Abstract: Systems, devices, and methods for monitoring and assessing blood glucose level in a patient are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. The physiologic information is correlated to, and different from, a direct glucose level measurement. The system determines a glucose index indicative of an abnormal blood glucose level using the received physiologic information by the two or more physiologic sensors. The system may use the glucose index to initiate or adjust a therapy, or to trigger a glucose sensor, separate from the two or more physiologic sensors, to directly measure blood glucose concentration.

Abstract: According to an embodiment of the present application, as a method of determining whether to output an alert of a user's thyroid dysfunction, there may be provided a thyroid dysfunction monitoring method including receiving a user's medication information from an external device; selecting a monitoring algorithm to be used to determine whether to output the alert on the basis of the medication information; and determining whether to output the alert on the basis of the selected monitoring algorithm.

Abstract: Sleep conditions such as moderate-to-severe sleep apnea can be assessed using a multi-night assessments. A respiration signal (e.g., acquired from a sensor strip) can be processed via a computing device. The respiration signal can be segmented and the segments can be classified to identify one or more apnea/hypopnea events. In some examples, some of the segments can be normalized such that each segment input for classification can be of the same size. The identified one or more apnea/hypopnea events can be used to estimate a nightly parameter indicative of a severity of (or presence of) sleep apnea. The nightly parameters from a multi-night period can be used to estimate a multi-night parameter indicative of the severity of (or presence of) sleep apnea. In some examples, quality checks can be performed to filter out some data (e.g., to exclude data from entire nights or exclude a portion of data from individual nights).

Abstract: A body fluid testing device having an improved illumination, includes: a test unit including: a sample part having a sheet portion, with body fluid of a user applied onto a first surface thereof; an illumination part having a light source for providing light to the sample part; a battery for supplying power to the illumination part; and a casing receiving a lens group for magnifying the body fluid applied onto the sheet portion; and a user terminal configured such that a camera takes an image of the sample part magnified by the lens group, prior to analyzing the image by the user terminal.

Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.

Abstract: Devices and methods for predicting risk and likelihood of post-operative gastrointestinal impairment based on regression analysis of multiple spectral events related to intestinal sounds, with decreased or eliminated falsely elevated values of those events due to ambient noise.

Abstract: A non-invasive analyte sensor device that includes a sensor housing, and a decoupled antenna/detector array having at least one transmit antenna/element and at least one receive antenna/element. The sensor housing has a maximum length dimension no greater than 50 mm, a maximum width dimension no greater than 50 mm, a maximum thickness dimension no greater than 25 mm, and a total interior volume of no greater than about 62.5 cm3. In addition, the at least one transmit antenna/element and the at least one receive antenna/element have a maximum spacing therebetween that does not exceed 50 mm and a minimum spacing therebetween that is at least 1.0 mm, and the at least one transmit antenna/element and the at least one receive antenna/element are less than 95% coupled to one another, or less than 90% coupled to one another, or less than 85% coupled to one another, or less than 75% coupled to one another.

Abstract: An insertion device includes an upper casing, an insertion module and a lower casing. The insertion module is disposed in the upper casing, and includes a main body assembly, an insertion seat, a first elastic member, a retraction seat and a second elastic member. When the upper casing is depressed, the insertion seat is driven by the first elastic member to perform an automatic-insertion operation, such that limiting structure between the insertion seat and the retraction seat collapses upon the collapse of another limiting structure between the insertion seat and the main body assembly, and that the retraction seat is driven by the second elastic member to perform an automatic-retraction operation.

Abstract: An example device includes processing circuitry configured to receive, from an oxygen sensor, an ambient air signal indicative of an oxygen partial pressure of ambient air. The processing circuitry is further configured to receive, from an atmospheric pressure sensor, an atmospheric pressure sensor signal indicative of atmospheric pressure. The processing circuitry is configured to determine, based on the atmospheric pressure sensor signal, an oxygen partial pressure of the ambient air, determine, based at least in part on the oxygen partial pressure of the ambient air and the ambient air signal, the one or more calibration parameters, and calibrate, based on the one or more calibration parameters, the oxygen sensor. The calibrated oxygen sensor may be used to, for example, determine the oxygen content of urine of a patient to monitor renal function of the patient.

Abstract: A method is provided for constructing a structured test having user-defined adherence criteria. The method includes: presenting a patient with a plurality of contextual criterion for a structured test; receiving selection of one or more contextual criterion from the plurality of contextual criterion; and constructing a structured test that includes the contextual criterion selected by the patient. During administration of the structured test, each of the contextual criteria selected by the patient is evaluated. Sample data acquired during the structured test is reported as compliant when each of the context criterion selected by the patient was met during the administration of the structured test or tagged as non-compliant when at least one contextual criterion was not met during the administration of the structured test.

Abstract: Methods and systems for monitoring blood pressure in a person are disclosed. A method for monitoring a blood pressure in a person involves transmitting millimeter range radio waves over a three-dimensional (3D) space below the skin surface of a person, receiving radio waves on multiple receive antennas, the received radio waves including a reflected portion of the transmitted radio waves that is reflected by blood in a blood vessel in the 3D space, isolating a signal that corresponds to the portion of the transmitted radio waves that is reflected by blood in the blood vessel in response to receiving the radio waves on the multiple receive antennas, and outputting a signal that corresponds to a blood pressure level in the person in response to the isolated signal.

Abstract: The present invention relates to a device (10) for determining an arterial compliance of a subject (12). The device (10) comprises an inflatable cuff (14), a pressure sensor (18) which is configured to sense a pressure signal (52) that is indicative of a pressure within the cuff (14), a second sensor (20) which is at least partly integrated in the cuff (14) and configured to sense a second signal (56) that is responsive to expansions and contractions of the cuff (14) caused by a pulsating blood flow in an artery (50) of the subject (12), and a processing unit (22). The processing unit is configured to determine based on said part of the pressure signal (52) a pulse pressure of the subject (12), to determine based on said part of the second signal (56) an arterial volume change of the artery (50) of the subject (12) during at least one cardiac cycle, and to determine the arterial compliance of the subject (12) based on pulse pressure and the arterial volume change.

Abstract: Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.

Abstract: Provided are a fluid control device capable of operating a piezoelectric pump even in a case where a low discharge pressure or a slow pressurization speed is required and a sphygmomanometer including the fluid control device. A fluid control device includes a piezoelectric pump that includes a piezoelectric element, a self-excited circuit that performs, upon application of a driving power source voltage thereto, self-excited oscillation to drive the piezoelectric element, a switch that interrupts the driving power source voltage for the self-excited circuit, and a control circuit that changes an on duty ratio of the self-excited circuit by switching between states of the switch at a predetermined switching frequency and a predetermined on duty ratio.

Abstract: A measurement method includes a first measurement in which a characteristic amount of a specific analyte in a biological fluid is measured with a biosensor. The method also includes a second measurement in which motion information of living activity is measured. Additionally, the method may include recording the motion information and the characteristic amount measured in the first measurement with the motion information and characteristic amount associated with each other.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprises at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: Continuous glucose monitoring (CGM) may include applying a periodic excitation signal via an electrode of a CGM sensor to human interstitial fluid to drive an oxidation/reduction reaction, and measuring the current through the electrode. In some embodiments, the measured current is sampled and digitized, and various harmonics of the excitation signal's fundamental frequency are extracted. A set of relationships of at least two harmonics each is generated from the spectral amplitudes of a set of pairs, triplets, etc., of the harmonics, and the set of relationships is mapped to a glucose concentration such as based on the contents of a harmonic relationship database having a pre-existing set of harmonic relationships and glucose concentrations to which those sets of harmonic relationships correspond, for example. Numerous other embodiments are provided.

Abstract: A blood-pressure-related information display device includes a data acquisition unit, a risk value calculator, and a display processor. The data acquisition unit acquires blood pressure data including a systolic blood pressure and a diastolic blood pressure for the subject. The risk value calculator obtains a systolic risk value representing a risk corresponding to the acquired systolic blood pressure and a diastolic risk value representing a risk corresponding to the acquired diastolic blood pressure based on a predetermined blood pressure standard. The display processor performs processing of displaying a risk range from the systolic risk value to the diastolic risk value in a curved or straight elongated display region defining a one-dimensional risk coordinate in the display screen.

Abstract: Various analyte sensor systems for controlling activation of analyte sensor electronics circuitry are provided. Related methods for controlling analyte sensor electronics circuitry are also provided. Various analyte sensor systems for monitoring an analyte in a host are also provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller responsive to a wake up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronics circuitry utilizing a magnetic sensor are further provided. One or more display device configured to display one or more analyte concentration values are also provided.

Abstract: Continuous glucose monitoring (CGM) may include applying a periodic excitation signal via an electrode of a CGM sensor to human interstitial fluid to drive an oxidation/reduction reaction, and measuring the current through the electrode. In some embodiments, the measured current is sampled and digitized, and various harmonics of the excitation signal's fundamental frequency are extracted. A set of relationships of at least two harmonics each is generated from the spectral amplitudes of a set of pairs, triplets, etc., of the harmonics, and the set of relationships is mapped to a glucose concentration such as based on the contents of a harmonic relationship database having a pre-existing set of harmonic relationships and glucose concentrations to which those sets of harmonic relationships correspond, for example. Numerous other embodiments are provided.