Abstract: A heteroaryl[4,3-c]pyrimidin-5-amine derivative, a preparation method therefor, and medical uses thereof are provided. Specifically, a heteroaryl[4,3-c]pyrimidin-5-amine derivative of formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and uses thereof as therapeutic agents are provided. In particular, the provided compounds can be used as A2a receptor antagonists and for treatment of conditions or symptoms that are ameliorated by inhibiting the A2a receptor. The various substituent groups in the formula (I) have the meanings as described in the specification.

Abstract: An example joiner system for joining a first section and a second section of a fixture includes a joiner bracket that has formed therein a depressed ramp region. A joiner fastener, such as a screw, may engage against the angled walls of the joiner bracket ramp, to translate the vertical movement of the screw into a horizontal, longitudinal movement of the joiner bracket. The joiner bracket may be rigidly coupled to one section of a light fixture assembly, such that engaging the screw ramp with a fastener that extends through another section of the light fixture causes the two fixture sections to move toward each other. As vertical movement of a fastener produces horizontal movement of the joiner bracket, the joiner fastener or set screw may extend outside of the light fixture assembly, so as to be readily accessible by a technician.

Abstract: Provided herein are processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide.

Abstract: A self-centering cable strap centers items such as cables, wires and tubes, or bundles thereof, on a bed of the strap. A cinch strap extends from one side of the bed and abutment figures extend from a side of the bed opposite the cinch strap and project laterally and axially relative to the bed.

Abstract: An arrangement for fastening at least one elongated object (1) in a motor vehicle is suggested, where by means of a fastening means (4) the elongated object (1) is attached to at least one fixed point on the fastening element (2). The fastening element (2) is releasably connectable to the receiving element (3) and fixedly mounted at the fixed point.

Abstract: Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.

Abstract: An anchor assembly for hanging an object on a wall includes a first anchor component and a second anchor component. The first anchor component includes a base having front, back, top, bottom, left and right sides, and at least one wall penetrating retainer extending from the base and having a wall penetrating extent that protrudes rearwardly of the base and has a downwardly curved configuration. The second anchor component includes a base having front, back, top, bottom, left and right sides, at least one wall penetrating retainer extending from the base of the second anchor component and having a wall penetrating extent that protrudes rearwardly of the base of the second anchor component and has a curved configuration. The second anchor component is pivotably associated with the first anchor component for movement between an anchoring orientation and a non-anchoring orientation.

Abstract: The present invention provides compounds of the Formula wherein L is selected from the group consisting of —CH2NHCH2—, —CH2NH—, —NH—, —S—, —S(O)—, —S(O)2—, —O—, —OCH2—, —OCH2CH2O—, —NHSO2NH—, or a pharmaceutically acceptable salt thereof; a compound of the formula: processes for preparing the compounds and their salts, a pharmaceutical composition, and methods of treating patients in need of such treatment.

Abstract: A flexible lap food and beverage drip guard is disclosed. The food and drip guard may include a non-slide surface to act as a desk top for mobility devices such as, for example, cell phones and lap top computers. The device may further include textured upper surface to divert the flow of fluids to a catch pocket on either side of the device, and the bottom surface may be textured or honey combed to provide insulating properties to the user.

Abstract: The present invention relates to a method of separating racemic nicotine of Formula (1-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (1-b) and (1-c), by adding a mixture of the L- and the D-enantiomer of a O,O?-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (1-b), or by adding O,O?-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (1-c).

Abstract: A system for mounting an object in an opening in a structural member that has opposing first and second surfaces, the system including a housing with an interior to house the object and receivable within the opening in the structural member, the housing having at least one bendable tab to bear against and support the housing on the first surface of the structural member, the housing further including at least one pair of openings, and a trim ring having an interior side and an opposing exterior side, the interior side having one tab shaped to engage an opening in the pair of openings, the trim ring further including at least a second tab sized and shaped to engage an opening in a second pair of openings in the housing and thereby hold the trim ring in place on the housing while bearing against the second surface of the structural member.

Abstract: The Present Invention relates to process for the preparation of 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one represented by the following structural formula-1.

Abstract: The present invention relates to certain novel substituted thiophene compounds and the finding that they display useful efficacy in the inhibition of the p38? MAPK enzyme. This provides for use of the compounds in various treatment methodologies related to MAPK inhibition, including the treatment of inflammation.

Abstract: The present invention relates to cyclopentane compounds of Formula (I), physical forms thereof, processes for their production and their use in medicine.

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.

Abstract: An apparatus that at least stores objects of varying sizes, said apparatus includes adjustable trays configured to support the objects at bottom surfaces thereof and stationary or mobile panels for mounting the trays in a generally vertical plane. The panels can be provided as pegboard types or as slatwall types. The adjustable trays include a pair of brackets connected with a guide. A mounting portion of each bracket is adapted to mate with the corresponding panel type.

Abstract: A ladder tray assembly includes a case that has a recess integrated therein. A lid is hingedly coupled to the case for opening and closing the case. A pole is extendable through the case and the pole is inserted into a rung of a ladder thereby mounting the case to the ladder. A case member is coupled to and extends away from the case and a grip is coupled to the case member. The grip extends around the pole when the pole is extended through the case and the grip extends around the rung through which the pole is extended. A pair of storage units is each attachable to the lid when the lid is in an open position to facilitate tools stored in the storage units to be accessible to a user.

Abstract: Halogenated analogs of 5-aza-2?-deoxycytidine, such as halogenated analogs of 5-aza-4?-thio-2?-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated analogs to inhibit neoplasia are described.

Abstract: The invention relates to process for the preparation of grapiprant and its intermediates thereof. The invention also relates to grapiprant having a purity 98% or more and compounds of Formula (A), (B), (C) and (D) in an amount of 0.5 or less, relative to grapiprant, by area percentage of HPLC. The invention also relates to an amorphous form of grapiprant and process for preparation thereof.