Abstract: An attachment mechanism is used to attach a component to a particular location on a tube in a blood sampling-blood pressure monitoring system by a user. The attachment mechanism may include a piercing feature. The piercing feature may be used to pierce the tube to attach the component to the particular location on the tube of the blood sampling-blood pressure monitoring system selected by the user.

Abstract: Blood pressure signals are reconstructed from PhotoPlethysmoGraphy (PPG) signals by: receiving PPG signals including systolic, diastolic and dicrotic phases; and determining first and second derivatives of the PPG signals and: a first set of values indicative of lengths of the signal paths of the PPG signal, the first derivative and the second derivative thereof in the systolic, diastolic and dicrotic phases; a second set of values indicative of relative durations of the PPG signal and the first and second derivatives thereof in the systolic, diastolic and dicrotic phases; and a third set of values indicative of the time separation of peaks and/or valleys in subsequent waveforms of the PPG signal. Reconstruction also includes applying artificial neural network processing to the first, second and third set of values. The artificial neural network processing includes artificial neural network training as a function of blood pressure signals to produce reconstructed blood pressure signals.

Abstract: A pulse signal generator circuit generates first and second pulse signals for electrodes placed on the chest of a subject with phases that differ by 180°. A rectifier circuit receives a potential difference signal, which reflects an impedance between the electrodes that changes according to respiratory motion and in which timing of changes caused by changes in the first pulse signal or the second pulse signal is delayed from the timing of the changes in the first pulse signal and the second pulse signal, and outputs a rectified signal produced by rectifying the potential difference signal. A control signal generator circuit causes the rectifier circuit to invert the potential difference signal, which becomes a negative voltage value from the certain timing, to a positive voltage value from the certain timing. An AD converter circuit outputs a digital value based on the magnitude of the rectified signal.

Abstract: A sensor is configured for measuring skin conductance. An amplifier is used to convert the skin conductance into an analog output voltage which is then converted into the digital domain by an analog-to-digital converter, so that an increase in the tonic skin conductance and the phasic skin conductance response are obtained in the digital domain. The amplifier has a non-linear logarithmic gain, with a decreasing gain for increasing skin conductance values. The sensor enables detection of increases in both tonic and phasic signals over a wide range of skin conductance. This allows the use of a lower resolution, and therefore lower cost, analog-to-digital converter.

Abstract: A wearable health monitoring device is disclosed. The device includes an attachment feature configured to engage with an attachment feature of an alignment element that is to be worn on the skin of a person, An RF front-end including a semiconductor substrate, at least one transmit antenna configured to transmit radio waves below the skin surface of the person, and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, a digital baseband system configured to generate digital data in response to the signals, wherein the digital data is indicative of a health parameter of the person, and a communications interface configured to transmit the digital data generated by the digital baseband system from the wearable health monitoring device.

Abstract: Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprise at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

Abstract: Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensity associated with a stationary blood sample and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage.

Abstract: A pulse wave detection method includes: increasing a pressing force of a pressing member for pressing a strain sensor fixed thereto against a body surface, the flexible strain sensor having a plurality of strain detection elements arranged on a substrate; determining a deformation stop timing at which deformation of a detection face of the strain sensor has been stopped based on the strain detection signal detected by each of the plurality of strain detection elements in a pressure raising process in which the pressing force is increased; setting a level of the strain detection signal detected at the deformation stop timing as a reference level; calibrating the first strain detection signal detected after the deformation stop timing based on the reference level; and generating a pressure signal from the calibrated first strain detection signal.

Abstract: Provided herein are systems, methods and apparatuses for an Antenna Design for Biomarker Monitoring.

Abstract: A method of simulating a tremor in a subject and evoking an empathetic response in the subject towards a patient suffering from tremors, the method comprising: synthesizing a tremor inducing signal, which may be done by capturing and analyzing EMG measures of electrical pulses derived from a sensed neuromuscular event associated with tremors experienced by a patient; and applying an electrical muscle stimulation to the subject using the synthesized pulses associated with the patient experiencing tremors.