Abstract: Pyrazolines of the following formula are insecticides: ##STR1## wherein R.sub.A, R.sub.B and R.sub.C are aromatic groups; R.sub.N is hydrogen or lower alkyl; and W is oxygen or sulfur.
Abstract: Compounds of formula: ##STR1## and stereoisomers thereof, wherein R.sup.1 is unsubstituted or substituted aryl or heteroaryl; R.sup.2 is H, alkyl, alkenyl or alkynyl; X is O, NH, or S; R.sup.3 being alkyl, alkenyl, alkynyl or COR.sup.4 where R.sup.4 has an R.sup.3 value, when X is O; R.sup.3 being --CO-- alkyl when X is NH; and R.sup.3 being alkyl, alkenyl or CSNR.sup.5 R.sup.6 where R.sup.5 and R.sup.6, which may be the same or different, are H, alkyl, alkenyl or, together with the adjacent N atom, constitute a ring, when X is S; or XR.sup.3 together represent --CN; and salts and metal complexes thereof, have fungicidal and plant growth regulating activity.
Abstract: The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which the variables are as defined in the specification.The compounds of formula (I) show pharmacological activity as selective histamine H.sub.2 -antagonists.Also disclosed are intermediates in the preparation of the compounds of the formula (I).
Type:
Grant
Filed:
February 6, 1986
Date of Patent:
August 16, 1988
Assignee:
Glaxo Group Limited
Inventors:
John W. Clitherow, John Bradshaw, John W. M. Mackinnon, Barry J. Price, Michael Martin-Smith, Duncan B. Judd
Abstract: 1-Hydroxypyrazoles of the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 independently of one another are each hydrogen or halogen, and microbicides containing these compounds.
Type:
Grant
Filed:
May 29, 1987
Date of Patent:
August 16, 1988
Assignee:
BASF Aktiengesellschaft
Inventors:
Klaus Wagner, Norbert Rieber, Ernst-Heinrich Pommer
Abstract: 5-Dichloracetamido-4-nitro-1-aryl-pyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen, fluorine, chlorine or bromine,R.sup.2 represents hydrogen, fluorine or chlorine,R.sup.3 represents halogen, halogenoalkyl, halogenoalkoxy, halogenoalkylthio or halogenoalkylsulphonyl,R.sup.4 represents hydrogen, fluorine, or chlorine, andR.sup.5 represents fluorine, chlorine or bromine, but in the case in which R.sup.1 and R.sup.5 simultaneously represent chlorine and in addition R.sup.2 and R.sup.4 simultaneously represent hydrogen, R.sup.3 does not represent chlorine or trifluoromethyl,exhibit herbicidal and plant growth-regulating properties. Novel intermediates therefor are also shown.
Type:
Grant
Filed:
November 24, 1986
Date of Patent:
August 16, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Reinhold Gehring, Otto Schallner, Jorg Stetter, Albrecht Marhold, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
Abstract: Liquid/liquid extraction process for copper from an aqueous sulphuric acid solution acting on the concentrated mineral or semi-finished product to be treated.The extraction is carried out in an organic solvent containing in solution an extraction agent derived from 2-phenyl-4-acyl-(3H)-pyrazol-3-ones, with the phenyl group substituted or unsubstituted.Application to the upgrading of minerals.
Type:
Grant
Filed:
December 10, 1986
Date of Patent:
August 2, 1988
Assignee:
Societe Nationale des Poudres et Explosifs
Inventors:
Jean-Claude Gautier, Serge Lecolier, Claude Soriaux, Sammy Chlvalier
Abstract: 1-Aryl-pyrazoles of the general formula ##STR1## in which Hal represents halogen,R.sup.1 and R.sup.3 independently of one another represent cyano, nitro, halogen, alkyl, alkoxy, alkoxycarbonyl, halogenoalkyl, halogenoalkoxy or a radical --S(O).sub.n --R.sup.6 andR.sup.2, R.sup.4 and R.sup.5 independently of one another and independently of R.sup.1 and R.sup.3 represent the same radicals as R.sup.1 and R.sup.3, and additionally represent hydrogen,and whereinR.sup.6 represents alkyl, halogenoalkyl, amino, alkylamino or dialkylamino and n-represents the number 0, 1 or 2 are disclosed.These compounds can be nitrated to form herbicially effective 1-aryl-4-nitropyrazoles.
Type:
Grant
Filed:
February 19, 1987
Date of Patent:
July 19, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt
Abstract: A compound of formula I ##STR1## in which formula: R.sub.1 represents hydrogen or an alkyl group;R.sub.2 -R.sub.5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; andn is 1 or 2.
Type:
Grant
Filed:
November 10, 1986
Date of Patent:
July 12, 1988
Assignee:
National Research Development Corporation
Inventors:
Israr Ahmed, Gerald E. Adams, Ian J. Stratford, David Gibson
Abstract: As compounds is provided a pyrazole derivative of the formula ##STR1## wherein R.sub.1a, R.sub.1b and R.sub.1c are each a hydrogen atom, a halogen atom, a nitro group, an amino group, a (lower) alkyl group, a halo-(lower)alkyl group, a(lower)alkenyl group, a (lower)alkynyl group, a (lower)alkylcarbonylamino group, a (lower)alkoxycarbonylamino group, a mono-(lower) alkylaminocarbonylamino group or a di-(lower)alkylaminocarbonylamino group;R.sub.2 is a hydrogen atom, a (lower)alkyl group, a (lower)alkenyl group, a (lower)alkynyl group, a (lower) alkoxy(lower)alkyl group, a (lower)alkylthio(lower)alkyl group, a (lower)alkylcarbonyl(lowr)alkyl group, a (lower) alkoxycarbonyl(lower)alkyl group, a (lower)alkylthiocarbonyl(lower)alkyl group, a cyano(lower)alkyl group, a (lower)alkylsulfonyl group, phenylsulfonyl group, a halogen-substituted phenylsulfonyl group or a (lower) alkyl-substituted phenylsulfonyl group, andX and Y are the same or different and each are a halogen atom.
Abstract: A compound of the general formula (I): ##STR1## wherein R is C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl, both optionally substituted by lower alkyl, halogen or trialkylsilyl; E is CN or CSHN.sub.2 ; and Y is C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, 1-pyrazolyl or 2-furyl. The compounds have fungicidal and plant growth regulating activity.
Type:
Grant
Filed:
November 18, 1986
Date of Patent:
June 21, 1988
Assignee:
Imperial Chemical Industries PLC
Inventors:
Stephen P. Heaney, Patrick J. Crowley, Laurence G. Reynolds
Abstract: A compound of the formula: ##STR1## wherein R is a C.sub.2 -C.sub.3 alkyl group, a C.sub.3 -C.sub.4 alkenyl group or a C.sub.3 -C.sub.4 alkynyl group and X is a chlorine atom or a bromine atom, which is useful as a herbicide.
Type:
Grant
Filed:
February 5, 1985
Date of Patent:
June 21, 1988
Assignee:
Sumitomo Chemical Co., Ltd.
Inventors:
Toru Haga, Eiki Nagano, Ryo Sato, Ryo Yoshida
Abstract: Herbicidally active 1-aryl-4-cyano-5-halogenopyrazoles of the formula ##STR1## in which R is hydrogen or alkyl,Hal is halogen, andAr is substituted phenyl or represents polysubstituted pyridyl.Intermediates of the formulas ##STR2## are also disclosed.
Type:
Grant
Filed:
May 22, 1986
Date of Patent:
May 31, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Reinhold Gehring, Uta Jensen-Korte, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt
Abstract: A process for the preparation of phenylthiopyrimidines which comprises: (a) reacting a thiopyrimidine; with sulfuryl chloride in the presence of a suitable solvent to form the sulfenyl chloride of said thiopyrimidine; (b) reacting said sulfenyl chloride of said thiopyrimidine with a phenol or substituted phenol, optionally in the presence of a Friedal-Crafts catalyst, to form a thiopyrimidinyl phenol; and (c) reacting said thiopyrimidinylphenol formed in step (b) with a base and an alkylating agent to form the end product.
Abstract: Herbicidally and insecticidally active 4-nitro-1-phenylpyrazoles of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl or halogenoalkyl,R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently is hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, or --(X).sub.n --R.sup.8,X is oxygen, sulphur, sulphinyl or sulphonyl,n is 0 or 1, andR.sup.8 is halogenoalkyl.
Type:
Grant
Filed:
March 4, 1986
Date of Patent:
May 24, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Reinhold Gehring, Uta Jensen-Korte, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Wolfgang Behrenz
Abstract: Pyrazole derivatives of the formula I: ##STR1## wherein R represents a lower alkyl group or a lower alkenyl group atoms which may be substituted by halogen atom,X represents a halogen atom, a lower alkyl group, nitro group, cyano group, a lower alkylsulfonyl group or trifluoromethyl group,n is an integer of 2 to 4,Q represents hydrogen atom; an aralkyl group which may be substituted by halogen atom, nitro group, cyano group or a lower alkyl group; benzenesulfonyl group which may be substituted by a lower alkyl group or halogen atom; benzoyl group which may be substituted by a lower alkyl group or halogen atom; phenacyl group which may be substituted by a lower alkyl group or halogen atom; a lower alkyl group which may be substituted by halogen atom; a lower alkenyl group which may be substituted by halogen atom; or a lower alkynyl group,and a method for preparation of said derivatives, a selective herbicidal composition containing said derivatives as active ingredient,as well as a method for controlling weeds
Abstract: Fungicidally active substituted pyrazolin-5-ones of the formula ##STR1## in which R.sup.1 and R.sup.2 independently of one another each represents hydrogen, alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, alkylaminocarbonylalkyl or dialkylaminocarbonylalkyl, or represents in each case optionally substituted oxiranylalkyl, aralkyl, heterocyclyl or aryl, andR.sup.3 represents halogenoalkyl, halogenoalkenyl or halogenoalkinyl, or represents substituted cycloalkyl, or represents substituted cycloalkylalkyl.
Type:
Grant
Filed:
October 31, 1986
Date of Patent:
May 10, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus Jelich, Wilhelm Brandes, Gerd Hanssler, Paul Reinecke
Abstract: Compounds having the formula: ##STR1## which are ester prodrugs of potent dopamine-.beta.-hydroxylase inhibitors and thus are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmeceutical compositions including these compounds, and methods of using these compounds to inhibit dopamine-.beta.-hydroxylase activity in mammals.
Type:
Grant
Filed:
April 8, 1986
Date of Patent:
May 10, 1988
Assignee:
SmithKline Beckman Corporation
Inventors:
James S. Frazee, Carl Kaiser, Lawrence I. Kruse, Stephen T. Ross
Abstract: Orally active prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2 -one are disclosed. Pharmaceutical formulations containing such compounds are also provided.
Type:
Grant
Filed:
October 17, 1986
Date of Patent:
May 10, 1988
Assignee:
Berlex Laboratories, Inc.
Inventors:
Paul W. Erhardt, Alfred A. Hagedorn, III