Abstract: A sensor for detecting infiltration at a catheter infusion site may include a first elongate sensor member couplable to a first location proximate the catheter infusion site, and a second elongate sensor member couplable to a second location proximate the catheter infusion site. The first elongate sensor member may include a first marking and the second elongate sensor member may include a second marking. The first elongate sensor member may slidably couple with and translate relative to the second elongate sensor. The first and second markings may indicate a range of relative positions between the first and second elongate sensor members as the first and second elongate sensor members translate relative to each other. At least one relative position within a range of relative positions between the first and second elongate sensor members may be indicative of infiltration at the catheter infusion site.

Abstract: An apparatus, a system and methods are disclosed in relation to the configuration and compatibility of a removable delivery section of the apparatus, and delivering a substance via the apparatus to an animal. In an aspect, a hand held apparatus for delivering a substance to an animal includes a removable delivery section including a delivery arrangement adapted to deliver the substance to the animal; and a drive section including a drive arrangement adapted to actuate the delivery arrangement in a coupled condition in which the removable delivery section is coupled to the drive section. The delivery section includes an electronic device adapted to communicate with a control system associated with at least the drive section in the coupled condition, the electronic device being configurable so to be readable by the control system such that the control system is able to identify and operate the removable delivery section.

Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A medicament delivery device includes a body having a proximal end and a distal end, in turn comprising a distal housing part, and a medicament container holder, adapted to receive a medicament container; a dose setting drum for setting a dose when rotated in a first direction and for delivering a dose when rotated in a second direction, and a drive drum sleeve selectively operably connectable to a piston plunger for delivering a dose.

Abstract: A handheld injection device includes a housing containing a cartridge, a dose setting means being operable in a first direction to set a desired dose to be dispensed, a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from the cartridge, and a first clicker component, which is largely rotationally constrained to the housing, and a second clicker component, which is rotatable relative to the housing during dose dispensing. The clicker components are adapted to contact each other only at the end of dispensing of a set dose to thereby provide an audible and/or tactile first feedback to a user. The first clicker component is displaceable relative to the housing between a proximal dose setting position and a distal dose dispensing position.

Abstract: Polymeric tubing, for use with catheters or other medical devices, where the polymeric tubing can have regions of customized properties including, but not limited to, durometer, torque control, flexibility, axial strength, stiffness, etc. One variation of the device allows for transitions between regions to be configured such that there can be gradual or customized transitions between various regions such that the structural characteristics differential between the regions are selectively designed. Additional variations include outer layers having a plurality of material sections extending in a spiral direction along the axial length to form a continuous wall of the outer layer. In certain variations, the structural characteristic differential is minimized or eliminated as compared to conventional catheters.

Abstract: A surgical cannula assembly includes an elongate cannula member having a plurality of longitudinal ribs extending along the longitudinal axis with adjacent longitudinal ribs defining a longitudinal channel therebetween, a fluid port mounted adjacent the proximal end of the cannula member and configured for coupling to a source of inflation fluids, a conduit positioned within at least one longitudinal channel of the cannula member and in fluid communication with the fluid port, and an expandable balloon mounted adjacent the distal end of the cannula member and in fluid communication with the conduit. The expandable balloon is configured to transition from an initial unexpanded condition to an at least partially expanded condition upon passage and entry of inflation fluids from the fluid port, through the conduit and within an internal volume of the expandable balloon.

Abstract: A drug applicator for a system for ultrasound-enhanced delivery of at least one drug to a target site in a intraocular space, the system comprising a signal generating unit operationally connected to an ultrasound transducer, wherein the drug applicator comprises at least one space hold the drug, is made from a low ultrasound attenuation material, is configured to provide low ultrasound loss coupling of the system to the sclera, and is configured to be mechanically coupled to the system and further configured to be coupled to the ultrasound transducer with low ultrasound loss. The signal generating unit and/or the ultrasound transducer are configured to emit an ultrasound wave form in at least one application cycle, the application cycle comprising at least one ultrasound emitting event with a time duration TA and a waiting period with a time duration TW.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: A syringe or medical device, especially adapted and suited for use with children, having a label with non-transparent and transparent portions positioned on the syringe or medical device so as to avoid covering measurement graduations or indicia needed by a medical practitioner for performing a medical procedure, such as an injection or blood collection, and using attention grabbing graphic images on the non-transparent portion of the label for distracting the patient's attention from fluids and/or hypodermic needles involved in the medical procedure.

Abstract: A system is disclosed. The system includes a reservoir for containing a fluidic medium, the reservoir including a front surface, a resilient cylindrical flexure portion connected to the front surface, the resilient cylindrical flexure portion comprising an accordion-like structure that is able to expand and contract to change an interior volume within the resilient cylindrical flexure portion, a central passageway within the resilient cylindrical flexure, and a collection chamber connected to the central passageway. Also, a system including a reservoir, a plunger head located within the reservoir, a plunger arm connected to the plunger head, a driving shaft connected to the plunger arm, and a motor connected to the driving shaft, the motor controllable to move the drive shaft in a first motion and a second motion so as to move the advance plunger head and retract the plunger head within the reservoir.

Abstract: A direct sodium removal (“DSR”) infusate regimen and methods of use are provided for removing sodium and reducing fluid overload in patients with severe renal dysfunction and/or heart failure, in which a patient has at least a first DSR session with a first DSR infusate having no or low sodium that is instilled into a patient's peritoneal cavity for a first dwell period to cause sodium and excess fluid to migrate to the patient's peritoneal cavity, and thereafter, the patient may undergo conventional dialysis to rebalance the patient's fluid and sodium levels.

Abstract: A non-occluding drug-coated balloon catheter device for use in a blood vessel transporting blood comprises a catheter shaft including a guidewire lumen, a fluid lumen and a connector port. A balloon is mounted on the catheter shaft and includes an outer envelope surrounding the guidewire lumen in fluid communication with the fluid lumen; a drug coating applied on the exterior surface of the outer envelope; and at least one bypass lumen forming a passage extending from the proximal end of the outer envelope to the distal end of the outer envelope. When the balloon is positioned in a blood vessel and inflated, the exterior surface of the outer envelope presses the drug coating against the blood vessel and the bypass lumen is open between the distal end of the outer envelope and the proximal end of the outer envelope such that blood transport continues through the bypass lumen.

Abstract: System and methods are provided for harvesting one or more organs, e.g., a lung from a donor body. In one embodiment, a distal end of a tubular member is introduced into the donor body's vasculature via a percutaneous access site, and the tubular member is manipulated until the distal end of the tubular member is disposed within the thoracic duct. Fluid is removed from the thoracic duct through the tubular member to a location exterior to the patient's body, and one or more organs are removed from the donor body. Optionally, one or more parameters within the thoracic duct or other parameters of the donor body may be monitored and fluid removal may be adjusted to reduce fluid accumulation within the one or more organs.

Abstract: The present application relates to pressure sensors for injection devices. According to a first aspect, the specification discloses an injection device comprising: a medicament container comprising medicament container walls and a sealing element; a stopper translatably disposed inside the medicament container; a pressure sensor; and a plunger passing through an axial bore of the sealing element, the plunger being operable to displace the stopper, wherein the sealing element, stopper and medicament container walls define a cavity inside the medicament container; and wherein the pressure sensor is configured to measure the pressure inside the cavity during an injection.

Abstract: A drug tracking device used in combination with a drug injection device. The drug tracking device may comprise a housing configured to engage with the drug injection device, an optical sensor configured to capture an image of a portion of the drug injection device. The portion of the drug injection device displays indicia of drug doses, such that a captured image includes at least one indicia of a drug dose. The drug tracking device may include a memory module having pre-stored indicia of drug doses, and a processor having instructions operating thereon configured to cause the processor to determine an injected drug dose by comparing at least one indicia of the drug dose in the captured image with the pre-stored indicia of drug doses.

Abstract: A drug solution administration method using an inkjet device including an inkjet head that ejects a drug solution, and a controller that controls the ejection of the drug solution from the inkjet head, wherein the drug solution is made to pierce a target site and is administered to the target site by ejecting the drug solution from the inkjet head so that a diameter of the drug solution when it is ejected from the inkjet head is 20 ?m or more and 200 ?m or less and an ejection rate of the drug solution when it is ejected from the inkjet head is 30 m/s or more under control of the controller.

Abstract: A stabilization device for a low-profile feeding device may include a pad and a stabilizer body. The low-profile feeding device may have a tube, an external bolster, and an internal bolster. The pad may include an opening extending from a top surface to a bottom surface thereof and configured for receiving the tube therethrough. The stabilizer body may be fixedly attached to the top surface of the pad and configured for extending over the external bolster. The stabilizer body may include a cavity configured for receiving a base portion of the external bolster therein, an opening extending from the cavity to a top surface of the stabilizer body and configured for allowing access to an access port of the external bolster, and a slit extending from the top surface toward a bottom surface of the stabilizer body and from the opening to a first end of the stabilizer body.