oxygen, or represents a radical .dbd.N--O--R.sup.4, or represents a radical ##STR2## wherein R.sup.4 represents hydrogen, alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, alkoxyalkyl or alkylthioalkyl, or represents optionally substituted aralkyl, or represents optionally substituted aryl,R.sup.5 represents hydrogen or alkyl andR.sup.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: January 24, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jorg Stetter, Otto Schallner, Reinhold Gehring, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen, Harry Strang
  • Patent number: 4797489
    Abstract: The compounds ##STR1## wherein R.sup.1 is 1-adamantyl, 3-methyl-1-adamantyl, 9-fluorenyl or 1-fluorenyl;n is 0 or 1;m is 1, 2, 3, 4 or 5; andX is ##STR2## where R.sup.2 is phenyl, benzyl, pyridinyl, pyrimidinyl, pyrazinyl or substituted phenyl or benzyl in which the substituent is alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, cyano, nitro or trifluoromethyl, ##STR3## where R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, cyano or nitro;or pharmaceutically acceptable salts thereof are useful antidepressant and/or anxiolytic agents.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: January 10, 1989
    Assignee: American Home Products Corp.
    Inventors: Magid A. Abou-Gharbia, Gary P. Stack, John P. Yardley
  • Patent number: 4792565
    Abstract: Novel pyrazole derivatives of the general formula (I) ##STR1## wherein R.sup.1 represents an alkyl, haloalkyl, alkenyl, haloalkenyl or phenyl group, R.sup.2 and R.sup.3 each represent a hydrogen or halogen atom, or an alkyl, haloalkyl, alkoxy, alkoxyalkyl or phenyl group, and R.sup.4 represents an alkyl, alkenyl, haloalkenyl or phenyl group, or a heterocyclic aromatic group which contains at least one of oxygen, nitrogen and sulfur atoms and may be unsubstituted or substituted,which are useful as agricultural and horticultural fungicides. The pyrazole derivatives can be produced by reacting compounds of the general formula (III) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, and X represents a halogen atom,with aminoacetonitriles of the general formula (IV) ##STR3## wherein R.sup.4 is as defined above, or salts thereof.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: December 20, 1988
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Hitoshi Shimotori, Tutomu Ishii, Hideo Yamazaki, Toshiaki Kuwatsuka, Yuji Yanase, Yoshinori Tanaka
  • Patent number: 4791212
    Abstract: A 5-aminopyrazole of the formula ##STR1## in which R.sup.1 represents alkoxycarbonyl, alkenyloxycarbonyl, alkinyloxycarbonyl, alkenylaminocarbonyl or alkinylaminocarbonyl andR.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, which are identical or different, represent hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylsulphonyl, alkoxycarbonyl or a radical --(X)n--R.sup.8whereinX represents oxygen, sulphur, sulphinyl or sulphonyl,n represents 0 or 1 andR.sup.8 represents halogenoalkyl, with the proviso that at least one of the radicals R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 represents a radical --(X).sub.n --R.sup.8, but R.sup.1 does not represent cyano if R.sup.1 represents trifluoromethyl.These compounds are intermediates useful in the preparation of herbicidally active substituted 5-acylamino-1-phenylpyrazoles.
    Type: Grant
    Filed: December 30, 1986
    Date of Patent: December 13, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Erich Klauke, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4791213
    Abstract: The invention provides thioxanthone derivatives of general formula ##STR1## wherein one of R.sup.2, R.sup.3 and R.sup.4 is a group of formula ##STR2## in which one of R.sup.5, R.sup.6 and R.sup.7 is an alkyl or a benzyl group, the others being alkyl groups and A.sup.- represents an anion, and R.sup.1 and the others of R.sup.2, R.sup.3, and R.sup.4 are independently selected from hydrogen atoms, alkyl groups and alkoxy groups; and the use of such derivatives as photoinitiators, particularly in aqueous photopolymerizable compositions for the production of stencils for screen printing.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: December 13, 1988
    Assignee: Ward Blenkinsop & Company Limited
    Inventors: George Gawne, Peter N. Green, William A. Green
  • Patent number: 4787930
    Abstract: Herbicidal and plant growth regulating 5-amino-1-phenyl-pyrazoles of the formula ##STR1## in which R.sup.1 to R.sup.4 each represents hydrogen or various organic radicals,X represents oxygen or sulphur,n represents the number 0, 1 or 2, andm represents the number 1, 2 or 3,but wherein, in the case where R.sup.1 and R.sup.3 represent hydrogen and R.sup.2 represents nitro, R.sup.4 does not simultaneously represent a propionyl radical.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: November 29, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
  • Patent number: 4788293
    Abstract: 1-Pyrazolines are prepared by oxidation of a 1,3-diamine with sodium hypochlorite and a peroxide in aqueous solution.
    Type: Grant
    Filed: July 15, 1986
    Date of Patent: November 29, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Eckhard Stroefer, Wolfgang Rohr, Gerhard W. Rotermund, Rolf Fischer, Reinhard Neudert
  • Patent number: 4783535
    Abstract: A process for the preparation of 1,4-oxazepinones and thiones having the formula: ##STR1## wherein A is an aromatic ring selected from benzene, naphthalene, quinoline or pyridine; n is 1 to 3; Z is an amino radical; R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl; and R.sup.4 and R.sup.5 are hydrogen and loweralkyl starting from chloroaromatic carboxylates and alkanolamines is disclosed. The oxazepinones and oxazepinethiones prepared by the process have utility as antihistaminics with low sedative potential. Novel intermediate compounds are also disclosed.
    Type: Grant
    Filed: March 18, 1986
    Date of Patent: November 8, 1988
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Young S. Lo, Albert D. Cale, Jr.
  • Patent number: 4780543
    Abstract: A compound of the formula: ##STR1## wherein E is an ethenyl group of the formula: ##STR2## in which X is H when Y is NO.sub.2 ;Y is H when X is NO.sub.2 ; orX is CN when Y is CNwhich has the capacity to form a crystal in which the molecules are aligned substantially in the same manner giving it non-linear optical properties. The crystalline product is thus adapted for use in devices exhibiting non-linear optical effects.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: October 25, 1988
    Assignee: Imperial Chemical Industries PLC
    Inventors: Paul Gordon, Brian Bothwell