Patents Examined by Lakshmi Channavajjala
  • Multi-layered microcapsules and method of preparing same
    Patent number: 7157102
    Abstract: A multi-layered microcapsule containing one or more active ingredients and process for preparing the same is disclosed. The multi-layered microcapsule comprises an inner solid microparticle core, typically composed of a biodegradable polymer, and having one or more alternating layers of polymer, active ingredient or polymer/active ingredient mixtures to produce a multi-layered microcapsule wherein the polymer or active ingredient in each layer may be the same or different or have the same or different concentration of the polymer or active ingredient in other layers.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: January 2, 2007
    Assignee: Biotek, Inc.
    Inventor: Elie S. Nuwayser
  • Methods for preventing photodamaged skin by administering selegiline or desmethylselegiline
    Patent number: 7147864
    Abstract: The present invention is directed to methods that can be used in the treatment of wounds, burns, and photodamaged skin. Methods can be used for both humans and animals and involve the administration of compositions containing selegiline and/or desmethylselegiline.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: December 12, 2006
    Assignee: Somerset Pharmaceuticals, Inc.
    Inventor: Mark G. Resnick
  • S(+) desmethylselegiline and its use to treat narcolepsy
    Patent number: 7144584
    Abstract: The present invention provides novel compositions and methods for using the S(+) enantiomer of desmethylselegiline (N-methyl-N-(prop-2-ynyl)-2-aminophenylpropane), for the treatment of selegiline-responsive diseases and conditions. Diseases and conditions responsive to selegiline include those produced by neuronal degeneration or neuronal trauma and those due to immune system dysfunction. Effective dosages are a daily dose of at least about 0.015 mg/kg of body weight.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: December 5, 2006
    Inventor: Anthony R. DiSanto
  • Compositions and techniques for localized therapy
    Patent number: 7135189
    Abstract: A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: November 14, 2006
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: David Knapp
  • Transnasal anticonvulsive compositions and modulated process
    Patent number: 7132112
    Abstract: A novel method of vehicle modulated administration of an anticonvulsive agent to the mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol (10–80%) or a glycol (10–80%), and their combinations with a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: November 7, 2006
    Assignee: SK Corporation
    Inventors: Yong Moon Choi, Lianli Li, Kwon H. Kim
  • Pharmaceutical composition containing fenofibrate and the preparation method
    Patent number: 7101574
    Abstract: The invention concerns a pharmaceutical composition containing micronized fenofibrate, a surfactant and a binding cellulose derivative, as solubilizing adjuvant, preferably hydroxypropylmethylcellulose. The cellulose derivative represents less than 20 wt. % of the composition. The association of micronized fenofibrate with a binding cellulose derivative, as solubilizing adjuvant and a surfactant enables enhanced bioavailability of the active principle. The invention also concerns a method for preparing said composition without using any organic solvent.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: September 5, 2006
    Assignee: Laboratoires des Produits Ethiques Ethypharm
    Inventors: Bruno Criere, Pascal Suplie, Philippe Chenevier
  • Coated filter bag material for oral administration of medicament in liquid and methods of making same
    Patent number: 7090858
    Abstract: A coated filter bag for use in cold or hot drinks, in particular, a novel method for administration of pharmaceutical actives, supplemental nutrients, genetically derived materials, or other beneficial agents using a coated filter bag that includes at least one agent that solubilizes when in contact with liquid and is dispersed in the proper dosage amount into the liquid for oral consumption.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: August 15, 2006
    Inventor: Swaminathan Jayaraman
  • No-synthase inhibitors
    Patent number: 7083799
    Abstract: The use of an effective amount of at least one nitric oxide synthase inhibitor in a cosmetic composition or for making a pharmaceutical composition is disclosed, said inhibitor or pharmaceutical composition being intended to reduce the skin irritant effect of topically applied cosmetic or pharmaceutical substances. A cosmetic or pharmaceutical composition containing an effective amount of at least one nitric oxide synthase inhibitor, and a cosmetic treatment method using said cosmetic composition, are also disclosed.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: August 1, 2006
    Assignee: L'Oreal
    Inventor: Paolo Giacomoni
  • Hydrogel biomedical articles
    Patent number: 7070809
    Abstract: Hydrogel biomedical articles formed from macromers having a polymeric backbone comprising 1,2-diol and/or 1,3-diol units, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: July 4, 2006
    Assignee: BioCure, Inc.
    Inventors: Dennis W. Goupil, Hassan Chaouk, Troy Holland, Bruktawit T. Asfaw, Stephen D. Goodrich, Lucas Latini
  • Hair bleach product
    Patent number: 7056497
    Abstract: The present invention relates to a substantially ammonia free hair bleach product. Specifically, the invention concerns hair bleach products that comprise a hydrogen peroxide developer; a powder activator containing a mixed persulfate oxidizing system, and a monoethanolamine alkalizing agent.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: June 6, 2006
    Assignee: The Procter & Gamble Company
    Inventors: Anne Marie Lenzi-Brangi, Mary Larkin, Stephen Casperson
  • Timed pulsatile drug delivery systems
    Patent number: 7048945
    Abstract: A pharmaceutical dosage form such as a capsule capable of delivering therapeutic agents into the body in a time-controlled or position-controlled pulsatile release fashion, is composed of a multitude of multicoated particulates (beads, pellets, granules, etc.) made of one or more populations of beads. Each of these beads except an immediate release bead has at least two coated membrane barriers. One of the membrane barriers is composed of an enteric polymer while the second membrane barrier is composed of a mixture of water insoluble polymer and an enteric polymer. The composition and the thickness of the polymeric membrane barriers determine the lag time and duration of drug release from each of the bead populations. Optionally, an organic acid containing intermediate membrane may be applied for further modifying the lag time and/or the duration of drug release.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 23, 2006
    Assignee: Eurand Pharamaceuticals, Ltd.
    Inventors: Phillip J. Percel, Krishna S. Vishnupad, Gopi M. Venkatesh, Der Yang Lee
  • Use of moxonidine for postmyocardial infarction treatment
    Patent number: 7041303
    Abstract: A method of treating myocardial damage secondary to myocardial infarction using moxonidine or a physiologically compatible salt thereof. Pharmaceutical preparations containing moxonidine and its physiologically compatible acid addition salts are suitable for use in acute myocardial infarction and/or postmyocardial infarction management. In addition to a beneficial influence, promoting recovery and/or rehabilitation, on the myocardial status following myocardial infarction, moxonidine and its physiologically compatible acid addition salts, especially when used in the management of postmyocardial infarction patients in the chronic stage, also show a preventive effect against the progression of heart failure after myocardial infarction.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: May 9, 2006
    Assignee: Solvay Pharmaceuticals GmbH
    Inventor: Regina Geertruida Schoemaker
  • Antimycotic nail varnish composition
    Patent number: 7033578
    Abstract: The present invention relates to a composition comprising a) at least one antimycotic agent and b) at least one film forming agent wherein component b) is a derivative of chitosan selected from hydroxyalkylchitosans and carboxyalkylchitosans and its use as a nail varnish. The present invention is further directed to the use of a water soluble film forming agent selected from hydroxyalkylchitosans and carboxyalkylchitosans as an additive in a nail varnish.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: April 25, 2006
    Assignee: Polichem S.A.
    Inventor: Federico Mailland
  • Parenteral formulation for epothilone analogs
    Patent number: 7022330
    Abstract: A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog and the resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil and a preferred diluent is Lactated Ringer's Injection.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rebanta Bandyopadhyay, Timothy M. Malloy, Andrea Panaggio, Krishnaswamy Srinivas Raghavan, Sailesh Amilal Varia
  • High dose solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate and process for making same
    Patent number: 7014866
    Abstract: A solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate is provided comprising amorphous nelfinavir mesylate in an amount of from about 400 mg to about 700 mg calculated as nelfinavir base, and a pharmaceutically acceptable water soluble, non-ionic synthetic block copolymer of ethylene oxide and propylene oxide, the copolymer having a melting point of at least about 45° C. and an HLB value at 25° C. of from about 18 to about 29, wherein the copolymer is present from about 40% to about 65% by weight of the nelfinavir mesylate. A hot melt granulation process for making the dosage form is provided.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: March 21, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Howard Infeld, Wantanee Phuapradit, Navnit Hargovindas Shah, Lin Zhang
  • Prodrug compositions and drug delivery methods using synthetic receptors
    Patent number: 7005132
    Abstract: The present invention provides prodrug and multiprodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence of a targeted pathophysiologic receptor. Methods for preparation end use of these prodrug complexes in drug delivery systems are also provided.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: February 28, 2006
    Assignee: Molecular Machines, Inc.
    Inventor: Roger S. Cubicciotti
  • Oral drug delivery compositions and methods
    Patent number: 7005141
    Abstract: The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: February 28, 2006
    Assignee: Emisphere Technologies Inc.
    Inventors: Sam J. Milstein, Evgueni N. Barantsevitch, Donald J. Sarubbi, Andrea Leone-Bay, Duncan R. Paton
  • Scalp cosmetic compositions and corresponding methods of application to provide scalp moisturization and skin active benefits
    Patent number: 7001594
    Abstract: Disclosed are topical leave-on cosmetic compositions, including packaged leave-on compositions, for direct application to the scalp, comprising a) from about 40% to about 99% by weight of a volatile liquid, b) from about 0.005% to about 20% by weight of a skin active agent, and c) from about 0.1% to about 20% by weight of a moisturizing material, preferably a liquid humectant. The composition is a leave-on formulation that is substantially free of cleansing surfactants and is applied directly to the scalp. Also disclosed are methods of treating the scalp by directly applying the topical composition to the scalp. It has been found that the compositions and methods of the present invention can provide improved scalp moisturization and improved deposition of an anti-dandruff or other skin active agent on the skin, without unduly affecting hair cosmetics.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: February 21, 2006
    Assignee: The Procter & Gamble Company
    Inventors: Marjorie Mossman Peffly, Anthony Raymond Marchetta
  • Composition for the relief of heat stress
    Patent number: 7001612
    Abstract: A composition for the relief of heat stress, particularly for restoration of electrolyte balance due to passive exposure to heat resulting in excessive transpiration/perspiration, without strenuous physical activity, contains predetermined levels of selected electrolytes including, in part by weight, sodium ion not exceeding 250 parts, at least 100 parts of potassium ion, at least 100 parts of magnesium ion, and carbohydrates not exceeding 2.5% by weight, as needed for organoleptic purposes only. The composition can further include up to 30 parts of zinc, up to 10 parts of manganese, and from 65 to 400 parts of calcium. Furthermore, the composition can contain oligoelements, dermoprotective vitamins and anti-oxidants so as to compensate for the chemical changes which might occur in the skin of a person passively exposed to heat.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: February 21, 2006
    Assignee: All Sun HSF Company Limited
    Inventors: Fausto Armonti, Donato Mitola, Jacobus C. Samson
  • Multi-layered osmotic device
    Patent number: RE39069
    Abstract: The present invention provides a simple and improved multi-layered osmotic device (1) that is capable of delivering a first active agent in an outer lamina (2) to one environment of use and a second active agent in the core (5) to another environment of use. Particular embodiments of the invention provide osmotic devices in which the first and second active agents are similar or dissimilar. An erodible polymer coat (3) between an internal semipermeable membrane (4) and a second active agent-containing external coat (2) comprises poly(vinylpyrrolidone)-(vinyl acetate) copolymer. This particular erodible polymer results in an improved multi-layered osmotic device possessing advantages over related devices known in the art. The active agent in the core (5) is delivered through a pore (6) containing an erodible plug (7). The osmotic device (1) can be coated by a final finish coat (8).
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: April 18, 2006
    Assignee: Osmotica Corp.
    Inventors: Joaquina Faour, Jorge E. Mayorga