Patent number: 4690942
Abstract: The invention relates to 1-aryl-2-fluoro-2-azolyl alkanones, alkanols, esters and ethers of formula I ##STR1## wherein Az is 1H-1,2,4-triazole, 4H-1,2,4-triazole or 1H-imidazole;T is --C(O)--, --CH(OH)-- or one of the groups ##STR2## wherein R.sub.7 is C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by C.sub.1 -C.sub.3 -alkoxy, halogen or cyano, or is C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, 2-furyl, 2-tetrahydrofuryl, or is phenyl or benzyl, each unsubstituted or substituted by halogen, nitro, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkyl and/or C.sub.1 -C.sub.3 haloalkoxy;R.sub.8, R.sub.9 and R.sub.10 are each independently hydrogen, nitro, halogen, cyano, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkoxy, --COO(C.sub.1 -C.sub.3 alkyl), NH.sub.2 or NHCOCH.sub.3 ;R is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.1 and R.sub.2 are each independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.
Type:
Grant
Filed:
December 14, 1984
Date of Patent:
September 1, 1987
Assignee:
CIBA-GEIGY Corporation
Inventors:
Willy Frick, Alfred Meyer, Robert Nyfeler
Patent number: 4689414
Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3, or halo substituted alkyl;R.sub.4 is aryl or heterocyclo;R.sub.5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, ##STR2## Y.sub.1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH.sub.2).sub.m --O--, mercapto, alkylthio, aryl-(CH.sub.2).sub.m --S--, amino, substituted amino, carbamoyl, ##STR3## Y.sub.2 is cycloalkyl, aryl, heterocyclo, carbamoyl, ##STR4## amino, or substituted amino; m is 0 or an integer of 1 to 6;n is an integer of 1 to 6; andp is an integer of 2 to 6.
Type:
Grant
Filed:
February 24, 1986
Date of Patent:
August 25, 1987
Assignee:
E. R. Squibb & Sons, Inc.
Inventor:
Karnail Atwal