Abstract: The present invention discloses a process for the purification of Mitragynine, particularly discloses purification of Mitragynine from the crude extracts, for the pharmaceutical preparations. More particularly, the present invention discloses purification of Mitragynine using weak acid and weak base. The obtained purified Mitragynine is with fewer impurities.

Abstract: The present disclosure relates to anti-microbial film, and more particularly to anti-microbial film for packaging of a perishable item. According to an aspect, the present disclosure is directed to a packaging film comprising a polymer film having a surface, and an antimicrobial agent chemically linked to the surface. According to an aspect, the present disclosure is directed to a method of preparing a packaging film, the method comprising: (a) providing a polymer film having a surface; (b) modifying the surface by UV, plasma or corona treatment; and (c) chemically linking an antimicrobial agent to the modified surface. In an embodiment, the packaging film may be used in packaging for a perishable item.

Abstract: Present invention teaches the method of using a keratin hydrolysis peptide (“KHP”) solution to promote the growth of soybean plants under flood stress. By selectively choosing specific weights of feathers and water, and treating the mixture to a high-temperature high-pressure hydrolysis process, the resulting solution is confirmed to contain at least 253 peptides and then apply to the soil containing the soybean at a specific growth stage after germination. Optionally, the KHP solution can be diluted by water as disclosed in the application.

Abstract: Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.

Abstract: Disclosed are compositions, materials, garments, devices, and methods for controlling or neutralizing offensive odors associated with mammalian urine. For example, disclosed are personal care products (e.g., diapers), deodorizing colloidal compositions, urine-based fertilizers, portable urination systems, and methods of their use. Such deodorizing colloidal compositions, urine-based fertilizers, portable urination systems are characterized in that they contain an acrylate polymer comprising at least one acrylic acid monomer or salt thereof, which imparts an odor-neutralizing effect. Also provided are methods of recovering water from the systems disclosed herein.

Abstract: The present invention relates to a composition for hangover relief, comprising a noni fruit extract or a fraction thereof, and more specifically provides a noni fruit extract or a fraction thereof, which is prepared using a certain concentration of ethanol as an extraction solvent, to contain a large amount of polysaccharides having excellent hangover relieving functionality and an average molecular weight of 8 kDa to 10 kDa.

Abstract: Provided are an ultrafine gold nanocomposite, and a preparation method and use thereof. The preparation method of the ultrafine gold nanocomposite includes the following steps: mixing a cyclodextrin metal-organic framework (CD-MOF) material, chloroauric acid and a solvent to obtain a mixture, and subjecting the mixture to incubation to obtain the ultrafine gold nanocomposite.

Abstract: The present invention relates to methods and compositions for monitoring a cellular membrane or a cellular membrane coated nanoparticle after in vivo administration.

Abstract: A method and device provide vaginal protection from entrance of substances and includes a device for insertion into the human vagina/vaginal canal to prevent unintentional entry of substance of materials into the vagina/vaginal canal such as soaps, irritants, waxes in the case of bikini waxing and specifically Brazilian waxing procedure, pubic hair removal creams/lotions and the like, that may initiate or foster regional infections etc. The method and device also serve to block odors when inside the vagina/vaginal canal.

Abstract: Disclosed herein are DNA origami nanostmcture that can be functionalized for personalized and targeted drug delivery. The disclosed nanostructures enter cells through the endolysosomal pathway and circumvent drug resistance mechanisms in target cells. The disclosed nanostructures can be loaded small molecule drugs (e.g. anthracyclines, anti-metabolites) and nucleic acids (e.g. antisense oligonucleotides, siRNA, miRNA) with targeting and/or therapeutic antibodies against tumor-specific antigens (e.g. anti-CD33, anti-CD20) that can be modified to treat to a wide range of cancers and ultimately tailored to specific patients' needs for precision medicine.

Abstract: The object of the present invention concerns a hair restructuring association comprising or alternatively consisting of: (a) a quaternary ammonium salt of formula (I) and (b) at least one sulpho-derivative of vegetable fatty acids, wherein R5, R6 are independently chosen between hydrogen and a radical R0, R0 consists of the following structure of formula (II), R1 is chosen from the group consisting of: hydrogen, methyl, isopropyl, sec-butyl, isobutyl, ethylenemethylthio, benzyl, para-hydroxybenzyl and 3-methylene-1H-indole, R2, R3, R4 are independently chosen from the group consisting of: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, mX? is chosen from the group consisting of: formic acid, acetic acid, unsaturated monocarboxylic acids, adipic acid, aldaric acid, oxalic acid, phthalic acid, azelaic acid, sebacic acid, malonic acid, succinic acid, tartaric acid, glutaric acid, pimelic acid, maleic acid, malic acid, fumaric acid and suberic acid, isocitric acid, citric acid, fa

Abstract: A method for translocating a cationic micro/nanoparticle across a mucus layer, the method including (a) contacting the mucus layer with at least one alginate oligomer, the alginate oligomer having at least 70% mannuronate residues, together with the cationic micro/nanoparticle; or (b)(i) contacting the cationic micro/nanoparticle with an alginate oligomer having at least 70% mannuronate residues thereby forming a micro/nanoparticle carrying the alginate oligomer, and (b)(ii) contacting the mucus layer with the micro/nanoparticle prepared in step (b)(i).

Abstract: Described herein are pet food compositions for reducing circulating pro-inflammatory cytokines in companion animals. Methods of making and using the same are also described.

Abstract: The present disclosure relates to a composition for preventing or treating lung cancer, comprising a compound isolated from a Cephalotaxus extract as an active ingredient. Isoharringtonine, which is the compound isolated from the Cephalotaxus extract according to the present disclosure, induces apoptosis and exhibits the effect of inhibiting the growth of non-small cell lung cancer cell lines, and thus can be useful in the prevention or treatment of lung cancer. In addition, the combined treatment of isoharringtonine and siNR4A1 enhances anticancer activity, and the combined treatment of isoharringtonine and cisplatin, which is a conventional anticancer drug, induces a high anticancer effect at a low concentration of cisplatin, thereby reducing side effects of anticancer treatment.

Abstract: The invention described herein relates to a therapeutic, moisturizing coating composition for elastomeric articles which is applied directly onto the skin-contacting surface of the article as part of the manufacturing process. The coating composition is thermally stable and subsequently hydrates when contacted with a moisturized skin surface to convert into a liquid “lotion” form during wearing of the article. The coating composition provides therapeutic benefits to the wearer's skin as a result of wearing the article, such as improved skin moisturization, softness of feel, improved skin elasticity and firmness, and reduced redness and irritation. The invention is particularly useful in medical gloves, including examination and surgical gloves.

Abstract: Provided is a pharmaceutical composition and application thereof, specifically, said pharmaceutical composition comprises: salvianolic acid B as a first active ingredient; and ginsenoside Rg1 as a second active ingredient, and the weight ratio of the first active ingredient to the second active ingredient being 5:(1-4.5). The pharmaceutical composition has a better active-ingredient proportion than the prior art, has a better therapeutic efficacy in preventing and/or treating ischemic diseases, and ischemia-reperfusion tissue or organ damage, and can be used for treating ischemia and/or ischemia-reperfusion damage of different tissues and organs.

Abstract: A solid material including a matrix, dispersed in which are microparticles of at least one antimicrobial agent for preventing, limiting and/or eliminating the contamination of the material and/or the contamination of a composition which is in contact with the material for at least a given time, and/or preventing, eliminating and/or slowing down the formation of biofilms on the surface of the material, wherein the antimicrobial agent is an oxide of at least one positively charged metal ion and the antimicrobial agent does not migrate out of the material. Also, the use of such material for manufacturing an article, to the process for manufacturing the article, and to the article obtained.

Abstract: The present application provides powder metal ion disinfectant compositions, methods for preparing powder metal ion disinfectant compositions, and methods of disinfecting an article and/or maintaining the pathogenic sterility of the article using the solid powder metal ion disinfectant composition. These solid powder disinfectant compositions are light stable heat stable, non-toxic, and non-corrosive, achieve a greater than 99% kill rate of a variety of pathogens for up to 60 days on a variety of surfaces, and do not contain nanoparticles.

Abstract: Compositions and methods for improving one or more agronomic traits of a plant are provided, which include the use of one or more fatty acids that kill or inhibit the growth of cells in the shoot apical meristem and optionally one or more surfactants. Use of the composition between vegetative growth stage 1 (V1) and vegetative growth stage 6 (V6) is described.

Abstract: A refining method according to the present invention is a refining method for crystallizing a compound with at least one crystal form, including: setting, as a target wavelength, a specific infrared wavelength at which a specific crystal form precipitates from a solution of the compound dissolved in a solvent; and using an infrared radiation apparatus capable of emitting infrared radiation including the target wavelength to evaporate the solvent and precipitate the specific crystal form while irradiating the solution with infrared radiation including the target wavelength. The specific infrared wavelength is preferably set as the target wavelength based on an infrared absorption spectrum of the crystal form and the dissolution rate of the compound in the solvent.