Abstract: The disclosure relates to a metal phenolic network (MPN) composition for treating algae in an aqueous environment, in particular to entrap/capture, flocculate, and settle or otherwise remove the algae from a location where it damages the aqueous environment and/or harms organisms in the aqueous environment. The MPN composition includes a metal phenolic network (MPN) film and a secondary flocculant such as a clay material or ionic flocculant. Application of the MPN composition to an aqueous environment, for example a marine environment containing a harmful algal bloom (HAB) induces flocculation of the algae with the MPN composition and sedimentation of the resulting floc. Algae removed from a surface region of the aqueous environment in this way eventually kills the algae at least due to a lack of sunlight, and reduces or eliminates the ability of the algae to further damage the aqueous environment until its eventual death.
Type:
Grant
Filed:
November 2, 2020
Date of Patent:
September 13, 2022
Assignee:
The Administrators of the Tulane Educational Fund
Abstract: A polyethylene terephthalate functionalized with polyether amine to obtain antibacte-rial properties is described. Described are also uses of and methods for producing this functionalized polyester.
Abstract: Suggested is a preservative mixture with improved solubility comprising or consisting of (a) 4-isopropyl-3-methylphenol; (b) at least one hydrophilic solvent having a log Po/w of 1.2 or below; and (c) at least one lipophilic solvent having a log Po/w of above 1.2.
Type:
Grant
Filed:
August 24, 2016
Date of Patent:
August 2, 2022
Assignee:
Symrise AG
Inventors:
Manuel Pesaro, Sabine Lange, Vanessa Schade
Abstract: A wound dressing including a hydropolymer matrix crosslinked with genipin and a plurality of thymol nanoparticles loaded into the hydropolymer matrix. The plurality of thymol nanoparticles has a concentration between 0.01 wt. % and 1 wt. % of dry weight of the wound dressing. The hydropolymer matrix includes gelatin, chitosan, polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC).
Abstract: A liquid formulation is described for the treatment of wood in plants such as vines, almond trees and the like, to enhance self-defences and resistance of the plant against fungal diseases. The formulation consists in a compound made from copper, essential plant amino acids, menadione sodium bisulphite and water, where the copper is incorporated in the form of nanoparticles with a size under 60 nm, and in a proportion of less than 1.0% by weight. The application of the formulation allows incorporation thereof in different fertiliser irrigation methods, or via the leaves with a spraying device.
Type:
Grant
Filed:
March 12, 2018
Date of Patent:
June 28, 2022
Assignee:
AGROSTOCK, S.A.
Inventors:
Jorge Casas Chiné, Jose Luis Ordoñez Ramos, Ernesto Francisco Simó Alfonso, Enrique Javier Carrasco Correa
Abstract: Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.
Type:
Grant
Filed:
October 19, 2018
Date of Patent:
June 28, 2022
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Jason J. Locklin, Qiaohong Liu, Priyadarshini Singha, Hitesh Handa, Jitendra Pant, Marcus J. Goudie, Sean P. Hopkins
Abstract: Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
Type:
Grant
Filed:
March 25, 2019
Date of Patent:
June 21, 2022
Assignee:
YALE UNIVERSITY
Inventors:
Yang Deng, Asiri Ediriwickrema, William M. Saltzman
Abstract: Sunscreen compositions containing bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT) and zinc oxide, especially non-nano zinc oxide materials, with synergistic effects on enhancing in vivo sun protection factor (SPF) and UVA protection factor (PFA) values, and methods of preparation and applications thereof are disclosed.
Type:
Grant
Filed:
June 1, 2017
Date of Patent:
June 14, 2022
Assignee:
Kobo Products, Inc.
Inventors:
David Schlossman, Yun Shao, Luna Fascina
Abstract: The present disclosure provides a method for preparing inorganic nanoparticle-gelatin core-shell composite nanoparticles, comprising: dissolving gelatin in a aqueous solution (in which inorganic nanoparticles are dispersed in) to obtain the gelatin-contained aqueous solution, dropwise adding a polar organic solvent to obtain a suspension of inorganic nanoparticle-gelatin core-shell composite particles of nanometer size or submicrometer size, then adding a cross-linking agent thereto to cross-link the gelatin components of the composite particles, followed by washing step to finally obtain inorganic nanoparticle-gelatin core-shell composite micro/nano-particles with inorganic nanoparticles as the core and gelatin as the shell.
Abstract: The invention provides buffers stable to oxidants, including chlorine and hypochlorous acid, which are usable in the pH range 3-7. The invention also provides stable, buffered solutions comprising hypochlorous acid, having a pH between 3 and 7, and disposable wiping articles impregnated with these solutions.
Type:
Grant
Filed:
January 17, 2018
Date of Patent:
May 3, 2022
Assignee:
Pharmocon LLC
Inventors:
John F O'Connell, Jr., James P Demers, Darryl C Rideout
Abstract: A pharmaceutical pellet is disclosed, comprising a spherical core containing active ingredient with a smooth surface and a coating on the core which controls the release of the active ingredient in a pH-independent manner. With such a pellet the release of the active ingredient can follow a profile with a lag phase of 60 minutes to 840 minutes, a proportion of 5 wt. % or less of the active ingredient being released during the lag phase. The active ingredient can furthermore be released from the pellet with a profile such that after the lag phase the release of the active ingredient amounts to between 3 and 25 wt. % per hour.
Type:
Grant
Filed:
August 10, 2005
Date of Patent:
April 26, 2022
Assignee:
ADD ADVANCED DRUG DELIVERY TECHNOLOGIES LTD.
Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
April 26, 2022
Assignee:
Washington University
Inventors:
Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
Abstract: Organosilicon compound microparticles and process for their preparation It is provided a combination of an organosilicon compound and arabic gum in the form of microparticles, wherein the organo silicon has the formula (I): wherein R1 and R2 are independently selected from hydrogen and a (CrC4)alkyl group; R3 is hydroxyl; and R4 is hydroxyl or a (CrC4) alkyl group; the arabic gum is forming a polymeric matrix having interspaces, and the organosilicon compound is distributed in the interspaces of the polymeric matrix. It is also provided a process for its preparation and a composition comprising the mentioned combination.
Abstract: The present invention is directed to copolypeptide hydrogels (DCH) containing non-ionic hydrophilic residues (DCHEO), incorporation of thermoresponsive elements into DCHEO, to generate thermoresponsive DCH (DCHT), and hydrogels that include a combination of DCHEO and DCHT. The invention includes preparation, uses, compositions containing the hydrogels and methods of tuning the hydrogels. The hydrogels can be used to deliver an agent or cells to an organism.
Type:
Grant
Filed:
October 1, 2015
Date of Patent:
April 12, 2022
Assignee:
The Regents of the University of California
Inventors:
Timothy J. Deming, Michael V. Sofroniew, Shanshan Zhang
Abstract: A system for delivering a therapeutic agent to cell or tissue of a subject includes a mesoporous silica iron oxide nanoparticle with one or more therapeutic agents that are contained in a mesoporous silica layer of the nanoparticle and a remote radiofrequency (RF) energy source for applying RF energy to the nanoparticle effective to release the one or more therapeutic agents from the nanoparticle by mechanical tumbling and/or vibration of the nanoparticle, wherein release of the one or more therapeutic agents not caused by a hyperthermic response of the nanoparticle to the RF energy.
Type:
Grant
Filed:
October 17, 2018
Date of Patent:
March 1, 2022
Assignee:
CASE WESTERN RESERVE UNIVERSITY
Inventors:
Efstathios Karathanasis, Watuthentrige Pubudu M. Peiris, Vindya Perera, Lisa Bauer
Abstract: Provided is a transdermal absorption preparation having superior drug skin permeability, which can uniformly disperse the drug in the preparation and maintain the uniform dispersion state of the drug. A transdermal absorption preparation having a plaster layer containing a drug, a polymer and a pH adjuster, in which the aforementioned polymer contains a polymer having a particular glass transition temperature of 30° C.-200° C., and the surface of the plaster layer has a pH of 6.7-10.0.
Abstract: An extrudable polyvinyl alcohol (PVA) powder with improved flowability containing particles of PVA, which has been cryo-milled, and which has d50 particle sizes in the range of 45 to 1400 ?m; or which has a particle size distribution of d10=20±10 ?m, d20=30±10 ?m, d50=70±10 ?m, d90=200±30 ?m, and d99=300±30 ?m; and a powdery composition for the preparation of pharmaceutical formulations which contains the polyvinyl alcohol homogeneously mixed with at least one active pharmaceutical ingredient (API); and a process for producing a solid pharmaceutical dosage form by extruding or forming a homogeneous melt of a mixture of ingredients containing the powdered polyvinyl alcohol and at least one active pharmaceutical ingredient (API), and forming a powder or a molded form.
Type:
Grant
Filed:
May 10, 2017
Date of Patent:
February 15, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Dieter Lubda, Mengyao Zheng, Nicole Di Gallo, Anja-Nadine Knuettel
Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.
Type:
Grant
Filed:
October 16, 2019
Date of Patent:
February 15, 2022
Assignee:
AbbVie Inc.
Inventors:
Nancy E. Sever, Ulrich Westedt, Ute Lander, Katrin Schneider, Benedikt Steitz, Thomas Mueller, Regina Reul, Constanze Obermiller, Adivaraha Jayasankar, Michael Simon, Yi Gao, Harald Hach, Samuel Kyeremateng, Katharina Asmus, Ping Tong, Donghua Zhu, Marius Naris, Colleen Garrett
Abstract: Compositions comprising complexes of 1-methylcyclopropene and ?-cyclodextrin, and articles including the composition, are provided. Methods for using the compositions and articles in delaying the maturation of fruits, vegetables, and plants are also provided.
Type:
Grant
Filed:
May 8, 2020
Date of Patent:
February 15, 2022
Assignee:
Fresh Inset S.A.
Inventors:
Andrzej Wolan, Mariusz Bosiak, Marcin Pakulski, Lucyna Czajkowska, Katarzyna Anna Guranowska, Roksana Katarzyna Radlowska
Abstract: The present invention relates to a composition in the form of an O/W emulsion, comprising: (a) at least one hydrocarbon-based block copolymer comprising at least one styrene block and at least one block comprising units chosen from butadiene, ethylene, propylene, butylene and isoprene or a mixture thereof, which are optionally hydrogenated; (b) at least one film-forming linear ethylenic polymer devoid of styrene; (c) at least one oil; and (d) water. The composition according to the present invention can maintain the form of an O/W emulsion for a long period of time, and can exhibit good cosmetic properties such as soft feeling to the touch, uniform adhesion to the skin and long lasting cosmetic effects.