Abstract: Continuous glucose monitoring (CGM) may include applying a periodic excitation signal via an electrode of a CGM sensor to human interstitial fluid to drive an oxidation/reduction reaction, and measuring the current through the electrode. In some embodiments, the measured current is sampled and digitized, and various harmonics of the excitation signal's fundamental frequency are extracted. A set of relationships of at least two harmonics each is generated from the spectral amplitudes of a set of pairs, triplets, etc., of the harmonics, and the set of relationships is mapped to a glucose concentration such as based on the contents of a harmonic relationship database having a pre-existing set of harmonic relationships and glucose concentrations to which those sets of harmonic relationships correspond, for example. Numerous other embodiments are provided.

Abstract: The present invention provides a sampling capsule and a sampling capsule system. The sampling capsule includes an enclosure, a partition wall arranged in the enclosure, and a sample chamber enclosed by the partition wall and the enclosure at a first side of the partition wall. The sampling capsule further includes an inner sample inlet on the partition wall, an outer sample inlet, a sampling tube and a switch assembly. The outer sample inlet is on the enclosure at a second side of the partition wall. The sampling tube connects the outer sample inlet and the inner sample inlet, and the switch assembly clamps or unclamps a portion of the sampling tube. When sampling is needed, the switch assembly unclamps the sampling tube to sample liquid. When sampling ends, the switch assembly tightly clamps the sampling tube to prevent sample liquid leak or contamination.

Abstract: Systems and methods for lean muscle mass monitoring of patients and for identifying and treating at least one of Cachexia or Sarcopenia are disclosed. The system may include a dynamometer provided to patients, the dynamometer being configured to perform remote monitoring. The dynamometer may be used and data may be collected by patients without the supervision of a healthcare professional. Using the collected data, lean muscle mass may be tracked over time, to provide fast and accurate assessment of conditions. Using such an assessment, early treatment options can be targeted to patients to avoid progression into various disease states, for examples, more severe states of at least one of Cachexia or Sarcopenia.

Abstract: An apparatus and method for detecting a bio-signal feature are provided. The apparatus according to one aspect may include: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to generate an envelope signal of the bio-signal, and detect at least one feature of the bio-signal based on a difference between the envelope signal and the bio-signal.

Abstract: A removable smartphone case is disclosed. The removable smartphone case includes a case body configured to receive a smartphone, a radio frequency (RF) front-end connected to the case body and including a semiconductor substrate, at least one transmit antenna configured to transmit radio waves below the skin surface of a person, and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, a digital baseband system configured to generate digital data in response to the signals, wherein the digital data is indicative of a health parameter of the person, and a communications interface configured to transmit the digital data generated by the semiconductor substrate from the removable smartphone case.

Abstract: A puncture apparatus includes: a needle member having a tubular shape and comprising a flexible portion that is deformable; and a puncture assisting member that is movable or deformable in an axial direction of the needle member between: a restricting position in which the puncture assisting member is located outside the flexible portion of the needle member in a radial direction of the needle member, and thereby restricts deformation of the flexible portion, and a permissive position in which the puncture assisting member is not located outside the flexible portion in the radial direction, and thereby permits deformation of the flexible portion. The puncture assisting member is configured to move or deform from the restricting position to the permissive position in conjunction with an operation of inserting the flexible portion into a living body at a time of puncturing the living body with the needle member.

Abstract: What is disclosed is a system for measurement and analysis of blood pressure of a test subject comprising a blood pressure measuring cuff unit; a waveform analysis subsystem coupled to said blood pressure measuring cuff unit via a network; and wherein said cuff unit acquires a digital pulse pressure waveform from a wrist of the test subject, said digital pulse pressure waveform is transmitted over said network to said waveform analysis subsystem, and said waveform analysis subsystem processes said digital pulse pressure waveform to extract one or more blood pressure parameters and hemodynamic parameters.

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

Abstract: A method of in vivo conditioning of an indwelling sensor to reduce run-in time, (stabilization time) comprising: a) applying a first potential to the sensor and measuring a first current at the first potential; b) applying a second potential to the sensor and measuring a second current at the second potential; c) determining a relationship of the first current measured to the second current measured; repeating a, b, and c until the relationship between the first current measured and the second current measured has stabilized, thereby reducing sensor run-in time.

Abstract: A fluid control device includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has sequestration portion that can be vented or evacuated. The fluid control device has a first state in which an initial volume of bodily fluid can flow from the inlet to the sequestration portion and a second state in which (1) the initial volume is sequestered in the sequestration portion, and (2) a subsequent volume of bodily fluid, being substantially free of contaminants, can flow through at least a portion of the fluid control device and into the fluid collection device. The fluid control device can transition automatically or in response to an actuation of a portion of the fluid control device after the sequestration portion receives the initial volume.

Abstract: A system and method for extracting breathing patterns from PPG signals are provided. The method includes designing a filter for extracting breathing patterns from PPG signals. Designing the filter includes defining filter specifications for extraction of breathing pattern from the PPG signals. Herein, the filter specifications includes a type, an order and a cut-off frequency of the filter. Designing the filter further includes generating a transfer function associated with the filter specifications, and computing a plurality of filter coefficients using filtfilt function for allowing filtering of the PPG signals. Using the filter comprising the plurality of filter coefficients, a filtered PPG signal is generated by removing DC component from PPG signals obtained from a wearable device being worn by a subject. The filtered PPG signal is indicative of the breathing pattern of the subject.

Abstract: There is provided a device and method of filtering outliers from physiological values. The method comprises: (a) populating a window with n physiological values taken, in sequence, from a sequence of physiological values, wherein n is a positive integer; (b) determining whether the variability in the physiological values within the window is less than a predetermined threshold; (c) responsive to the variability in the physiological values within the window being less than a predetermined threshold, determining that the window comprises no outliers, and/or responsive to the variability in the physiological values within the window not being less than a predetermined threshold, determining that the window comprises at least one outlier.

Abstract: Disclosed herein are sensors for sensing analyte concentration values, and methods of operating such sensors. The sensors include a sensor probe comprising two electrodes; a voltage controller operably connected to the two electrodes of the probe, the voltage controller operable to apply multiple voltage pulses to one of the electrodes; a current sensor operable to measure a current response to the multiple voltage pulses; and a processor module operably connected to the current sensor, the processor module operable to calibrate the current sensor on the basis of the current response.

Abstract: Disclosed herein are a system and a method for volitional electromyography (vEMG) signal detection from an EMG signal when functional electrical stimulation (FES) is applied. The system for vEMG signal detection includes a receiver for receiving data from an EMG electrode when FES is applied, a memory for storing a program for detecting a vEMG signal using the received data, and a processor for executing the program, wherein the processor cuts the data received from the EMG electrode disposed at a predetermined position, calculates a difference between data for previous FES and data for current FES, and detects the vEMG signal using the calculated difference.

Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.

Abstract: Various analyte sensor systems for controlling activation of analyte sensor electronics circuitry are provided. Related methods for controlling analyte sensor electronics circuitry are also provided. Various analyte sensor systems for monitoring an analyte in a host are also provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller responsive to a wake up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronics circuitry utilizing a magnetic sensor are further provided. One or more display device configured to display one or more analyte concentration values are also provided.

Abstract: A height correction device measures height information on the reference position of the heart and height information on the wrist to which a blood pressure measurement device is attached using communication technology when the body of a subject rotates or moves at the position where the measurement device is attached during the measurement period including the sleep period, subjects the obtained blood pressure measurement values to height correction using height information, and approximates the obtained blood pressure measurement values to blood pressure measurement values measured at the reference position of the heart, to thereby obtain highly accurate measurement values.

Abstract: System comprises a first sensing unit, attached to a proximal portion of a human body with a joint of the human body as a reference, for measuring an acceleration of the proximal portion or an angular velocity of the proximal portion; a second sensing unit, attached to a distal end portion of the human body, for measuring an acceleration of the distal end portion or the angular velocity of the distal end portion; a processing unit for determining an angle of the joint between the proximal portion and the distal end portion on the basis of the measured acceleration or the measured angular velocity and determining a spasticity time point at which resistance to motion of the distal end portion is received; and a display unit for displaying spasticity evaluation information for a spasticity evaluation on the basis of the angle of the joint and the spasticity time point.

Abstract: An exercise support apparatus is capable of supporting exercise taken by a patient during blood purification treatment and includes an estimation generating device that generates an estimation representing a circulating-blood-volume rate of change regarding a circulating blood volume that is estimated to be observed after the exercise is started, the estimation being generated after the blood purification treatment is started and from a continuous measurement of the circulating-blood-volume rate of change as regarding changes in circulating blood volume that is conducted before the exercise is started; a calculating device that calculates a difference between a measured value of the circulating-blood-volume rate of change that is acquired after the exercise during the blood purification treatment is started and a value of the estimation generated by the estimation generating device; and a first monitoring device that monitors whether the difference or ratio calculated by the first calculating device is over a

Abstract: A blood pressure data processing apparatus including a peak selection unit, a frequency component suppression unit, a respiratory fluctuation calculation unit, an attenuation amount calculation unit, and a respiratory cycle determination unit. The frequency component suppression unit suppresses components of the selected peak frequency within the first spectrum, and generates a second spectrum. The respiratory fluctuation calculation unit calculates a first respiratory fluctuation in second blood pressure data, and calculates a second respiratory fluctuation in third blood pressure data, which is a time domain representation of the second spectrum. The attenuation amount calculation unit calculates an attenuation amount of the second respiratory fluctuation relative to the first respiratory fluctuation. The respiratory cycle determination unit determines a cycle corresponding to the selected peak frequency as a respiratory cycle of a user if the attenuation amount is greater than a threshold.